Tuesday, April 5, 2022

Parasites thrive if hosts survive

The Australian native social parasitic bee Inquilina and its host Exoneura
Credit: Flinders University

Like diseases affecting humans, parasites can wage a deadly evolutionary ‘arms race’ against their hosts. But can hosts and parasites upgrade their weapons at the same rate?

The parasite bee and host species have evolved in complementary ways.

This can be a very unequal battle for two reasons, Flinders University researchers say. If the parasite is too successful it will wipe out its host, and therefore lose its only means of surviving.

At the same time, evolutionary ‘wars’ between hosts and their parasites depend on their rates of evolution; we can think of that as their ability to ‘upgrade their weapons’, says Associate Professor Mike Schwarz, from the College of Science and Engineering.

The Flinders University study examined this conundrum by examining a native Australian social bee (Exoneura) and its social parasite, another bee (Inquilina).

“These parasitic species spend their entire life cycle within the nest of the host species and have extreme adaptations to social parasitism, they are not able to survive without their hosts,” says first author Dr Nahid Shokri-Bousjein in an article in Ecology and Evolution.

The ability of species to adapt to existential challenges depends on their ability to ‘discover’ new strategies via random mutations.

The more individuals in a species, the greater the likelihood that a favorable mutation will arise amongst one of them, and that means that species with larger populations should generally win any “wars” against their enemies. So, what happens when species and their parasites or pathogens have very different population sizes?

“We can see this problem play out with COVID-19. The virus has a much bigger population size than its host (us!), so its ability to evolve around our defenses is great,” says co-author Associate Professor Mike Schwarz. “We see this in terms of new COVID variants emerging and then spreading.”

The native bee colonies exist in small pockets of southern Australia, including in parts of Victoria’s Dandenong Ranges.

But what happens when the pathogen has very small population sizes? “In our previous studies, we found that the population sizes of the parasite species are an order of magnitude lower than their host. Surprisingly, our analyses of molecular data showed that rates of evolution were similar between host and parasite.”

Associate Professor Schwarz says that “evolutionary wars between species and their enemies may be much more complex than we have thought”.

“Large population sizes might allow more strategies to arise, but maybe the critical issue is how effective those strategies are.

“Species like these bee social parasites are on the very edge of survival: they might tell us something about how you can survive when your very existence is under threat.

“There might be some lessons we can learn from these bees as we deal with the covid-19 pandemic.”

The article, ‘Does effective population size affect rates of molecular evolution: Mitochondrial data for host/parasite species pairs in bees suggests not’ (2022) by Nahid Shokri Bousjein, Simon M Tierney, Michael G Gardner and Michael P Schwarz has been published in Ecology and Evolution DOI: 10.1002/ece3.8562

Source/Credit: Flinders University