Three-dimensional image of noradrenergic nerve cells in the envelope of locus coeruleus. Photo credit: Gilvesy et al. |
With the help of a new imaging technique for 3D, researchers at Karolinska Institutet, among others, have been able to characterize a part of the brain that shows the most accumulation of tau protein, an important biomarker for the development of Alzheimer's disease. The results published in the journal Acta Neuropathologica may in the future make it possible to have a more accurate neuropathological diagnosis of Alzheimer's disease spectrum at a very early stage.
Intracellular accumulation of pathological tau protein in the brain is a hallmark of several age-related neurodegenerative diseases, including Alzheimer's disease, which accounts for 60-80 percent of all dementia cases worldwide.
In a new study, researchers at Karolinska Institutet, SciLifeLab in Stockholm and several universities from Hungary, Canada, Germany and France have applied a state-of-the-art immune imaging technology, in combination with light sheet microscopy, to investigate a human brain stem core, locus coeruleus, which is an important core in the mammalian brain.