Nasal drops fight brain tumors noninvasively

Researchers at WashU Medicine have developed a noninvasive medicine delivered through the nose that successfully eliminated deadly brain tumors in mice. The medicine is based on a spherical nucleic acid, a nanomaterial (labeled red) that travels along a nerve (green) from the nose to the brain, where it triggers an immune response to eliminate the tumor.
Image Credit: Courtesy of Alexander Stegh

Researchers at Washington University School of Medicine in St. Louis, along with collaborators at Northwestern University, have developed a noninvasive approach to treat one of the most aggressive and deadly brain cancers. Their technology uses precisely engineered structures assembled from nano-size materials to deliver potent tumor-fighting medicine to the brain through nasal drops. The novel delivery method is less invasive than similar treatments in development and was shown in mice to effectively treat glioblastoma by boosting the brain’s immune response.

Glioblastoma tumors form from brain cells called astrocytes and are the most common kind of brain cancer, affecting roughly three in 100,000 people in the U.S. Glioblastoma generally progresses very quickly and is almost always fatal. There are no curative treatments for the disease, in part because delivering medicines to the brain remains extremely challenging.

Rice engineers show lab grown diamond films can stop costly mineral buildup in pipes

Pulickel Ajayan and Xiang Zhang
Photo Credit: Jeff Fitlow/Rice University

In industrial pipes, mineral deposits build up the way limescale collects inside a kettle ⎯ only on a far larger and more expensive scale. Mineral scaling is a major issue in water and energy systems, where it slows flow, strains equipment and drives up costs.

A new study by Rice University engineers shows that lab-grown diamond coatings could resolve the issue, providing an alternative to chemical additives and mechanical cleaning, both of which offer only temporary relief and carry environmental or operational downsides.

“Because of these limitations, there is growing interest in materials that can naturally resist scale formation without constant intervention,” said Xiang Zhang, assistant research professor of materials science and nanoengineering and a first author on the study alongside Rice postdoctoral researcher Yifan Zhu. “Our work addresses this urgent need by identifying a coating material that can ‘stay clean’ on its own.”

Innovation turns building vents into carbon-capture devices

A carbon nanofiber-based direct air capture filter developed by the University of Chicago Pritzker School of Molecular Engineering could turn existing building ventilation systems into carbon-capture devices while cutting homeowners’ energy costs. Through life cycle assessment, the air filter shows a carbon removal efficiency of 92.1% from cradle to grave.
Photo Credit: Elaina Eichorn

With a newly developed nanofiber filter, air conditioners, heaters and other HVAC systems could remove airborne carbon dioxide while cutting energy costs

A nanofiber air filter developed at the University of Chicago could turn existing building ventilation into carbon-capture devices while cutting homeowners’ energy costs.

In a paper recently published in Science Advances, researchers from the lab of Asst. Prof. Po-Chun Hsu in the Pritzker School of Molecular Engineering (UChicago PME) developed a distributed carbon nanofiber direct air capture filter that could potentially turn every home, office, school or other building into a small system working toward the global problem of airborne carbon dioxide.

A life-cycle analysis shows that—even after factoring this extra CO2 released by everything from manufacture and transportation to maintenance and disposal—the new filter is more than 92% efficient in removing the gas from the air.

A system for targeted drug delivery using magnetic microrobots

Microrobots can be transported and activated in a safe and controlled manner, marking a decisive step forward in the use of these technological devices in targeted medical treatments.
Photo Credit: Courtesy of University of Barcelona

The study, led by the Swiss Federal Institute of Technology Zurich (ETH Zurich) and published in the journal Science, involves Professor Josep Puigmartí-Luis from the Faculty of Chemistry and the Institute of Theoretical and Computational Chemistry (IQTC) of the University of Barcelona. He is the only researcher from a Spanish institution to sign this paper, which is the result of the European ANGIE project, an initiative coordinated by Professor Salvador Pané (ETH) in collaboration with the Chemistry In Flow and Nanomaterials Synthesis (ChemInFlow) research group, led by Professor Puigmartí. 

The new microrobotic platform presents an innovative strategy for administering drugs in a precise and targeted manner. It is scalable and can be applied to numerous situations in which the administration of therapeutic agents is difficult to access, such as tumors, arteriovenous malformations, localized infections, or tissue injuries. 

Nanorobots transform stem cells into bone cells

Prof. Berna Özkale Edelmann, together with researchers at her Microrobotic Bioengineering Lab at the Technical University of Munich (TUM), developed a system in which stem cells can be transformed into bone cells through mechanical stimulation.
Photo Credit: Astrid Eckert / Technische Universität München

For the first time, researchers at the Technical University of Munich (TUM) have succeeded in using nanorobots to stimulate stem cells with such precision that they are reliably transformed into bone cells. To achieve this, the robots exert external pressure on specific points in the cell wall. The new method offers opportunities for faster treatments in the future.

Prof. Berna Özkale Edelmann’s nanorobots consist of tiny gold rods and plastic chains. Several million of them are contained in a gel cushion measuring just 60 micrometers, together with a few human stem cells. Powered and controlled by laser light, the robots, which look like tiny balls, mechanically stimulate the cells by exerting pressure. “We heat the gel locally and use our system to precisely determine the forces with which the nanorobots press on the cell – thereby stimulating it,” explains the professor of nano- and microrobotics at TUM. This mechanical stimulation triggers biochemical processes in the cell. Ion channels change their properties, and proteins are activated, including one that is particularly important for bone formation.

New nanomedicine wipes out leukemia in animal study

The real-time cellular uptake of spherical nucleic acids (SNAs) and fusion with leukemia cells’ lysosomes, where the SNAs degrade and release potent chemotherapeutics. SNAs are shown in red; cells’ cytoskeletons are green; and cells’ nuclei are blue.
Video Credit: Chad A. Mirkin Research Group

In a promising advance for cancer treatment, Northwestern University scientists have re-engineered the molecular structure of a common chemotherapy drug, making it dramatically more soluble and effective and less toxic.

In the new study, the team designed a new drug from the ground up as a spherical nucleic acid (SNA) — a nanostructure that weaves the drug directly into DNA strands coating tiny spheres. This design converts a poorly soluble, weakly performing drug into a powerful, targeted cancer killer that leaves healthy cells unharmed.

Nanopore signals, machine learning unlocks new molecular analysis tool

Illustration of voltage-matrix nanopore profiling. The artistic rendering depicts proteins (colored shapes) being analyzed by solid-state nanopores under varying voltage conditions. By combining nanopore signals with machine learning, researchers can discriminate protein mixtures and detect changes in molecular populations.
Image Credit: ©2025 Sotaro Uemura, The University of Tokyo

Understanding molecular diversity is fundamental to biomedical research and diagnostics, but existing analytical tools struggle to distinguish subtle variations in the structure or composition among biomolecules, such as proteins. Researchers at the University of Tokyo have developed a new analytical approach, which helps overcome this problem. The new method, called voltage-matrix nanopore profiling, combines multivoltage solid-state nanopore recordings with machine learning for accurate classification of proteins in complex mixtures, based on the proteins’ intrinsic electrical signatures.

The study, published in Chemical Science, demonstrates how this new framework can identify and classify “molecular individuality” without the need for labels or modifications. The research holds promise of providing a foundation that could lead to more advanced and wider applications of molecular analysis in various areas, including disease diagnosis.

DNA nanospring measures cellular motor power

Experimental design for the force measurement of KIF1A.
An inert protein known as KIF5B serves as the anchor from which KIF1A pulls the nanospring. As with more familiar springs, the extended length correlates with the force being applied. But in this case, the DNA nanospring is also labeled with fluorescent molecules which give away how far it stretches to make visualization of KIF1A’s motile strength possible.
Image Credit: ©2025 Hayashi et al
(CC BY-ND 4.0)

Cells all require the transport of materials to maintain their function. In nerve cells, a tiny motor made of protein called KIF1A is responsible for that. Mutations in this protein can lead to neurological disorders, including difficulties in walking, intellectual impairment and nerve degradation. It’s known that mutations in KIF1A also result in a weakened motor performance, but this has been difficult to measure so far. Researchers including those from the University of Tokyo and the National Institute of Information and Communications Technology (NICT) in Japan have measured changes in the force of KIF1A using a nanospring, a tiny, coiled structure, made of DNA which could lead to improved diagnosis of diseases related to the protein’s mutations.

Scientists uncover room-temperature route to improved light-harvesting and emission devices

Dasom Kim
Photo Credit: Jorge Vidal/Rice University

Atoms in crystalline solids sometimes vibrate in unison, giving rise to emergent phenomena known as phonons. Because these collective vibrations set the pace for how heat and energy move through materials, they play a central role in devices that capture or emit light, like solar cells and LEDs.

A team of researchers from Rice University and collaborators have found a way to make two different phonons in thin films of lead halide perovskite interact with light so strongly that they merge into entirely new hybrid states of matter. The finding, reported in a study published in Nature Communications, could provide a powerful new lever for controlling how perovskite materials harvest and transport energy.

To get a specific light frequency in the terahertz range to interact with phonons in the halide perovskite crystals, the researchers fabricated nanoscale slots ⎯ each about a thousand times thinner than a sheet of cling wrap ⎯ into a thin layer of gold. The slots acted like tiny metallic traps for light, tuning its frequency to that of the phonons and thus giving rise to a strong form of interaction known as “ultrastrong coupling.”

Supercharging vinegar’s wound healing power

Image Credit: Courtesy of Flinders University

A new study suggests adding microscopic particles to vinegar can make them more effective against dangerous bacterial infections, with hopes the combination could help combat antibiotic resistance.

The research, led by researchers at QIMR Berghofer, Flinders University and the University of Bergen in Norway, has resulted in the ability to boost the natural bacterial killing qualities of vinegar by adding antimicrobial nanoparticles made from carbon and cobalt.

Wounds that do not heal are often caused by bacterial infections and are particularly dangerous for the elderly and people with diabetes, cancer and other conditions.

Acetic acid (more commonly known as vinegar) has been used for centuries as a disinfectant, but it is only effective against a small number of bacteria, and it does not kill the most dangerous types.

The findings have been published in the international journal ACS Nano.

Scientists visualize atomic structures in moiré materials

On the left is an artistic depiction of a twisted double layer forming a moiré pattern created by overlapping 2D sheets; each layer’s structure is shown separately on the right.
Image Credit: Sumner Harris/ORNL, U.S. Dept. of Energy

Researchers with the Department of Energy’s Oak Ridge National Laboratory and the University of Tennessee, Knoxville, have created an innovative method to visualize and analyze atomic structures within specially designed, ultrathin bilayer 2D materials. When precisely aligned at an angle, these materials exhibit unique properties that could lead to advancements in quantum computing, superconductors and ultraefficient electronics.

These developments bolster U.S. leadership in materials innovation, energy technologies and secure communication, and they lay the groundwork for a future defined by leading-edge progress.

Shining a light on germs

Microbe hunters: Empa researchers Paula Bürgisser and Giacomo Reina from the Nanomaterials in Health laboratory in St. Gallen.
Photo Credit: Empa

Light on – bacteria dead. Disinfecting surfaces could be as simple as that. To turn this idea into a weapon against antibiotic-resistant germs, Empa researchers are developing a coating whose germicidal effect can be activated by infrared light. The plastic coating is also skin-friendly and environmentally friendly. A first application is currently being implemented for dentistry.

Antibiotic-resistant bacteria and emerging viruses are a rapidly increasing threat to the global healthcare system. Around 5 million deaths each year are linked to antibiotic-resistant germs, and more than 20 million people died during the COVID-19 virus pandemic. Empa researchers are therefore working on new, urgently needed strategies to combat such pathogens. One of the goals is to prevent the spread of resistant pathogens and novel viruses with smart materials and technologies.

Surfaces that come into constant contact with infectious agents, such as door handles in hospitals or equipment and infrastructure in operating theaters, are a particularly suitable area of application for such materials. An interdisciplinary team from three Empa laboratories, together with the Czech Palacký University in Olomouc, has now developed an environmentally friendly and biocompatible metal-free surface coating that reliably kills germs. The highlight: The effect can be reactivated again and again by exposing it to light.

Collection of tiny antennas can amplify and control light polarized in any direction

New polarization-independent, highly resonant metasurfaces can precisely amplify and control light without requiring incoming light (top left) to be oriented and traveling in a certain direction.
Image Credit: Bo Zhao

Antennas receive and transmit electromagnetic waves, delivering information to our radios, televisions, cell phones and more. Researchers in the McKelvey School of Engineering at Washington University in St. Louis imagines a future where antennas reshape even more applications.

Their new metasurfaces, ultra-thin materials made of tiny nanoantennas that can both amplify and control light in very precise ways, could replace conventional refractive surfaces from eyeglasses to smartphone lenses and improve dynamic applications such as augmented reality/virtual reality and LiDAR.

While metasurfaces can manipulate light very precisely and efficiently, enabling powerful optical devices, they often suffer from a major limitation: Metasurfaces are highly sensitive to the polarization of light, meaning they can only interact with light that is oriented and traveling in a certain direction. While this is useful in polarized sunglasses that block glare and in other communications and imaging technologies, requiring a specific polarization dramatically reduces the flexibility and applicability of metasurfaces.

Nanomaterials are emerging as a powerful tool for coastal oil spill cleanup

Oil Spill
Image Credit: Gemini 

Cleaning up after a major oil spill is a long, expensive process, and the damage to a coastal region’s ecosystem can be significant. This is especially true for the world’s Arctic region, where newly opened sea lanes will expose remote shorelines to increased risks due to an anticipated rise in sea traffic.

Current mitigation techniques even in heavily populated regions face serious limitations, including low oil absorption capacity, potential toxicity to marine life and a slow remediation process.

However, advances in nanotechnology may provide solutions that are more effective, safer and work much faster than current methods. That’s according to a new paper in Environmental Science: Nano by a Concordia-led team of researchers.

“Using nanomaterials as a response method has emerged as a promising sustainable approach,” says lead author Huifang Bi, a PhD candidate in the Department of Building, Civil and Environmental Engineering at the Gina Cody School of Engineering and Computer Science.

Better digital memories with the help of noble gases

Adding the noble gas xenon when manufacturing digital memories enables a more even material coating even in small cavities.
Photo Credit: Olov Planthaber

The electronics of the future can be made even smaller and more efficient by getting more memory cells to fit in less space. One way to achieve this is by adding the noble gas xenon when manufacturing digital memories. This has been demonstrated by researchers at Linköping University in a study published in Nature Communications. This technology enables a more even material coating even in small cavities.

Twenty-five years ago, a camera memory card could hold 64 megabytes of information. Today, the same physical size memory card can hold 4 terabytes – over 60,000 times more information.

An electronic storage space, such as a memory card, is created by alternating hundreds of thin layers of an electrically conductive and an insulating material. A multitude of very small holes are then etched through the layers. Finally, the holes are filled with a conductive material. This is done by using a technique in which vapors of various substances are used to create thin material layers.

Lavender oil for longer-lasting sodium-sulfur batteries

In the future, linalool, a main component of lavender, could help to make sodium-sulfur batteries more durable and efficient.
Photo Credit: Dan Meyers

Lavender oil could help solve a problem in the energy transition. A team from the Max Planck Institute of Colloids and Interfaces has created a material from linalool, the main component of lavender oil, and sulfur that could make sodium-sulfur batteries more durable and powerful. Such batteries could store electricity from renewable sources.

It is a crucial question in the energy transition: how can electricity from wind power and photovoltaics be stored when it is not needed? Large batteries are one option. And sulfur batteries, in particular sodium-sulfur batteries offer several advantages over lithium batteries as stationary storage units. The materials from which they are made are much more readily available than lithium and cobalt, two essential components of lithium-ion batteries. The mining of these two metals also often damages the environment and locally causes social and political upheaval. However, sodium-sulfur batteries can store less energy in relation to their weight than lithium batteries and are also not as durable. Lavender oil with its main component linalool could now help to extend the service life of sodium-sulfur-batteries, as a team from the Max Planck Institute of Colloids and Interfaces reports in the journal Small.  "It's fascinating to design future batteries with something that grows in our gardens," says Paolo Giusto, group leader at the Max Planck Institute of Colloids and Interfaces.

Scientists Have Given a Second Life to Paper Production Waste

Lignosulphonate is a safe waste from pulp and paper industries.
Photo Credit: Rodion Narudinov

Ural Federal University specialists have developed a new method of obtaining growth stimulators for agriculture plants. Waste from pulp and paper industries, lignosulphonate, became the basis for the production of biologically active stimulants of prolonged action for plant crops. Due to the structural features, the obtained samples can be used not only to improve crop growth, but also to remove some toxic substances from wastewater. The results were published in the Journal of Molecular Liquids. 

The Sulfite method is one of the currently used methods for extracting cellulose (the basis of any paper) from wood. In addition to the target product, large-capacity waste is formed in the form of salts lignosulphonic acids or lignosulphonates. These compounds are not toxic, they are biocompatible, water-soluble and relatively cheap.

Lignosulphonate-based nanoparticles have a porous structure and high mass content of carbon atoms that can be absorbed by the soil. Due to this fact, researchers consider them as “sponges” for dyes that can enter wastewater, and even as sorbents for oil. However, there is currently no efficient and cheap way to produce nanomaterials from this class of waste in industry. 

Rice researchers unlock new insights into tellurene, paving the way for next-gen electronics

Shengxi Huang is an associate professor of electrical and computer engineering and materials science and nanoengineering at Rice University, and corresponding author on a study published in Science Advances.
Photo Credit: courtesy of Shengxi Huang/Rice University

To describe how matter works at infinitesimal scales, researchers designate collective behaviors with single concepts ⎯ like calling a group of birds flying in sync a “flock” or “murmuration.” Known as quasiparticles, the phenomena these concepts refer to could be the key to next-generation technologies.

In a recent study published in Science Advances, a team of researchers led by Shengxi Huang, associate professor of electrical and computer engineering and materials science and nanoengineering at Rice, describe how one such type of quasiparticle ⎯ polarons ⎯ behaves in tellurene, a nanomaterial first synthesized in 2017 that is made up of tiny chains of tellurium atoms and has properties useful in sensing, electronic, optical and energy devices.

“Tellurene exhibits dramatic changes in its electronic and optical properties when its thickness is reduced to a few nanometers compared to its bulk form,” said Kunyan Zhang, a Rice doctoral alumna who is a first author on the study. “Specifically, these changes alter how electricity flows and how the material vibrates, which we traced back to the transformation of polarons as tellurene becomes thinner.”

Tracking delivery: new technology for nanocarriers

Lipid nanoparticles visualized using SCP-Nano technology at the cellular level in lung tissue.
Image Credit: © Ali Ertürk / Helmholtz Munich

How can we ensure that life-saving drugs or genetic therapies reach their intended target cells without causing harmful side effects? Researchers at Helmholtz Munich, LMU and Technical University Munich (TUM) have taken an important step to answer this question. They have developed a method that, for the first time, enables the precise detection of nanocarriers – tiny transport vehicles – throughout the entire mouse body at a single-cell level. This innovation, called “Single-Cell Profiling of Nanocarriers” or short “SCP-Nano”, combines advanced imaging with artificial intelligence to provide unparalleled insights into the functionality of nanotechnology-based therapies. The results, published in Nature Biotechnology, pave the way for safer and more effective treatments, including mRNA vaccines and gene therapies.

Nanocarriers will play a central role in the next wave of life-saving medicines. They enable the targeted delivery of drugs, genes, or proteins to cells within patients. With SCP-Nano, researchers can analyze the distribution of extremely low doses of nanocarriers throughout the entire mouse body, visualizing each cell that has taken them up. SCP-Nano combines optical tissue clearing, light-sheet microscopy imaging, and deep-learning algorithms. First, whole mouse bodies are made transparent. After the three-dimensional imaging of whole mouse bodies, nanocarriers within the transparent tissues can then be identified down to the single-cell level. By integrating AI-based analysis, researchers can quantify which cells and tissues are interacting with the nanocarriers and precisely where this occurs.

The Rotisserie-Inspired Device That Could Revolutionize Cancer Surgery

The Zavaleta Lab’S Raman Rotisserie Device Creates a Map of the Surface of a Resected Tumor to Aid Surgeons in the Operating Room.
Photo Credit: Alex Czaja

Like many Texans, Cristina Zavaleta grew up enjoying the culinary delights of the state’s famous smokehouse BBQs. She couldn’t have imagined that those humble rotisseries of her childhood would one day inspire a game-changing device for the operating room that could help surgeons prevent tumor recurrence.

On a team excursion to Disneyland, the WiSE Gabilan Assistant Professor of Biomedical Engineering and her students were reminded of rotisseries when they encountered a food vendor at the Star Wars-themed land, Galaxy’s Edge. It was a lightbulb moment. The rotisserie configuration was a perfect way of intricately scanning excised tumors, with the help of the Zaveleta Lab’s unique nanoparticles, to light up where the cancerous tissue may not have been entirely removed from the patient. Surgeons could then be guided to precisely remove the remaining tumor, all while the patient is still under anesthesia. The result would reduce the need for traumatic repeat surgeries and potential cancer recurrence and metastasis.

Zavaleta and her team built the device, which they dubbed the Raman Rotisserie. It physically rotates a tumor specimen and works in conjunction with an imaging technique known as Raman spectroscopy, which scans the surface of the excised tumor. Their research, which aims to improve the success rate of breast cancer lumpectomies, has now been published in NPJ Imaging.