New research identifies who should be offered testing for coeliac disease

Targeted testing of individuals with a range of signs and symptoms could improve diagnosis of coeliac disease, a new National Institute for Health Research (NIHR) funded study led by the University of Bristol and published in PLOS ONE has found. Signs and symptoms include family history of coeliac disease, dermatitis herpetiformis, anemia, type 1 diabetes, osteoporosis and chronic liver disease.

The researchers, based at the NIHR Applied Research Collaboration (ARC) West, the University of Bristol, University of Southampton, the Royal Hospital for Sick Children, University College London and York Teaching Hospital NHS Foundation Trust, undertook an analysis of the results from 191 studies, reporting on 26 signs, symptoms and risk factors to inform their findings.

Around one in 100 people in the UK have coeliac disease, where a person’s immune response to gluten attacks the tissues in their digestive system. Diagnosing the disease can be difficult. Some patients may not have symptoms, while others have non-specific symptoms such as indigestion or bloating. It’s thought only one in three people with coeliac disease are actually diagnosed. The only treatment available is a gluten free diet.

Guidelines recommend that adults and children “at high risk” of coeliac disease should be offered testing. However, it has not been clear until now which groups are at high enough risk to justify routine testing or which symptoms should lead to testing.

Dark-field X-ray technology

PD Dr. med. Andreas Sauter evaluating the X-ray images. Image: A. Heddergott / TUM

Dark-field X-ray technology improves diagnosis of pulmonary ailments New X-ray technology first used with patients

For the first time, researchers at the Technical University of Munich (TUM) have successfully used a new X-ray method for respiratory diagnostics with patients. Dark-field X-rays visualize early changes in the alveolar structure caused by the lung disease COPD and require only one fiftieth of the radiation dose typically applied in X-ray computed tomography. This permits broad medical application in early detection and treatment follow-up of respiratory ailments.

There are millions of cases in which serious respiratory system illnesses place limitations on quality of life. Every year more than four million people die of serious respiratory ailments worldwide. Partially destroyed alveoli and an over-inflation of the lungs (emphysema) are typical of the life-threatening ailment Chronic Obstructive Pulmonary Disease (COPD).

However, the fine distinctions between healthy and diseased tissue are barely visible on conventional chest X-rays. Detailed diagnostic information is only available using three-dimensional computed tomography approaches, in which the computer assembles many individual images. Until now there has been no fast and cost-effective option for early detection and follow-up examinations with a low radiation exposure as used in plain chest X-rays.

A procedure developed at the Technical University of Munich could now fill this gap: dark-field chest X-rays. In the current issue of "Lancet Digital Health" a research team led by Franz Pfeiffer, Professor for Biomedical Physics and Director of the Munich Institute of Biomedical Engineering at TUM, is now presenting the results of an initial clinical patient study, which used the new X-ray technology for the diagnosis of the lung disease COPD.

Researchers discover a way to increase the effectiveness of antibiotics

A multi-disciplinary project driven by EMBL Australia researchers at Monash University and Harvard University has found a way to make antibiotics more effective against antibiotic-resistant bacteria - also known as ‘superbugs.

Antimicrobial resistance to superbugs has been evolving and is one of the top 10 global public health threats facing humanity, according to the World Health Organization.

This new research will provide a pathway to increasing the effectiveness of antibiotics, without clinicians having to resort to risky strategies of giving patients higher doses or relying on the discovery of new types of antibiotics.

During a bacterial infection, the body uses molecules called chemoattractants to recruit neutrophils to the site of the infection. Neutrophils are immune cells with the ability to encapsulate and kill dangerous bacteria, critical to the immune response. Researchers attached a chemoattractant to an antibiotic, enabling them to enhance the recruitment of immune cells and improve their killing ability.

The findings have now been published in Nature Communications.

What is drawing humpback whale super-groups to the African coast?

Super-groups of up to 200 humpback whales appearing off the coast of South Africa are following changing ocean currents and phytoplankton blooms, a new study has found.

Researchers at Griffith University were part of an international team led by the University of Cape Town (UTC) which combined satellite observations and a physical ocean model to intricately map the ocean circulation and productivity using chlorophyll levels in the region over the past 10 years in order to understand environmental drivers of these behavioral changes in feeding humpbacks.

“While humpback whales in the Southern Hemisphere are known for annual migrations between the summer high-latitude Southern Ocean feeding grounds and the winter mating and calving grounds in subtropical coastal waters, feeding in such dense packs is unprecedented,” said Dr. Olaf Meynecke, a whale researcher and Manager of the Griffith Whales and Climate Program.

Dr. Subhra Prakash Dey from the Department of Oceanography UCT said the formation of whale super-groups in recent years suggested a potential change in oceanographic or ecological characteristics which provide the conditions for this new feeding strategy.

“Through the development of fine scale ocean models our team was able to reveal these oceanographic and ecological changes in the area, the Southern Benguela Upwelling System (SBUS) off South Africa, that had previously remained hidden,” Dr. Meynecke said.

Urgent action needed to reduce uncertainty on CO2 storage prospects

(From left to right)
Dr Chris Greig, Dr Joe Lane and Professor Andrew Garnett

An urgent increase in policy support and investment would be needed for carbon capture and storage (CCS) to achieve the scale needed to meet global decarbonization goals, according to University of Queensland and Princeton University researchers.

The study’s lead author, Dr Joe Lane, said CCS was regarded as a key technology for reducing energy and industrial sector emissions and for achieving negative emissions when coupled with bioenergy or direct air capture of carbon dioxide.

“Most scenarios for deep decarbonization of the global economy rely on massive scale CCS to be compliant with the Paris Agreement - which means between three and 20 gigatons of CO2 per year being captured and stored, world-wide by 2050,” Dr Lane said.

“Even the lower targets imply an extremely challenging pace and scale of CCS deployment across all major economies.”

UQ Centre for Natural Gas Director Professor Andrew Garnett said more information is needed globally to support such high expectations.

“Those scenarios typically assume that there is more than enough storage volume available in porous geological reservoirs around the world,” Professor Garnett said

“But the essence of our abatement challenge is not the volume of storage available, it’s the rate at which CO2 can be safely injected and permanently contained that counts.

Clues from the ancient past can help predict abrupt climate change

Climate ‘tipping points’ can be better understood and predicted using climate change data taken from the ancient past, new research led by scientists from the universities of Birmingham and Bristol shows.

Current understanding of tipping points, in which the climate system exceeds a threshold beyond which large and often irreversible changes occur, is limited. This is because such an event has not occurred in recent times and certainly not since scientists started to record climate data.

Earth System models, routinely used to estimate and predict climate, are taken from our understanding of the physical, chemical and biological processes that work together to shape our planet.

Scientists know that these models do not provide a complete picture, however, because they fail to simulate known climate events from the past.

In a new study published today in Proceedings of the National Academy of Sciences, researchers at the University of Birmingham and the University of Bristol demonstrate how knowledge of climate reconstructions from thousands of years ago can be used to fine-tune Earth System models to provide a more accurate understanding of climate system thresholds.

Senior author, Dr Peter Hopcroft, of the University of Birmingham’s School of Geography, Earth and Environmental Sciences, said: “Climate modelling is the only way we have to predict future climate change, but when models are developed, they are only evaluated with weather observations from the past 150 years or so.

Erie researchers identify new threat to American chestnut trees

Emily Dobry, a graduate student conducting research at the Lake Erie Regional Grape Research and Extension Center, has identified a new fungal threat to the American chestnut tree. 
Image Credit: Penn State Behrend

For lumber companies, the American chestnut was a nearly perfect tree — tall, straight, rot-resistant and easy to split. It also was prolific, sending up new shoots that grew quickly.

In the early 1900s, the species made up a substantial portion of eastern hardwood forests. There were nearly four billion American chestnut trees in the United States, each growing up to 100 feet, with trunks four to seven feet thick. Healthy trees lived for 400 to 600 years, producing several bushels of nuts every year.

Today, however, it can be difficult to find a healthy American chestnut. A fungal pathogen on trees imported from Japan and China wiped the species out in less than 40 years. That loss is considered to be the greatest ecological disaster to ever strike the world’s forests.

“The pathogen is native to Chinese and Japanese chestnuts, so the two co-evolved,” said Emily Dobry, a Penn State Behrend graduate now in Penn State’s plant sciences horticulture master’s-degree program. She is doing research work at the University’s Lake Erie Regional Grape Research and Extension Center (LERGREC) in North East. “The American chestnut had never been exposed to it before, however, so it had little natural resistance. Think of it as smallpox for trees.”

Environmentally hazardous coal waste diminished by citric acid

Sandia National Laboratories researcher Guangping Xu adds coal ash into a citric acid mixture. This solution will be fed into a reactor — operating at about 70 times atmospheric pressure — where supercritical carbon dioxide aids citric acid in extracting rare-earth metals.
(Photo by Rebecca Lynne Gustaf)

In one of nature’s unexpected bounties, a harmless food-grade solvent has been used to extract highly sought rare-earth metals from coal ash, reducing the amount of ash without damaging the environment and at the same time increasing an important national resource.

Coal ash is the unwanted but widely present residue of coal-fired power. Rare-earth metals are used for a variety of high-tech equipment from smartphones to submarines.

The separation method, which uses carbon dioxide, water and food-grade citric acid, is the subject of a Sandia National Laboratories patent application.

“This technique not only recovers rare-earth metals in an environmentally harmless manner but would actually improve environments by reducing the toxicity of coal waste dotting America,” said Guangping Xu, lead Sandia researcher on the project.

“Harmless extraction of rare-earth metals from coal ash not only provides a national source of materials essential for computer chips, smart phones and other high-tech products — including fighter jets and submarines — but also makes the coal ash cleaner and less toxic, enabling its direct reuse as concrete filler or agricultural topsoil,” he said.

The method, if widely adopted, could make coal ash, currently an environmental pariah, into a commercially viable product, Xu said.

COVID-19 risks explained with new tool

A calculator to help people understand their risk factors for COVID-19 infection and vaccination has been launched by the Immunization Coalition in collaboration with Australian researchers.

The tool’s three co-lead researchers are University of Queensland virologist Dr Kirsty Short, CoRiCal instigator from Flinders University Associate Professor John Litt and GP Dr Andrew Baird.

Dr Kirsty Short said the Immunization Coalition COVID-19 Risk Calculator (CoRiCal) was an online tool to support GPs and community members in their discussions about the benefits and risks of COVID-19 vaccines.

"This tool is really designed to help people make an informed decision around vaccination based on their current circumstances and also see their risk for getting COVID-19 under different transmission scenarios," Dr Short said.

"Users can access the tool and input their age, sex, community transmission and vaccination status to find out their personalized risk calculation.

"For example, you can find out your chance of being infected with COVID-19 versus your chance of dying from the disease.

"You can also find out your chance of developing an atypical blood clot from the AstraZeneca vaccine and see this data in the context of other relatable risks – like getting struck by lightning or winning OzLotto."

AstraZeneca’s vaccine dosing ‘mistake’ led to new dosage finding in mice

 

A dosing error made during an AstraZeneca-University of Oxford COVID-19 vaccine trial has led to a new dosage finding in mice, reports a new Northwestern Medicine study.

During the AstraZeneca-Oxford trial, some human participants erroneously received a half dose of their first shot, followed by a full dose for their second shot. Paradoxically, the trial showed that volunteers who got a lower dose of the first shot were better protected against COVID-19 than those who received two full doses.

However, it was not clear if the improvement of the low-dose vaccine was due to the dose itself or the fact that people who received the lower dose had also had a longer time between the first and the second shot, known as an extended prime-boost interval.

Scientists from Northwestern University Feinberg School of Medicine tested the effect of a SARS-CoV-2 vaccine prime dose in mice and found that a lower-dose first shot, followed by a full-dose booster shot, significantly improved the potency of a SARS-CoV-2 vaccine. The booster shot produced more antibodies and T-cells in the mice, allowing them to develop much more robust immune responses against SARS-CoV-2, the study found.

The findings were recently published in the journal Science Immunology.