Hungry yeast are tiny, living thermometers

This fluorescence microscopy image shows yeast vacuoles that have undergone phase separation.Luther Davis/Alexey Merz/University of Washington

Membranes are crucial to our cells. Every cell in your body is enclosed by one. And each of those cells contains specialized compartments, or organelles, which are also enclosed by membranes.

Membranes help cells carry out tasks like breaking down food for energy, building and dismantling proteins, keeping track of environmental conditions, sending signals and deciding when to divide.

Biologists have long struggled to understand precisely how membranes accomplish these different types of jobs. The primary components of membranes — large, fat-like molecules called lipids and compact molecules like cholesterol — make great barriers. In all but a few cases, it’s unclear how those molecules help proteins within membranes do their jobs.

In a paper published Jan. 25 in the Proceedings of the National Academy of Sciences, a team at the University of Washington looked at phase separation in budding yeast — the same single-celled fungus of baking and brewing fame — and reports that living yeast cells can actively regulate a process called phase separation in one of their membranes. During phase separation, the membrane remains intact but partitions into multiple, distinct zones or domains that segregate lipids and proteins. The new findings show for the first time that, in response to environmental conditions, yeast cells precisely regulate the temperature at which their membrane undergoes phase separation. The team behind this discovery suggests that phase separation is likely a “switch” mechanism that these cells use to govern the types of work that membranes do and the signals they send.

How a Smart Electric Grid Will Power Our Future

The Electricity Infrastructure Operations Center, located at PNNL, allows researchers to evaluate electric grid scenarios in the context of current industry conditions.
Photo by Andrea Starr | Pacific Northwest National Laboratory

A novel plan that offers partnership in keeping the United States electric grid stable and reliable could be a win-win for consumers and utility operators.

The largest ever simulation of its kind, modeled on the Texas power grid, concluded that consumers stand to save about 15 percent on their annual electric bill by partnering with utilities. In this system, consumers would coordinate with their electric utility operator to dynamically control big energy users, like heat pumps, water heaters and electric vehicle charging stations.

This kind of flexible control over energy supply and use patterns is called “transactive” because it relies on an agreement between consumers and utilities. But a transactive energy system has never been deployed on a large scale, and there are a lot of unknowns. That’s why the Department of Energy’s Office of Electricity called upon the transactive energy experts at Pacific Northwest National Laboratory to study how such a system might work in practice. The final multi-volume report was released today.

Hayden Reeve, a PNNL transactive energy expert and technical advisor, led a team of engineers, economists and programmers who designed and executed the study.

Novel research identifies fresh 'mixers' in river pollution 'cocktail'

Researchers from the Universities of Manchester, Birmingham and Mahavir Cancer Sansthan collecting field data along the River Ganga in Bihar
Photo - Aman Gaurav

Water quality in rivers is affected by underpinning ‘natural’ hydrogeological and biogeochemical processes, as well as interactions between people and their environment that are accelerating stress on water resources at unprecedented rates.

Pollutants can move at different speeds and accumulate in varying quantities along rivers where the mix of the complex ‘cocktail’ of chemicals that is making its way towards the ocean is constantly changing, a new study reveals.

Researchers have discovered characteristic breakpoints – often found when a tributary joins the main river or significant point sources exist – can change the behavior of some compounds, causing the concentration of these chemicals to change drastically, depending on where they are on their journey down the river.

Experts discovered the phenomenon after piloting a new, systematic approach to understanding hydrogeochemical dynamics in large river systems along the entire length of India’s River Ganges (Ganga) – from close to its source in the Himalayas down to the Indian Ocean.

This new research approach proven successful at the iconic Ganga can be applied to other large river systems across the world – hopefully shedding new light on how to tackle the global challenge of aquatic pollution by multiple interacting contaminants.

Calculating the best shapes for things to come

Wei Lu 
Professor  Mechanical Engineering 
University of Michigan

Maximizing the performance and efficiency of structures—everything from bridges to computer components—can be achieved by design with a new algorithm developed by researchers at the University of Michigan and Northeastern University.

It’s an advancement likely to benefit a host of industries where costly and time-consuming trial-and-error testing is necessary to determine the optimal design. As an example, look at the current U.S. infrastructure challenge—a looming $2.5 trillion backlog that will need to be addressed with taxpayer dollars.

Planners searching for the best way to design a new bridge need to answer a string of key questions. How many pillars are needed? What diameter do those pillars need to be? What should the radius of the bridge’s arch be? The new algorithm can determine the combination that gives the highest load capacity with lowest cost.

The team tested their algorithm in four optimization scenarios: designing structures to maximize their stiffness for carrying a given load, designing the shape of fluid channels to minimize pressure loss, creating shapes for heat transfer enhancement, and minimizing the material of complex trusses for load bearing. The new algorithm reduced the computational time needed to reach the best solution by roughly 100 to 100,000 times over traditional approaches. In addition, it outperformed all other state-of-the-art algorithms.

“It’s a tool with the potential to influence many industries—clean energy, aviation, electric vehicles, energy efficient buildings,” said Wei Lu, U-M professor of mechanical engineering and corresponding author of the study in Nature Communications.

The new algorithm plays in a space called topology optimization—how best to distribute materials within a given space to get the desired results.

“If you really want to design something rationally, you’re talking about a large number of calculations, and doing those can be difficult with time and cost considerations,” Lu said. “Our algorithm can reduce the calculations and facilitate the optimization process.”

Worldwide assessment of protected areas

According to a TUM-led study, mountain habitats as seen here in Pakistan’s Deosai National Park are quite well protected. Many other habitats do not yet have this level of protection.
Image: Ch. Hof / TUM

Protected areas are among the most effective tools for preserving biodiversity. However, new protected areas are often created without considering existing ones. This can lead to an overrepresentation of the biophysical characteristics, such as temperature or topography, that define a certain area. A research group at the Technical University of Munich (TUM) has now assessed a global analysis of the scope of protection of various biophysical conditions.

Protected areas are important for maintaining populations of various species. They ensure that many animals and plants do not lose their habitat and thus help to protect endangered species and safeguard biodiversity.

The worldwide protected area network is steadily growing in number and extent. “From a conservation standpoint, this is generally a welcome trend. But the uncoordinated expansion of protected areas can result in wasted resources worldwide if care is not taken to protect as many species communities and environmental conditions as possible,” says Dr. Christian Hof, the director of the junior research group “MintBio – Climate change impacts on biological diversity in Bavaria: Multidimensional Integration for better BIOdiversity projections” under the auspices of the Bavarian climate research network bayklif at TUM.

Do you see faces in things?

Composite image: Dr Jessica Taubert

Seeing faces in everyday objects is a common experience, but research from The University of Queensland has found people are more likely to see male faces when they see an image on the trunk of a tree or in burnt toast over breakfast.

Dr Jessica Taubert from UQ’s School of Psychology said face pareidolia, the illusion of seeing a facial structure in an everyday object, tells us a lot about how our brains detect and recognize social cues.

“The aim of our study was to understand whether examples of face pareidolia carry the kinds of social signals that faces normally transmit, such as expression and biological sex,” Dr Taubert said.

“Our results showed a striking bias in gender perception, with many more illusory faces perceived as male than female.

“As illusory faces do not have a biological sex, this bias is significant in revealing an asymmetry in our face evaluation system when given minimal information.

“The results demonstrate visual features required for face detection are not generally sufficient for the perception of female faces.”

More than 3800 participants were shown numerous examples of face pareidolia and inanimate objects with no facial structure and they were asked to indicate whether each example had a distinct emotional expression, age, and biological sex, or not.

Overweight dogs respond well to high-protein, high-fiber diet

Overfed dogs experience some of the same maladies associated with overweight and obesity in humans. A new study finds that overweight dogs also benefit from a high-protein, high-fiber weight loss regimen. 
Photo by www.pixel.la, CC0 1.0 Universal Public Domain Dedication

A study of overweight dogs fed a reduced calorie, high-protein, high-fiber diet for 24 weeks found that the dogs’ body composition and inflammatory markers changed over time in ways that parallel the positive changes seen in humans on similar diets. The dogs achieved a healthier weight without losing too much muscle mass, and their serum triglycerides, insulin and inflammatory markers all decreased with weight loss.

All such changes are beneficial, said University of Illinois Urbana-Champaign animal sciences professor Kelly Swanson, who led the new research.

Mixed Reality and AI to aid surgeons with keyhole heart valve surgery

Cardiac surgeons could in the future be conducting procedures virtually before even stepping into an operating theatre thanks to researchers from the University of West of England who are working with cardiac surgeons from the University of Bristol on new technology that will allow surgeons to better predict risks and help prevent the conversion of a keyhole heart valve operation to open heart surgery.

The research team from UWE Bristol’s Big Data lab and Faculty of Health and Applied Sciences (HAS) is developing technology that uses artificial intelligence (AI), augmented reality (AR) and virtual reality (VR) to assist cardiac surgeons in planning and preparing for complex keyhole heart valve surgery. The team is initially collaborating with the Bristol Heart Institute (BHI), a Specialist Research Institute at the University of Bristol, whose surgeons will test the system when preparing for minimally invasive cardiac valve surgery (MICVS).

Compared to conventional open-heart surgery involving cutting through the breastbone to reach the heart, MICVS is less intrusive as the heart is accessed through smaller incisions using endoscopic instruments. And patient recovery time is generally quicker after this keyhole surgery.

However, MICVS is complex and requires hours of pre-operative planning and preparation.

Dr Hunaid Vohra, Consultant Cardiac Surgeon and Honorary Senior Lecturer and Researcher at the BHI, who is collaborating with UWE Bristol, said: “In the operating room, despite pre-planning, it is currently very common to find unexpected challenges, as every patient’s height, weight and heart-lung anatomy is different. And patients’ frailty varies.

Mystery of sweet potato origin uncovered

Ipomoea aequatoriensis flowers at
University of Oxford Department of Plant Sciences.
Photographs by Tom Wells

New scientific research from Oxford University's Plant Sciences department transforms our understanding of the origins of the sweet potato - identifying a key piece in the puzzle of the evolutionary history of one of the world’s most important staple crops.

Years of careful taxonomic research by a team led by Robert Scotland, Professor of Systematic Botany at Oxford Plant Sciences, has concluded with the discovery of a new species that is sweet potato’s closest wild relative, Ipomoea aequatoriensis.

"How the sweet potato evolved has always been a mystery. Now, we have found this new species in Ecuador...a fundamental piece of the puzzle to understand the origin and evolution of this top-ten global food crop"

Professor Robert Scotland

This species, which most likely played a key role in the origin of the crop, is the latest in a series of discoveries by the Oxford team and collaborators at USDA and the International Potato Centre Peru, and one that represents an ‘extraordinary discovery in untangling the evolution’ of the plant, according to the researchers.

Professor Scotland says, ‘How the sweet potato evolved has always been a mystery. Now, we have found this new species in Ecuador that is the closest wild relative of sweet potato known to date and is a fundamental piece of the puzzle to understand the origin and evolution of this top-ten global food crop.’

Researchers discover way to disarm potentially deadly Listeria bacteria

A drug-like inhibitor that stops Listeria from making virulence proteins helps immune cells control and kill the bacteria.
Image: Dr Carmen Mathmann

University of Queensland researchers have unlocked a way of fighting Listeria infections, which can cause severe illness in pregnant women and people with compromised immune systems.

During the study, researchers discovered a way to block Listeria from making the proteins that allow bacteria to survive and multiply in immune cells.

UQ Diamantina Institute’s Professor Antje Blumenthal said using a small, drug-like inhibitor has improved their understanding of the Achilles heel of Listeria.

“Listeria is found in the soil and sometimes in raw foods. Once ingested it can hide from the immune system and multiply inside immune cells,” Professor Blumenthal said.

“Instead of killing the bacteria, the immune cells are used by the bacteria to multiply and are often killed by Listeria growing inside them.

“Our study showed the bacteria could be cleared with a small drug-like inhibitor that targets the 'master regulator’ of the proteins that help Listeria grow in immune cells. The inhibitor helped the immune cells survive infection and kill the bacteria.”