Scientists Nail Down 'Destination' for Protein That Delivers Zinc

Brookhaven Lab biologist Crysten Blaby and postdoctoral fellow Nicolas Grosjean and colleagues ran genetic experiments, biochemical assays, and computational modeling studies that identified ZNG1 as a zinc chaperone protein.
Credit: Brookhaven National Laboratory

Most people don’t think much about zinc. But all living things need zinc for survival. This trace element helps many proteins fold into the right shapes to do their jobs. And in proteins known as enzymes, zinc helps catalyze chemical reactions—including many important for providing energy to cells. If zinc is absent, people, pets, and plants don’t thrive.

That’s one reason biologists at the U.S. Department of Energy’s Brookhaven National Laboratory are so interested in this element.

“We're looking for ways to grow bioenergy plants—either plants that produce biofuels or whose biomass can be converted into fuel—and doing it on land that is not suitable for growing food crops,” said Brookhaven Lab biologist Crysten Blaby, who also holds an adjunct appointment at Stony Brook University. “So, we’re interested in strategies nature uses to survive when zinc and other micronutrients are lacking.”

In a paper just published in the journal Cell Reports, Blaby and her colleagues describe one such strategy: a so-called “chaperone” protein that delivers zinc to where it’s needed, which could be especially important when access to zinc is limited. Though scientists, including Blaby, have long suspected the existence of a zinc chaperone, the new research provides the first definitive evidence by identifying a “destination” for its deliveries.

A new mathematical model of cellular movement

A new mathematical model describes how cells change their shape during movement and suggests that the movement is mainly driven by the contraction of the skeletal proteins, called “myosin.” The image shows the shape of cells at various speeds as predicted by the model. Non-moving cells are circular but become asymmetric as they begin to move. The colors indicate the concentration of myosin in the cell with red indicating a higher concentration.
Credit: C. Alex Safsten, Penn State

A mathematical model that describes how cells change their shape during movement suggests that the movement is mainly driven by the contraction of the skeletal proteins, called “myosin.” The new model developed at Penn State can help researchers to better understand the various biological processes where cellular movement plays a key role and also could inform the development of artificial systems that mimic biological processes.

“The focus of this work is on the development of minimal mathematical models that are simple enough to be amenable to rigorous analysis but still capture key biological phenomena,” said Leonid Berlyand, professor of mathematics at Penn State and the leader of this research team. “The point of our model is to capture the onset of cell motion driven by myosin contraction with focus on analyzing the stability of this motion observed in experiments.”

For large bone injuries, it’s Sonic hedgehog to the rescue

After surgical rib resection (top), a cartilage and bone bridge form (second from top) and then resolve (third from top) and remodel to regenerate the missing tissue in the gap (bottom). Blue shows cartilage matrix; red shows mineralized matrix.
Images by Stephanie Kuwahara and Max Serowoky/ Mariani Lab

A USC Stem Cell study in NPJ Regenerative Medicine presents intriguing evidence that large bone injuries might trigger a repair strategy in adults that recapitulates elements of skeletal formation in utero. Key to this repair strategy is a gene with a fittingly heroic name: Sonic hedgehog.

In the study, first author Maxwell Serowoky, a PhD student in the USC Stem Cell laboratory of Francesca Mariani, and his colleagues took a close look at how mice are able to regrow large sections of missing rib—an ability they share with humans, and one of the most impressive examples of bone regeneration in mammals.

To their surprise, the scientists observed an increase in the activity of Sonic hedgehog (Shh), which plays an important role in skeletal formation in embryos, but hasn’t previously been linked to injury repair in adults.

In their experiments, Shh appeared to play a necessary role in healing the central region of large sections of missing ribs, but not in closing small-scale fractures.

New Approach Allows for Faster Ransomware Detection

Photo credit: Michael Geiger

Engineering researchers have developed a new approach for implementing ransomware detection techniques, allowing them to detect a broad range of ransomware far more quickly than previous systems.

Ransomware is a type of malware. When a system is infiltrated by ransomware, the ransomware encrypts that system’s data – making the data inaccessible to users. The people responsible for the ransomware then extort the affected system’s operators, demanding money from the users in exchange for granting them access to their own data.

Ransomware extortion is hugely expensive, and instances of ransomware extortion are on the rise. The FBI reports receiving 3,729 ransomware complaints in 2021, with costs of more than $49 million. What’s more, 649 of those complaints were from organizations classified as critical infrastructure.

Extraterrestrial stone brings first supernova clues to Earth

A 3-gram sample of the Hypatia stone. Researchers found a consistent pattern of 15 elements in the Hypatia stone. The pattern is completely unlike anything in our solar system or our solar neighborhood, in the Milky Way.
Credit: Romano Serra 

New chemistry ‘forensics’ indicate that the stone named Hypatia from the Egyptian desert could be the first tangible evidence found on Earth of a supernova type Ia explosion. These rare supernovas are some of the most energetic events in the universe.

This is the conclusion from a new study published in the journal Icarus, by Jan Kramers, Georgy Belyanin and Hartmut Winkler of the University of Johannesburg, and others.

Since 2013, Belyanin and Kramers have discovered a series of highly unusual chemistry clues in a small fragment of the Hypatia Stone.

In new research, they eliminated 'cosmic suspects' for the origin of the stone in a painstaking process. They have pieced together a timeline stretching back to the early stages of the formation of Earth, our Sun and the other planets in our solar system.

Cutting air pollution emissions would save 50,000 U.S. lives, $600 billion each year

Image by Ralf Vetterle from Pixabay

Eliminating air pollution emissions from energy-related activities in the United States would prevent more than 50,000 premature deaths each year and provide more than $600 billion in benefits each year from avoided illness and death, according to a new study by University of Wisconsin–Madison researchers.

Published today in the journal GeoHealth, the study reports the health benefits of removing dangerous fine particulates released into the air by electricity generation, transportation, industrial activities and building functions like heating and cooking — also major sources of carbon dioxide emissions that cause climate change, since they predominantly rely on burning fossil fuels like coal, oil, and natural gas.

“Our work provides a sense of the scale of the air quality health benefits that could accompany deep decarbonization of the U.S. energy system,” says Nick Mailloux, lead author of the study and a graduate student at the Center for Sustainability and the Global Environment in UW–Madison’s Nelson Institute for Environmental Studies. “Shifting to clean energy sources can provide enormous benefit for public health in the near term while mitigating climate change in the longer term.”

Validation brings new predictive capability to global megafire smoke impacts

Recent megafires in Australia and British Columbia have injected unprecedented amounts of smoke into the stratosphere. Modeling led by Los Alamos National Laboratory will help predict the effects of similar future events.
Credit: David Peterson, FIREX-AQ

New research modeling smoke from two recent megafires sets the stage for better forecasting of how emissions from these global-scale events will behave and impact temperatures. As huge wildfires become more common under climate change, increased attention has focused on the intensity and duration of their emissions, which rival those of some volcano eruptions.

Megafires in British Columbia in 2017 and Australia in 2019-2020 injected massive amounts of smoke into the stratosphere, allowing first-ever detailed satellite- and ground-based measurements of such cataclysms. Using that data for validation, a Los Alamos National Laboratory–led team modeled the behavior and impacts of the smoke as it rose from the lower atmosphere into the high-riding stratosphere, then circulated the globe. The research appeared in the Journal of Geophysical Research – Atmospheres.

Lighting up breast tumors during surgery

Scanning electron microscopy image of a breast cancer cell.
Credit: Bruce Wetzel & Harry Schaefer,
courtesy of the National Cancer Institute.

Nearly 13 percent of women born in the U.S. today will develop breast cancer at some point during their lives. Treatment for early-stage disease often includes breast-conserving surgery, where the tumor and some surrounding healthy tissues (the tumor margin) are removed. However, around 20 percent of these surgeries require a second operation, generally because cancer cells are found within the tumor margins.

Now, NIBIB-funded researchers are developing an imaging method that would allow surgeons to better identify cancerous cells in the tumor margins during surgery. This technique could lead to a reduction in follow-up breast cancer surgeries and reduce rates of breast cancer recurrence. Results were recently published in eBioMedicine, a publication of The Lancet.

“Today, surgeons primarily rely on their sense of sight and touch to distinguish between healthy and cancerous tissues during surgery, which may lead to incomplete removal of the tumor,” said Tatjana Atanasijevic, Ph.D., manager of the NIBIB program in Molecular Probes and Imaging Agents. “This imaging technique provides real-time visual feedback during surgery, allowing surgeons to better gauge the breast tumor margins, and ultimately optimizing surgical excision.”

The technique relies on a method known as near-infrared imaging, which utilizes probes that fluoresce under near-infrared light. These fluorescent probes can allow clinicians to visualize features beyond the tissue surface, such as blood vessels or tumors, which can help to guide surgical procedures. However, there aren’t many near-infrared agents that are approved for clinical use by the U.S. Food and Drug Administration (FDA), and those that are approved are non-specific, meaning that they don’t home in on a specific target in the body. Further, the only near-infrared probe approved for surgery, indocyanine green (ICG), doesn't stay in the bloodstream for very long and therefore its utility for image-guided tumor resection is somewhat limited.

Green robotics start-up signs deal with energy giant

University of Bristol alumni and founders of Perceptual Robotics: Chief Operating Officer Dimitris Nikolaidis, Chief Technical Officer Kevin Driscoll-Lind and Chief Executive Officer Kostas Karachalios
Credit: University of Bristol

A start-up with University of Bristol roots has signed a deal with energy giant Enel to help keep its estimated 9,000 turbines spinning.

Perceptual Robotics use autonomous drones and artificial intelligence to detect damage in wind turbines early.

Now the company, founded by three Bristol alumni, has landed a deal to inspect turbines owned by Enel Green Power, a subsidiary of Enel, which is one of the biggest energy companies in the world.

Enel Green Power will use the data to carry out preventative maintenance - reducing costs and turbine stoppages while increasing safety.

Meanwhile, research published today shows that Perceptual Robotics’ technology is 14% better at detecting damage than expert humans carrying out the same inspections.

Perceptual Robotics says it can reduce the cost of wind turbine blade maintenance by 30%.

Kostas Karachalios, CEO of Perceptual Robotics, who studied for a Master of Engineering (MEng) at Bristol, said: “The task of inspecting and maintaining these structures is becoming ever more challenging, as the industry is increasingly recognized.

Using Bacteria to Accelerate CO2 Capture in Oceans

Berkeley Lab researcher Peter Agbo was awarded a grant for a carbon capture project under the Lab’s Carbon Negative Initiative.
Credit: Marilyn Sargent/Berkeley Lab

You may be familiar with direct air capture, or DAC, in which carbon dioxide is removed from the atmosphere in an effort to slow the effects of climate change. Now a scientist at Lawrence Berkeley National Laboratory (Berkeley Lab) has proposed a scheme for direct ocean capture. Removing CO2 from the oceans will enable them to continue to do their job of absorbing excess CO2 from the atmosphere.

Experts mostly agree that combating climate change will take more than halting emissions of climate-warming gases. We must also remove the carbon dioxide and other greenhouse gases that have already been emitted, to the tune of gigatons of CO2 removed each year by 2050 in order to achieve net zero emissions. The oceans contain significantly more CO2 than the atmosphere and have been acting as an important carbon sink for our planet.