The drug gabapentin may boost functional recovery after a stroke

These 3D images of mouse brain vasculature show normal conditions, top, and after an ischemic stroke, which occurs when a blood vessel clot blocks blood flow in the brain.
Credit: Andrea Tedeschi

The drug gabapentin, currently prescribed to control seizures and reduce nerve pain, may enhance recovery of movement after a stroke by helping neurons on the undamaged side of the brain take up the signaling work of lost cells, new research in mice suggests.

The experiments mimicked ischemic stroke in humans, which occurs when a clot blocks blood flow and neurons die in the affected brain region.

Results showed that daily gabapentin treatment for six weeks after a stroke restored fine motor functions in the animals’ upper extremities. Functional recovery also continued after treatment was stopped, the researchers found.

The Ohio State University team previously found that gabapentin blocks the activity of a protein that, when expressed at elevated levels after an injury to the brain or spinal cord, hinders re-growth of axons, the long, slender extensions of nerve cell bodies that transmit messages.

Medicine for Inflammatory Bowel Disease May Protect Against Severe COVID-19

Gil Melmed, MD

Getting the COVID-19 vaccination strengthened one type of immune response to the SARS-CoV-2 virus in inflammatory bowel disease

(IBD) patients even though they were taking immunosuppressant medication, according to investigators at Cedars-Sinai.

The findings of two studies focused on this topic have been published in the journals IBD, of the Crohn’s & Colitis Foundation, and Frontiers in Immunology.

“We found that with COVID-19 vaccination most of the main immunosuppressive treatments for IBD preserved the T-cell response, with one notable exception: anti-tumor necrosis factor (anti-TNF) drug therapy. This biologic treatment actually elevated T-cell activity in the vaccinated patients. We think this may help protect them from severe disease after breakthrough infection,” said Gil Melmed, MD, principal investigator of the study and director of Inflammatory Bowel Disease Clinical Research at Cedars-Sinai.

New Tech Aims to Drive Down Costs of Hydrogen Fuel

Researchers from North Carolina State University have developed a new technique for extracting hydrogen gas from liquid carriers which is faster, less expensive and more energy efficient than previous approaches.

“Hydrogen is widely viewed as a sustainable energy source for transportation, but there are some technical obstacles that need to be overcome before it can be viewed as a practical alternative to existing technologies,” says Milad Abolhasani, corresponding author of a paper on the new technique and an associate professor of chemical and biomolecular engineering at NC State. “One of the big obstacles to the adoption of a hydrogen economy is the cost of storage and transportation.”

Hydrogen fuel does not result in CO2 emissions. And hydrogen refueling stations could be located at existing gas stations, taking advantage of existing infrastructure. But transporting hydrogen gas is dangerous, so hydrogen needs to be transported via a liquid carrier. A key obstacle for this strategy is that extracting hydrogen from the liquid carrier at destination sites, such as fueling stations, is energy intensive and expensive.

“Previous research has shown that it is possible to use photocatalysts to release hydrogen gas from a liquid carrier using only sunlight,” Abolhasani says. “However, existing techniques for doing this were laborious, time consuming and required a significant amount of rhodium – a metal that is very expensive.”

Custom ‘Headphones’ Boost Atomic Radio Reception 100-Fold

Copper “headphones” boost the sensitivity of NIST’s atomic radio receiver, which is composed of a gas of cesium atoms prepared in a special state inside the glass container. When an antenna located above the setup sends down a radio signal, the headphones boost the strength of the received signal a hundredfold. 
Credit: NIST

Researchers at the National Institute of Standards and Technology (NIST) have boosted the sensitivity of their atomic radio receiver a hundredfold by enclosing the small glass cylinder of cesium atoms inside what looks like custom copper “headphones.”

The structure — a square overhead loop connecting two square panels — increases the incoming radio signal, or electric field, applied to the gaseous atoms in the flask (known as a vapor cell) between the panels. This enhancement enables the radio receiver to detect much weaker signals than before. The demonstration is described in a new paper in Applied Physics Letters.

The headphone structure is technically a split-ring resonator, which acts like a metamaterial — a material engineered with novel structures to produce unusual properties. “We can call it a metamaterials-inspired structure,” NIST project leader Chris Holloway said.

NIST researchers previously demonstrated the atom-based radio receiver. An atomic sensor has the potential to be physically smaller and work better in noisy environments than conventional radio receivers, among other possible advantages.

Discovery of 'ghost' fossils reveals plankton resilience to past global warming events

Ghost nannofossils (left) with virtual casts (right). The fossils are approximately 5 µm in length, 15 times narrower than the width of a human hair.
Credit: S.M Slater

An international team of scientists from UCL, the Swedish Museum of Natural History, the University of Florence and Natural History Museum have found a remarkable type of fossilization that has remained almost entirely overlooked until now.

The fossils are microscopic imprints, or “ghosts”, of single-celled plankton, called coccolithophores, that lived in the seas millions of years ago, and their discovery is changing our understanding of how plankton in the oceans are affected by climate change.

Coccolithophores are important in today’s oceans, providing much of the oxygen we breathe, supporting marine food webs, and locking carbon away in seafloor sediments. They are a type of microscopic plankton that surround their cells with hard calcareous plates, called coccoliths, and these are what normally fossilize in rocks.

Declines in the abundance of these fossils have been documented from multiple past global warming events, suggesting that these plankton were severely affected by climate change and ocean acidification.

Spinning is key for line-dancing electrons in iron selenide

Quantum physicists Pengcheng Dai (left) and Qimiao Si outside Rice’s Brockman Hall for Physics in November 2021.
Photo by Jeff Fitlow/Rice University

Rice University quantum physicists are part of an international team that has answered a puzzling question at the forefront of research into iron-based superconductors: Why do electrons in iron selenide dance to a different tune when they move right and left rather than forward and back?

A research team led by Xingye Lu at Beijing Normal University, Pengcheng Dai at Rice and Thorsten Schmitt at the Paul Scherrer Institute (PSI) in Switzerland used resonant inelastic X-ray scattering (RIXS) to measure the behavior of electron spins in iron selenide at high energy levels.

Spin is the property of electrons related to magnetism, and the researchers discovered spins in iron selenide begin behaving in a directionally dependent way at the same time the material begins exhibiting directionally dependent electronic behavior, or nematicity. The team’s results were published online this week in Nature Physics.

How seascapes of the ancient world shaped genetic structure of European populations

Reconstructed view of the burial caves of the Xaghra Circle (Libby Mulqueeney after an original by Caroline Malone). Source Malone et al.2009. Mortuary Customs in Prehistoric Malta.Cambridge: McDonald, pp 375, 377. Malone, C., Stoddart, S., Trump, D. & Bonanno, A. (eds.). 2009. Mortuary Customs in prehistoric Malta. Excavations at the Brochtorff Circle at Xaghra (1987-1994). Cambridge: McDonald Institute.

Trinity scientists, along with international colleagues, have explored the importance of sea travel in prehistory by examining the genomes of ancient Maltese humans and comparing these with the genomes of this period from across Europe. Previous findings from the archaeological team had suggested that towards the end of the third millennium BC the use of the Maltese temples declined.

Now, using genetic data from ancient Maltese individuals the current interdisciplinary research team has suggested a potential contributing cause. Researchers found that these ancient humans lacked some of the signatures of genetic changes that swept across Europe in this period, because of their island separation. Scientists concluded that physical topography, in particular seascapes played a central role as barriers to genetic exchange.

The study is just published in the journal Current Biology.

Unraveling a perplexing explosive process that occurs throughout the universe

Physicist Kenan Qu with images of fast radio burst in two galaxies.Top and bottom photos at left show the galaxies, with digitally enhanced photos shown at the right. Dotted oval lines mark burst locations in the galaxies.
Qu photo by Elle Starkman; galaxy photos courtesy of NASA; collage by Kiran Sudarsanan

Mysterious fast radio bursts release as much energy in one second as the Sun pours out in a year and are among the most puzzling phenomena in the universe. Now researchers at Princeton University, the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) and the SLAC National Accelerator Laboratory have simulated and proposed a cost-effective experiment to produce and observe the early stages of this process in a way once thought to be impossible with existing technology.

Producing the extraordinary bursts in space are celestial bodies such as neutron, or collapsed, stars called magnetars (magnet + star) enclosed in extreme magnetic fields. These fields are so strong that they turn the vacuum in space into an exotic plasma composed of matter and anti-matter in the form of pairs of negatively charged electrons and positively charged positrons, according to quantum electrodynamic (QED) theory. Emissions from these pairs are believed to be responsible for the powerful fast radio bursts.

Paleontologists Found the Jaws of an Extremely Rare Bear in Tavrida

The bones of an Etruscan bear in the cave were discovered by Dmitry Gimranov and Aleksandr Lavrov.
 Photo: Anastasia Mavrenkova

Ural paleontologists discovered the lower jaws of an Etruscan bear from the Early Pleistocene (2-1.5 million years ago) in the Taurida Cave (Crimean Peninsula). The finding is extremely important, because it is rare and indicates that the territory of Crimea almost 2 million years ago, most likely lived an ancestor of modern man, early Homo. Scientists reported the finding in the international journal of paleobiology Historical Biology.

Remains of Etruscan bears (which is the ancestor of brown and cave bears) as part of the fauna of large mammals of the Early Pleistocene were found in Western Europe, in Asia, as well as in North Africa, but not in Russia. The fact is that in Russia, Early Pleistocene faunas with remains of large terrestrial vertebrates were practically not known before. Crimea in this regard is an attractive and informative place for scientists.

"Our finding, on the one hand, extends the geography of the distribution of the Etruscan bear in Eastern Europe, and on the other hand, indicates that the "Crimean" bear is a link between Asian and European counterparts. It also helps to characterize the evolutionary features within bears and the historical biogeography of this species," says Dmitry Gimranov, senior researcher at the Laboratory of Natural Science Methods in Humanities at Ural Federal University and the Paleoecology Institute of Plant and Animal Ecology, Ural Branch of the Russian Academy of Sciences.

Neuromorphic Memory Device Simulates Neurons and Synapses​

A neuromorphic memory device consisting of bottom volatile and top nonvolatile memory layers emulating neuronal and synaptic properties, respectively
Credit: KAIST

Researchers have reported a nano-sized neuromorphic memory device that emulates neurons and synapses simultaneously in a unit cell, another step toward completing the goal of neuromorphic computing designed to rigorously mimic the human brain with semiconductor devices.

Neuromorphic computing aims to realize artificial intelligence (AI) by mimicking the mechanisms of neurons and synapses that make up the human brain. Inspired by the cognitive functions of the human brain that current computers cannot provide, neuromorphic devices have been widely investigated. However, current Complementary Metal-Oxide Semiconductor (CMOS)-based neuromorphic circuits simply connect artificial neurons and synapses without synergistic interactions, and the concomitant implementation of neurons and synapses still remains a challenge. To address these issues, a research team led by Professor Keon Jae Lee from the Department of Materials Science and Engineering implemented the biological working mechanisms of humans by introducing the neuron-synapse interactions in a single memory cell, rather than the conventional approach of electrically connecting artificial neuronal and synaptic devices.