Scientists develop effective intranasal mumps-based COVID-19 vaccine candidate

Researchers used a modified live attenuated mumps virus, illustrated above, to develop a COVID-19 vaccine candidate.
Credit: Alissa Eckert | CDC

New research has advanced COVID-19 vaccine work in several ways: using a modified live attenuated mumps virus for delivery, showing that a more stable coronavirus spike protein stimulates a stronger immune response, and suggesting a dose up the nose has an advantage over a shot.

Based on these combined findings in rodent experiments, Ohio State University scientists envision one day incorporating a coronavirus antigen into the measles-mumps-rubella (MMR) vaccine as a way to produce COVID-19 immunity in kids.

“We were pushing to make a vaccine for infants and children with the idea that if we could incorporate the mumps COVID vaccine into the MMR vaccine, you’d have protection against four pathogens – measles, mumps, rubella and SARS-CoV-2 – in a single immunization program,” said Jianrong Li, senior author of the study and a professor of virology in Ohio State’s Department of Veterinary Biosciences and Infectious Diseases Institute.

“If infants and children could develop immunity against COVID infection with the MMR vaccine, that would be great – no extra immunization needed.”

The research is published today (July 27, 2022) in Proceedings of the National Academy of Sciences.

To create the antigen that stimulates immunity in this vaccine candidate, researchers used a prefusion version of the SARS-CoV-2 spike protein – the shape it is in on the surface of the virus before the virus infects a cell. The spike was locked into this form by changing six of its amino acids to prolines, an inflexible amino acid.

100000 and Counting Atomic Modeling Silicon

Jim Chelikowsky and recent Oden Institute PhD graduate, Kai-Hsin Liou, sitting in the Professor's Oden Institute office.
Credit: Oden Institute for Computational Engineering and Sciences

A new record has been set by the Oden Institute’s Center for Computational Materials for calculating the energy distribution function, or “density of states,” for over 100,000 silicon atoms, a first in computational materials science. Calculations of this kind enable greater understanding of both the optical and electronic properties of materials.

Jim Chelikowsky leads the Center for Computational Materials, which set a new standard for the number of atoms that can be modeled. They didn’t just raise the bar though. They smashed it – multiplying the previously held record number by a factor of 10.

Chelikowsky along with Oden Institute PhD graduate, Kai-Hsin Liou and postdoctoral fellow, Mehmet Dogan, led the team behind this significant technical advancement in atomic modeling. Working with silicon atoms, they increased the number that could be modeled simultaneously from around 10,000 to over 100,000.

One mathematical way to approach such complex systems is by describing solutions in sines and cosines. This is useful for crystalline matter because it is periodic and we know that the properties of a little piece of a crystal will inform the whole crystal.

Parasites may take a heavier toll on mammal populations than previously thought

Tapeworm infection is caused by ingesting food or water contaminated with tapeworm eggs or larvae.
 Credit: University of Alberta

A new study looking at research on parasitic worms suggests the pesky but pervasive creatures have a far greater impact on the health of mammal populations than previously known.

“Parasites don't have to kill the animal to control a population,” says Kyle Shanebeck, a PhD student in the Faculty of Science’s Department of Biological Sciences who led the research review.

Shanebeck’s analysis shows that helminths — large parasites such as tapeworms, flatworms and flukes — have negative effects on the energetic condition, or total body health, of their mammal hosts that can impair systemic functioning, repair, growth, environmental adaptability and reproduction.

“They can affect the animal’s ability to absorb nutrients, which can affect digestive health and behavior, making them more aggressive and even changing where they forage,” notes Shanebeck, whose research is supervised by assistant professor Stephanie Green. “Helminth parasites also suppress immune action or weaken it, as the body spends energy to mount an immune response to fight them which can make a secondary infection worse.”

As Shanebeck explains, assessing population health in wildlife typically focuses on pathogenic diseases — the often-fatal illnesses that can spread between species, and potentially from animals to humans. Parasites, on the other hand, don’t kill their hosts so they tend to be ignored in conservation and management models.

Scientists develop greener, more efficient method for producing next-generation antibiotics

With the addition of a murine-derived biocatalyst (green), this engineered protein can add a fluoride atom to create macrolide analogs (structure, right). This approach offers a greener, more efficient method for creating new antibiotics.
Credit: Martin Grininger and Rajani Arora

An international team of researchers has developed a method for altering one class of antibiotics, using microscopic organisms that produce these compounds naturally.

The findings, published in Nature Chemistry, could lead to more efficient production of antibiotics that are effective against drug-resistant bacteria.

The team started with a microorganism that is genetically programmed to produce the antibiotic erythromycin. Scientists from the Institute of Organic Chemistry and Chemical

Biology at Germany’s Goethe University wondered if the system could be genetically altered to assemble the antibiotic with one additional fluorine atom, which can often improve pharmaceutical properties.

“We had been analyzing fatty acid synthesis for several years when we identified a part of a mouse protein that we believed could be used for directed biosynthesis of these modified antibiotics, if added to a biological system that can already make the native compound,” said Martin Grininger, professor for biomolecular chemistry at Goethe University.

Model developed to predict landslides along wildfire burn scars

Drought, wildfires and intensified precipitation can lead to debris flows, a fast-moving, highly destructive landslide.
Credit: Tierney Acott/Institute for Sustainability and Energy at Northwestern

A wildfire followed by an intense rainstorm is often a recipe for disaster. Without vegetation to cushion rainfall, water runoff can turn into a fast-moving, highly destructive landslide, called a “debris flow,” which often has the power to wipe out cars, homes and highways — sometimes resulting in casualties.

Northwestern University researchers have augmented a physics-based numerical model to investigate and predict areas susceptible to debris flows. This augmented model eventually could be used in an early warning system for people living in high-risk areas, enabling them to evacuate before it’s too late. Information from model simulations also could be used to design new infrastructure — such as diversion bars that deflect fast-moving water away from homes and roads — for high hazard zones.

The research was published today (July 27) in the journal Natural Hazards and Earth System Sciences.

“People want to know about their immediate and future risk,” said Northwestern’s Daniel Horton, the study’s senior author. “Although it’s not yet to operational standards, this modelling framework could one day be instrumental in forecasting where debris flows are likely to occur and deciding who needs to be evacuated.”

Horton is an assistant professor of Earth and planetary sciences in Northwestern’s Weinberg College of Arts and Sciences, where he also leads the Climate Change Research Group. Chuxuan Li, a Ph.D. candidate in Horton’s laboratory, is the paper’s first author.

Viruses help combat antibiotic-resistant bacteria

Prof. Gil Westmeyer (l.) and his research team, in collaboration with Kilian Vogele (r.) and the start-up Invitris, have developed a new controlled production method to create bacteriophages for therapeutic use.
Credit: A. Heddergott / TUM

More and more bacteria are becoming resistant to antibiotics. Bacteriophages are one alternative in the fight against bacteria: These viruses attack very particular bacteria in a highly specific way. Now a Munich research team has developed a new way to produce bacteriophages efficiently and without risk.

The World Health Organization (WHO) regards multi-resistant germs as among the largest threats to health. In the European Union alone, 33,000 people die each year as the result of bacterial infections which cannot be treated with antibiotics. Alternative treatments or drugs are therefore urgently needed.

Bacteriophages, the natural enemies of bacteria, are one promising solution. There are millions of different types of these viruses on earth, each of which specializes in certain bacteria. In nature, the viruses use the bacteria to reproduce; they insert their DNA into the bacteria, where the viruses quickly multiply. Ultimately, they kill off the cell and move on to infect new cells. Bacteriophages work as a specific antibiotic by attacking and destroying a particular type of bacterium.

"Bacteriophages offer an enormous potential for the highly effective, personalized therapy of infectious bacterial diseases," observes Gil Westmeyer, Professor of Neurobiological Engineering at the Technical University of Munich (TUM) and Director of the Institute for Synthetic Biomedicine at Helmholtz Munich. "However, in the past, it wasn't possible to produce bacteriophages in a targeted, reproducible, safe and efficient manner – although these are exactly the decisive criteria for the successful production of pharmaceuticals."

New sensing platform deployed at controlled burn site, could help prevent forest fires

Argonne scientists conduct a controlled burn on the Konza prairie in Kansas using the Sage monitoring system. 
Resized Image using AI by SFLORG
Credit: Rajesh Sankaran/Argonne National Laboratory.

Smokey Bear has lots of great tips about preventing forest fires. But how do you stop one that’s started before it gets out of control? The answer may lie in pairing multichannel sensing with advanced computing technologies provided by a new platform called Sage.

Sage offers a one-of-a-kind combination. This combination involves both multiple types of sensors with computing ​“at the edge”, as well as embedded machine learning algorithms that enable scientists to process the enormous amounts of data generated in the field without having to transfer it all back to the laboratory. Computing ​“at the edge” means that data is processed where it is collected, in the field, while machine learning algorithms are computer programs that train themselves how to recognize patterns.

Sage is funded by the National Science Foundation and developed by the Northwestern-Argonne Institute for Science and Engineering (NAISE), a partnership between Northwestern University and the U.S. Department of Energy’s Argonne National Laboratory.

Hot on the trail of the causes of rapid ice sheet in­stabil­it­ies in cli­mate his­tory

The re­search ves­sel MARIA S. MERIAN leav­ing the har­bor of St. John’s (Canada). As a par­ti­cipant on Ex­ped­i­tion MSM 39 (2014), Lars Max, along with other re­search­ers, ob­tained the sample ma­ter­ial for this study.
Credit: MARUM – Cen­ter for Mar­ine En­vir­on­mental Sci­ences, Uni­versity of Bre­men; D. Kieke

Extreme cooling events during the last glacial, known as Heinrich Events in the North Atlantic, are a good example of how local processes change the global climate. While the impacts of Heinrich Events on the global glacial environment are well-documented in the scientific literature, their causes are still unclear. In a new study, researchers from Bremen, Kiel, Köln and São Paulo (Brazil) have now shown that an accumulation of heat in the deeper Labrador Sea caused instabilities in the Laurentide Ice Sheet, which covered much of North America at the time. The Heinrich Events were triggered as a result. The researchers demonstrated this by reconstructing past temperatures and salinities in the North Atlantic. Their results have now been published in Nature Communications.

Hein­rich Events or, more ac­cur­ately, Hein­rich Lay­ers, are re­cur­rent con­spicu­ous sed­i­ment lay­ers, usu­ally ten to 15 cen­ti­meters thick, with very coarse rock com­pon­ents that in­ter­rupt the oth­er­wise fine-grained oceanic de­pos­its in the North At­lantic. Dis­covered and de­scribed for the first time in the 1980s by geo­lo­gist Hart­mut Hein­rich, U.S. geo­chem­ist Wally Broecker later of­fi­cially named them Hein­rich Lay­ers, which has be­come a stand­ard term in pa­leocean­o­graphy.

The pres­ence of Hein­rich Lay­ers has been es­tab­lished throughout the North At­lantic, from off Ice­land, south­ward to a line run­ning from New York to North Africa. Such coarse rock debris could only have been trans­por­ted such a great dis­tance from its point of ori­gin in the Hud­son Bay by ice­bergs.

Gaming does not appear harmful to mental health, unless the gamer can't stop

Video gaming: Although today’s research suggests gaming may only be a negative influence only for those who feel compelled to game, rather than all users, there is much more to be learned, according to the Oii research.
Credit: Ella Don on Unsplash

Societies may tremble when a hot new video game is released, but the hours spent playing popular video games do not appear to be damaging players’ mental health, according to the largest-ever survey of nearly 40,000 gamers and their gaming habits, which was conducted over six weeks by a team from Oxford’s Internet Institute. That does not mean, however, that the research did not throw up some concerns – and, the team argues, much more information is needed before tech regulators can really rest easy.

The research, published in the journal Royal Society Open Science, found no ‘causal link’ between gaming and poor mental health – whatever sort of games are being played. But Professor Andrew K. Przybylski, OII Senior Research Fellow, says the research did show a distinct difference in the experience of gamers who play ‘because they want to’ and those who play ‘because they feel they have to’.

He maintains, ‘We found it really does not matter how much gamers played [in terms of their sense of well-being]. It wasn’t the quantity of gaming, but the quality that counted…if they felt they had to play, they felt worse. If they played because they loved it, then the data did not suggest it affected their mental health. It seemed to give them a strong positive feeling.’

"It wasn’t the quantity of gaming, but the quality that counted…if they felt they had to play, they felt worse. If they played because they loved it, then the data did not suggest it affected their mental health"

Professor Andrew K. Przybylski

Towards High-Quality Manganese Oxide Catalysts with Large Surface Areas

The octahedral molecular sieve (OMS-1) is a very powerful manganese oxide-based catalyst, and researchers from Tokyo Tech have found a remarkably simple way to synthesize it. By using a low-crystallinity precursor and a straightforward solid-state transformation method, they managed to produce high-quality OMS-1 nanoparticles. Their unprecedented catalytic performance and durability prove the potential of this novel synthesis approach for developing efficient catalysts and functional materials.

Manganese oxides have received much attention from materials scientists due to their widespread applications including electrodes, catalysts, sensors, supercapacitors, and biomedicine. Further, manganese is widely abundant and has many oxidation states, which allows it to form various interesting crystalline structures.

One such structure is the "todorokite-type manganese oxide octahedral molecular sieve (OMS-1)," a crystal whose unit cells (simplest repeating units of the crystal) consist of three-by-three MnO6 octahedral chains. Though promising as a catalyst, the potential of OMS-1 is limited by two reasons. First, its conventional synthesis methods are complex multi-step crystallization processes involving hydrothermal or reflux treatment. Second, these processes tend to create crystals with a higher particle size and a lower surface area, features detrimental to catalytic performance.