Brain activity during sleep differs in young people with genetic risk of psychiatric disorders

Photo by Lux Graves on Unsplash

Young people living with a genetic alteration that increases the risk of psychiatric disorders have markedly different brain activity during sleep, a study led by researchers from the Universities of Bristol and Cardiff published in the journal eLife shows.

The brain activity patterns during sleep shed light on the neurobiology behind a genetic condition called 22q11.2 Deletion Syndrome (22q11.2DS) and could be used as a biomarker to detect the onset of neuropsychiatric disorders in people with 22q11.2DS.

Caused by a gene deletion of around 30 genes on chromosome 22, 22q11.2DS occurs in one in 3000 births. It increases the risk of intellectual disability, autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and epileptic seizures. It is also one of the largest biological risk factors for schizophrenia. However, the biological mechanisms underlying psychiatric symptoms in 22q11.2DS are unclear.

Marianne van den Bree, co-senior author and Professor of Psychological Medicine at Cardiff said: “We have recently shown that the majority of young people with 22q11.2DS have sleep problems, particularly insomnia and sleep fragmentation, that are linked with psychiatric disorders. However, our previous analysis was based on parents reporting on sleep quality of their children, and the neurophysiology – what’s happening to brain activity – has not yet been explored.”

Scientists Determined Content of Harmful Substances in Ekaterinburg Mud

In Ekaterinburg, scientists made more than 60 mud samples.
Photo credit: Ilya Safarov

Scientists at Ural Federal University and the Institute of Industrial Ecology Ural Branch of the Russian Academy of Sciences, together with their colleagues from Southern Federal University, Egypt and Saudi Arabia, have studied the concentration of potentially harmful substances in surface sediments in Ekaterinburg and identified possible sources of pollution. The research contributes to the development and adoption of standards for the content of harmful substances in mud. The results of the research, funded by the Russian Science Foundation (Project №18-77-10024), are described in the journal Chemosphere.

Over several seasons, scientists took more than 60 mud samples collected at the same sites: first, in green areas with flower beds and lawns, second, from roads and, third, from neighborhoods, parking lots and sidewalks in residential areas of the 1.5 million metropolises. Dirt samples were dried under laboratory conditions for several weeks and then passed through a 1-mm sieve. The resulting dust was analyzed.

"In samples from all surveyed areas the highest concentrations of iron and manganese are found, as they are contained in rocks and soils, on which Yekaterinburg is located. Dust from green areas, in addition, has high concentrations of zinc and lead, in samples from roads - cobalt, nickel, tin and antimony, dust from yard passages, parking lots and sidewalks is full of zinc and copper," says Andrian Seleznev, Associate Professor of Department of Health and Safety at UrFU, Senior Scientist of Industrial Ecology Ural Branch of the Russian Academy of Sciences.

Archaeology and ecology combined sketch a fuller picture of past human-nature relationships

Hunting of a deer. Wall painting, 6th millennium BC. Museum of Anatolian Civilizations, Ankara.
 Image source: Wikimedia Commons

For decades now, archaeologists wielded the tools of their trade to unearth clues about past peoples, while ecologists have sought to understand current ecosystems. But these well-established scientific disciplines tend to neglect the important question of how humans and nature interacted and shaped each other across different places and through time. An emerging field called archaeoecology can fill that knowledge gap and offer insights into how to solve today’s sustainability challenges, but first, it must be clearly defined. A new paper by SFI Complexity Fellow Stefani Crabtree and Jennifer Dunne, SFI’s Vice President for Science, lays out the first comprehensive definition of archaeoecology and calls for more research in this nascent but important field.

While an archaeology or palaeobiology study might examine a particular relationship, such as how humans in New Guinea raised cassowaries during the Late Pleistocene, archaeoecology takes a much broader view. “It’s about understanding the whole ecological context, rather than focusing on one or two species,” Dunne explains.

3D imaging contributes to a better understanding of early stages of Alzheimer's disease

Three-dimensional image of noradrenergic nerve cells in the envelope of locus coeruleus.
Photo credit: Gilvesy et al.

With the help of a new imaging technique for 3D, researchers at Karolinska Institutet, among others, have been able to characterize a part of the brain that shows the most accumulation of tau protein, an important biomarker for the development of Alzheimer's disease. The results published in the journal Acta Neuropathologica may in the future make it possible to have a more accurate neuropathological diagnosis of Alzheimer's disease spectrum at a very early stage.

Intracellular accumulation of pathological tau protein in the brain is a hallmark of several age-related neurodegenerative diseases, including Alzheimer's disease, which accounts for 60-80 percent of all dementia cases worldwide.

In a new study, researchers at Karolinska Institutet, SciLifeLab in Stockholm and several universities from Hungary, Canada, Germany and France have applied a state-of-the-art immune imaging technology, in combination with light sheet microscopy, to investigate a human brain stem core, locus coeruleus, which is an important core in the mammalian brain.

How Prehistoric Humans Simplified the World’s Food Webs

Illustration depicting all mammal species that would inhabit Southern California today if not for human-linked extinction. Extinct species appear in black and white.
Credit: Oscar Sanisidro/University of Alcalá

Research conducted with the help of a University at Albany anthropologist has revealed the cascading effects that humans have had on mammal declines and their food webs over the last 130,000 years, a new study in the journal Science shows.

The study, which was carried out by researchers in the United States, United Kingdom, Denmark and Spain, set out to determine the magnitude of food web loss among mammals since the Late Pleistocene, following the arrival and expansion of human populations around the world.

“We’ve known for a long time that as humans spread out of Africa, everywhere they went, waves of animal extinctions followed their arrival,” said John Rowan, an assistant professor of anthropology at UAlbany who co-authored the study. “When humans got to North America, there were saber-toothed cats, dire wolves, mammoths, mastodons and giant bears. But all these animals start to disappear soon after our species show up.”

While scientists were aware of the human link to mammal extinctions, little was understood regarding how those losses reverberated throughout food webs, which characterize how species interact with one another in an ecosystem. Extinction alone can impact the links in a food web, but so can reductions and shifts in geographic range due to human impacts, such as habitat destruction.

Scientists Grow Lead-Free Solar Material With a Built-In Switch

Light microscopy image of nanowires, 100 to 1,000 nanometers in diameter, grown from cesium germanium tribromide (CGB) on a mica substrate. The CGB nanowires are samples of a new lead-free halide perovskite solar material that is also ferroelectric.
Credit: Peidong Yang and Ye Zhang/Berkeley Lab

Solar panels, also known as photovoltaics, rely on semiconductor devices, or solar cells, to convert energy from the sun into electricity.

To generate electricity, solar cells need an electric field to separate positive charges from negative charges. To get this field, manufacturers typically dope the solar cell with chemicals so that one layer of the device bears a positive charge and another layer a negative charge. This multilayered design ensures that electrons flow from the negative side of a device to the positive side – a key factor in device stability and performance. But chemical doping and layered synthesis also add extra costly steps in solar cell manufacturing.

Now, a research team led by scientists at DOE’s Lawrence Berkeley National Laboratory (Berkeley Lab), in collaboration with UC Berkeley, has demonstrated a unique workaround that offers a simpler approach to solar cell manufacturing: A crystalline solar material with a built-in electric field – a property enabled by what scientists call “ferroelectricity.” The material was reported earlier this year in the journal Science Advances.

Researchers produce nanodiamonds capable of delivering medicinal and cosmetic remedies through the skin

Nanodiamond applied on skin samples and penetrated through all skin layers: nanodiamond concentration reduces as the layer is deeper
Credit: Prof. Dror Fixler, Bar-Ilan University 

The skin is one of the largest and most accessible organs in the human body, but penetrating its deep layers for medicinal and cosmetic treatments still eludes science.

Although there are some remedies -- such as nicotine patches to stop smoking -- administered through the skin, this method of treatment is rare since the particles that penetrate must be no larger than 100 nanometers (one thousandth of a centimeter). Creating effective tools using such tiny particles is a great challenge. Because the particles are so small and difficult to see, it is equally challenging to determine their exact location inside the body – information necessary to ensure that they reach the intended target tissue. Today such information is obtained through invasive, often painful, biopsies.

A novel approach, developed by researchers at Bar-Ilan University in Israel, provides an innovative solution to overcoming both of these challenges. Combining techniques in nanotechnology and optics, they produced tiny (nanometric) diamond particles so small that they are capable of penetrating skin to deliver medicinal and cosmetic remedies. In addition, they created a safe, laser-based optical method that quantifies nanodiamond penetration into the various layers of the skin and determines their location and concentration within body tissue in a non-invasive manner – eliminating the need for a biopsy.

X-shaped radio galaxies might form more simply than expected

When astronomers use radio telescopes to gaze into the night sky, they typically see elliptical-shaped galaxies, with twin jets blasting from either side of their central supermassive black hole. But every once in a while, — less than 10% of the time — astronomers might spot something special and rare: An X-shaped radio galaxy, with four jets extending far into space.

Although these mysterious X-shaped radio galaxies have confounded astrophysicists for two decades, a new Northwestern University study sheds new insight into how they form — and its surprisingly simple. The study also found that X-shaped radio galaxies might be more common than previously thought.

The study was published in the Astrophysical Journal Letters. It marks the first large-scale galaxy accretion simulation that tracks the galactic gas far from the supermassive black hole all the way toward it.

Simple conditions lead to messy result

Using new simulations, the Northwestern astrophysicists implemented simple conditions to model the feeding of a supermassive black hole and the organic formation of its jets and accretion disk. When the researchers ran the simulation, the simple conditions organically and unexpectedly led to the formation of an X-shaped radio galaxy.

Dolphins form largest alliance network outside humans

Male trio with female.
Credit: Dr Simon Allen

Male bottlenose dolphins form the largest known multi-level alliance network outside humans, an international team led by researchers at the University of Bristol have shown. These cooperative relationships between groups increase male access to a contested resource.

The scientists, with colleagues from the University of Zurich and University of Massachusetts, analyzed association and consortship data to model the structure of alliances between 121 adult male Indo-Pacific bottlenose dolphins at Shark Bay in Western Australia. Their findings have been published in The Proceedings of the National Academy of Sciences (PNAS).

Male dolphins in Shark Bay form first-order alliances of two-three males to cooperatively pursue consortships with individual females. Second-order alliances of four-14 unrelated males compete with other alliances over access to female dolphins and third-order alliances occur between cooperating second-order alliances.

Co-lead author Dr Stephanie King, Associate Professor from Bristol’s School of Biological Sciences explained: “Cooperation between allies is widespread in human societies and one of the hallmarks of our success. Our capacity to build strategic, cooperative relationships at multiple social levels, such as trade or military alliances both nationally and internationally, was once thought unique to our species.

“Not only have we shown that male bottlenose dolphins form the largest known multilevel alliance network outside humans, but that cooperative relationships between groups, rather than simply alliance size, allows males to spend more time with females, thereby increasing their reproductive success.”

University Created Glass with Outstanding Radiation Protection Properties

Boron-based glass is one of the best known and highest quality systems.
Photo credit: Ilya Safarov

Physicists at Ural Federal University, together with colleagues from universities in Germany, Pakistan, and Egypt, have synthesized new glass with outstanding radiation protection properties. The glass can be used in such fields as nuclear medicine, astronaut spacesuits, and spacecraft production. An article about the research was published in the Journal of Inorganic and Organometallic Polymers and Materials.

A novel boro-bariofluoride sodium calcium nickel glasses were created using a conventional melt-hardening technique. By heating the composition to melting temperature and then abruptly cooling it to room temperature, the researchers obtained a homogeneous mixture of boron oxide, barium fluoride, calcium oxide, sodium oxide, and nickel oxide.

"Research of physical and optical properties of glasses synthesized in this way showed that as nickel oxide is added to the composition, all optical characteristics of the initial boro-bariofluoride and sodium-calcium glass samples obtained from it improve. The density of glasses increases, the absorption spectrum increases, shifting towards longer wavelengths of radiation, and the ability of the system to shield photons carrying electromagnetic radiation increases," explains Ali Abouhaswa, Senior Researcher of the Section of Solid State Magnetism at UrFU, a co-author of the article.

According to the scientist, the adding of nickel oxide makes the glass applicable to optoelectronic and photoelectric devices, such as gas sensors, UV-photosensors, photovoltaic cells, photocatalysts, and electrochromic devices.