Signal transmission in the immune and nervous system using NEMO

Jörg Tatzelt, Konstanze Winklhofer and Simran Goel (from left) carried out the investigations together.
 Photo Credit: RUB, Marquard

Certain biomolecules in the form of active complexes temporarily accumulate in cells. This can be crucial for their functionality.

When transmitting signals within cells, many individual steps interlock. Among other things, proteins are provided with certain building blocks that switch their function on or off. In order to ensure fast signal transmission, these building blocks accumulate in the cell at certain locations for a limited time; Researchers speak of biomolecular condensates. A team around Prof. Dr. Konstanze Winklhofer, head of the Molecular Cell Biology Chair at the Ruhr University Bochum, has shown that the NEMO protein also forms condensates and which mechanism underlies NEMO condensate formation. The findings are important for understanding signal transmissions in the immune and nervous systems. The researchers report in the Life Science Alliance journal.

Small isolated wetlands are pollution-catching powerhouses

Photo Credit: Herbert Aust

Small isolated wetlands that are full for only part of the year are often the first to be removed for development or agriculture, but a new study shows that they can be twice as effective in protecting downstream lake or river ecosystems than if they were connected to them. 

Using a new method involving satellite imagery and computer modelling, researchers from the University of Waterloo found that since these small wetlands are disconnected, pollutants such as nitrogen and phosphorous get trapped. This is the first study to use satellite data for estimating nutrient retention. 

All wetlands act like sponges, providing flood protection by absorbing the vast volume of water that can be suddenly released from rainfall or snowmelt. Improving water quality, providing habitat, increasing biodiversity and trapping carbon are just some of the many environmental benefits wetlands provide. Their destruction increases our vulnerability to the extreme effects of climate change, including flooding, drought and the frequency of storms. 

Researchers devise a new path toward ‘quantum light’

Photo Credit: Scientific Frontline stock image

The researchers, from the University of Cambridge, along with colleagues from the US, Israel and Austria, developed a theory describing a new state of light, which has controllable quantum properties over a broad range of frequencies, up as high as X-ray frequencies. Their results are reported in the journal Nature Physics.

The world we observe around us can be described according to the laws of classical physics, but once we observe things at an atomic scale, the strange world of quantum physics takes over. Imagine a basketball: observing it with the naked eye, the basketball behaves according to the laws of classical physics. But the atoms that make up the basketball behave according to quantum physics instead.

“Light is no exception: from sunlight to radio waves, it can mostly be described using classical physics,” said lead author Dr Andrea Pizzi, who carried out the research while based at Cambridge’s Cavendish Laboratory. “But at the micro and nanoscale so-called quantum fluctuations start playing a role and classical physics cannot account for them.”

Algae bio hacks itself in adapting to climate change

Phytoplankton - the foundation of the oceanic food chain.
Photo Credit: NOAA

Clear evidence that marine phytoplankton are much more resilient to future climate change than previously thought is the focus of a study published in Science Advances by an international team of scientists, including University of Hawaiʻi at Mānoa oceanography professor David Karl.

“Knowing how marine algae will respond to global warming and to associated decline of nutrients in upper ocean waters is crucial for understanding the long-term habitability of our planet,” said Karl.

Combining data from the long-term Hawaiʻi Ocean Time-series program at UH Mānoa with new climate model simulations conducted on one of South Korea’s fastest supercomputers, the scientists revealed that a mechanism, known as nutrient uptake plasticity, allows marine algae to adapt and cope with nutrient-poor ocean conditions that are expected to occur over the next decades in response to global warming of the upper ocean.

HudsonAlpha scientists make new discovery linked to Alzheimer’s disease

Senior Scientist Lindsay Rizzardi, PhD
Photo Credit: Courtesy of HudsonAlpha

HudsonAlpha scientists identify transcription factors that may be involved in altered gene expression seen in Alzheimer’s disease

The human brain contains many types of cells that work together to ensure it functions properly. As arguably the most important organ in the human body, if something goes amiss with any brain cells or their connections to other cells, varying levels of neurological dysfunction can occur. Many neurological disorders arise from damage to brain cells due to a build-up of misfolded or aggregated proteins in the brain, like the tau protein and the amyloid-beta protein. Specific genes contain the instructions cells need for producing proteins. Changes to those genes can affect the protein production cycle, causing a change in the amount of protein produced or the conformation or quality of that protein. 

Alterations to the DNA code itself are only one of the ways that protein production can go awry. A class of proteins called transcription factors are a key component of how genes are expressed, causing a protein product to be made at higher or lower amounts than needed. These transcription factors act without changing the genetic makeup of the gene. These factors bind to DNA and recruit repressors or activators like RNA polymerase that coordinate DNA transcription and, ultimately, translation into a protein. 

Like mushroom out ants

Argentine ant workers with brood. Ants react immediately to contamination with pathogens and not only to the later developing symptoms of a disease. The nest comrades efficiently clean colony members of infectious particles.
Photo Credit: Sina Metzler & Roland Ferrigato / ISTA

An Austrian-German research team discovered how disease-causing fungi adapt to the collective hygiene measures of ants.

Ants show many social behaviors. For example, they care for sick individuals and make it difficult to spread pathogens among the people with joint hygiene measures. Germs not only have to outsmart the immune system of individual ants, but also the health care of the whole group.

A new study, the journal, shows how the pathogens do this Nature Ecology & Evolution is published. It was presented by the team of Professor Sylvia Cremer from the Institute of Science and Technology Austria (ISTA) in cooperation with the animal ecologist Professor Thomas Schmitt from the Biozentrum of the Julius Maximilians University in Würzburg (JMU).

Molecular machines could treat fungal infections

Schematic representation of the mechanisms by which light-activated molecular machines kill fungi. Molecular machines bind to fungal mitochondria, decreasing adenosine triphosphate (ATP) production and impairing the function of energy-dependent transporters that control the movement of ions, such as calcium. This leads to the influx of water, which causes the organelles to swell and eventually the cells to burst.
Image Credit: Tour Group/Rice University

That stubborn athlete’s foot infection an estimated 70% of people get at some point in their life could become much easier to get rid of thanks to nanoscale drills activated by visible light.

Proven effective against antibiotic-resistant infectious bacteria and cancer cells, the molecular machines developed by Rice University chemist James Tour and collaborators are just as good at combating infectious fungi, according to a new study published in Advanced Science.

Based on the work of Nobel laureate Bernard Feringa, the Tour group’s molecular machines are nanoscale compounds whose paddlelike chain of atoms moves in a single direction when exposed to visible light. This causes a drilling motion that allows the machines to bore into the surface of cells, killing them.

Researchers Develop New Method to Improve Burn Assessment

The handheld THz Scanner is shown in operation.
Photo Credit: Terahertz Biophotonics Laboratory, Stony Brook University

Stony Brook Engineers Employ New Device and Neural Networks with Terahertz Spectroscopy

An important component to a more successful treatment course for burns is correctly assessing them, and current methods are not accurate enough. A team of Stony Brook University researchers believe they created a new method to significantly improve burn assessment. They are employing a physics-based neural network model that uses terahertz time-domain spectroscopy (THz-TDS) data for non-invasive burn assessment. The team combines the approach with a handheld imaging device that they developed specifically for fast THz-TDS imaging of burn injuries. Details of their method are published in a paper in Biomedical Optics Express.

Studies have shown that the accuracy of burn diagnosis is only about 60 to 75 percent when trying to decide which one of the burns needs surgical intervention (skin grafting) or which burns can heal spontaneously. The Stony Brook team has found with their method using THz-TDS — broadly defined as detecting and measuring properties of matter with picosecond short pulses of electromagnetic fields — that THz spectroscopic imaging can increase the accuracy rate of burn diagnosis and classification to approximately 93 percent.

DARPA Selects Performer Teams for Liberty Lifter X-Plane Program

Liberty Lifter
Illustration Credit: Defense Advanced Research Projects Agency

Two teams -- General Atomics working with Maritime Applied Physics Corporation and Aurora Flight Sciences working with Gibbs & Cox and ReconCraft -- will develop designs for DARPA’s Liberty Lifter Seaplane Wing-in-Ground Effect full-scale demonstrator. The Liberty Lifter program aims to demonstrate a leap-ahead in operational capability by designing, building, floating, and flying a long-range, low-cost X-Plane capable of seaborne strategic and tactical heavy lift.

The planned Liberty Lifter demonstrator will be a large flying boat similar in size and capacity to the C-17 Globemaster III transport aircraft. Goals include takeoff and land in Sea State 4, sustained on-water operation up to Sea State 5, and extended flight close to the water in ground effect with the capability to fly out of ground effect at altitudes up to 10,000 feet above sea level.

“We are excited to kick off this program and looking forward to working closely with both performer teams as they mature their point-of-departure design concepts through Phase 1,” said DARPA Liberty Lifter Program Manager Christopher Kent. “The two teams have taken distinctly different design approaches that will enable us to explore a relatively large design space during Phase 1.”

Genes decide the willow warbler’s migration routes

A young willow warbler
Photo Credit: sharkolot

Since antiquity, humans have been fascinated by birds’ intercontinental migratory journeys. A new study from Lund University in Sweden shows that two areas in their genome decide whether a willow warbler flies across the Iberian Peninsula to western Africa, or across the Balkans to eastern and southern Africa.

Researchers have long known that the behavior that causes songbirds to migrate in a specific direction towards a remote winter location is something they are born with. The recent study aims to further understanding of the genetics behind this behavior. With the help of modern technology, and 20 years of research into the genetics of songbirds and their migration routes, the researchers managed to identify which parts of the genome that determine the songbirds’ routes.

“The songbirds’ direction of travel is determined by two areas in the genome. Genes from the southern subspecies take the bird towards the southwest, across the Iberian peninsula to their wintering grounds in western Africa. Genes belonging to the northern subspecies instead lead the willow warblers towards the southeast, over the Balkans, to locations in eastern and southern Africa,” says Staffan Bensch, biology researcher at Lund University.