Large-scale genetic analysis shows microRNAs in human pancreas associated with diabetes

 NIH study identifies new molecules involved in diabetes.
Illustration Credit: CFVI

In a new large-scale genetic analysis, scientists have found a set of small RNA molecules, called microRNAs, in human pancreatic cells that are strongly associated with type 2 diabetes. Researchers discovered the microRNAs in groups of cells called pancreatic islets, which produce hormones, such as insulin, that the body uses to regulate energy levels.

In people with diabetes, the islets fail to produce sufficient insulin to control blood sugar, which is why understanding the basic biology of pancreatic islets is important for human health.

The study, led in part by scientists at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, will inform future studies on the early detection and treatment of diabetes. The results were published in Proceedings of the National Academy of the Sciences.

Previous research with animal or cell-based models over the past two decades suggests that certain microRNAs, which are involved in controlling which genes are turned on and off in cells, may help pancreatic islets normally develop and function.

Mushrooms magnify memory by boosting nerve growth

Lion's mane mushroom
Photo Credit: Kier... in Sight

Researchers from The University of Queensland have discovered an active compound from an edible mushroom that boosts nerve growth and enhances memory.

Professor Frederic Meunier from the Queensland Brain Institute said the team had identified new active compounds from the mushroom, Hericium erinaceus.

“Extracts from these so-called ‘lion’s mane’ mushrooms have been used in traditional medicine in Asian countries for centuries, but we wanted to scientifically determine their potential effect on brain cells,” Professor Meunier said.

“Pre-clinical testing found the lion’s mane mushroom had a significant impact on the growth of brain cells and improving memory.

“Laboratory tests measured the neurotrophic effects of compounds isolated from Hericium erinaceus on cultured brain cells, and surprisingly we found that the active compounds promote neuron projections, extending and connecting to other neurons.

Harmful Effects of Long-Term Alcohol Use Documented in Blood Protein Snapshot

Jon Jacobs recently found that a particular combination of blood proteins indicates alcohol-associated hepatitis, a deadly liver disease. 
Photo Credit: Eddie Pablo III | Pacific Northwest National Laboratory

Biochemist Jon Jacobs has analyzed the blood of patients with diseases and conditions such as Ebola, cancer, tuberculosis, hepatitis, diabetes, Lyme disease, brain injury and influenza.

But never has he seen blood chemistry gone so awry as when he and colleagues took an in-depth look at the protein activity in the blood of patients with alcohol-associated hepatitis, a severe form of liver disease caused by heavy drinking for many years.

“The proteins in these patients are more dysregulated than in any other blood plasma that we’ve analyzed,” said Jacobs, a scientist at the Department of Energy’s Pacific Northwest National Laboratory. “Almost two-thirds of the proteins we measured are at unusual levels. This is a snapshot of what’s going on in the body of a person with this disease and reflects just how severe a disease this is.”

That “snapshot” is a measurement of proteins that change in patients with the disease. The unique combination of changes in protein activity marks an important step toward development of a simple blood test to diagnose alcohol-associated hepatitis.

Jacobs and colleagues, including scientists and physicians from the Veteran Affairs Long Beach Healthcare System and the University of Pittsburgh, published their findings recently in the American Journal of Pathology. Corresponding authors of the study are Jacobs and Timothy Morgan, a gastroenterologist at VA Long Beach who has treated patients with the disease for more than 35 years.

Can clay capture carbon dioxide?

Sandia National Laboratories bioengineer Susan Rempe, left, and chemical engineer Tuan Ho peer through an artistic representation of the chemical structure of a kind of clay. Their team is studying how clay could be used to capture carbon dioxide.
Photo Credit: Craig Fritz

The atmospheric level of carbon dioxide — a gas that is great at trapping heat, contributing to climate change — is almost double what it was prior to the Industrial Revolution, yet it only constitutes 0.0415% of the air we breathe.

This presents a challenge to researchers attempting to design artificial trees or other methods of capturing carbon dioxide directly from the air. That challenge is one a Sandia National Laboratories-led team of scientists is attempting to solve.

Led by Sandia chemical engineer Tuan Ho, the team has been using powerful computer models combined with laboratory experiments to study how a kind of clay can soak up carbon dioxide and store it.

The scientists shared their initial findings in a paper published earlier this week in The Journal of Physical Chemistry Letters.

“These fundamental findings have potential for direct-air capture; that is what we’re working toward,” said Ho, lead author on the paper. “Clay is really inexpensive and abundant in nature. That should allow us to reduce the cost of direct-air carbon capture significantly, if this high-risk, high-reward project ultimately leads to a technology.”

Scientists boost quantum signals while reducing noise

This superconducting parametric amplifier can achieve quantum squeezing over much broader bandwidths than other designs, which could lead to faster and more accurate quantum measurements.
 Image Credit: Courtesy of the researchers

A certain amount of noise is inherent in any quantum system. For instance, when researchers want to read information from a quantum computer, which harnesses quantum mechanical phenomena to solve certain problems too complex for classical computers, the same quantum mechanics also imparts a minimum level of unavoidable error that limits the accuracy of the measurements.

Scientists can effectively get around this limitation by using “parametric” amplification to “squeeze” the noise –– a quantum phenomenon that decreases the noise affecting one variable while increasing the noise that affects its conjugate partner. While the total amount of noise remains the same, it is effectively redistributed. Researchers can then make more accurate measurements by looking only at the lower-noise variable.

A team of researchers from MIT and elsewhere has now developed a new superconducting parametric amplifier that operates with the gain of previous narrowband squeezers while achieving quantum squeezing over much larger bandwidths. Their work is the first to demonstrate squeezing over a broad frequency bandwidth of up to 1.75 gigahertz while maintaining a high degree of squeezing (selective noise reduction). In comparison, previous microwave parametric amplifiers generally achieved bandwidths of only 100 megahertz or less.

Doubling protected lands for biodiversity could require tradeoffs with other land uses

Scientists show how 30% protected land targets may not safeguard biodiversity hotspots and may negatively affect other sectors – and how data and analysis can support effective conservation and land use planning
Photo Credit: Federico Respini

Although more than half the world’s countries have committed to protecting at least 30% of land and oceans by 2030 in support of biodiversity, various questions emerge: Where and what type of land should be protected? How will new land protections impact carbon emissions and climate change, or the land needed for energy and food production? As a result, many decision makers are left questioning how to take action around protecting new land as they set their sights on achieving ambitious targets to preserve biodiversity in regions around the globe. New science tools can shed light on some of those questions.

A recent study led by climate scientists from the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) aims to inform the discussion around how protecting additional land to meet conservation goals may impact land use (such as agricultural) and land cover (such as grass, water, or vegetation). The research is among the first to explore how potential pathways to achieve these bold targets affect agricultural expansion, and its findings suggest that meeting the 30% protection targets could lead to substantial regional shifts in land use and in some cases still fail to protect the world’s most biodiverse hotspots.

“It is important that we protect land if we want to stem additional ecosystem degradation,” said the paper’s lead author Alan Di Vittorio, a research scientist in Berkeley Lab’s Earth and Environmental Sciences Area. “But protecting land entails tradeoffs with other land uses and could have negative impacts on the agricultural sector, such as less land for bioenergy crops or less forest land for timber.”

Tracking ocean microplastics from space

Video Credit: University of Michigan

Microplastic pollution can be spotted from space because its traveling companion alters the roughness of the ocean’s surface

New information about an emerging technique that could track microplastics from space has been uncovered by researchers at the University of Michigan. It turns out that satellites are best at spotting soapy or oily residue, and microplastics appear to tag along with that residue.

Microplastics—tiny flecks that can ride ocean currents hundreds or thousands of miles from their point of entry—can harm sea life and marine ecosystems, and they’re extremely difficult to track and clean up. However, a 2021 discovery raised the hope that satellites could offer day-by-day timelines of where microplastics enter the water, how they move and where they tend to collect, for prevention and clean-up efforts.

The team noticed that data recorded by the Cyclone Global Navigation Satellite System (CYGNSS), showed less surface roughness—that is, fewer and smaller waves—in areas of the ocean that contain microplastics, compared to clean areas.

Marine reserves unlikely to restore marine ecosystems

The study used visual censuses and the analysis of stable isotopes to determine the abundance and trophic niche of carnivorous fish in marine reserves and areas open to fishing.
Photo Credit: Lluís Cardona

Protected marine areas are one of the essential tools for the conservation of natural resources affected by human impact —mainly fishing—, but are they enough to recover the functioning of these systems? A study published in the ICES Journal of Marine Science, led by researchers from the Biodiversity Research Institute (IRBio) of the University of Barcelona, in collaboration with researchers from the Group of Ecosystem Oceanography (GRECO) of the Oceanographic Center of the Balearic Islands, highlights the limitations of marine reserves in restoring food webs to their pristine state prior to the impact of intensive fishing.

Protected marine areas are one of the essential tools for the conservation of natural resources affected by human impact —mainly fishing—, but are they enough to recover the functioning of these systems? A study published in the ICES Journal of Marine Science, led by researchers from the Biodiversity Research Institute (IRBio) of the University of Barcelona, in collaboration with researchers from the Group of Ecosystem Oceanography (GRECO) of the Oceanographic Center of the Balearic Islands, highlights the limitations of marine reserves in restoring food webs to their pristine state prior to the impact of intensive fishing.

Spokes move along Saturn's rings

Spokes move along Saturn's rings
Seven Hubble Space Telescope images, each taken about four minutes apart, are stitched together to show "spoke" features rotating around Saturn. The puzzling, transient features have defied easy characterization. Their rotation rate does not quite match up with the rotation of the rings or of the planet's magnetic field. The spokes are known to appear during the period leading up to and following the planet's equinox. With the northern hemisphere autumnal equinox approaching on May 6, 2025, scientists are hoping new observations by Hubble will help them to put the clues together and solve the spoke mystery—what are they, and why do they form? Hubble observations will be compared with those made by NASA's Cassini spacecraft in the period surrounding Saturn's last equinox, in 2009. With the Cassini mission completed, Hubble's annual observations of Saturn as part of its Outer Planet Atmospheres Legacy (OPAL) program will be crucial to studying and better understanding this dynamic world.
Credits: SCIENCE: NASA, ESA, Amy Simon (NASA-GSFC) ANIMATION: Alyssa Pagan (STScI)

New images of Saturn from NASA's Hubble Space Telescope herald the start of the planet's "spoke season" surrounding its equinox, when enigmatic features appear across its rings. The cause of the spokes, as well as their seasonal variability, has yet to be fully explained by planetary scientists.

Like Earth, Saturn is tilted on its axis and therefore has four seasons, though because of Saturn's much larger orbit, each season lasts approximately seven Earth years. Equinox occurs when the rings are tilted edge-on to the Sun. The spokes disappear when it is near summer or winter solstice on Saturn. (When the Sun appears to reach either its highest or lowest latitude in the northern or southern hemisphere of a planet.) As the autumnal equinox of Saturn's northern hemisphere on May 6, 2025, draws near, the spokes are expected to become increasingly prominent and observable.

Less is more

The ability to genetically change bacteria is the key to researching the microbial world.
Image Credit: Braňo

Scientists from Würzburg and Braunschweig have developed a new approach that enables more efficient processing of bacterial genomes.

The ability to genetically change bacteria is the key to researching the microbial world. Genome editing - i.e. processing the genome such as DNA - is essential in order to develop new antibiotics and to use bacteria as miniature factories for the sustainable production of chemicals, materials and therapeutics. Tools based on the CRISPR gene scissors have proven helpful here because they make it possible to change different bacteria quickly, easily and reliably.

The underlying technology requires CRISPR ribonucleic acid (crRNA), which serves as a "lead RNA". It helps to control certain regions of a genome for targeted DNA cleavage. Proteins involved in homologous recombination - a natural process of exchanging genetic material between chromosomes - then insert the designed "repair template" to create a processed sequence of the DNA strand.