Lipid analysis of alcohol-related liver disease offers potential new therapeutic targets

Illustration Credit: youngseok park

Analyses of lipids identified differences between normal liver samples and liver samples from patients with alcohol-related liver disease. The information could be used to find new treatments and for earlier detection of the disease.

Alcohol-related liver disease (ALDs) is prevalent, with one in five people that misuse alcohol found to have exhibited liver fibrosis – damaged and scarred liver tissue and a marker of advanced ALDs such as cirrhosis. Alcohol is a leading cause of cirrhosis with half of worldwide deaths from cirrhosis being caused by alcohol.

ALD is characterized by severe liver damage that causes swelling, weight loss, drowsiness and vomiting blood. The number of people with ALD in the UK has risen in the last few decades as alcohol misuse has increased.

It is widely understood that excessive alcohol consumption affects liver function and the transport of lipids. But researchers and clinicians currently don’t understand the molecular development of alcohol-related liver diseases, particularly its early development.

Deeper insights into bacteria

Image Credit: NCI

RNA sequencing technologies provide valuable insights into how individual cells work. A research team at the University of Würzburg has now developed a technique that provides an even more detailed view.

How do cells work in a normal state? How do they change when they cause disease? Do they react as desired to new drugs? Nowadays, anyone seeking answers to these – and other related – questions in the laboratory can hardly do without a special technique: single-cell RNA sequencing, or "scRNA-seq" for short. This technique provides an accurate picture of gene expression in a single cell at a specific point of time, as well as the associated regulatory networks, allowing conclusions to be drawn about the molecular basis of cell activity.

A research team at the Julius-Maximilians-Universität Würzburg (JMU) has now further improved a single-cell RNA sequencing technique it previously developed for use in bacteria. This means that the work in the laboratory is even faster than before and provides much more precise information. The team presents its development in the journal mBio.

Stress memory in plants could hold key to growing disease resistant crops

Scientists at the University of Sheffield have discovered a mechanism behind how plants can acquire long-lasting resistance against attacks from insects
Illustration Credit: Courtesy of The University of Sheffield

A mechanism behind how plants can develop long-term immunity to stress has been discovered by scientists at the University of Sheffield.

Biotic stress experienced by plants can take the form of attacks by insect herbivores or disease-causing pathogens. In crops grown for food production, this stress provides a substantial risk to crop yields and is currently managed with the widespread use of pesticides, which are damaging for the environment and can pose a risk to human health.

Due to the urgent need to find better and more sustainable plant protection methods, Professor Jurriaan Ton, from the University of Sheffield’s Institute for Sustainable Food, and his team, investigated how plants are able to acquire long-lasting immunity against these stressors.

The findings, published in Nature Plants, explain a mechanism of how plants ‘remember’ the stress from a previous attack, and that this long-term memory is encoded in a family of 'junk DNA’ that can prime defense genes for several weeks against further attacks.

Researchers take a step towards turning interactions that normally ruin quantum information into a way of protecting it

Illustration of non-Hermitian topology and open quantum systems.
Illustration Credit: Jose Lado/Aalto University.

A new method for predicting the behavior of quantum devices provides a crucial tool for real-world applications of quantum technology

Researchers have found a way to predict the behavior of many-body quantum systems coupled to their environment. The work represents a way to protect quantum information in quantum devices, which is crucial for real-world applications of quantum technology.

In a study published in Physical Review Letters, researchers at Aalto University in Finland and IAS Tsinghua University in China report a new way to predict how quantum systems, such as groups of particles, behave when they are connected to the external environment. Usually, connecting a system such as a quantum computer to its environment creates decoherence and leaks, which ruin any information about what’s happening inside the system. Now, the researchers have developed a technique which turns that problem into its solution.

The research was carried out by Aalto doctoral researcher Guangze Chen under the supervision of Professor Jose Lado and in collaboration with Fei Song from IAS Tsinghua. Their approach combines techniques from two domains, quantum many-body physics and non-Hermitian quantum physics.

Nanotube sensors are capable of detecting and distinguishing gibberellin plant hormones

The continued study of gibberellins could lead to further breakthroughs in agricultural science and have implications for food security.
Photo Credit: Courtesy of SMART.

Researchers from the Disruptive and Sustainable Technologies for Agricultural Precision (DiSTAP) interdisciplinary research group of the Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, and their collaborators from Temasek Life Sciences Laboratory have developed the first-ever nanosensor that can detect and distinguish gibberellins (GAs), a class of hormones in plants that are important for growth. The novel nanosensors are nondestructive, unlike conventional collection methods, and have been successfully tested in living plants. Applied in the field for early-stage plant stress monitoring, the sensors could prove transformative for agriculture and plant biotechnology, giving farmers interested in high-tech precision agriculture and crop management a valuable tool to optimize yield.

The researchers designed near-infrared fluorescent carbon nanotube sensors that are capable of detecting and distinguishing two plant hormones, GA3 and GA4. Belonging to a class of plant hormones known as gibberellins, GA3 and GA4 are diterpenoid phytohormones produced by plants that play an important role in modulating diverse processes involved in plant growth and development. GAs are thought to have played a role in the driving forces behind the “green revolution” of the 1960s, which was in turn credited with averting famine and saving the lives of many worldwide. The continued study of gibberellins could lead to further breakthroughs in agricultural science and have implications for food security.

COVID-19 infections raise risk of long-term gastrointestinal problems

Ziyad Al-Aly, MD, has led multiple studies on long COVID-19 as a clinical epidemiologist at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system. His latest findings show that people who have been infected with COVID-19 are at an increased risk of developing a range of gastrointestinal conditions within the first month to a year after illness.
Photo Credit: Matt MIller / School of Medicine / Washington University in St. Louis

People who have had COVID-19 are at increased risk of developing gastrointestinal (GI) disorders within a year after infection compared with people who haven’t been infected, according to an analysis of federal health data by researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system.

Such conditions include liver problems, acute pancreatitis, irritable bowel syndrome, acid reflux and ulcers in the lining of the stomach or upper intestine. The post-COVID-19 GI tract also is associated with an increased likelihood of constipation, diarrhea, abdominal pain, bloating and vomiting.

“Gastrointestinal problems were among the first that were reported by the patient community,” said senior author Ziyad Al-Aly, MD, a clinical epidemiologist at Washington University who has studied extensively the long-term effects of COVID-19 infection. “It is increasingly clear that the GI tract serves as a reservoir for the virus.”

Blood test identifies acute myeloid leukemia patients at greater risk for relapse after bone marrow transplant

Photo Credit: Tatiana

A small portion of adults in remission from a deadly blood cancer had persisting mutations that were detected, which predicted their risk of death from having the cancer return.

Researchers at the National Institutes of Health show the benefits of screening adult patients in remission from acute myeloid leukemia (AML) for residual disease before receiving a bone marrow transplant. The findings, published in JAMA, support ongoing research aimed at developing precision medicine and personalized post-transplant care for these patients.

About 20,000 adults in the United States are diagnosed each year with AML, a deadly blood cancer, and about one in three live past five years. A bone marrow transplant, which replaces unhealthy blood-forming cells with healthy cells from a donor, often improves these chances. However, research has shown that lingering traces of leukemia can make a transplant less effective. 

Researchers in the current study wanted to show that screening patients in remission for evidence of low levels of leukemia using standardized genetic testing could better predict their three-year risks for relapse and survival. To do that, they used ultra-deep DNA sequencing technology to screen blood samples from 1,075 adults in remission from AML. All were preparing to have a bone marrow transplant. The study samples were provided through donations to the Center for International Blood and Marrow Transplant Research.

Laser shots at National Ignition Facility could spark additional discoveries in astrophysics

Image of the Crab Nebula, a remnant of a supernova explosion. Scientists are studying the extreme environments in supernovae to understand where the heavy elements came from.
Image Credit: NASA, ESA, J. Hester, A. Loll (ASU)

In December, the National Ignition Facility (NIF) at the U.S. Department of Energy’s (DOE) Lawrence Livermore National Laboratory made headlines worldwide. Scientists at the NIF performed the first nuclear fusion experiment in which the energy produced from fusion exceeded the amount of energy directly applied to the fuel to ignite it. This first-of-its-kind result will provide invaluable insight into the potential for clean energy from fusion. 

But the NIF’s scientific impact doesn’t end there. Using the Argonne Tandem Linac Accelerator System (ATLAS), a DOE Office of Science user facility located at DOE’s Argonne National Laboratory, a team of scientists is studying the extreme, star-like environment created during laser shots at the NIF to better understand its potential as a testbed for nuclear astrophysics research. The work could also provide insight into the nature of stars and the origin of the elements. 

“If we can reproduce these astrophysical conditions on earth in a laboratory, we can study stellar processes in detail in a well-characterized environment close to home.” — ATLAS user Michael Paul, Hebrew University of Jerusalem 

Does current shellfish culture gear curb ‘crunching’ rays?

Whitespotted eagle rays “crunching” on clams in a large outdoor tank with clams housed within a variety of anti-predator materials.

Video Credit: Florida Atlantic University / Harbor Branch Oceanographic Institute 

According to NOAA Fisheries, more than 80 percent of marine aquaculture production in the United States consists of bivalve mollusks such as oysters, clams and mussels. However, it’s not just humans who enjoy eating these shellfish, so do marine rays. They like to “crunch” on clams, which can sometimes take a big bite out of clammers’ profits.

Part of the process of culturing hard clams (Mercenaria mercenaria) involves deploying them in submerged bottom leases in the marine environment where clams can grow to market size. When deployed onto the clam lease, clammers incorporate a variety of anti-predator materials to protect their product, such as woven mesh netting and/or additional mesh, plastic or wire covers.

However, the effectiveness of these materials against highly mobile predators like rays has not been experimentally tested. Some rays, like the whitespotted eagle ray (Aetobatus narinari), are equipped with strong jaws, plate-like teeth and nimble pectoral fins, which make them formidable and highly maneuverable predators of clams.

Plastic containers can contain PFAS — and it’s getting into food

Illustration Credit: University of Notre Dame

Researchers at the University of Notre Dame are adding to their list of consumer products that contain PFAS (per- and polyfluoroalkyl substances), a toxic class of fluorine compounds known as “forever chemicals.”

In a new study published in Environmental Science and Technology Letters, fluorinated high-density polyethylene (HDPE) plastic containers — used for household cleaners, pesticides, personal care products and, potentially, food packaging — tested positive for PFAS. Following a report conducted by the EPA that demonstrated this type of container contributed high levels of PFAS to a pesticide, this research demonstrates the first measurement of the ability of PFAS to leach from the containers into food as well as the effect of temperature on the leaching process.

Results also showed the PFAS were capable of migrating from the fluorinated containers into food, resulting in a direct route of significant exposure to the hazardous chemicals, which have been linked to several health issues including prostate, kidney and testicular cancers, low birth weight, immunotoxicity and thyroid disease.

“Not only did we measure significant concentrations of PFAS in these containers, we can estimate the PFAS that were leaching off creating a direct path of exposure,” said Graham Peaslee, professor of physics in the Department of Physics and Astronomy at Notre Dame and an author of the study.