Machine learning models rank predictive risks for Alzheimer’s disease

Xiaoyi Raymond Gao, PhD Associate Professor
Photo Credit: Courtesy of Ohio State University

Once adults reach age 65, the threshold age for the onset of Alzheimer’s disease, the extent of their genetic risk may outweigh age as a predictor of whether they will develop the fatal brain disorder, a new study suggests. 

The study, published recently in the journal Scientific Reports, is the first to construct machine learning models with genetic risk scores, non-genetic information and electronic health record data from nearly half a million individuals to rank risk factors in order of how strong their association is with eventual development of Alzheimer’s disease.

Researchers used the models to rank predictive risk factors for two populations from the UK Biobank: White individuals aged 40 and older, and a subset of those adults who were 65 or older. 

Results showed that age – which constitutes one-third of total risk by age 85, according to the Alzheimer’s Association – was the biggest risk factor for Alzheimer’s in the entire population, but for the older adults, genetic risk as determined by a polygenic risk score was more predictive. 

“We all know Alzheimer’s disease is a later-onset disease, so we know age is an important risk factor. But when we consider risk only for people age 65 or older, then genetic information captured by a polygenic risk score ranks higher than age,” said lead study author Xiaoyi Raymond Gao, associate professor of ophthalmology and visual sciences and of biomedical informatics in The Ohio State University College of Medicine. “That means it’s really important to consider genetic information when we work on Alzheimer’s disease.” 

Lab-made antibodies offer potential cure for yellow fever

Captured through a microscope, this enlarged image illustrates how yellow fever virus (purple coloring) is below detectable levels in the blood of research animals given a monoclonal antibody after being exposed to the virus (bottom squares). By comparison, yellow fever virus is clearly visible in the blood of research animals that didn’t receive a monoclonal antibody (top squares). This research suggests lab-made antibodies may be able to cure people who get sick with yellow fever, a disease for which there is no approved treatment.
Image Credit: Oregon Health & Science University

New research from Oregon Health & Science University and collaborators indicates lab-made antibodies may be able to cure people infected with yellow fever, a virus for which there is no treatment.

The natural immune response to invading pathogens normally involves making protective proteins called antibodies. A study published in Science Translational Medicine suggests that a single monoclonal antibody infusion can strengthen the body’s fight against yellow fever.

In the study, the yellow fever virus was undetectable in all animals that received monoclonal antibody infusions after being exposed to the virus.

“Two monoclonal antibodies that we evaluated completely removed all signs of infection from research animals,” said the study’s corresponding author, Ben Burwitz, Ph.D., associate professor at OHSU’s Vaccine and Gene Therapy Institute and affiliate associate professor at OHSU’s Oregon National Primate Research Center.

Vegan protein supports muscle building as effectively as animal protein

Photo Credit: Daniela

Fungi-derived mycoprotein is just as effective at supporting muscle building during resistance training as animal protein, according to the findings of a new study from the University of Exeter.

The study, published in the Journal of Nutrition, is the first to explore if a vegan diet rich in mycoprotein – the naturally high-fiber fungi that is best known as Quorn – can support muscle growth during resistance training to the same extent as an omnivorous diet. It comes as a growing number of adults are eating less meat1, with latest figures showing that there are approximately 7.2m adults who now follow a meat free diet2.

The randomized trial was split into two phases: in the first phase, 16 healthy young adults completed a three-day diet where their protein was derived from either omnivorous or exclusively vegan (predominantly Quorn’s mycoprotein) sources, whilst detailed measures of metabolism were taken. In phase two, 22 healthy young adults completed a 10-week high volume progressive resistance training program while consuming a high protein omnivorous diet or a vegan diet rich in mycoprotein.

The results demonstrated comparable increases in muscle mass and strength in response to both diets, with no significant differences between the two. The group on the high protein omnivorous diet gained 2.6 kg of whole-body lean mass, while the group on the vegan diet gained 3.1 kg. Both groups also increased the size of their thigh muscles by the same amount (8.3%) over the course of the trial.

Juvenile black rockfish affected by marine heat wave but not always for the worse, research shows

A juvenile black rockfish
Photo Credit: Will Fennie

Larvae produced by black rockfish, a linchpin of the West Coast commercial fishing industry for the past eight decades, fared better during two recent years of unusually high ocean temperatures than had been feared, new research by Oregon State University shows.

“The study is important for gauging the conditions and making management plans that will affect the species’ survival as the ocean experiences increasing variability because of climate change,” said Will Fennie, the study’s lead author.

Findings were published in Nature’s Scientific Reports.

Rockfish, a diverse genus with many species, are a group of ecologically as well as economically important fishes found from Baja California to British Columbia.

They are known for lifespans that can reach triple digits, an ability to produce prodigious numbers of offspring and variable survival during their early life stages, during which they are highly sensitive to environmental conditions.

Coconuts and lemons enable a thermal wood for indoor heating and cooling

Peter Olsén and Céline Montanari, researchers in the Department of Biocomposites at KTH Royal Institute of Technology in Stockholm, say the new wood composite uses components of lemon and coconuts to both heat and cool homes.
Photo Credit: David Callahan

A building material that combines coconuts, lemons and modified wood could one day be enough to heat and cool your home. The three renewable sources provide the key components of a wood composite thermal battery, which was developed by researchers at KTH Royal Institute of Technology in Stockholm.

Researchers reported the development in the scientific journal Small. Peter Olsén, researcher in the Department of Biocomposites at KTH, says the material is capable of storing both heat and cold. If used in housing construction, the researchers say that 100 kilos of the material can save about 2.5 kWh per day in heating or cooling—given an ambient temperature of 24C.

KTH researcher Céline Montanari says that besides sunlight, any heat source can charge the battery. “The key is that the temperature fluctuates around the transition temperature, 24C, which can of course be tailored depending on the application and location,” she says.

Deep ocean currents around Antarctica headed for collapse

Direct measurements taken from the deep ocean have established that warming is already underway.
Photo Credit: Pixabay

Antarctic circulation could slow by more than 40 per cent over the next three decades, with significant implications for oceans and the climate.

The deep ocean circulation that forms around Antarctica could be headed for collapse, say scientists.

Such a decline would stagnate the bottom of the oceans and affect climate and marine ecosystems for centuries to come.

The results are detailed in a new study coordinated by Scientia Professor Matthew England, Deputy Director of the ARC Centre for Excellence in Antarctic Science (ACEAS) at UNSW Sydney. The work, published today in Nature, includes lead author Dr Qian Li – formerly from UNSW and now at the Massachusetts Institute of Technology (MIT) – as well as co-authors from the Australian National University (ANU) and CSIRO.

Cold water that sinks near Antarctica drives the deepest flow of the overturning circulation – a network of currents that spans the world’s oceans. The overturning carries heat, carbon, oxygen and nutrients around the globe. This influences climate, sea level and the productivity of marine ecosystems. 

Drug overdose fatalities among US older adults has quadrupled over 20 years

Photo Credit: Christina Victoria Craft

Overdose mortality among people age 65 and older quadrupled over 20 years, suggesting the need for greater mental health and substance use disorder policies addressed at curbing the trend, a new research paper finds.

The deaths stemmed from both suicides and accidental overdoses, with nearly three-fourths of the unintended fatalities involving illicit drugs such as synthetic opioids like fentanyl, heroin, cocaine, and methamphetamines.  Prescription opioids, antidepressants, benzodiazepines, antiepileptics and sedatives were used in 67% of intentional overdoses.

“The dramatic rise in overdose fatalities among adults over 65 years of age in the past two decades underscores how important it is for clinicians and policymakers to think of overdose as a problem across the lifespan,” said co-author Chelsea Shover, assistant professor of medicine in the division of general internal medicine and health services research at the David Geffen School of Medicine at UCLA. “Updating Medicare to cover evidence-based treatment for substance use disorders is crucial, as is providing harm reduction supplies such as naloxone to older adults.”

Mimicking biological enzymes may be key to hydrogen fuel production

Nickel-iron hydrogenase, described by researchers as “one of nature’s most complicated and beautiful enzymes,” may be crucial in the world’s push toward a renewable energy economy. 
Illustration Credit: Courtesy Mirica group

An ancient biological enzyme known as nickel-iron hydrogenase may play a key role in producing hydrogen for a renewables-based energy economy. Careful study of the enzyme has led chemists from the University of Illinois Urbana-Champaign to design a synthetic molecule that mimics the hydrogen gas-producing chemical reaction performed by the enzyme.

The researchers reported their findings in the journal Nature Communications. 

Currently, industrial hydrogen is usually produced by separating hydrogen gas molecules from oxygen atoms in water using a process called electrolysis. To boost this chemical reaction in the industrial setting, platinum metal is used as a catalyst in the cathodes that direct the reaction. However, many studies have shown that the expense and rarity of platinum make it unattractive as the world pushes toward more environmentally sound energy sources.

Rainbow Trout Subspecies Newly Named

The McCloud River Redband Trout is known as “cali sulat” in the Winnemem Wintu language, with “cali” meaning good or beautiful and “sulat” the term for trout.
Photo Credit: Steve MacMillan

The McCloud River redband trout, or O. mykiss calisulat, is newly identified as its own distinct subspecies of rainbow trout in a study from the University of California, Davis. It is the first newly identified subspecies of Pacific trout since 2008 and the youngest rainbow trout subspecies by more than 100 years.

The study, published in the journal Zootaxa, notes that fish biologists have suspected the McCloud River redband trout was its own subspecies since at least the 1970s, but only newer genetics techniques — including genomewide DNA sequencing — allowed the UC Davis-led team to tease the puzzle apart and confirm it as a subspecies.

Northern California’s McCloud River originates from spring-fed streams near Mount Shasta before passing over a series of waterfalls, the McCloud Falls. The waterfalls are impassable to upstream movement of fishes and divide the Upper McCloud River from the Lower McCloud River.

The McCloud River redband trout is the only known native fish found in the Upper McCloud Basin.

“It’s persisted so long in isolation,” said lead author Matthew “Mac” Campbell, a research affiliate with the Department of Animal Science’s Genomic Variation Laboratory. “They’ve survived in glacial refugia during the Pleistocene era and have been above those waterfalls for at least 10,000 years.”

Cell mapping and ‘mini placentas’ give new insights into human pregnancy

Cells of the placenta 
Image Credit: Kenny Roberts, Wellcome Sanger Institute

Researchers from the University of Cambridge, the Wellcome Sanger Institute, the Friedrich Miescher Institute for Biomedical Research (FMI), Switzerland, EMBL’s European Bioinformatics Institute (EMBL-EBI), and collaborators, have created an in-depth picture of how the placenta develops and communicates with the uterus.

The study, published today in the journal Nature, is part of the Human Cell Atlas initiative to map every cell type in the human body. It informs and enables the development of experimental models of the human placenta.

"For the first time, we have been able to draw the full picture of how the placenta develops and describe in detail the cells involved in each of the crucial steps. This new level of insight can help us improve laboratory models to continue investigating pregnancy disorders, which cause illness and death worldwide,” said Anna Arutyunyan, co-first author at the University of Cambridge and Wellcome Sanger Institute.

The placenta is a temporary organ built by the fetus that facilitates vital functions such as fetal nutrition, oxygen and gas exchange, and protects against infections. The formation and embedding of the placenta into the uterus, known as placentation, is crucial for a successful pregnancy.