Screening in zebrafish identifies a drug to potentially improve recovery from spinal cord injury

Zebra fish
Photo Credit: © Center for Regenerative Therapies Dresden / Technische Universität Dresden

Scientists from the Center for Regenerative Therapies Dresden (CRTD) at TUD Dresden University of Technology, the University of Edinburgh, and the Research Institute of the McGill University Health Centre in Montreal, investigated potential drugs to improve recovery from spinal cord injury. After testing over a thousand molecules, they identified cimetidine, an existing drug, to improve spinal repair in zebrafish and mice. Their work uncovers a promising route to new treatments and highlights the potential of zebrafish to screen for molecules that aid in spinal repair. The work was published in the journal Theranostics.

Sudden impacts to the spinal cord, such as those caused by a car accident, can cause lifelong injuries. The healing of an injury can be prolonged or even prevented by inflammation caused by an overreaction of the body’s immune system. Reducing inflammation with existing anti-inflammatory drugs suppresses the immune response as a whole, inhibiting the immune cells that are beneficial and promote injury repair.

In a new study, scientists from the Center for Regenerative Therapies Dresden (CRTD) at TUD Dresden University of Technology, the University of Edinburgh, and the Research Institute of the McGill University Health Centre tested more than a thousand drugs in zebrafish larvae for their ability to prevent excessive inflammation during an immune response. Through this screening process, the research team identified an existing drug – cimetidine – that improved spinal cord repair in zebrafish.

Brain receptor patterns separate sensory and cognitive networks

Receptor patterns define key organizational principles in the brain, scientists have discovered.
Photo Credit: Pete Linforth

An international team of researchers, studying macaque brains, have mapped out neurotransmitter receptors, revealing a potential role in distinguishing internal thoughts and emotions from those generated by external influences.

The comprehensive dataset has been made publicly available, serving as a bridge linking different scales of neuroscience - from the microscopic to the whole brain.

Lead author Sean Froudist-Walsh, from the University of Bristol’s Department of Computer Science explained: “Imagine the brain as a city. In recent years, brain research has been focused on studying its roads, but in this research, we've made the most detailed map yet of the traffic lights - the neurotransmitter receptors - that control information flow.

“We've discovered patterns in how these 'traffic lights' are arranged that help us understand their function in perception, memory, and emotion.

“It's like finding the key to a city's traffic flow, and it opens up exciting possibilities for understanding how the normal brain works.

“Potentially in the future, other researchers may use these maps to target particular brain networks and functions with new medicines.

Clean, sustainable fuels made ‘from thin air’ and plastic waste

Carbon capture from air and its photoelectrochemical conversion into fuel with simultaneous waste plastic conversion into chemicals. 
Photo Credit: Ariffin Mohamad Annuar

Researchers have demonstrated how carbon dioxide can be captured from industrial processes – or even directly from the air – and transformed into clean, sustainable fuels using just the energy from the sun.

The researchers from the University of Cambridge developed a solar-powered reactor that converts captured CO2 and plastic waste into sustainable fuels and other valuable chemical products. In tests, CO2 was converted into syngas, a key building block for sustainable liquid fuels, and plastic bottles were converted into glycolic acid, which is widely used in the cosmetics industry.

Unlike earlier tests of their solar fuels technology however, the team took CO2 from real-world sources – such as industrial exhaust or the air itself. The researchers were able to capture and concentrate the CO2 and convert it into sustainable fuel.

Although improvements are needed before this technology can be used at an industrial scale, the results, reported in the journal Joule, represent another important step toward the production of clean fuels to power the economy, without the need for environmentally destructive oil and gas extraction.

GE Aerospace runs one of the world’s largest supercomputer simulations to test revolutionary new open fan engine architecture

CFM’s RISE open fan engine architecture.
Image Credit: GE Aerospace

To support the development of a revolutionary new open fan engine architecture for the future of flight, GE Aerospace has run simulations using the world’s fastest supercomputer capable of crunching data in excess of exascale speed, or more than a quintillion calculations per second.

To model engine performance and noise levels, GE Aerospace created software capable of operating on Frontier, a recently commissioned supercomputer at the U.S. Department of Energy’s (DOE) Oak Ridge National Laboratory with processing power of about 37,000 GPUs. For comparison, Frontier’s processing speed is so powerful, it would take every person on Earth combined more than four years to do what the supercomputer can in one second.  

By coupling GE Aerospace’s computational fluid dynamics software with Frontier, GE was able to simulate air movement of a full-scale open fan design with incredible detail.

“Developing game-changing new aircraft engines requires game-changing technical capabilities. With supercomputing, GE Aerospace engineers are redefining the future of flight and solving problems that would have previously been impossible,” said Mohamed Ali, vice president and general manager of engineering for GE Aerospace.

“Predatory bacteria” provide hope for chlorine-free drinking water

The inside of a water pipe
Photo Credit: Krisjtan Pullerits / Lund University

In a unique study carried out in drinking water pipes in Sweden, researchers from Lund University and the local water company tested what would happen if chlorine was omitted from drinking water. The result? An increase in bacteria, of course, but after a while something surprising happened: a harmless predatory bacteria grew in numbers and ate most of the other bacteria. The study suggests that chlorine is not always needed if the filtration is efficient - and that predatory bacteria could perhaps be used to purify water in the future.

Just as human intestines contain a rich bacterial flora, many types of bacteria thrive in our drinking water and the pipes that transport them. On the inside of pipe walls is a thin, slippery coating, called a biofilm, which protects and supports bacteria. These bacteria have adapted to life in the presence of chlorine, which otherwise has the primary task to kill bacteria, particularity bacteria that can make humans sick.  

An ordinary glass of drinking water contains a lot of harmless bacteria. Chlorine, however, which in the studied piping system was added in the form of monochloramine, is not wholly unproblematic.

Climate impact of natural gas often worse than assumed

Dr. Florian Dietrich (blue shirt) and prof. Jia Chen check the measuring systems on the roof of the TUM.
Photo Credit: Andreas Heddergott / Technical University of Munich

Heating and cooking with natural gas often has a greater impact on the climate than commonly believed. This is a conclusion of a new calculation model developed by researchers at the Technical University of Munich (TUM). The difference: the researchers’ model also takes into account the enormous quantities of unused gas released into the atmosphere.

“We wanted to know whether – when gas leakage is also considered – gas or electricity is more climate friendly for heating and cooking,” explains Dr. Florian Dietrich, a researcher at the TUM Associate Professorship of Environmental Sensing and Modeling. In collaboration with researchers at ETH Zurich, the University of Utrecht and the Dutch organization for applied research in natural sciences TNO, the international team used a high-tech measurement station to capture carbon dioxide, methane and carbon monoxide. They also used laser spectrometers for onsite methane measurements. They then combined all variables in a specially designed calculation model. The results were published and verified in a peer review process.

Simple maintenance can reduce hospital Legionella risks

Photo Credit: PublicDomainPictures

Hospital water systems are a significant source of Legionella, resulting in the potentially fatal Legionnaires’ disease – but Flinders University researchers have proven simple maintenance that involves running hot water regularly and flushing the pipes has a huge effect in reducing the risk of the disease.

One of the biggest challenges for Legionella management within large hospital systems is that under unfavorable conditions, Legionella transforms itself into a state (called viable but non culturable – VBNC) that cannot be detected using standard methods.

To understand the extent of the problem, Flinders University researchers conducted the first comprehensive study that quantified all Legionella, including those in the VBNC state, and free-living amoebae from a hospital water system under dynamic flow and temperature conditions.

“We took a different approach because we didn’t know how often the standard method was returning false negative results for Legionella and it’s really hard to determine the optimal management approach if you can’t trust your testing method,” says Flinders University’s Associate Professor Harriet Whiley.

Gravity foundations: A marine-friendly future for wind turbines

Photo Credit: Tom Swinnen

Gravity-base structures may offer a porpoise and dolphin-friendly construction alternative to traditional pile-driven wind turbine foundations, new research suggests.

Marine scientists from Newcastle University investigated short- and long-term impacts of this new wind turbine installation method on cetaceans off Blyth, Northumberland. The response of dolphins and harbor porpoises was investigated using cetacean echolocation recorders over a three-year period, covering one year before, during and after the installation.

The findings revealed that wind turbine installation using gravity-base foundations had no long-term effects on the occurrence of dolphins or porpoises.

“Our findings are important in light of the global expansion of offshore wind farms and the need to find installation methods that have less impact to the marine environment”, says lead author and master’s graduate Kelsey Potlock. “These findings are promising for conservationists, marine environmental managers, and for the future of offshore renewable energy.”

Physicists Have Presented a New Way to Control Wheat Quality

Russia is one of the world's largest grain producers
Photo Credit: Andriy Nestruiev

A team of scientists from the Ural Federal University and the Ural Branch of the Russian Academy of Sciences has tested a new method that can be used to verify whether wheat has been irradiated and how safe the consequences are for consumers. Without documentation and sophisticated equipment, it is difficult to determine whether grain has been treated. Currently, there are methods for testing irradiated products, but they are more expensive and not as accurate, physicists say. The method of verification proposed by the scientists can make the analysis easier and cheaper, because the products themselves will act as an alternative to the detector in the radiation treatment. The study was supported by the Russian Foundation for Basic Research (project № 20-58-26002). The experimental results were published in the journal Radiation Physics and Chemistry.

Ionizing radiation of agricultural products is an effective method of disinfecting and neutralizing harmful microorganisms. This method is widely used in many countries and is approved by international organizations such as the World Health Organization, the Food and Agriculture Organization, and the International Atomic Energy Agency. After irradiation, the product is safe and does not lose its beneficial properties. Moreover, the destruction of harmful microorganisms (for example, mold) can increase the safety of the same wheat for further planting. In Russia, radiation treatment of agricultural products is allowed by law. There are several facilities in the country that use this type of decontamination. However, this type of food decontamination is not as widespread as, for example, in the United States or China.

Chemistry without detours: TUD researchers introduce a two-step process for producing phosphorus-containing chemicals

Example of a complex biomolecule from the group of functionalized nucleotides, achieved through the method developed by the Weigand Research Group using conventional phosphoric acid.
Image Credit: © Weigand Group

Professor Jan J. Weigand and his team from the TUD Dresden University of Technology have achieved a ground breaking advancement in the production of phosphorus-containing chemicals. In a recent publication in the renowned scientific journal Nature Synthesis, they present an innovative synthesis method that requires only two process steps for the previously complex production of functionalized phosphates. This promising innovation not only contributes to environmental protection but also saves significant time and costs. Furthermore, it offers the industry the opportunity to become less dependent on third countries. The research team has already filed two patents for this new process.

Phosphorus and its compounds are essential components of life and indispensable in our daily lives. In the human body, this element plays a crucial role in energy transfer and numerous cellular functions. Phosphorus compounds are used in fertilizers, detergents, medications, and many other products. Additionally, phosphorus is an essential ingredient in flame retardants, battery electrolytes, and catalysts. On Earth, phosphorus exists exclusively in the form of phosphates. The production of phosphorus-containing chemicals typically involves a complex and energy-intensive multi-step process. Initially, highly toxic white phosphorus (P4) is produced via a redox pathway and then further processed into phosphorus trichloride (PCl3) and other problematic and sometimes highly toxic intermediate products. Phosphorus chemistry based on P4 is associated with significant challenges but plays an indispensable role in the chemical industry due to its great importance.