Weekly insulin injections have the potential to be as effective

Photo Credit: Peter Stanic

Insulin icodec, a once-weekly basal injection to treat type 1 diabetes, has the potential to be as effective in managing the condition as daily basal insulin treatments, according to research from the University of Surrey. The results of the year-long phase 3 clinical trial could revolutionize the future of diabetes care and help millions of people better manage their condition. 

During this pioneering study, scientists across 12 countries at 99 sites, led by Professor David Russell-Jones from Surrey, tested the efficacy and safety of a weekly basal injection of icodec (a long-lasting type of insulin) and compared it to a daily basal injection of insulin degludec in adults with type 1 diabetes. Short acting insulin to cover meals was used in both groups. 

Professor David Russell-Jones, Professor of Diabetes and Endocrinology at the University of Surrey and a Consultant at the Royal Surrey Foundation Trust, said: 

"Many people find managing a long-term condition such as diabetes very difficult and report missing vital insulin injections. Missed injections can affect glycaemic control, and a lack of consistency in the treatment has been linked to increased rates of diabetic ketoacidosis, a serious complication of the condition that can be life-threatening. Reducing insulin injection frequency could lessen the burden of treatment for some people with the condition and improve their glycaemic control." 

Type 1 diabetes occurs when the body cannot produce enough of the hormone insulin, causing the level of glucose (sugar) in the blood to become too high, leading to an increased risk of developing heart, eye, and kidney disease. 

To learn more about the efficacy of icodec, scientists recruited 582 participants with type 1 diabetes. Participants were split into two groups; the first received once-weekly injections of icodec (700U/ml), and the second received daily injections of degludec (100 U/ml), both in combination with aspart, a short-acting insulin at mealtimes. 

After 26 weeks, scientists identified HbA1C (a protein within red blood cells with glucose attached to it and the universal marker for overall diabetes control) levels in those who had taken icodec had decreased from a mean of 7.59 percent at baseline to an estimated mean of 7.15 percent, and for degludec, the mean had decreased from 7.63 percent to 7.10 percent. The estimated treatment difference between them being 0.05 percent, confirming the non-inferiority of icodec to degludec, but with a significantly reduced injection frequency for patients to manage. 

 Scientists did also identify higher rates of hypoglycemic episodes (abnormally low levels of glucose in the blood) in the icodec group compared to degludec. However, despite the higher levels in the icodec group, scientists noted that incidences were low in both groups, with most episodes only requiring oral carbohydrate administration. For icodec, time below 3.0 mmol/L was at the threshold of the internationally recommended targets during weeks 22-26 and below recommended targets during weeks 48-52.  

 Professor Russell-Jones added: 

 "What we have found is that once-weekly icodec injections showed non inferiority to once-daily injections of degludec in reducing HbA1C after 26 weeks. Although there is a slightly higher rate of hypoglycaemia under this regime, we found this could be easily managed. We’ve concluded this new insulin may have a role in reducing the burden of daily basal injections for patients managing type 1 diabetes. 

 "Our findings are very promising, but further analysis of continuous glucose monitoring data and real-world studies are needed." 

Funding: Provided by Novo Nordisk. 

Published in journal: The Lancet

Source/Credit: University of Surrey

Reference Number: phar103023_01

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Humans have substantially altered the relationship between wolves and deer

A breeding female wolf traveling on a logging road carrying a deer fawn back to her pups in June 2023.
 Photo Credit: Voyageurs Wolf Project

New research from the University of Minnesota’s Voyageurs Wolf Project found that human activities in northern Minnesota — logging, road and trail creation, and infrastructure development — have profoundly impacted where wolves hunt and kill deer fawns. By altering forest ecosystems, humans have created an environment that possibly favors predators. 

This research, recently published in Ecological Applications, is a collaboration between the University of Minnesota, Northern Michigan University, the University of Manitoba, Voyageurs National Park, and the Voyageurs Wolf Project. The Voyageurs Wolf Project is funded, in part, by the Minnesota Environment and Natural Resources Trust Fund as recommended by the Legislative-Citizen Commission on Minnesota Resources (LCCMR). 

“The premise is really quite simple: human activities change where deer are on the landscape, and wolves go where the deer are,” said co-lead author Thomas Gable, a postdoctoral researcher at the University of Minnesota and project lead for the Voyageurs Wolf Project. 

New antibody could target breast cancers

A synthetic antibody called RD-43, developed by graduate student Zhe Qian in collaboration with CSHL’s Antibody & Phage Display Shared Resource, may help stop the spread of breast cancer by degrading the PTPRD enzyme.
Image Credit: Courtesy of Cold Spring Harbor Laboratory

An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of Cold Spring Harbor Laboratory Professor Nicholas Tonks. With further development, the antibody might offer an effective drug treatment for those same breast cancers.

The new antibody targets an enzyme called PTPRD that is overabundant in some breast cancers. PTPRD belongs to a family of molecules known as protein tyrosine phosphatases (PTPs), which help regulate many cellular processes. They do this by working in concert with enzymes called kinases to control how other proteins inside cells behave. Kinases add small chemical regulators called phosphates to proteins. PTPs take them off.

Disruptions in the addition or removal of phosphates can contribute to inflammation, diabetes, and cancer. Some disruptions can be corrected with kinase-blocking drugs. Tonks explains:

Tackling the growing issue of light pollution

An experimental street light erected at Cockle Park Farm, Newcastle University
Photo Credit: Courtesy of Newcastle University

Light pollution, or excessive artificial light at night, is now recognized as a major driver of environmental change, adversely impacting wildlife and even human health. But predicting how entire communities of plants and animals respond to light pollution is difficult. Published today (30 October) in the Philosophical Transactions of the Royal Society B, the world’s longest running scientific journal, a team of Guest Editors that includes researchers from Newcastle University have compiled a theme issue titled ‘light pollution in complex ecological systems’ that draws together 17 papers from experts in the field.

Professor Darren Evans from the School of Natural and Environmental Sciences, who is a Guest Editor and author of three of the published papers, said: “Street lights, vehicles, commercial buildings and domestic sources are all contributing to night-time light pollution, and it is becoming increasingly clear that it affects a range of plants and animals, including humans. But most studies to date have tended to look at the responses of individual species, rather than looking at the responses of whole communities at the ecosystem scale. This theme issue goes some way to addressing that gap.”

The collection of studies in the theme issue aims to dive deeper into how light pollution affects the natural environment. Newly published articles investigate light pollution ecology at various scales and in a range of environments, from single processes to whole communities, to better understand the relationship between light pollution, ecological balance, and human influence.

Using lasers to ‘heat and beat’ 3D-printed steel could help reduce costs

Retrieval of a stainless steel part made by 3D printing 
Photo Credit: Jude E. Fronda

The method, developed by a research team led by the University of Cambridge, allows structural modifications to be ‘programmed’ into metal alloys during 3D printing, fine-tuning their properties without the ‘heating and beating’ process that’s been in use for thousands of years.

The new 3D printing method combines the best qualities of both worlds: the complex shapes that 3D printing makes possible, and the ability to engineer the structure and properties of metals that traditional methods allow. The results are reported in the journal Nature Communications.

3D printing has several advantages over other manufacturing methods. For example, it’s far easier to produce intricate shapes using 3D printing, and it uses far less material than traditional metal manufacturing methods, making it a more efficient process. However, it also has significant drawbacks.

“There’s a lot of promise around 3D printing, but it’s still not in wide use in industry, mostly because of high production costs,” said Dr Matteo Seita from Cambridge’s Department of Engineering, who led the research. “One of the main drivers of these costs is the amount of tweaking that materials need after production.”

The brain may learn about the world the same way some computational models do

Two new MIT studies offer evidence supporting the idea that the brain uses a process similar to a machine-learning approach known as “self-supervised learning.”
Illustration Credit: geralt

To make our way through the world, our brain must develop an intuitive understanding of the physical world around us, which we then use to interpret sensory information coming into the brain.

How does the brain develop that intuitive understanding? Many scientists believe that it may use a process similar to what’s known as “self-supervised learning.” This type of machine learning, originally developed as a way to create more efficient models for computer vision, allows computational models to learn about visual scenes based solely on the similarities and differences between them, with no labels or other information.

A pair of studies from researchers at the K. Lisa Yang Integrative Computational Neuroscience (ICoN) Center at MIT offers new evidence supporting this hypothesis. The researchers found that when they trained models known as neural networks using a particular type of self-supervised learning, the resulting models generated activity patterns very similar to those seen in the brains of animals that were performing the same tasks as the models.

The findings suggest that these models are able to learn representations of the physical world that they can use to make accurate predictions about what will happen in that world, and that the mammalian brain may be using the same strategy, the researchers say.

Two bee species become one as researchers solve identity puzzle

The male Xanthesma (Xenohesma) brachycera.
Photo Credit: Courtesy of Curtin University

A new study by Curtin and Flinders Universities has found that what were thought to be two different species of native Australian bee are in fact one.

Lead researcher Dr Kit Prendergast from the Curtin School of Molecular and Life Sciences said the study, based on native bee surveys at Perth locations of Wireless Hill, Shenton Park and Russo Reserve, fundamentally alters previous thinking.

“Essentially the research team used DNA sequencing to show that what we used to think of as two different species of bees are actually just the males and females of one, single species,” Dr Prendergast said.

“For many native bee species in Australia, their descriptions were based on only one sex. Identifying males and females as belonging to the same species solely through observation can be challenging, as both sexes of the same species often display noticeable differences.

Native waterfall-climbing fish threatened by climate change, human activity

ʻOʻopu nākea is a type of goby fish found only in Hawaiʻi.
Photo Credit: Courtesy of University of Hawaiʻi

New research out of the University of Hawaiʻi at Mānoa is highlighting the importance of the ma uka (mountain) to ma kai (ocean) approach to the stewardship of Hawaiʻi’s natural and cultural resources.

The research focused on ʻoʻopu nākea, a type of goby fish found only in Hawaiʻi. ʻOʻopu nākea spends the larval part of its life in the ocean before returning to the freshwater streams to complete adulthood. It is also one of five freshwater fishes endemic to Hawaiʻi with fused pelvic fins that act as a suction cup to help climb waterfalls as they migrate upstream.

Unfortunately, like so many endemic species to Hawaiʻi, ʻoʻopu nākea are under threat from climate change and human activity and previous research indicated the species no longer needed to reach the ocean to complete their life cycle.

The UH Mānoa-led team utilized the latest microchemistry methods and found that 100% of ʻoʻopu nākea are still using the ocean as an important part of larval development. The study, “Understanding Amphidromy in Hawaiʻi: ʻOʻopu nākea (Awaous stamineus),” was published in the Journal of Fish Biology, and although the findings were positive, they still highlight the importance of preserving Hawaiʻi’s freshwater streams and bodies of water.

Mechanics of breast cancer metastasis discovered, offering target for treatment

A human breast cancer cell, adenocarcinoma MDA-MB-231, demonstrates metastatic-like adhesion, spreading and migrating in a collagen matrix designed to mimic soft tissue. New research led by Penn State reveals for the first time the mechanics behind how breast cancer cells may invade healthy tissues. The discovery, showing that a motor protein called dynein powers the movement of cancer cells in soft tissue models, offers new clinical targets against metastasis and has the potential to fundamentally change how cancer is treated. 
Image Credit: Erdem Tabdanov / Pennsylvania State University
(CC BY-NC-ND 4.0 DEED)

The most lethal feature of any cancer is metastasis, the spread of cancer cells throughout the body. New research led by Penn State reveals for the first time the mechanics behind how breast cancer cells may invade healthy tissues. The discovery, showing that a motor protein called dynein powers the movement of cancer cells in soft tissue models, offers new clinical targets against metastasis and has the potential to fundamentally change how cancer is treated.

“This discovery marks a paradigm shift in many ways,” said Erdem Tabdanov, assistant professor of pharmacology at Penn State and a lead co-corresponding author on the study, recently published in the journal Advanced Science. “Until now, dynein has never been caught in the business of providing the mechanical force for cancer cell motility, which is their ability to move themselves. Now we can see that if you target dynein, you could effectively stop motility of those cells and, therefore, stop metastatic dissemination.”

The project began as a collaboration between Penn State’s Department of Chemical Engineering and Penn State’s College of Medicine, before growing into a multi-institution partnership with researchers at the University of Rochester Medical Center, Georgia Institute of Technology, Emory University, and the U.S. Food and Drug Administration.

Spinaron: A Rugby in a Ball Pit. New Quantum Effect Demonstrated for the First Time

The cobalt atom (red) has a magnetic moment (“spin,” blue arrow ), which is constantly reoriented (from spin-up to spin-down) by an external magnetic field. As a result, the magnetic atom excites the electrons of the copper surface (gray), causing them to oscillate (creating ripples). This revelation by the Würzburg-Dresden Cluster of Excellence ct.qmat was made possible thanks to the physicists’ inclusion of an iron tip (yellow) on their scanning tunneling microscope.
Illustration Credit: © Juba Bouaziz/Ulrich Puhlfürst

For the first time, experimental physicists from the Würzburg-Dresden Cluster of Excellence ct.qmat have demonstrated a new quantum effect aptly named the “spinaron.” In a meticulously controlled environment and using an advanced set of instruments, they managed to prove the unusual state a cobalt atom assumes on a copper surface. This revelation challenges the long-held Kondo effect – a theoretical concept developed in the 1960s, and which has been considered the standard model for the interaction of magnetic materials with metals since the 1980s. These groundbreaking findings were published today in the esteemed journal Nature Physics.

Ultra-Cold & Ultra-Strong: Pushing Boundaries in the Lab

Extreme conditions prevail in the Würzburg laboratory of experimental physicists Professor Matthias Bode and Dr. Artem Odobesko. Affiliated with the Cluster of Excellence ct.qmat, a collaboration between JMU Würzburg and TU Dresden, these visionaries are setting new milestones in quantum research. Their latest endeavor is unveiling the spinaron effect. They strategically placed individual cobalt atoms onto a copper surface, brought the temperature down to 1.4 Kelvin (–271.75° Celsius), and then subjected them to a powerful external magnetic field. “The magnet we use costs half a million euros. It’s not something that’s widely available,” explains Bode. Their subsequent analysis yielded unexpected revelations.