The Evolutionary Timeline of Diminished Boric Acid and Urea Transportation in Aquaporin 10

Aquaporin (Aqp) 10 water channels in humans allow the free passage of water, glycerol, urea, and boric acid across cells. However, Aqp10.2b in pufferfishes allows only the passage of water and glycerol and not urea and boric acid. Researchers from the Tokyo Institute of Technology sought to understand the evolutionary timeline that resulted in the variable substrate selection mechanisms among Aqp10s. Their results indicate that Aqp10.2 in ray-finned fishes may have reduced or lost urea and boric acid permeabilities through evolution.

Aquaporins (Aqps) are proteins that form water channels in the membranes of living cells, including those of bacteria, fungi, animals, and plants. These channels facilitate water transportation across cells more rapidly than diffusion through the membrane phospholipid bilayer.

Aqp10 belongs to the aquaglyceroporin subfamily of water channels. These proteins facilitate many of our body's physiological processes, including gut function, liver and fat cell metabolism, and skin elasticity. Water and solutes, such as glycerol, urea, and boric acid, get transported through human Aqp10 depending on concentration gradients across the membrane.

Sarcopterygians, which include coelacanths, lungfish, and tetrapods (such as amphibians, reptiles, birds, and mammals), are known to have a single gene that codes for Aqp10. In contrast, actinopterygians, such as ray-finned fishes, have paralogs, or near-identical copies, of the aqp10 gene, such as aqp10.1 and aqp10.2. Interestingly, the ray-finned Japanese pufferfish has paralog called aqp10.2b that shows permeability to water and glycerol but not to urea and boric acid.

Western Cascades landscapes in Oregon historically burned more often than previously thought

Students, tribal members and others visit the study site.
Photo Credit: Sarah Altemus Pope of the Southern Willamette Forest Collaborative.

Forests on the west slope of Oregon’s Cascade Range experienced fire much more often between 1500 and 1895 than had been previously thought, according to new research by scientists at Oregon State University.

The findings provide important insight, the authors say, into how landscapes might adapt to climate change and future fire regimes.

James Johnston of the OSU College of Forestry led the study, which was published in Ecosphere.

“Wildland fire is a fundamental forest ecosystem process,” he said. “With temperatures rising and more and more area burning, we need to know as much as we can about the long-term variability in fire.”

Johnson and collaborators at Oregon State, the University of Oregon and the U.S. Forest Service gathered tree ring data at 16 sites in the southern part of the Willamette National Forest, in the general vicinity of Oakridge.

Trees form scars after cambial cells are killed by wildfire heat, he said. These scars are partially or completely covered by new tissue as a tree grows, and tree rings tell the story of when the fire exposure occurred.

Risk of young-onset dementia could be reduced through targeting health and lifestyle factors

Researchers have identified a wide range of risk factors for young-onset dementia. The findings challenge the notion that genetics are the sole cause of the condition, laying the groundwork for new prevention strategies.

The largescale study identified 15 risk factors, which are similar to those for late-onset dementia. For the first time, they indicate that it may be possible to reduce the risk of young-onset dementia by targeting health and lifestyle factors.

Relatively little research has been done on young-onset dementia, though globally there are around 370,000 new cases of young-onset dementia each year.

Published in JAMA Neurology, the new research by the University of Exeter and Maastricht University followed more than 350,000 participants younger than 65 across the United Kingdom from the UK Biobank study. The team evaluated a broad array of risk factors ranging from genetic predispositions to lifestyle and environmental influences. The study revealed that lower formal education, lower socioeconomic status, genetic variation, lifestyle factors such as alcohol use disorder and social isolation, and health issues including vitamin D deficiency, depression, stroke, hearing impairment and heart disease significantly elevate risk of young-onset dementia

Blue PHOLEDs: Final color of efficient OLEDs finally viable in lighting

Jaesang Lee, Electrical Engineering PhD Student, demonstrates use of an earlier blue PHOLED innovation by University of Michigan professor Steve Forrest’s research group in 2014. Forrest’s lab introduced PHOLEDs to the world in the early 2000s and has been trying to improve the lifetime of blue PHOLEDs ever since. Now, they might finally be hardy enough to use in lighting applications. Image credit: Joseph Xu, Michigan Engineering Communications & Marketing The blue LEDs were developed in EECS Professor Stephen Forrest’s lab groups and are for use in cell phones, tablets, and other electronics. The LEDs’ lifetime has been enhanced by a factor of ten, allowing for more efficient use.
Photo Credit: Joseph Xu, Michigan Engineering Communications & Marketing

Lights could soon use the full color suite of perfectly efficient organic light-emitting diodes, or OLEDs, that last tens of thousands of hours, thanks to an innovation from physicists and engineers at the University of Michigan.

The U-M team’s new phosphorescent OLEDs, commonly referred to as PHOLEDs, can maintain 90% of the blue light intensity for 10-14 times longer than other designs that emit similar deep blue colors. That kind of lifespan could finally make blue PHOLEDs hardy enough to be commercially viable in lights that meet the Department of Energy’s 50,000-hour lifetime target. Without a stable blue PHOLED, OLED lights need to use less-efficient technology to create white light.

The lifetime of the new blue PHOLEDs currently is only long enough to use as lighting, but the same design principle could be combined with other light-emitting materials to create blue PHOLEDs hardy enough for TVs, phone screens and computer monitors. Display screens with blue PHOLEDs could potentially increase a device’s battery life by 30%.

How antibiotic-resistant bacteria can teach us to modify behavior

UCLA researchers used knowledge of biological resistance to build a framework for modifying behavior that contributes to climate change.
Photo Credit: Arndt-Peter Bergfeld

Most people want to do something about climate change, but lifestyle trade-offs and a narrowing window to enact broad changes to industrial, transportation, and consumption patterns are daunting enough to make them resist.  

Resistance has different meanings across different fields of study. But UCLA biologists who study resistance in the natural world believe insights gleaned from some of its smallest inhabitants could help identify barriers to social changes, including those required to resolve human–wildlife conflicts, and formulate specific strategies for overcoming them.

Biologists have long studied how agricultural pests become resistant to pesticides and how bacteria evolve antibiotic resistance. UCLA researchers have pinpointed several effective tactics to counter this resistance that could help humans embrace urgently needed changes, they suggest in a paper published in Evolutionary Applications. 

The team built a framework of biologically derived resistance management strategies, suggesting that the different views of resistance can help to identify friction points between humans and the natural world, and between humans and their social worlds.  

Nanoscale Analysis Provides Key Answers for Modeling Mineralization in Basalt

A methodology on resolving nanoscale processes during carbon mineralization—discovered and led by Pacific Northwest National Laboratory Post Doctoral Researcher Xiaoxu Li and Chemist Emily Nienhuis—provides insight into the previous knowledge gaps needed for accurate reservoir models.  
Composite Credit: Mike Perkins | Pacific Northwest National Laboratory

Removing carbon dioxide (CO2) from industrial emissions and from the atmosphere and then safely storing it into the Earth’s deep subsurface is becoming increasingly essential to meeting decarbonization goals and preserving a livable planet.

Pacific Northwest National Laboratory (PNNL) scientists discovered how to store supercritical CO2—carbon dioxide in its fluid state—in basalt reservoirs safely and permanently. This process is called geologic carbon sequestration, or carbon mineralization. But for the technology to be deployed commercially in the United States a Class VI well permit must first be attained.

“In order to apply for and be issued this permit, there has to be what is called a reservoir model for us to understand the fate and behavior of the injected CO2,” said PNNL Chemist Emily Nienhuis. “In other words, if we inject x amount of CO2 into a reservoir, where does it go? And how long does it take to mineralize or become rock?”

New study examines the relationship between the rate of wound healing, the circadian rhythm, and ‘hair’ on cells

Fibroblasts need to accumulate at the wound site when repairing wounds such as skin wounds. We found that fibroblasts with long primary cilia migrate slower to the wound site than fibroblasts with short primary cilia.
Illustration Credit: Ryota Nakazato/Hiroshima University

We’re all familiar with our body’s internal clock: it gives us cues on when to wake and when to rest, but it also can determine the rate and time of day at which your body most effectively heals wounds.

Nearly every organism on Earth follows a natural circadian rhythm that is coded by your cell’s clock genes, which do exactly as you suspect from the name: regulate your body’s rhythm on a 24-hour basis. Most cells in mammalian bodies have cilia of some sort, which are hair-like structures that perform a variety of functions such as movement for motile cilia and aiding in structure in function for non-motile, or primary, cilia. The primary cilia also act as a sensory organ for the cell, a function which has illuminated the primary cilia’s potential role in the healing process and how bodies heal at a different rate according to our circadian rhythm. In this research, the role of the primary cilia, biological clock and wound healing is explored.

Ural Scientists Assessed How Vegetation Changes in the Mountains

As scientists explain, the woody vegetation of high mountains is a sensitive indicator of climate change.
 Photo Credit: Pavel Yelfimov

Specialists of the Ural Carbon test site, researchers from the Ural Federal University (UrFU) with colleagues from the Ural State Forestry Technical University, have proposed a methodology for automated mapping of high mountain woody vegetation. The methodology is based on the comparison of data from archival aerial images and modern satellite images, RIA Novosti reported. The work of researchers will help to objectively assess the peculiarities of the appearance of new trees on unforested territory depending on the influence of the environment. The description of the methodology is published in the journal Forests.

"Woody vegetation of high mountains, near its upper limit of growth, is a sensitive indicator of climate change. Therefore, mountain ranges in different regions of the Earth are considered as areas for studying the early vegetation response to regional climate change. The aim of our work was twofold. The first part involves demonstrating an effective method of automated mapping of vegetation cover units: forest, sparse woodland, open stand, and tundra with freestanding trees developed by us, and to analyze changes occurring in plant communities under the conditions of modern climate warming near the upper limit of tree growth. The second part includes evaluating the efficiency of the method on the example of assessing the expansion of Siberian larch into mountain tundra in the Polar Urals over the past 50 years," explains Valery Fomin, Vice-Rector for Research and Innovation at Ural State Forestry Technical University and researcher at UrFU.

Shock wave photographed passing through a single cell

Images of an underwater shock wave moving through a HeLa cell.
Using this new technology, the researchers could see the difference between how the shock wave moved inside and outside of a cell submerged in water. They noted that the results suggested that the cell structure shifts with the visualized wavefront position (shown in the red/ orange line in the image).
 Image Credit: © 2023 Saiki et al. University of Tokyo

A microscopic shock wave has been photographed passing through a single biological cell, thanks to a new photography technique. Nanosecond photography uses ultrafast electronic cameras to take images at the speed of a billionth of a second. However, image quality and exposure time are typically limited. Now, a team led by researchers at the University of Tokyo has achieved superfine images taken over multiple timescales at high-speed using a system they named spectrum circuit. Spectrum circuit bridges the gap between optical imaging and conventional electronic cameras, enabling photography at ultrafast speeds with less blur and more accuracy. This technology has potential applications for science, medicine and industry.

You’re waiting with your camera for just the right moment. Suddenly, your subject speeds by and you’ve barely clicked the shutter. Missed it. Timing can be everything in photography and capturing images at high speed poses a particular challenge. But thanks to advances in camera technology, these days we can see the world like never before. Whether it’s the sweat on a racing cyclist’s brow, the focus in the eyes of a swooping falcon or, with this latest improvement in nanosecond photography, the movement of a shock wave passing through a microscopic single cell at high speed.

Light color is less important for the internal clock than originally thought

To what extent does the color of light influence our internal clock and sleep? The results of a study conducted in Basel shed light on this.
Photo Credit: Josh Hild

Light in the evening is thought to be bad for sleep. However, does the color of the light play a role? Researchers from the University of Basel and the Technical University of Munich (TUM) compared the influence of different light colors on the human body. The researchers’ findings contradict the results of a previous study in mice.

Vision is a complex process. The visual perception of the environment is created by a combination of different wavelengths of light, which are decoded as colors and brightness in the brain. Photoreceptors in the retina first convert the light into electrical impulses: with sufficient light, the cones enable sharp, detailed, and colored vision. Rods only contribute to vision in low light conditions allowing for different shades of grey to be distinguished but leaving vision much less precise. The electrical nerve impulses are finally transmitted to ganglion cells in the retina and then via the optic nerve to the visual cortex in the brain. This region of the brain processes the neural activity into a colored image.