NIH study offers new clues into the causes of post-infectious ME/CFS

In-depth study finds brain, immune, and metabolic abnormalities linked to debilitating chronic disease.
Image Credit: John A Beal
(CC BY 4.0 DEED)

In a detailed clinical study, researchers at the National Institutes of Health have found differences in the brains and immune systems of people with post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS). They also found distinct differences between men and women with the disease. The findings were published in Nature Communications.

“People with ME/CFS have very real and disabling symptoms, but uncovering their biological basis has been extremely difficult,” said Walter Koroshetz, M.D., director of NIH’s National Institute of Neurological Disorders and Stroke (NINDS). “This in-depth study of a small group of people found a number of factors that likely contribute to their ME/CFS. Now researchers can test whether these findings apply to a larger patient group and move towards identifying treatments that target core drivers of the disease.”

A team of multidisciplinary researchers discovered how feelings of fatigue are processed in the brains of people with ME/CFS. Results from functional magnetic resonance imaging (fMRI) brain scans showed that people with ME/CFS had lower activity in a brain region called the temporal-parietal junction (TPJ), which may cause fatigue by disrupting the way the brain decides how to exert effort.

They also analyzed spinal fluid collected from participants and found abnormally low levels of catecholamines and other molecules that help regulate the nervous system in people with ME/CFS compared to healthy controls. Reduced levels of certain catecholamines were associated with worse motor performance, effort-related behaviors, and cognitive symptoms. These findings, for the first time, suggest a link between specific abnormalities or imbalances in the brain and ME/CFS.

Mitochondrial activation in transplanted cells promotes regenerative therapy for heart healing

Regenerative therapy to treat heart failure is more effective when the mitochondria of the regenerative cells are activated prior to treatment.
Image Credit: Gemini Advance

Heart failure stands as a leading cause of mortality worldwide, demanding advanced treatment options. Despite the urgency for more effective treatments, options for severe heart failure remain limited. Cell transplantation therapy has emerged as a promising ray of hope, as it can be used in regenerative therapy to heal the heart.

A research team led by Professor Yuma Yamada of Hokkaido University’s Faculty of Pharmaceutical Science has developed a technique to promote cardiac regeneration by delivering mitochondrial activators to cardiac progenitor cells. Their findings were published in the Journal of Controlled Release.

“Cardiomyocytes efficiently use the mitochondrial tricarboxylic acid cycle to produce large amounts of adenosine triphosphate from several substrates via oxidative phosphorylation (OXPHOS),” explains Yamada. “Based on the energy metabolism of cardiomyocytes, we hypothesized that activating the mitochondrial function of transplanted cells may improve the outcome of cell transplantation therapy.”

Sleep improves ability to recall complex events

Sleep is important for reinforcing complex associations, the basis for completing memories of entire events
Photo Credit: Shane

Researchers have known for some time that sleep consolidates our memories of facts and episodic events. However, the research to date has concentrated mainly on simple associations – that is to say, connections between elements, such as we make when learning new vocabulary. “But in real life, events are generally made up of numerous components – for example, a place, people, and objects – which are linked together in the brain,” explains Dr. Nicolas Lutz from LMU’s Institute of Medical Psychology. These associations can vary in strength and some elements might be connected with each other only indirectly. “Thanks to the neural connections that underlie these associations, a single cue word is often all it takes for somebody to recall not only individual aspects of an event but multiple aspects at once.” This process, which is known as pattern completion, is a fundamental feature of episodic memory. Lutz is lead author of a study recently published in the journal Proceedings of the National Academy of Sciences (PNAS), which investigated the effect of sleep on memory of such complex events.

Cloud model could help with climate research

Clouds have a number of important functions. They act as reflectors whereby water droplets in the cloud reflect radiation back to the Earth, which contributes to the greenhouse effect.
Photo Credit: Rodion Kutsaiev

When clouds meet clear skies, cloud droplets evaporate as they mix with dry air. A new study involving researchers from the University of Gothenburg has succeeded in capturing what happens in a model. Ultimately, this could lead to more accurate climate modeling in the future.

The clouds in the sky have a significant impact on our climate. Not only do they produce precipitation and provide shade from the sun, they also act as large reflectors that prevent the radiation of heat from the Earth – commonly known as the greenhouse effect.

“Although clouds have been studied for a long time, they are one of the biggest sources of uncertainty in climate models,” explains Bernhard Mehlig, Professor of Complex Systems at the University of Gothenburg. “This is because there are so many factors that determine how the clouds affect radiation. And the turbulence in the atmosphere means that everything is in constant motion. This makes things even more complicated.”

New non-toxic method for producing high-quality graphene oxide

Alexandr Talyzin and his research group at the Department of Physics have developed a new method to synthesize graphene oxide.
Photo Credit: Mattias Pettersson

Researchers from Umeå have found a new way to synthesize graphene oxide which has significantly fewer defects compared to materials produced by the most common method. Similarly good graphene oxide could be synthesized previously only using a rather dangerous method involving extremely toxic fuming nitric acid.

Graphene oxide is often used to produce graphene by removing oxygen. However, if you have holes in graphene oxide, you have holes also after converting it into graphene. Therefore, the quality of the graphene oxide is very important. Alexandr Talyzin and his research group at Umeå University have now cracked the puzzle of how to safely make good graphene oxide. Their results were recently published in the scientific journal Carbon.

Graphene is often described as a “wonder material thanks to its flexibility, high mechanical strength and conductivity. But all properties of graphene are affected by defects. Graphene produced from graphene oxide has much worse than expected mechanical properties and conductivity.

Learning How Cells Dispose of Unwanted Materials is Key to Potential New Therapeutics

Gary Kleiger, UNLV professor and chair of the department of chemistry and biochemistry in the College of Sciences.
Photo Credit: Lonnie Timmons III / University of Nevada, Las Vegas

Are you sick and tired of getting sick and tired? A UNLV-led research team is exploring whether the reason we sometimes feel ill in the first place is because our body’s cells suffer from trash that accumulates within them.

Gary Kleiger, professor and chair of the department of chemistry and biochemistry at UNLV, along with Brenda Schulman, director of the Munich-based Max Planck Institute of Biochemistry, and their teams are working on ways to help our bodies hunt down and destroy disease-causing proteins. They’re the authors of a groundbreaking new study published Feb. 20 in the journal Molecular Cell that furthers our understanding of how enzymes called cullin-RING ligases (or CRLs) help cells get rid of proteins that are no longer needed. The results also point to a potential Achilles heel for proteins that make us ill. 

“Cullin-RING-ligases (CRLs) are complex nanomachines that are crucial for the cell’s intricate disposal and recycling systems,” said Schulman. “CRLs tag defective, toxic, or superfluous proteins with a small protein called ubiquitin, and mutations or malfunctions impairing CRLs are often associated with diseases, like developmental disorders or cancers.” 

Physically impaired primates find ways to modify their behaviors to compensate for their disabilities

Infant macaque at the Awajishima Monkey Center.
Photo Credit: Sarah Turner

Primates show a remarkable ability to modify their behaviors to accommodate their physical disabilities and impairments according to a new literature review by Concordia researchers.

Whether the disabilities are the result of congenital malformations or injuries, many primate species exhibited behavioral flexibility and innovation to compensate for their disabilities. They also benefitted from flexible and innovative behavior by their mothers early in life and from their peers within their population group as they aged.

Researchers at the Primatology and Interdisciplinary Environmental Studies (PIES) Lab looked at 114 studies and published their findings in the American Journal of Primatology.

The survey also revealed something the researchers had not anticipated.

“Brogan Stewart, a PhD candidate and the paper’s lead author, noticed that a high proportion of the papers mentioned a connection to human activity as a potential or actual cause of impairment,” says co-corresponding author Sarah Turner, an associate professor in the Department of Geography, Planning and Environment in the Faculty of Arts and Science.

“The disabilities may be the result of primates being caught in snares intended for other animals, or farmers trying to deter crop foraging. Perhaps they are the result of vehicle collision, or sometimes there are links between a small population’s genetics and the impairments, or diseases transmitted from people or contaminants in the environment.”

Could Ultra-Processed Foods Be the New ‘Silent’ Killer?

Hundreds of novel ingredients never encountered by human physiology are now found in nearly 60 percent of the average adult’s diet and nearly 70 percent of children’s diets in the U.S.
Photo Credit: Nico Smit

From fizzy drinks to cereals and packaged snacks to processed meat, ultra-processed foods are packed with additives. Oil, fat, sugar, starch and sodium, as well as emulsifiers such as carrageenan, mono- and diglycerides, carboxymethylcellulose, polysorbate and soy lecithin continue to strip food of healthy nutrients while introducing other ingredients that could also be detrimental to human health.

Hundreds of novel ingredients never encountered by human physiology are now found in nearly 60 percent of the average adult’s diet and nearly 70 percent of children’s diets in the United States.

While obesity and lack of physical activity are well recognized contributors to avoidable morbidity and mortality in the U.S., another emerging hazard is the unprecedented consumption of these ultra-processed foods in the standard American diet. This may be the new “silent” killer, as was unrecognized high blood pressure in previous decades.

Physicians from Florida Atlantic University’s Schmidt College of Medicine explored this hypothesis and provide important insights to health care providers in a battle where the entertainment industry, the food industry and public policy do not align with their patients’ needs. Their findings are published in a commentary in The American Journal of Medicine.

The Radcliffe Wave is Waving

How the Radcliffe Wave moves through the backyard of our Sun (yellow dot). Blue dots are clusters of baby stars. The white line is a theoretical model by Ralf Konietzka and collaborators that explains the current shape and motion of the Wave. The magenta and green lines at the beginning show how and to what extent the Radcliffe Wave will move in the future. Background is a cartoon model of the Milky Way. 
Illustration Credit: Ralf Konietzka, Alyssa Goodman & WorldWide Telescope

CfA astronomers report oscillation of our giant, gaseous neighbor.

A few years ago, astronomers at the Center for Astrophysics | Harvard & Smithsonian (CfA) uncovered one of the Milky Way's greatest secrets: an enormous, wave-shaped chain of gaseous clouds in our sun’s backyard, giving birth to clusters of stars along the spiral arm of the galaxy we call home.

Naming this astonishing new structure the Radcliffe Wave, in honor of the Harvard Radcliffe Institute where the undulation was originally discovered, astronomers at CfA now report in Nature that the Radcliffe Wave not only looks like a wave, but also moves like one – oscillating through space much like "the wave" moving through a stadium full of fans.

"By using the motion of baby stars born in the gaseous clouds along the Radcliffe Wave," said Ralf Konietzka, the paper's lead author and a Ph.D. student at Harvard’s Kenneth C. Griffin Graduate School of Arts and Sciences and CfA, "we can trace the motion of their natal gas to show that the Radcliffe Wave is actually waving."

Scientists use Summit supercomputer to explore exotic stellar phenomena

Astrophysicists at the State University of New York, Stony Brook, and University of California, Berkeley created 3D simulations of X-ray bursts on the surfaces of neutron stars. Two views of these X-ray bursts are shown: the left column is viewed from above while the right column shows it from a shallow angle above the surface. The panels (from top to bottom) show the X-ray burst structure at 10 milliseconds, 20 milliseconds and 40 milliseconds of simulation time.
Image Credit: Michael Zingale/Department of Physics and Astronomy at SUNY Stony Brook.

Understanding how a thermonuclear flame spreads across the surface of a neutron star — and what that spreading can tell us about the relationship between the neutron star’s mass and its radius — can also reveal much about the star’s composition. 

Neutron stars — the compact remnants of supernova explosions — are found throughout the universe. Because most stars are in binary systems, it is possible for a neutron star to have a stellar companion. X-ray bursts occur when matter accretes on the surface of the neutron star from its companion and is compressed by the intense gravity of the neutron star, resulting in a thermonuclear explosion. 

Astrophysicists at the State University of New York, Stony Brook, and University of California, Berkeley, used the Oak Ridge Leadership Computing Facility’s Summit supercomputer, located at the Department of Energy’s Oak Ridge National Laboratory, to compare models of X-ray bursts in 2D and 3D. 

“We can see these events happen in finer detail with a simulation. One of the things we want to do is understand the properties of the neutron star because we want to understand how matter behaves at the extreme densities you would find in a neutron star,” said Michael Zingale, a professor in the Department of Physics and Astronomy at SUNY Stony Brook who led the project.