Liquid crystal nanoparticles supercharge antibiotics for cystic fibrosis

Image Credit: Copilot Dall E-3 AI generated

Cystic fibrosis is the most common, life-limiting genetic condition in Australia. It affects the lungs, digestive system, and reproductive system, producing excess mucus, infections, and blockages.

Now, thanks to a $500,000 grant from Brandon BioCatalyst's CUREator incubator, through their CSIRO-funded Minimizing Antimicrobial Resistance Stream, University of South Australia researchers are advancing the development of liquid crystal nanoparticle-formulated antibiotics to more accurately target and eliminate difficult-to-cure lung infections in people with cystic fibrosis.

Funded by the Medical Research Future Fund CUREator provides grant funding to support the development of Australian biomedical research and innovations.

The study will use a patent-protected platform technology, invented by UniSA’s Centre for Pharmaceutical Innovation to establish new therapies for cystic fibrosis sufferers. UniSA will also work with the Cystic Fibrosis Airways Research Group at the Women’s and Children’s Hospital to advance the platform.

True trans visibility requires better data

The influential book Invisible Women articulates some of the countless ways in which women are missing from the data we use to understand the world, including the testing of many drugs, consideration of how best to support refugees, and others. The book is powerful, because it shines a light into how, by missing women out, we (unintentionally) do harm.

This trans visibility day, we’ve been thinking about whether a similar book could be written for trans people, and have had to conclude that it could not. Trans people and their experiences are so missing from the datasets that shape social science that we cannot even begin to fully understand the extent of their absence, and how this affects their lives.

Trans identities are missing from our datasets, meaning that their experiences in a number of domains cannot be studied quantitatively. The way in which many of our datasets are constructed reinforces a cis-normative understanding of the world, where people are pushed into the false binary of describing themselves as either male or female. Even less desirably, their gender is often assumed by the person administering the dataset, or worse, lumped into the amorphous category of “other” – literally othering survey respondents with a trans or non-binary identity.

Unleashing Disordered Rocksalt Oxides as Cathodes for Rechargeable Magnesium Batteries

Schematics of the battery and present cathode material. The present material contains many metal elements as cations thanks to the effect of the high configurational entropy.
Illustration Credit: ©Tohoku University

Researchers at Tohoku University have made a groundbreaking advancement in battery technology, developing a novel cathode material for rechargeable magnesium batteries (RMBs) that enables efficient charging and discharging even at low temperatures. This innovative material, leveraging an enhanced rock-salt structure, promises to usher in a new era of energy storage solutions that are more affordable, safer, and higher in capacity.

Details of the findings were published in the Journal of Materials Chemistry. 

The study showcases a considerable improvement in magnesium (Mg) diffusion within a rock-salt structure, a critical advancement since the denseness of atoms in this configuration had previously impeded Mg migration. By introducing a strategic mixture of seven different metallic elements, the research team created a crystal structure abundant in stable cation vacancies, facilitating easier Mg insertion and extraction.

This represents the first utilization of rocksalt oxide as a cathode material for RMBs. The high-entropy strategy employed by the researchers allowed the cation defects to activate the rocksalt oxide cathode.

New Method Developed to Isolate HIV Particles

The image shows PNF-coated magnetic microbeads that bind HIV particles to their surface.
Image Credit: Torsten John

Researchers at Leipzig University and Ulm University have developed a new method to isolate HIV from samples more easily, potentially making it easier to detect infection with the virus. They focus on peptide nanofibrils (PNFs) on magnetic microparticles, a promising tool and hybrid material for targeted binding and separation of viral particles. They have published their new findings in the journal Advanced Functional Materials.

“The presented method makes it possible to efficiently capture, isolate and concentrate virus particles, which may improve the sensitivity of existing diagnostic tools and analytical tests,” says Professor Bernd Abel of the Institute of Technical Chemistry at Leipzig University. The nanofibrils used – small, needle-like structures – are based on the EF-C peptide, which was first described in 2013 by Professor Jan Münch from Ulm University and Ulm University Medical Center. EF-C is a peptide consisting of twelve amino acids that forms nanoscale fibrils almost instantaneously when dissolved in polar solvents. These can also be applied to magnetic particles. “Using the EF-C peptide as an example, our work shows how peptide fibrils on magnetic particles can have a completely new functionality – the more or less selective binding of viruses. Originally, fibrils of this kind were more likely to be associated with neurodegenerative diseases,” adds Dr Torsten John, co-first author of the study and former doctoral researcher under Professor Abel at Leipzig University. He is now a junior researcher at the Max Planck Institute for Polymer Research in Mainz, Germany.

Key Ocean Current Contains a Warning on Climate

Scientists extracted a 5.3 million-year record of the Antarctic Circumpolar Current by drilling sediment cores in the Earth’s most remote waters. Here, the drill ship JOIDES Resolution makes its way through the far southeast Pacific.
Photo Credit: Gisela Winckler

It carries more than 100 times as much water as all the world’s rivers combined. It reaches from the ocean’s surface to its bottom, and measures as much as 2,000 kilometers across. It connects the Indian, Atlantic and Pacific oceans, and plays a key role in regulating global climate. Continuously swirling around the southernmost continent, the Antarctic Circumpolar Current is by far the world’s most powerful and consequential mover of water. In recent decades it has been speeding up, but scientists have been unsure whether that is connected to human-induced global warming, and whether the current might offset or amplify some of warming’s effects.

In a new study, an international research team used sediment cores from the planet’s roughest and most remote waters to chart the ACC’s relationship to climate over the last 5.3 million years. Their key discovery: During past natural climate swings, the current has moved in tandem with Earth’s temperature, slowing down during cold times and gaining speed in warm ones―speedups that abetted major losses of Antarctica’s ice. This suggests that today’s speedup will continue as human-induced warming proceeds. That could hasten the wasting of Antarctica’s ice, increase sea levels, and possibly affect the ocean’s ability to absorb carbon from the atmosphere.

“This is the mightiest and fastest current on the planet. It is arguably the most important current of the Earth climate system,” said study coauthor Gisela Winckler, a geochemist at Columbia University’s Lamont-Doherty Earth Observatory who co-led the sediment sampling expedition. The study “implies that the retreat or collapse of Antarctic ice is mechanistically linked to enhanced ACC flow, a scenario we are observing today under global warming,” she said.

New Nanoceramics Could Help Improve Smartphone and TV Displays

Nanoceramics are strong because they are made under high pressure.
Photo Credit: Anna Marinovich

Scientists from the Ural Federal University, together with colleagues from India and the Ural Branch of the Russian Academy of Sciences, have developed a nanoceramic that glows in three main colors - red, green, and blue. The new material is extremely strong because it is created under high pressure. Scientists believe that the characteristics of the new nanoceramics - luminescence, strength, and transparency - will be useful for creating screens with improved brightness and detail for smartphones, televisions, and other devices. The scientists published detailed information about the new nanoceramics and their properties in the journal Applied Materials Today. 

"We obtained optically transparent nanoceramics capable of luminescing in red, green, and blue colors. This was made possible by adding carbon particles that act as carbon nanodots. During the synthesis process, the carbon components are encapsulated between the ceramic particles, creating defects on their surface. We believe that these defects create several energy levels in the carbon nanodots, allowing the material to glow in different colors in the visible spectrum", explains Arseny Kiryakov, the co-author of the work, Associate Professor of the UrFU Department of Physical Techniques and Devices for Quality Control.

New rapid method to predict effects of conservation actions on complex ecosystems

From left: Dr Matthew Adams, Sarah Vollert, Professor Drovandi
Photo Credit: Courtesy of Queensland University of Technology

A new way to analyze the effects of conservation actions on complex ecosystems has cut the modelling time from 108 days to six hours, QUT statisticians have found:

• Some conservation efforts backfire, eg eradicating feral cats could lead to rabbit explosion

• Modeling predicts the cascading effects through species in a complex ecosystem, but is computationally slow

• New method cuts prediction time from 3.5 months to six hours

PhD researcher Sarah Vollert, from the School of Mathematical Sciences and the QUT Centre for Data Sciences, said it was impossible to predict exactly how conservation actions would affect each species.

“Though well-intentioned, conservation actions have the potential to backfire,” Ms. Vollert said.

“For example, if decision-makers decide to eradicate feral cats, it could lead to explosive populations of their prey species, like rabbits.

“Uncontrolled rabbit populations could then have devastating effects on the vegetation, destroying the habitat native species need to survive.

A Tiny Spot Leads to a Large Advancement in Nano-processing, Researchers Reveal

A conceptual illustration of single-shot laser processing by an annular-shaped radially polarized beam, focused on the back surface of a glass plate.
Illustration Credit: ©Y. Kozawa et al.

Focusing a tailored laser beam through transparent glass can create a tiny spot inside the material. Researchers at Tohoku University have reported on a way to use this small spot to improve laser material processing, boosting processing resolution.

Laser machining, like drilling and cutting, is vital in industries such as automotive, semiconductors, and medicine. Ultra-short pulse laser sources, with pulse widths from picoseconds to femtoseconds, enable precise processing at scales ranging from microns to tens of microns. But recent advancements demand even smaller scales, below 100 nanometers, which existing methods struggle to achieve.

The researchers focused on a laser beam with radial polarization, known as a vector beam. This beam generates a longitudinal electric field at the focus, producing a smaller spot than conventional beams.

Scientists have identified this process as promising for laser processing. However, one drawback is that this field weakens inside the material due to light refraction at the air-material interface, limiting its use.

A new type of cooling for quantum simulators

Tiantian Zhang and Maximilian Prüfer discussing measurements in the quantum lab
Photo Credit: Courtesy of Technische Universität Wien

Quantum experiments always have to deal with the same problem, regardless of whether they involve quantum computers, quantum teleportation or new types of quantum sensors: quantum effects break down very easily. They are extremely sensitive to external disturbances - for example, to fluctuations caused simply by the surrounding temperature. It is therefore important to be able to cool down quantum experiments as effectively as possible.

At TU Wien (Vienna), it has now been shown that this type of cooling can be achieved in an interesting new way: A Bose-Einstein condensate is split into two parts, neither abruptly nor particularly slowly, but with a very specific temporal dynamic that ensures that random fluctuations are prevented as perfectly as possible. In this way, the relevant temperature in the already extremely cold Bose-Einstein condensate can be significantly reduced. This is important for quantum simulators, which are used at TU Wien to gain insights into quantum effects that could not be investigated using previous methods.

Researchers Identify Microbes That Help Plants Thwart Parasite

Sorghum crops in sub-Saharan Africa suffer heavy losses from the parasitic plant witchweed (Striga hermonthica). A new study shows how soil microbes can help protect sorghum from this pest and could be the basis for a soil probiotic treatment.
Photo Credit: Sabine

Bacteria that could help one of Africa’s staple crops resist a major pest have been identified by researchers at the University of California, Davis. Their findings, published in Cell Reports, could improve yields of sorghum, a mainstay of food and drink in West and East African countries.

About 20 percent of Africa’s sorghum crop is lost due to witchweed (Striga hermonthica), a parasitic plant that steals nutrients and water by latching onto the plant’s roots.

In a new study, UC Davis researchers show that soil microbes induce changes in sorghum roots that make the plant more resistant to infection by witchweed. They identified specific strains of bacteria that trigger these resistance traits and could be applied as a soil “probiotic” to improve sorghum yields in future.

“These microbes have great promise as soil additives that can help farmers grow sorghum successfully in sub-Saharan Africa,” said Siobhan Brady, a professor in the Department of Plant Biology and Genome Center and a senior author on the paper.