Risk factors for faster aging in the brain revealed in new study

Governments have been urged to act decisively before 2035 to ensure global warming can be kept below 2°C by 2100.
Photo Credit: Nöel Puebla

Researchers from the Nuffield Department of Clinical Neurosciences at the University of Oxford have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.

The researchers had previously identified a ‘weak spot’ in the brain, which is a specific network of higher-order regions that not only develop later during adolescence, but also show earlier degeneration in old age. They showed that this brain network is also particularly vulnerable to schizophrenia and Alzheimer’s disease.

In this new study, published in Nature Communications, they investigated the genetic and modifiable influences on these fragile brain regions by looking at the brain scans of 40,000 UK Biobank participants aged over 45.

The researchers examined 161 risk factors for dementia, and ranked their impact on this vulnerable brain network, over and above the natural effects of age. They classified these so-called ‘modifiable’ risk factors − as they can potentially be changed throughout life to reduce the risk of dementia − into 15 broad categories: blood pressure, cholesterol, diabetes, weight, alcohol consumption, smoking, depressive mood, inflammation, pollution, hearing, sleep, socialization, diet, physical activity, and education.

Not unique to humans but uniquely human: researchers identify factor involved in brain expansion in humans

A microscopy image of a human brain organoid.
Image Credit: © Janine Hoffmann

What makes us human? According to neurobiologists it is our neocortex. This outer layer of the brain is rich in neurons and lets us do abstract thinking, create art, and speak complex languages. An international team led by Dr. Mareike Albert at the Center for Regenerative Therapies Dresden (CRTD) of TUD Dresden University of Technology has identified a new factor that might have contributed to neocortex expansion in humans. The results were published in the EMBO Journal.

The neocortex is the characteristic folded outer layer of the brain that resembles a walnut. It is responsible for higher cognitive functions such as abstract thinking, art, and language. “The neocortex is the most recently evolved part of the brain,” says Dr. Mareike Albert, research group leader at the CRTD. “All mammals have a neocortex, but it varies in size and complexity. Human and primate neocortices have folds while, for example, mice have a completely smooth neocortex, without any creases.”

The folds characteristic of the human brain increases the surface area of the neocortex. The human neocortex has a greater number of neurons that support complex cognitive functions.

The molecular mechanisms driving neocortex evolution are still largely unknown. “Which genes are responsible for inter-species differences in neocortex size? What factors have contributed to brain expansion in humans? Answering these questions is crucial to understanding human brain development and potentially addressing mental health disorders,” explains Dr. Albert.

Liquid crystal nanoparticles supercharge antibiotics for cystic fibrosis

Image Credit: Copilot Dall E-3 AI generated

Cystic fibrosis is the most common, life-limiting genetic condition in Australia. It affects the lungs, digestive system, and reproductive system, producing excess mucus, infections, and blockages.

Now, thanks to a $500,000 grant from Brandon BioCatalyst's CUREator incubator, through their CSIRO-funded Minimizing Antimicrobial Resistance Stream, University of South Australia researchers are advancing the development of liquid crystal nanoparticle-formulated antibiotics to more accurately target and eliminate difficult-to-cure lung infections in people with cystic fibrosis.

Funded by the Medical Research Future Fund CUREator provides grant funding to support the development of Australian biomedical research and innovations.

The study will use a patent-protected platform technology, invented by UniSA’s Centre for Pharmaceutical Innovation to establish new therapies for cystic fibrosis sufferers. UniSA will also work with the Cystic Fibrosis Airways Research Group at the Women’s and Children’s Hospital to advance the platform.

True trans visibility requires better data

The influential book Invisible Women articulates some of the countless ways in which women are missing from the data we use to understand the world, including the testing of many drugs, consideration of how best to support refugees, and others. The book is powerful, because it shines a light into how, by missing women out, we (unintentionally) do harm.

This trans visibility day, we’ve been thinking about whether a similar book could be written for trans people, and have had to conclude that it could not. Trans people and their experiences are so missing from the datasets that shape social science that we cannot even begin to fully understand the extent of their absence, and how this affects their lives.

Trans identities are missing from our datasets, meaning that their experiences in a number of domains cannot be studied quantitatively. The way in which many of our datasets are constructed reinforces a cis-normative understanding of the world, where people are pushed into the false binary of describing themselves as either male or female. Even less desirably, their gender is often assumed by the person administering the dataset, or worse, lumped into the amorphous category of “other” – literally othering survey respondents with a trans or non-binary identity.

Unleashing Disordered Rocksalt Oxides as Cathodes for Rechargeable Magnesium Batteries

Schematics of the battery and present cathode material. The present material contains many metal elements as cations thanks to the effect of the high configurational entropy.
Illustration Credit: ©Tohoku University

Researchers at Tohoku University have made a groundbreaking advancement in battery technology, developing a novel cathode material for rechargeable magnesium batteries (RMBs) that enables efficient charging and discharging even at low temperatures. This innovative material, leveraging an enhanced rock-salt structure, promises to usher in a new era of energy storage solutions that are more affordable, safer, and higher in capacity.

Details of the findings were published in the Journal of Materials Chemistry. 

The study showcases a considerable improvement in magnesium (Mg) diffusion within a rock-salt structure, a critical advancement since the denseness of atoms in this configuration had previously impeded Mg migration. By introducing a strategic mixture of seven different metallic elements, the research team created a crystal structure abundant in stable cation vacancies, facilitating easier Mg insertion and extraction.

This represents the first utilization of rocksalt oxide as a cathode material for RMBs. The high-entropy strategy employed by the researchers allowed the cation defects to activate the rocksalt oxide cathode.

New Method Developed to Isolate HIV Particles

The image shows PNF-coated magnetic microbeads that bind HIV particles to their surface.
Image Credit: Torsten John

Researchers at Leipzig University and Ulm University have developed a new method to isolate HIV from samples more easily, potentially making it easier to detect infection with the virus. They focus on peptide nanofibrils (PNFs) on magnetic microparticles, a promising tool and hybrid material for targeted binding and separation of viral particles. They have published their new findings in the journal Advanced Functional Materials.

“The presented method makes it possible to efficiently capture, isolate and concentrate virus particles, which may improve the sensitivity of existing diagnostic tools and analytical tests,” says Professor Bernd Abel of the Institute of Technical Chemistry at Leipzig University. The nanofibrils used – small, needle-like structures – are based on the EF-C peptide, which was first described in 2013 by Professor Jan Münch from Ulm University and Ulm University Medical Center. EF-C is a peptide consisting of twelve amino acids that forms nanoscale fibrils almost instantaneously when dissolved in polar solvents. These can also be applied to magnetic particles. “Using the EF-C peptide as an example, our work shows how peptide fibrils on magnetic particles can have a completely new functionality – the more or less selective binding of viruses. Originally, fibrils of this kind were more likely to be associated with neurodegenerative diseases,” adds Dr Torsten John, co-first author of the study and former doctoral researcher under Professor Abel at Leipzig University. He is now a junior researcher at the Max Planck Institute for Polymer Research in Mainz, Germany.

Key Ocean Current Contains a Warning on Climate

Scientists extracted a 5.3 million-year record of the Antarctic Circumpolar Current by drilling sediment cores in the Earth’s most remote waters. Here, the drill ship JOIDES Resolution makes its way through the far southeast Pacific.
Photo Credit: Gisela Winckler

It carries more than 100 times as much water as all the world’s rivers combined. It reaches from the ocean’s surface to its bottom, and measures as much as 2,000 kilometers across. It connects the Indian, Atlantic and Pacific oceans, and plays a key role in regulating global climate. Continuously swirling around the southernmost continent, the Antarctic Circumpolar Current is by far the world’s most powerful and consequential mover of water. In recent decades it has been speeding up, but scientists have been unsure whether that is connected to human-induced global warming, and whether the current might offset or amplify some of warming’s effects.

In a new study, an international research team used sediment cores from the planet’s roughest and most remote waters to chart the ACC’s relationship to climate over the last 5.3 million years. Their key discovery: During past natural climate swings, the current has moved in tandem with Earth’s temperature, slowing down during cold times and gaining speed in warm ones―speedups that abetted major losses of Antarctica’s ice. This suggests that today’s speedup will continue as human-induced warming proceeds. That could hasten the wasting of Antarctica’s ice, increase sea levels, and possibly affect the ocean’s ability to absorb carbon from the atmosphere.

“This is the mightiest and fastest current on the planet. It is arguably the most important current of the Earth climate system,” said study coauthor Gisela Winckler, a geochemist at Columbia University’s Lamont-Doherty Earth Observatory who co-led the sediment sampling expedition. The study “implies that the retreat or collapse of Antarctic ice is mechanistically linked to enhanced ACC flow, a scenario we are observing today under global warming,” she said.

New Nanoceramics Could Help Improve Smartphone and TV Displays

Nanoceramics are strong because they are made under high pressure.
Photo Credit: Anna Marinovich

Scientists from the Ural Federal University, together with colleagues from India and the Ural Branch of the Russian Academy of Sciences, have developed a nanoceramic that glows in three main colors - red, green, and blue. The new material is extremely strong because it is created under high pressure. Scientists believe that the characteristics of the new nanoceramics - luminescence, strength, and transparency - will be useful for creating screens with improved brightness and detail for smartphones, televisions, and other devices. The scientists published detailed information about the new nanoceramics and their properties in the journal Applied Materials Today. 

"We obtained optically transparent nanoceramics capable of luminescing in red, green, and blue colors. This was made possible by adding carbon particles that act as carbon nanodots. During the synthesis process, the carbon components are encapsulated between the ceramic particles, creating defects on their surface. We believe that these defects create several energy levels in the carbon nanodots, allowing the material to glow in different colors in the visible spectrum", explains Arseny Kiryakov, the co-author of the work, Associate Professor of the UrFU Department of Physical Techniques and Devices for Quality Control.

New rapid method to predict effects of conservation actions on complex ecosystems

From left: Dr Matthew Adams, Sarah Vollert, Professor Drovandi
Photo Credit: Courtesy of Queensland University of Technology

A new way to analyze the effects of conservation actions on complex ecosystems has cut the modelling time from 108 days to six hours, QUT statisticians have found:

• Some conservation efforts backfire, eg eradicating feral cats could lead to rabbit explosion

• Modeling predicts the cascading effects through species in a complex ecosystem, but is computationally slow

• New method cuts prediction time from 3.5 months to six hours

PhD researcher Sarah Vollert, from the School of Mathematical Sciences and the QUT Centre for Data Sciences, said it was impossible to predict exactly how conservation actions would affect each species.

“Though well-intentioned, conservation actions have the potential to backfire,” Ms. Vollert said.

“For example, if decision-makers decide to eradicate feral cats, it could lead to explosive populations of their prey species, like rabbits.

“Uncontrolled rabbit populations could then have devastating effects on the vegetation, destroying the habitat native species need to survive.

A Tiny Spot Leads to a Large Advancement in Nano-processing, Researchers Reveal

A conceptual illustration of single-shot laser processing by an annular-shaped radially polarized beam, focused on the back surface of a glass plate.
Illustration Credit: ©Y. Kozawa et al.

Focusing a tailored laser beam through transparent glass can create a tiny spot inside the material. Researchers at Tohoku University have reported on a way to use this small spot to improve laser material processing, boosting processing resolution.

Laser machining, like drilling and cutting, is vital in industries such as automotive, semiconductors, and medicine. Ultra-short pulse laser sources, with pulse widths from picoseconds to femtoseconds, enable precise processing at scales ranging from microns to tens of microns. But recent advancements demand even smaller scales, below 100 nanometers, which existing methods struggle to achieve.

The researchers focused on a laser beam with radial polarization, known as a vector beam. This beam generates a longitudinal electric field at the focus, producing a smaller spot than conventional beams.

Scientists have identified this process as promising for laser processing. However, one drawback is that this field weakens inside the material due to light refraction at the air-material interface, limiting its use.