Scientists link certain gut bacteria to lower heart disease risk

Rod-shaped Oscillibacter sp. bacteria take up fluorescently labeled cholesterol (here shown in green).
Image Credit: Ahmed Mohamed 

Changes in the gut microbiome have been implicated in a range of diseases including type 2 diabetes, obesity, and inflammatory bowel disease. Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has found that microbes in the gut may affect cardiovascular disease as well. In a study published in Cell, the team has identified specific species of bacteria that consume cholesterol in the gut and may help lower cholesterol and heart disease risk in people.

Members of Ramnik Xavier’s lab, Broad’s Metabolomics Platform, and collaborators analyzed metabolites and microbial genomes from more than 1,400 participants in the Framingham Heart Study, a decades-long project focused on risk factors for cardiovascular disease. The team discovered that bacteria called Oscillibacter take up and metabolize cholesterol from their surroundings, and that people carrying higher levels of the microbe in their gut had lower levels of cholesterol. They also identified the mechanism the bacteria likely use to break down cholesterol. The results suggest that interventions that manipulate the microbiome in specific ways could one day help decrease cholesterol in people. The findings also lay the groundwork for more targeted investigations of how changes to the microbiome affect health and disease.

“Our research integrates findings from human subjects with experimental validation to ensure we achieve actionable mechanistic insight that will serve as starting points to improve cardiovascular health,” said Xavier, who is a core institute member, director of the Immunology Program, and co-director of the Infectious Disease and Microbiome Program at the Broad. He is also a professor at Harvard Medical School and Massachusetts General Hospital.

Older trees help to protect an endangered species

The longest-lived trees in the Pyrenees facilitate the survival of wolf lichen, a species threatened throughout Europe.
Photo Credit: Ot Pasques

The oldest trees in the forest help to prevent the disappearance of endangered species in the natural environment, according to a study led by the University of Barcelona. This is the case of the wolf lichen — threatened throughout Europe —, which now finds refuge in the oldest trees in the high mountains of the Pyrenees. This study reveals for the first time the decisive role of the oldest trees in the conservation of other living beings thanks to their characteristic and unique physiology.

Conserving the oldest trees in forests will be essential to protect biodiversity in forest ecosystems, which are increasingly affected by the impact of global change. This is stated on a new study published in the journal Proceedings of the National Academy of Sciences. The study is signed by the experts Sergi Munné-Bosch and Ot Pasques, from the Faculty of Biology and the UB Biodiversity Research Institute (IRBio).

Ultrasound therapy shows promise as a treatment for Alzheimer’s disease

Professor Jürgen Götz with an ultrasound machine.
Photo Credit: Courtesy of University of Queensland

University of Queensland researchers have found targeting amyloid plaque in the brain is not essential for ultrasound to deliver cognitive improvement in neurodegenerative disorders.

Dr Gerhard Leinenga and Professor Jürgen Götz from UQ’s Queensland Brain Institute (QBI) said the finding challenges the conventional notion in Alzheimer’s disease research that targeting and clearing amyloid plaque is essential to improve cognition.

“Amyloid plaques are clumps of protein that can build up in the brain and block communication between brain cells, leading to memory loss and other symptoms of Alzheimer’s disease,” Dr Leinenga said.

“Previous studies have focused on opening the blood-brain barrier with microbubbles, which activate the cell type in the brain called microglia which clears the amyloid plaque. 

“But we used scanning ultrasound alone on mouse models and observed significant memory enhancement.”

Corn reduces arsenic toxicity in soil

Corn plants in a field experiment near Liesberg, Baselland.
Photo Credit: Veronica Caggìa

When crops grow in arsenic-contaminated soil, this toxic element accumulates in the food chain. A study involving the University of Basel has now discovered a mechanism used by corn plants to reduce arsenic uptake: the key factor is a special substance released into the soil by the roots.

Arsenic is a toxic metalloid of natural origin. Arsenic-contaminated soils and waters are found all over the world, especially in southeastern Asian countries like Bangladesh, Vietnam, and China. Also, Switzerland has a few natural hot spots where arsenic is found in above-average concentrations. An example is soil at Liesberg in the canton of Baselland.

“The particular problem for plants is that arsenic behaves chemically similar to phosphorus,” says Professor Klaus Schlaeppi of the Department of Environmental Sciences at the University of Basel. Phosphorus is an important nutrient that plants take up through special transport channels in their roots. “The arsenic enters the plants through these channels.” As a result, more and more of the toxic substance accumulates in the biomass and gets into the food chain. On the long run, this negatively affects human health. High arsenic exposure can cause neurological damage and cancer, for example.

Pilot study shows ketogenic diet improves severe mental illness

A study led by researchers at Stanford Medicine showed that diet can help those with serious mental illness.

Video Credit: Stanford Medicine

For people living with serious mental illness like schizophrenia or bipolar disorder, standard treatment with antipsychotic medications can be a double-edged sword. While these drugs help regulate brain chemistry, they often cause metabolic side effects such as insulin resistance and obesity, which are distressing enough that many patients stop taking the medications.

Now, a pilot study led by Stanford Medicine researchers has found that a ketogenic diet not only restores metabolic health in these patients as they continue their medications, but it further improves their psychiatric conditions. The results published in Psychiatry Research, suggest that a dietary intervention can be a powerful aid in treating mental illness.

“It’s very promising and very encouraging that you can take back control of your illness in some way, aside from the usual standard of care,” said Shebani Sethi, MD, associate professor of psychiatry and behavioral sciences and the first author of the new paper.

AI breakthrough: UH researchers help uncover climate impact on whales

Underside of a humpback whale’s tail fluke which can serve as a “finger-print” for identification.
Photo Credit: Adam Pack

More than 10,000 images of humpback whale tail flukes collected by University of Hawaiʻi researchers have played a pivotal role in revealing both positive and negative impacts on North Pacific humpback whales, positive trends in the historical annual abundance of North Pacific humpback whales, and how a major climate event negatively impacted the population. Adam Pack, who heads the UH Hilo Marine Mammal Laboratory, Lars Bejder, director of the UH Mānoa Marine Mammal Research Program (MMRP) and graduate students Martin van Aswegen and Jens Currie, co-authored a study on humpback whales in the North Pacific Ocean, and the images—along with artificial intelligence (AI)-driven image recognition—were instrumental in tracking individuals and offering insights into their 20% population decline observed in 2012–21.

“The underside of a humpback whales tail fluke has a unique pigmentation pattern and trailing edge that can serve as the ‘finger-print’ for identifying individuals,” said Pack.

Atmospheric Scientists Link Arctic Sea Loss Ice to Strong El Niño Events

El Niño, a climate pattern where warm waters in the eastern Pacific fuel hotter weather, is finally beginning to wane after bringing a long stretch of record heat and heavy precipitation across the world since last summer. 

A new study, published in Science Advances by researchers at the University at Albany and Nanjing University of Information Science and Technology in China, has found that these events, which typically occur once every few years, might become even stronger due to melting Arctic sea ice.

Using a combination of climate model simulations and observational data, the researchers found that the current interaction of Arctic sea ice with the atmosphere reduces the strength of El Niño events by up to 17 percent, compared to when the interaction is removed.

The amount of sea ice that survives the Arctic summer has declined 12.2 percent per decade since the late 1970s and projections show the region could experience its first ice-free summer by 2040. 

“Climate models are already projecting a strengthened El Niño in the upcoming decades due to global warming. Arctic sea ice is also projected to decline rapidly in the upcoming decades, said Aiguo Dai, a Distinguished Professor in the Department of Atmospheric and Environmental Sciences and study co-author. 

Chickadees are Memory Geniuses. Their Barcode-Like Neural Activity May Be to Thank.

Chickadee caching a seed overlaid with a neural ‘barcode’ activity
Image Credit: Columbia’s Zuckerman Institute

Black-capped chickadees have extraordinary memories that can recall the locations of thousands of morsels of food to help them survive the winter. Now scientists at Columbia's Zuckerman Institute have discovered how the chickadees can remember so many details: they memorize each food location using brain cell activity akin to a barcode. These new findings may shed light on how the brain creates memories for the events that make up our lives.

"We see the world through our memories of objects, places and people," said Dmitriy Aronov, PhD, a principal investigator at Columbia’s Zuckerman Institute and an assistant professor of neuroscience at Columbia’s Vagelos College of Physicians and Surgeons. "Memories entirely define the way we see and interact with the world. With this bird, we have a way to understand memory in an incredibly simplified way, and in understanding their memory, we will understand something about ourselves."

This barcode-like formatting of memory, revealed for the first time today in the journal Cell, may be a common tactic in animal brains, including those of humans. "There are many findings in humans that are totally consistent with a barcode mechanism," said postdoctoral research fellow Selmaan Chettih, PhD, the study's co-first author along with Emily Mackevicius, PhD.

‘Frankenstein design’ enables 3D printed neutron collimator

Images of the 3D printed “Frankenstein design” collimator show the “scars” where the individual parts are joined, which are clearly visible at right.
Photo Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

The time-tested strategy of divide and conquer took on a new, high-tech meaning during neutron experiments by scientists at the Department of Energy’s Oak Ridge National Laboratory. They discovered that the problems they faced while attempting to 3D print a one-piece collimator could be solved by instead developing a “Frankenstein design” involving multiple body parts – and some rather obvious scars.

Collimators are important components used in neutron scattering. Similar to X-rays, neutrons are used to study energy and matter at the atomic scale. Neutron collimators can be thought of as funnels that help guide neutrons toward a detector after they interact with experimental sample materials. These funnels primarily serve to reduce the number of stray neutrons that interfere with data collection, for example, neutrons that scatter off sample holders, or from other apparatuses used in the experiment such as high-pressure cells. 

During this process, most of the unwanted neutrons, those scattering from features other than the sample, enter channels inside the collimators at odd angles and are absorbed by channel walls, also referred to as blades. The blades act like the gutters on a bowling lane, which capture bowling balls that are not headed toward the pins.

SwRI to build the spacecraft bus for in-space refueler servicer program

The spacecraft, called the Astroscale Prototype Servicer for Refueling (APS-R), will be able to refuel other vehicles while in geostationary orbit. Image Credit: Courtesy of Astroscale U.S.

Southwest Research Institute (SwRI) will build, integrate and test a small demonstration spacecraft as part of a $25.5 million Space Mobility and Logistics (SML) prototyping project funded by the U.S. Space Force and led by prime contractor Astroscale U.S. The spacecraft, called the Astroscale Prototype Servicer for Refueling (APS-R), will refuel other compatible vehicles while in geostationary orbit.

“Running low on fuel is a common issue for spacecraft in Earth orbit,” said SwRI Staff Engineer Steve Thompson, the SwRI project systems engineer. “When they have expended all of their fuel, their mission ends — even though the vehicle may be in otherwise excellent health. A refueling vehicle can extend those missions, and we can get additional lifetime out of spacecraft that are already in orbit.”

The APS-R will operate in geostationary orbit around the Earth, meaning it will follow a circular orbit in sync with the Earth’s rotational period of 24 hours. The spacecraft will carry hydrazine propellant from a depot, also in geostationary orbit, to the spacecraft in need of fuel. The APS-R can service any spacecraft fitted with a compatible refueling port.