UP-led astronomy research team explores formation of giant radio galaxies

An artistic representation of a what a giant cosmic jet the size of the distance between the Milky Way and Andromeda could look like
Illustration Credit: Courtesy of University of Pretoria

Enabled by supercomputing, University of Pretoria (UP) researchers have led an international team of astronomers that has provided deeper insight into the entire life cycle (birth, growth and death) of giant radio galaxies, which resemble “cosmic fountains” – jets of superheated gas that are ejected into near-empty space from their spinning supermassive black holes.

The findings of this breakthrough study were published in the journal Astronomy & Astrophysics, and challenge known theoretical models by explaining how extragalactic cosmic fountains grows to cover such colossal distances, raising new questions about the mechanisms behind these vast cosmic structures.

The research team – which was led by astrophysicist Dr Gourab Giri, who holds a postdoctoral fellowship from the South African Radio Astronomy Observatory at UP –  consisted of Associate Professor Kshitij Thorat and Extraordinary Professor Roger Deane of UP’s Faculty of Natural and Agricultural Sciences; Prof Joydeep Bagchi of Christ University in India; Prof DJ Sailkia of the Inter-University Centre for Astronomy and Astrophysics, also in India; and Dr Jacinta Delhaize of the University of Cape Town (UCT).

This study tackles a key question in modern astrophysics: how these structures, which are larger than galaxies and are made up of black hole jets, interact over cosmological timescales with their very thin, gaseous surroundings. 

Titanium-Based Prosthesis Alloy Scientists Have Tested Deformation

The co-authors of the development, as well as specialists from the UrFU Department of Heat Treatment and Metal Physics.
Photo Credit: Rodion Narudinov

Scientists from Ural Federal University, Institute of Strength Physics and Materials Science of the SB RAS and National Research Tomsk Polytechnic University have tested new titanium-based alloys, which have several advantages over traditional medical ones. Two types of titanium alloys — TNZ (including niobium and zirconium) and multi-element TNZTS (with niobium, zirconium, tantalum and tin) — were subjected to uniaxial pressing and multi-pass rolling. As a result of exposure, ultrafine-grained structures were formed in the alloys, which significantly increased the strength and hardness of the material. The results of the research were published in the Materials Letters Journal. 

Crystal structure of titan (α-phase) that formed after tests trial improved the strength characteristics of the TNZ-alloy, but at the same time reduced its plasticity and Young’s modulus, important characteristics of materials for prostheses. In case of elastic deformations of the bone—implant system, the load on the tissue depends on the ratio of the Young's modulus of the implant material and bone tissue. The lower this ratio, the lower the probability of necrosis and destruction of bone by implant pressure. Mechanical and biocompatibility increase the prospects for the introduction of materials developed by scientists in medicine, aerospace and defense industries.

Lockheed Martin Matures Next Secure Communications Satellite Solution for U.S. Space Force with Major Design Milestone

MUOS Satellite From Lockheed Martin
Mobile User Objective System (MUOS) satellites, the fifth one of which is seen here in production at Lockheed Martin, are vital to providing secure communications for allied military forces around the world.
Photo Credit: Lockheed Martin.

Lockheed Martin has now proven the readiness of its satellite design in support of the U.S. Space Force (USSF) Space Systems Command’s upcoming Mobile User Objective System (MUOS) Service Life Extension (SLE) program through successful execution of an Early Design Review (EDR). Future MUOS satellites planned as part of the program will be critical in continuing to provide crystal-clear, secure communications to military forces on the move.

Lockheed Martin is one of two companies selected to develop future MUOS satellite concepts under Phase 1 of the program, centered on early design activities and risk reduction.

“In less than the initial one-year base period of performance, our team went above and beyond to deliver not only a successful early design review – but one so robust that it passed the rigorous standards of a more advanced design assessment,” said Maria Hartin-Swart, program management director for Lockheed Martin’s MUOS SLE development efforts.

Research in Fruit Flies Pinpoints Brain Pathways Involved in Alcohol-Induced Insomnia

Adrian Rothenfluh, PhD (left), and Maggie Chvilicek (right), authors on the recent study.
Photo Credit: Courtesy of University of Utah Health

Alcohol use disorder, which affects over 10% of Americans, can lead to persistent and serious insomnia. Difficulties falling asleep and staying asleep can last even after months of sobriety, increasing the risk of relapse. But treating withdrawal-related insomnia is difficult, partly because what’s going on in the brain in this condition remains largely mysterious.

 Now, research in fruit flies has identified specific brain signals and groups of brain cells that are involved in alcohol-induced insomnia. This work could ultimately lead to targeted treatments for alcohol-related sleep loss, helping people recover from alcohol use disorder.

  “The effects of alcohol on sleep seem to be localized to a particular cell type in the brain, which is not something that’s ever been shown before,” says Maggie Chvilicek, graduate researcher in neuroscience at the University of Utah and lead author on the study. She adds that these cells often do similar things in flies and humans. “The mechanism that we identified is something that very likely could also exist in a mammalian brain.”

Research Pinpoints Weakness in Lung Cancer’s Defenses

A microscope image of lung cancer cells (purple) containing the activated form of a metabolic enzyme called GUK1 (brown) that supports cancer growth.
Image Credit: Haigis lab

Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment.

While researchers have gleaned important insights into the basic biology of lung cancer, some of the disease’s molecular maneuvers have remained elusive.

Now, a team led by scientists at Harvard Medical School has made strides in understanding how a genetic flaw in some lung cancers alters cancer cell metabolism to fuel the disease.

Working with mouse models and human cancer cells, the researchers identified a metabolic enzyme called GUK1 in lung cancers harboring an alteration in the ALK gene. Their experiments showed that GUK1 plays an important role in boosting metabolism in tumor cells to help them grow.

The findings, reported in Cell and supported in part by federal funding, provide a clearer picture of how metabolism works in lung cancer.

The research could set the stage for developing therapies that target GUK1 to curb cancer growth, the team said.

UCLA researchers find high levels of the industrial chemical BTMPS in fentanyl

Image Credit: Colin Davis

A UCLA research team has found that drugs being sold as fentanyl contain high amounts of the industrial chemical bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate, or BTMPS. This new substance of concern emerged in the illicit drug supply nearly simultaneously in multiple U.S. locations from coast-to-coast.

From June through October 2024, the team quantitatively tested samples of drugs sold as fentanyl that had high levels of the chemical, which belongs to a class of compounds called hindered amine light stabilizers and has a variety of applications including as a sealant, adhesive, and additive to plastics. 

The paper is published in the peer-reviewed journal JAMA.

“The emergence of BTMPS is much more sudden than previous changes in the illicit drug supply, and the geographic range where it was detected nearly simultaneously suggests it may be added at a high level in the supply chain,” said study lead Chelsea Shover, an assistant professor-in-residence at the David Geffen School of Medicine at UCLA. “This is concerning because BTMPS is not approved for human consumption, and animal studies have shown serious health effects such as cardiotoxicity and ocular damage, and sudden death at certain doses.” 

Women of Science: A Legacy of Achievement

Future generations to pursue their passions and break down barriers in the pursuit of knowledge.
Image Credit: Scientific Frontline stock image

Throughout history, women have made groundbreaking contributions to science, despite facing significant societal barriers and a lack of recognition. Their relentless pursuit of knowledge and innovation has shaped our understanding of the world and paved the way for future generations of scientists. This article celebrates the achievements of some of these remarkable women, highlighting their struggles and the impact of their work.

The women featured in this article, along with countless others throughout history, have made invaluable contributions to the advancement of science. Their achievements, often accomplished in the face of adversity and societal barriers, have shaped our understanding of the world and paved the way for future generations of scientists. These women demonstrate the power of perseverance, the importance of challenging established norms, and the profound impact that individual dedication can have on scientific progress. By recognizing and celebrating their legacies, we not only honor their contributions but also inspire future generations to pursue their passions and break down barriers in the pursuit of knowledge.

Discovery of unexpected collagen structure could ‘reshape biomedical research’

Jeffrey Hartgerink is a professor of chemistry and bioengineering at Rice.
Photo Credit: Courtesy of Jeffrey Hartgerink / Rice University

Collagen, the body’s most abundant protein, has long been viewed as a predictable structural component of tissues. However, a new study led by Rice University’s Jeffrey Hartgerink and Tracy Yu, in collaboration with Mark Kreutzberger and Edward Egelman at the University of Virginia (UVA), challenges that notion, revealing an unexpected confirmation in collagen structure that could reshape biomedical research.

The researchers used advanced cryo-electron microscopy (cryo-EM) to determine the atomic structure of a packed collagen assembly that deviates from the traditionally accepted right-handed superhelical twist. Published in ACS Central Science, the study suggests collagen’s structural diversity may be greater than previously believed.

“This work fundamentally changes how we think about collagen,” said Hartgerink, professor of chemistry and bioengineering. “For decades, we have assumed that collagen triple helices always follow a strict structural paradigm. Our findings show that collagen assemblies can adopt a wider range of conformations than previously thought.”

Halas awarded Benjamin Franklin Medal in Chemistry

Rice University’s Naomi Halas is the recipient of the 2025 Benjamin Franklin Medal in Chemistry.
 Photo Credit: Jeff Fitlow/Rice University

Rice University’s Naomi Halas is the recipient of the 2025 Benjamin Franklin Medal in Chemistry, awarded “for the creation and development of nanoshells — metal-coated nanoscale particles that can capture light energy — for use in many biomedical and chemical applications.”

Halas’ work has pioneered new insights into how light and matter interact at the smallest scales. When she joined Rice in 1989 to support the efforts of the late Richard Smalley in advancing the burgeoning field of nanoscale science and technology, her experience working on laser science in the research-intensive milieus of IBM Yorktown and AT&T Bell Laboratories gave her a unique perspective: Halas recognized that the nanoscale world was not something foreign — it was, fundamentally, chemistry.

“A lot of people were talking about nano like it was something completely new,” said Halas, who is University Professor at Rice, the institution’s highest academic rank. “But I realized it was really just chemistry viewed in a different way, and that really got me thinking about how I can combine the worlds of laser science and nanoscience.”

That shift in perspective led to the development of a new family of nanoparticles with tunable optical properties, triggering a series of influential discoveries and enabling applications in fields ranging from cancer therapy to water purification to light-driven chemistry and renewable energy.

Biology Graduate Student Contributes to Research in Neurodegenerative Disease

PhD student Asmer Aliyeva
Photo Credit: Courtesy of University at Albany

Asmer Aliyeva, a fourth-year PhD candidate in the biology department at the College of Arts and Sciences, is working to reveal the molecular mechanisms behind neurodegenerative diseases. In collaboration with her colleagues in the Berglund Lab, Aliyeva aim is to identify possible therapeutic targets against this class of disease, with a focus on spinocerebellar ataxias (SCAs).

Spinocerebellar ataxias are a group of progressive neurodegenerative diseases that affect coordination and balance, for which there is currently no cure. Aliyeva’s research looks at transcriptomic changes in patient-derived cell lines that could holds clues for common disease mechanisms associated with different types of SCAs. 

Recent findings suggest that dysregulation of alternative splicing plays a key role in disease progression, which could lead to new biomarkers and therapeutic discoveries. Aliyeva recently led a study on this topic, coauthored with members of the Berglund Lab at the RNA Institute, published in the journal Human Molecular Genetics. 

Aliyeva's research also examines how defects in alternative splicing contribute to the disease and whether these changes can be used as potential biomarkers for monitoring disease onset and progression. This work is a crucial first step in providing a better understanding of potential pathways for future treatments of these diseases.