Fat particles could be key to treating metabolic brain disorders

For decades, it was widely accepted that neurons relied exclusively on glucose to fuel their functions in the brain. This is not the case.
Photo Credit: The University of Queensland

Scientific Frontline: Extended "At a Glance" Summary: Neuronal Lipid Metabolism

The Core Concept: Neurons, previously thought to rely entirely on glucose, actively utilize saturated free fatty acids produced by the DDHD2 gene to fuel their communication and functions.

Key Distinction/Mechanism: Rather than depending solely on sugars, healthy brain cells manufacture and consume small fat molecules for energy, and supplementing these fats can restore function when the natural metabolic pathways fail.

Origin/History: A 2025 University of Queensland study, led by Dr. Merja Joensuu, uncovered this mechanism while investigating the genetic basis of hereditary spastic paraplegia 54 (HSP54).

Major Frameworks/Components:

• The DDHD2 gene, which is responsible for regulating lipid balance and synthesizing necessary fatty acids.
• Saturated free fatty acids, which act as the alternative small fat molecules used for neuronal signaling.
• Hereditary spastic paraplegia 54 (HSP54), a debilitating metabolic disorder resulting from a loss of normal DDHD2 gene function.

Potential new therapeutic target for asthma discovered

Photo Credit: Cnordic Nordic

A new way to treat asthma symptoms and even repair previously irreversible lung damage could be on the horizon following the discovery of a potential new therapeutic target by scientists at the Universities of Aberdeen and Manchester.

Current treatments for asthma largely involve controlling the inflammation of lung tissue using steroid inhalers. However, 4 people die every day in the UK from asthma related complications. With funding from the Medical Research Foundation and Asthma UK, a team of researchers from the University of Aberdeen and the University of Manchester have investigated the scarring that occurs in lung tissue as a result of asthma and have been able to reverse these changes in animal models.

Although still in the early stages of development, this discovery paves the way for a new way to treat not only asthma, but many different diseases in which similar structural changes in tissues occur. Such diseases include conditions like chronic obstructive pulmonary disease (COPD), chronic heart disease and cirrhosis of the liver and account for approximately 40% of deaths worldwide.

Asthma affects more than 7 million people in the UK and severe asthma can have a hugely detrimental impact on an individual’s quality of life. Even when treated, asthma can be fatal and the most recent data shows it contributed to 1,465 deaths in the UK in 20221 – this is despite the availability of new treatments which aim to dampen down inflammation in the lungs.

Scientists uncover room-temperature route to improved light-harvesting and emission devices

Dasom Kim
Photo Credit: Jorge Vidal/Rice University

Atoms in crystalline solids sometimes vibrate in unison, giving rise to emergent phenomena known as phonons. Because these collective vibrations set the pace for how heat and energy move through materials, they play a central role in devices that capture or emit light, like solar cells and LEDs.

A team of researchers from Rice University and collaborators have found a way to make two different phonons in thin films of lead halide perovskite interact with light so strongly that they merge into entirely new hybrid states of matter. The finding, reported in a study published in Nature Communications, could provide a powerful new lever for controlling how perovskite materials harvest and transport energy.

To get a specific light frequency in the terahertz range to interact with phonons in the halide perovskite crystals, the researchers fabricated nanoscale slots ⎯ each about a thousand times thinner than a sheet of cling wrap ⎯ into a thin layer of gold. The slots acted like tiny metallic traps for light, tuning its frequency to that of the phonons and thus giving rise to a strong form of interaction known as “ultrastrong coupling.”

Study first to show if nesting heat affects sea turtle hatchling ‘IQ’

A loggerhead hatchling goes through the Y-maze to test its learning abilities.
Photo Credit: Sarah Milton, Florida Atlantic University

As sand temperatures continue to rise, concerns about the future of sea turtles are growing. Hotter nests not only skew sex ratios – producing more females – but also reduce hatchling survival, slow growth, and increase the likelihood of physical deformities. Yet one important and often overlooked question remains: does this heat also affect cognitive ability – how well hatchlings can learn, adapt and respond to the rapidly changing world they face from the moment they emerge?

A new study by researchers at Florida Atlantic University’s Charles E. Schmidt College of Science offers a surprising glimmer of hope. They are the first to test whether incubation temperature affects cognitive ability in loggerhead (Caretta caretta) hatchlings – how well they can learn, adapt and problem-solve. While animal cognition has been widely studied in birds and mammals, much is yet to be discovered in reptiles.

Using a Y-maze and a visual discrimination task, the researchers trained hatchlings incubated at two female-producing temperatures (88 F and a hotter 91 F) and then tested their ability to “reverse train” when the task rules changed. Eggs were collected during the summers of 2019 and 2020 from nesting beaches in Palm Beach County.

Study finds altering one brain area could rid alcohol withdrawal symptoms

David Rossi, left, an associate professor in the Integrative Physiology and Neuroscience Department in WSU's College of Veterinary Medicine, poses for a photo with Nadia McLean, right, a PhD student in Neuroscience, outside their lab in Pullman. Rossi and McLean are researching ways to curb the debilitating symptoms of alcohol withdrawal
Photo Credit: Ted S. Warren, College of Veterinary Medicine

By targeting a specific area of the brain, researchers at Washington State University may now hold the key to curbing the debilitating symptoms of alcohol withdrawal that push many people back to drinking.

The new study found the answer to helping people get through alcohol withdrawal may lie in a region of the brain known as the cerebellum. In mice experiencing withdrawal, scientists were able to ease the physical and emotional symptoms by altering brain function in this brain region using both genetic tools and a specialized compound. The findings, published in the journal Neuropharmacology, could help pave the way for targeted therapies that make recovery more manageable.

“Our research suggests the cerebellum could be a promising therapeutic target to help people get through the most difficult stage of alcohol use disorder,” said Nadia McLean, lead author and doctoral researcher in the Department of Integrative Physiology (IPN). “By targeting the cerebellum, we were able to ease both the physical motor discoordination and the emotional distress of withdrawal — the symptoms that so often drive people back to drinking.”

Researchers develop functional eggs from human skin cells

Researchers at OHSU have demonstrated a new technique to treat infertility by turning skin cells into oocytes, or eggs. Shown here, an image of an oocyte with a bright image of a skin cell nucleus before fertilization.
Image Credit: Oregon Health & Science University

Researchers at Oregon Health & Science University have accomplished a unique proof of concept to treat infertility by turning skin cells into eggs capable of producing early human embryos.

The research published today in the journal Nature Communications.

The development offers a potential avenue for in vitro gametogenesis — the process of creating gametes — to treat infertility for women of advanced maternal age or those who are unable to produce viable eggs due to previous treatment of cancer or other causes.

Microbial DNA sequencing reveals nutrient pollution and climate change reinforce lake eutrophication

Lake 227 of the Experimental Lakes Area.
Photo Credit: Rebecca Garner

The algal blooms increasingly seen in Canadian lakes have been linked to both nutrient pollution from agricultural runoff and climate change. However, a new Concordia-led study using DNA sequencing of lakebed microbes reveals that these two drivers amplify each other in ways that profoundly affect the health of lake ecosystems.

Using records and samples from the International Institute for Sustainable Development Experimental Lakes Area (ELA), a group of 58 lakes in northwestern Ontario designated freshwater research facilities, the researchers paired environmental monitoring data dating back more than five decades with paleogenetic reconstructions from lakebed microbes dating back more than a century.

By sequencing DNA found in lake sediments, the researchers got insight into past algal communities’ composition and compare them to communities today. This provided critical insight into how those communities changed over decades.

“The sediment DNA archives gave us a chronology of these lakes’ history,” says lead author Rebecca Garner, PhD 2023, and currently a postdoctoral fellow at the University of California, Berkeley. “This is the first study to show that we can reconstruct the community dynamics of that ecosystem and dramatically expands the diversity of microorganisms that we were able to study.”

The study was published in the journal Environmental Microbiology.

Hidden genetic risk could delay diabetes diagnosis for Black and Asian men

 

Photo Credit: Barbara Olsen

A common but often undiagnosed genetic condition may be causing delays in type 2 diabetes diagnoses and increasing the risk of serious complications for thousands of Black and South Asian men in the UK – and potentially millions worldwide.

The new study is conducted by the University of Exeter, in collaboration with Queen Mary University of London (QMUL) and funded through a Wellcome Discovery Award. It has found around one in seven Black and one in 63 South Asian men in the UK carry a genetic variant known as G6PD deficiency. Men with G6PD deficiency are, on average, diagnosed with type 2 diabetes four years later than those without the gene variant. But despite this, fewer than one in 50 have been diagnosed with the condition

G6PD deficiency does not cause diabetes, but it makes the widely used HbA1c blood test – which diagnoses and monitors diabetes – appear artificially low. This can mislead doctors and patients, resulting in delayed diabetes diagnosis and treatment.

Scientists solve mystery of loop current switching in Kagome metals

Structure and electron behavior in kagome metals: (A) The triangular atomic arrangement showing how tiny electrical currents flow in loops. (B) How electrons organize into wave-like density patterns. (C) How electrons normally move through the material. (D) How electron movement is affected by the wave patterns. (E) The special combined state where both loop currents and wave patterns exist together, creating the conditions for magnetic switching.
Image Credit: Tazai et al., 2025

Quantum metals are metals where quantum effects—behaviors that normally only matter at atomic scales—become powerful enough to control the metal's macroscopic electrical properties. 

Researchers in Japan have explained how electricity behaves in a special group of quantum metals called kagome metals. The study is the first to show how weak magnetic fields reverse tiny loop electrical currents inside these metals. These switching changes the material's macroscopic electrical properties and reverses which direction has easier electrical flow, a property known as the diode effect, where current flows more easily in one direction than the other.  

Why mamba snake bites worsen after antivenom

Photo Credit: Johan Marais

A breakthrough study at The University of Queensland has discovered a hidden dangerous feature in the Black Mamba, one of the most venomous snakes in the world.

Professor Bryan Fry from UQ’s School of the Environment said the study revealed  the venoms of 3 species of mamba were far more neurologically complex than previously thought, explaining why antivenoms were sometimes ineffective.

“The Black Mamba, Western Green Mamba and Jamesons Mamba snakes aren’t just using one form of chemical weapon, they’re launching a coordinated attack at 2 different points in the nervous system,” Professor Fry said.

“If you’re bitten by 3 out of 4 mamba species, you will experience flaccid or limp paralysis caused by postsynaptic neurotoxicity.

“Current antivenoms can treat the flaccid paralysis but this study found the venoms of these 3 species are then able to attack another part of the nervous system causing spastic paralysis by presynaptic toxicity.

Rapid flash Joule heating technique unlocks efficient rare‑earth element recovery from electronic waste

The research team’s method uses flash Joule heating.
Photo Credit: Jeff Fitlow/Rice University.

A team of researchers including Rice University’s James Tour and Shichen Xu has developed an ultrafast, one-step method to recover rare earth elements (REEs) from discarded magnets using an innovative approach that offers significant environmental and economic benefits over traditional recycling methods. Their study was published in the Proceedings of the National Academy of Sciences Sept. 29, 2025.

Conventional rare earth recycling is energy-heavy and creates toxic waste. The research team’s method uses flash Joule heating (FJH), which rapidly raises material temperatures to thousands of degrees within milliseconds, and chlorine gas to extract REEs from magnet waste in seconds without needing water or acids. The breakthrough supports U.S. efforts to boost domestic mineral supplies.

“We’ve demonstrated that we can recover rare earth elements from electronic waste in seconds with minimal environmental footprint,” said Tour, the T.T. and W.F. Chao Professor of Chemistry, professor of materials science and nanoengineering and study corresponding author. “It’s the kind of leap forward we need to secure a resilient and circular supply chain.”

The first animals on Earth may have been sea sponges, study suggests

Some of the first animals on Earth were likely ancestors of the modern sea sponge, according to MIT geochemists who unearthed new evidence in very old rocks.
Image Image: Jose-Luis Olivares, MIT
(CC BY-NC-ND 4.0)

A team of MIT geochemists has unearthed new evidence in very old rocks suggesting that some of the first animals on Earth were likely ancestors of the modern sea sponge.

In a study appearing today in the Proceedings of the National Academy of Sciences, the researchers report that they have identified “chemical fossils” that may have been left by ancient sponges in rocks that are more than 541 million years old. A chemical fossil is a remnant of a biomolecule that originated from a living organism that has since been buried, transformed, and preserved in sediment, sometimes for hundreds of millions of years.

The newly identified chemical fossils are special types of steranes, which are the geologically stable form of sterols, such as cholesterol, that are found in the cell membranes of complex organisms. The researchers traced these special steranes to a class of sea sponges known as demosponges. Today, demosponges come in a huge variety of sizes and colors, and live throughout the oceans as soft and squishy filter feeders. Their ancient counterparts may have shared similar characteristics.

More Signs of Phase-change 'Turbulence' in Nuclear Matter

 A view from the ground up of the three-story STAR detector at the Relativistic Heavy Ion Collider (RHIC).
Image Credit: Brookhaven National Laboratory

Members of the STAR Collaboration, a group of physicists collecting and analyzing data from particle collisions at the Relativistic Heavy Ion Collider (RHIC), have published a new high-precision analysis of data on the number of protons produced in gold-ion smashups over a range of energies. The results, published in Physical Review Letters, suggest one part of a key signature of a so-called “critical point.” That’s a unique point on the “map” of nuclear phases that marks a change in the way quarks and gluons, the building blocks of protons and neutrons, transform from one phase of matter to another.

Discovering the critical point has been a central goal of research at RHIC, a U.S. Department of Energy (DOE) Office of Science user facility for nuclear physics research at DOE’s Brookhaven National Laboratory. Like centuries-old efforts to map out the solid, liquid, and gaseous phases of substances like water, it’s considered essential for fully understanding and describing the quark-gluon plasma. This unique form of nuclear matter is generated by RHIC’s most energetic nuclear collisions, which effectively “melt” the protons and neutrons that make up the colliding gold ions, briefly liberating their innermost building blocks to form a nearly perfect fluid state that once filled our early universe.

Moon-forming disc around massive planet

An artistic rendering of a dust and gas disc encircling the young exoplanet, CT Cha b, 625 light-years from Earth. Spectroscopic data from the NASA/ESA/CSA James Webb Space Telescope suggest the disc contains the raw materials for moon formation. The planet appears at lower right, while its host star and surrounding protoplanetary disc are visible in the background. 
Image Credit: NASA, ESA, CSA, STScI, G. Cugno (University of Zürich, NCCR PlanetS), S. Grant (Carnegie Institution for Science), J, Olmsted (STScI), L. Hustak (STScI)

The NASA/ESA/CSA James Webb Space Telescope has provided the first direct measurements of the chemical and physical properties of a potential moon-forming disc encircling a large exoplanet. The carbon-rich disc surrounding the world called CT Cha B, which is located 625 light years away from Earth, is a possible construction yard for moons, although no moons are detected in the Webb data.

Our Solar System contains eight major planets, and more than 400 known moons orbiting six of these planets. Where did they all come from? There are multiple formation mechanisms. The case for large moons, like the four Galilean satellites around Jupiter, is that they condensed out of a dust and gas disc encircling the planet when it formed. But that would have happened over 4 billion years ago, and there is scant forensic evidence today.

Childhood overeating can be a harbinger of later mental health struggles in girls, study finds

Photo Credit: Toa Heftiba

Girls who overeat regularly in preschool years are more likely to experience anxiety, impulsivity and hyperactivity in adolescence, according to a new study led by researchers at McGill University and the Douglas Research Centre.

The study followed more than 2,000 Quebec children using provincial data, tracking eating patterns reported by caregivers in early childhood and assessing mental-health symptoms when participants turned 15. The link between overeating and later difficulties was seen in girls, but not in boys.