Vaccine against deadly chytrid fungus primes frog microbiome for future exposure

A new study led by researchers at Penn State found that a new vaccine against the deadly chytrid fungus in frogs can shift the composition of the microbiome, making frogs more resilient to future exposure to the fungus.
Photo Credit: Paul Bonnar

A human's or animal’s microbiome — the collection of often beneficial microorganisms, including bacteria and fungi, that live on or within a host organism — can play an important role in the host’s overall immune response, but it is unclear how vaccines against harmful pathogens impact the microbiome. A new study led by researchers at Penn State found that a new vaccine against the deadly chytrid fungus in frogs can shift the composition of the microbiome, making frogs more resilient to future exposure to the fungus. The study, published June 12 in a special issue of the journal Philosophical Transactions of the Royal Society B, suggests that the microbiome response could be an important, overlooked part of vaccine efficacy.

“The microorganisms that make up an animal’s microbiome can often help defend against pathogens, for example by producing beneficial metabolites or by competing against the pathogens for space or nutrients,” said Gui Becker, associate professor of biology at Penn State and leader of the research team. “But what happens to your microbiome when you get a vaccine, like a COVID vaccine, flu shot, or a live-attenuated vaccine like the yellow fever vaccine? In this study, we used frogs as a model system to start exploring this question.”

Frogs and other amphibians are threatened by the chytrid fungus, which has led to extinctions of some species and severe population declines in hundreds of others across several continents. In susceptible species, the fungus causes a sometimes-lethal skin disease.

Summit study fathoms troubled waters of ocean turbulence

Simulations performed on Oak Ridge National Laboratory’s Summit supercomputer generated one of the most detailed portraits to date of how turbulence disperses heat through ocean water under realistic conditions.
Image Credit: Miles Couchman

Simulations performed on the Summit supercomputer at the Department of Energy’s Oak Ridge National Laboratory revealed new insights into the role of turbulence in mixing fluids and could open new possibilities for projecting climate change and studying fluid dynamics.

The study, published in the Journal of Turbulence, used Summit to model the dynamics of a roughly 10-meter section of ocean. That study generated one of the most detailed simulations to date of how turbulence disperses heat through seawater under realistic conditions. The lessons learned can apply to other substances, such as pollution spreading through water or air.

“We’ve never been able to do this type of analysis before, partly because we couldn’t get samples at the necessary size,” said Miles Couchman, co-author and a postdoc at the University of Cambridge. “We needed a machine-like Summit that could allow us to observe these details across the vast range of relevant scales.”

Process turns harmful pollutants into harmless substances

Conceptual image
Illustration Credit: Evan Fields/UCR

As scientists look for ways to clean up “forever chemicals” in the environment, an increasing concern is a subgroup of these pollutants that contain one or more chlorine atoms in their chemical structure.

In a recent study published in the journal Nature Water, University of California, Riverside, environmental and chemical engineering Associate Professor Jinyong Liu and UCR graduate student Jinyu Gao describe newly discovered chemical reaction pathways that destroy chlorinated forever chemicals and render them into harmless compounds.

Known formally as PFAS or poly- and per-fluoroalkyl substances, forever chemicals have been used in thousands of products ranging from potato chip bags, stain and water repellents used on fabrics, cleaning products, non-stick cookware, and fire-suppressing foams. They are so named because they persist in the environment for decades or longer due to their strong fluorine-to-carbon chemical bonds.

Chlorinated PFAS are a large group in the forever chemical family of thousands of compounds. They include a variety of non-flammable hydraulic fluids used in industry and compounds used to make chemically stable films that serve as moisture barriers in various industrial, packaging, and electronic applications.

Sleep apnea link to cognitive decline

Photo Credit: SHVETS production

Flinders University experts are working on better solutions for sleep apnea to ward off a range of health risks, including cognitive decline.

Improved solutions for obstructive sleep apnea (OSA), insomnia and other sleep disorders are being developed by the Flinders Sleep Health experts to reduce the associated negative health effects such as cardiovascular harm, diabetes, anxiety and depression and even long-term cognitive decline.

Heightened risk of cognitive function decline from undiagnosed OSA – particularly in middle-aged men living in the community – is the focus of one of the latest studies published in Sleep Health.

The study recorded the sleep patterns of more than 470 men aged from 41-87 years alongside their daytime cognitive function for processing speed, visual attention, episodic memory recollection and other markers.

Measuring distinct features of brain electrical activity during non-REM sleep, called ‘sleep spindles’, the study aimed to explore if these features can serve as markers of cognitive function.

“Non-REM sleep includes light stage 1 and 2 sleep, as well as deeper stage 3 sleep which is thought to play an important role in learning and memory,” says Flinders University sleep researcher Dr Jesse Parker.

Why women with multiple sclerosis get better when pregnant

Women suffering from the autoimmune disease multiple sclerosis temporarily get much better when pregnant.
Photo Credit: Neal E. Johnson

Women suffering from the autoimmune disease multiple sclerosis temporarily get much better when pregnant. Researchers have now identified the beneficial changes naturally occurring in the immune system during pregnancy. The findings can show the way to new treatments.

Pregnancy is a very special condition from an immunological point of view. The immune system serves to defend us against foreign substances. However, although half of the genetic material of the fetus comes from the father, it is not rejected by the mother’s immune system. One reason why this balancing act is almost always successful is that during pregnancy the mother’s immune system is adapted to become more tolerant.

In multiple sclerosis, MS, nerve function is hampered due to the immune system attacking the fat that serves as an insulating sheath around the nerve fibers. The nerves become inflamed, which could lead to nerve damage. Although new and more effective treatment options are available, most MS patients deteriorate over time.

Researchers believe that the temporary dampening of the immune response could explain why women with MS actually get better when pregnant. Periods of symptoms, i.e. relapses, decrease by 70 percent during the last third of pregnancy. Also, some other autoimmune diseases, such as rheumatoid arthritis, temporarily ameliorate during pregnancy. But the reason for this has not been clear. This is why the researchers behind this study wanted to investigate what mechanisms that could be of particular importance for the decrease in symptoms during pregnancy, as a step to finding future treatment strategies that give the same effect in MS and possibly also other similar diseases.

Blocking immune system ‘messenger’ may treat severe asthma

Professor Toshiaki Kawakami, M.D., Ph.D.
Photo Credit: Courtesy of La Jolla Institute for Immunology

Asthma is more dangerous than many people realize. An estimated 10 Americans die every day from asthma, and the disease leads to around 439,000 hospitalizations and 1.3 million emergency room trips each year.

“Asthma is one of the most important allergic diseases to study,” says Professor Toshiaki Kawakami, M.D., Ph.D., a member of the Center for Autoimmunity and Inflammation at La Jolla Institute for Immunology (LJI).

In a new study, Kawakami and his colleagues at LJI investigated the molecular drivers of severe asthma and rhinovirus-induced asthma exacerbation (a type of asthma that can accompany a common cold). Their findings, published recently in The Journal of Allergy and Clinical Immunology, suggest people with both types of asthma may benefit from therapies that block interactions between a molecule called histamine-releasing factor (HRF) and antibodies called immunoglobulin E (IgE).

As Kawakami explains, many people with severe asthma aren’t responsive to current asthma therapies. He hopes two potential drug strategies from his laboratory might inhibit HRF and IgE interactions and deliver relief for these patients. “We hope this approach can be a means of treating severe asthma and asthma exacerbation,” he says.

New study links contraceptive pills and depression

According to the study, women who began to use contraceptive pills as teenagers had a 130 per cent higher incidence of symptoms of depression.
Photo Credit: Thought Catalog

Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study from Uppsala University. Contraceptive pills increased women’s risk by 73 per cent during the first two years of use.

In a global perspective, depression is the leading cause of ill health and disability. More than 264 million people are affected and at least 25 per cent of all women and 15 per cent of all men experience a depression that requires treatment at some point during their life.

The possibility that contraceptive pills might have negative effects on mental health and even lead to depression has long been discussed. Although many women choose to stop using contraceptive pills because of the influence on their mood, until now the picture emerging from research has not been straightforward. This study is one of the largest and widest-ranging to date, following more than a quarter of a million women from UK Biobank from birth to menopause.

First side-necked turtle ever discovered in UK

The fossil was found on a National Trust beach on the Isle of Wight
Photo Credit: Courtesy of University of Portsmouth

The first side-necked turtle ever to be found in the UK has been discovered by an amateur fossil collector and paleontologists at the University of Portsmouth.

The fossil remains are the earliest of a so-called side-necked pan-pleurodiran turtle, named as such because they fold their neck into their shell sideways when threatened. This does mean they can only see out with one eye.

Originally found on a beach on the Isle of Wight, the turtle fossil is an almost complete shell with cervical, dorsal and caudal vertebrae, scapulae, pelvic girdle and appendicular bones. Sadly, the skull was missing.

Lead author, Megan Jacobs, said: “This is an amazing discovery because it’s the first time this type of turtle has been found in the UK. Even more exciting is that we used a new technique of radiometric dating to determine the age of the fossil beyond any doubt. And to top it off, CT scanning revealed all the tiny bones inside. It’s really incredible for what looks like a rolled beach pebble!”

Dynamic plants: Origin and geographic evolution of cycads clarified

The African cycad Encephalartos altensteinii Lehm is widely cultivated in botanical gardens around Europe (like this one in the Botanical Garden of the University of Naples "Federico II"), including one specimen that was brought from South Africa to the UK in 1775 and that is still alive today. Large Encephalartos are highly prized as ornamental plants, and unfortunately many species have been brought to the brink of extinction by poaching.
Photo Credit: Mario Coiro

Paleobotanist Mario Coiro of the Institute of Paleontology at the University of Vienna and colleagues at the University of Montpellier (France) have made an important breakthrough in understanding the origin and geographic distribution of cycads. By combining genetic data with leaf morphological data from both fossil and living species for the first time, the researchers created a phylogenetic tree of these fascinating and endangered plants. The results of the study, which was funded by the Austrian Science Fund FWF, have now been published in the journal New Phytologist.

Cycads (order Cycadales) are an evolutionarily very old and once very diverse group of palm-like plants that were widespread worldwide at the time of the dinosaurs. Now their distribution is limited to subtropical regions of the earth with low latitudes, and some of them have been considered as "living fossils". Until now, little was known about the origin of these plants, which are also highly valued by garden lovers and collectors, and their evolutionary distribution paths – a fact that Mario Coiro's team have actively challenged. To this end, the researchers developed an innovative research approach that actually makes a significant contribution to clarifying the biogeographical distribution of cycads.

A Baking Soda Solution for Clean Hydrogen Storage

A research team at PNNL has proposed a safe pathway to store and release clean energy based on the chemistry of baking soda.   
Image Credit: Composite image by Shannon Colson | Pacific Northwest National Laboratory

In a world of continuously warmer temperatures, a growing consensus demands that energy sources have zero, or next-to-zero, carbon emissions. That means growing beyond coal, oil, and natural gas by getting more energy from renewable sources.

One of the most promising renewable energy carriers is clean hydrogen, which is produced without fossil fuels.

It’s a promising idea because the most abundant element in the universe is hydrogen, found in 75 percent of all matter. Moreover, a hydrogen molecule has two paired atoms—Gemini twins that are both non-toxic and highly combustible.

Hydrogen’s combustive potential makes it an attractive subject for energy researchers around the world.

At Pacific Northwest National Laboratory (PNNL), a team is investigating hydrogen as a medium for storing and releasing energy, largely by cracking its chemical bonds. Much of their work is linked to the Hydrogen Materials-Advanced Research consortium (HyMARC) at the Department of Energy (DOE).