Thousands of tons of microplastics found in Moreton Bay

Dr Elvis Okoffo has tested samples of mud from Moreton Bay for microplastics.
Photo Credit: Courtesy of University of Queensland

University of Queensland researchers estimate there could be up to 7000 tons of microplastics polluting vital ecosystems in Brisbane’s Moreton Bay.

Dr Elvis Okoffo from UQ’s Queensland Alliance for Environmental Health Sciences said the team measured plastic stored within 50 surface sediment samples collected across Moreton Bay.

“The level of plastic contamination we found is equivalent to three Olympic swimming pools full of plastic or 1.5 million single use plastic bags,” Dr Okoffo said.

“The main types of plastic detected were polyethylene (PE) and polyvinyl chloride (PVC).

“PE is used for single-use items such as plastic food wrapping, bags and bottles and PVC is used in pipes, building materials, electronics, and clothing.

Research uncovers a rare resin fossil find: A spider that aspires to be an ant

Ant-mimicking spider in fossilized resin
Photo Credit: George Poinar Jr / Oregon State University

Arachnophobia can make humans flee at the sight of a brown recluse, black widow or even a daddy long legs, but animal predators of spiders know no such fear.

That’s why paleobiologist George Poinar Jr. explains, some spider species have developed the defense of deception. They masquerade as a much less desirable prey – ants – and Poinar’s recent paper in Historical Biology presents an early record of an ant-mimicking spider in fossilized resin.

“Ants are particularly good creatures for spiders to pretend to be – many animals find ants distasteful or dangerous to eat,” said Poinar, who has a courtesy appointment in the Oregon State University College of Science. “Ants are aggressive in their own defense – they have a strong bite as well as stinging venom, and they can call in dozens of nestmates as allies. Spiders, meanwhile, have no chemical defenses and are loners, which makes them vulnerable to being hunted by larger spiders, wasps and birds – predators that would rather avoid ants. So, if a spider can be like an ant, it’s more likely to be unbothered.”

Spiders that disguise themselves as ants live in many locations around the globe but until now most had been able to avoid detection from fossil researchers as well as predators. The specimen that Poinar describes, which he named Myrmarachne colombiana, was entombed in a type of fossilized resin known as copal.

Signs of life detectable in single ice grain emitted from extraterrestrial moons

An artist’s rendition of Saturn’s moon Enceladus depicts hydrothermal activity on the seafloor and cracks in the moon’s icy crust that allow material from the watery interior to be ejected into space. New research shows that instruments destined for the next missions could find traces of a single cell in a single ice grain contained in a plume.
Illustration Credit: NASA/JPL-Caltech

The ice-encrusted oceans of some of the moons orbiting Saturn and Jupiter are leading candidates in the search for extraterrestrial life. A new lab-based study led by the University of Washington in Seattle and the Freie Universität Berlin shows that individual ice grains ejected from these planetary bodies may contain enough material for instruments headed there in the fall to detect signs of life, if such life exists.

“For the first time we have shown that even a tiny fraction of cellular material could be identified by a mass spectrometer onboard a spacecraft,” said lead author Fabian Klenner, a UW postdoctoral researcher in Earth and space sciences. “Our results give us more confidence that using upcoming instruments, we will be able to detect lifeforms similar to those on Earth, which we increasingly believe could be present on ocean-bearing moons.”

The open-access study was published March 22 in Science Advances. Other authors in the international team are from The Open University in the U.K.; NASA’s Jet Propulsion Laboratory; the University of Colorado, Boulder; and the University of Leipzig.

The Cassini mission that ended in 2017 discovered parallel cracks near the south pole of Saturn’s moon Enceladus. Emanating from these cracks are plumes containing gas and ice grains. NASA’s Europa Clipper mission, scheduled to launch in October, will carry more instruments to explore in even more detail an icy moon of Jupiter, Europa.

Mystery of unexplained kidney disease revealed to patients

Professor John Sayer
“What we are now able to do is give some patients a precise diagnosis, which allows their investigations, treatment and management to be tailored to their needs for the best possible outcomes.”
Photo Credit: Courtesy of Newcastle University

Scientists have identified a new method of analyzing genomic data in a major discovery that means patients with unexplained kidney failure are finally getting a diagnosis.

Experts at Newcastle University have worked with data from Genomics England 100,000 Genomes Project to establish a diagnosis in patients with unexplained kidney failure.

There are numerous reasons for kidney failure, which if left untreated is life-threatening, but often patients do not get a precise diagnosis which can make their best course of treatment unclear.

Missing genetic data

Research, published in the Genetics in Medicine Open, has now revealed that for these patients areas in their genome are missing so are not detected as faulty when using the routine genetic pipelines to analyze data. 

Scientists say that as this missing gene has now been identified, and mutations within it found, they have been able to classify this as NPHP1-related kidney failure.

Messenger RNAs with multiple “tails” could lead to more effective therapeutics

Graphic showing scientists adding "tails" to mRNA molecules
Illustration Credit: Catherine Boush, Broad Communications

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines. But mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being developed as a new class of drugs. For mRNAs to have broad therapeutic uses, however, the molecules will need to last longer in the body than those that make up the COVID vaccines. 

Researchers from the Broad Institute of MIT and Harvard and MIT have engineered a new mRNA structure by adding multiple “tails” to the molecules that boosted mRNA activity levels in cells by 5 to 20 times. The team also showed that their multi-tailed mRNAs lasted 2 to 3 times longer in animals compared to unmodified mRNA, and when incorporated into a CRISPR gene-editing system, resulted in more efficient gene editing in mice. 

The new mRNAs, reported in Nature Biotechnology, could potentially be used to treat diseases that require long-lasting treatments that edit genes or replace faulty proteins. 

“The use of mRNA in COVID vaccines is fantastic, which prompted us to explore how we could expand the possible therapeutic applications for mRNA,” said Xiao Wang, senior author of the new paper, a core institute member at the Broad and an assistant professor of chemistry at MIT. “We’ve shown that non-natural structures can function so much better than naturally occurring ones. This research has given us a lot of confidence in our ability to modify mRNA molecules chemically and topologically.”

Decoding the plant world’s complex biochemical communication networks

PhD candidate Shannon Stirling in Natalia Dudareva’s Lab, transfers DNA into a petunia by using a syringe to inject bacterium into the stigma to activate targeted genes, then isolating the resulting proteins.
Photo Credit: Purdue Agricultural Communications / Tom Campbell

A Purdue University-led research team has begun translating the complex molecular language of petunias. Their grammar and vocabulary are well hidden, however, within the countless proteins and other compounds that fill floral cells.

Being rooted to the ground, plants can’t run away from insects, pathogens or other threats to their survival. But plant scientists have long known that they do send warnings to each other via scent chemicals called volatile organic compounds.

“They use volatiles because they can’t talk,” said Natalia Dudareva, Distinguished Professor of Biochemistry and Horticulture and Landscape Architecture at Purdue. “Plants inform neighboring plants about pathogen attacks. It looks almost like immunization. Under normal conditions, you don’t see any changes in the receiver plant. But as soon as a receiver plant is infected, it responds much faster. It’s prepared for response.”

Plant scientists have long known about this immunization-like priming, but until a few years ago, they had no way to study the process. They needed a marker showing that the plants had detected the volatile compounds.

Dudareva and 13 co-authors describe new details of the detection process in the March 22, 2024, issue of the journal Science. The team includes researchers from Purdue; Université Jean Monnet Saint-Etienne in France; and the University of California, Davis.

Two keys needed to crack three locks for better engineered blood vessels

Two proteins can trigger the signaling cascades needed to help differentiate stem cells into endothelial cells that can form tubular-like vessels in a dish, according to a team led by Penn State researchers. The finding has implications for developing drug-testing platforms and other clinical applications. 
Image Credit: Lian Lab / Pennsylvania State University

Blood vessels engineered from stem cells could help solve several research and clinical problems, from potentially providing a more comprehensive platform to screen if drug candidates can cross from the blood stream into the brain to developing lab-grown vascular tissue to support heart transplants, according to Penn State researchers. Led by Xiaojun “Lance” Lian, associate professor of biomedical engineering and of biology, the team discovered the specific molecular signals that can efficiently mature nascent stem cells into the endothelial cells that comprise the vessels and regulate exchanges to and from the blood stream.

They published their findings in Stem Cell Reports. The team already holds a patent on foundational method developed 10 years ago and has filed a provisional application for the expanded technology described in this paper.

The reserchers found they could achieve up to a 92% endothelial cell conversion rate by applying two proteins — SOX17 and FGF2 — to human pluripotent stem cells. This type of stem cell, which the researchers derived from a federally approved stem cell line, can differentiate into almost any other cell type if provided the right proteins or other biochemical signals. SOX17 and FGF2 engage three markers in stem cells, triggering a growth cascade that not only converts them to endothelial cells but also enables them to form tubular-like vessels in a dish.

The aging brain: protein mapping furnishes new insights

Stained mouse microvessels under the fluorescence microscope (green: vascular endothelium, red: cell nuclei). 
Image Credit: © Dichgans Lab

For the neurons in the brain to work smoothly and be able to process information, the central nervous system needs a strictly regulated environment. This is maintained by the blood-brain barrier, whereby specialized brain endothelial cells lining the inner walls of blood vessels regulate the exchange of molecules between the circulatory and nervous systems. Earlier studies have shown that various functions that are dependent on these cells, such as the integrity of the blood-brain barrier or the regulation of blood supply to the brain, decline over the course of a person’s life. This dysregulation leads to a dysfunction of the brain vasculature and is therefore a major contributor to medical conditions such as strokes and dementia.

However, the molecular changes that underlie this loss of function have remained largely obscure. To improve our mechanistic understanding, researchers carry out molecular profiling studies to investigate the different components of brain endothelial cells and collect their findings in large databases. “The transcriptome – that is to say, the RNA contained in endothelial cells – has since been quite comprehensively mapped,” says LMU professor Martin Dichgans, Director of the Institute for Stroke and Dementia Research at University of Munich Hospital and Principal Investigator at the SyNergy Cluster of Excellence. “What has been lacking is corresponding data on the complete set of proteins in the cells, the proteome.” A study recently published in the journal Nature Aging, which had major contributions by researchers from LMU and SyNergy, has now closed this knowledge gap.

Bees need food up to a month earlier than provided by recommended pollinator plants

Buff-tailed bumblebee (Bombus terrestris).
Photo Credit Matthias Becher

New research from the Universities of Oxford and Exeter has revealed that plant species recommended as “pollinator friendly” * in Europe begin flowering up to a month too late in the spring to effectively contribute to bee conservation.

This “hungry gap” results in low colony survival and low production of queens for the following year.

The results showed that pollen and nectar availability during the early colony founding stage is a critical, and previously under-appreciated, factor in bee colony success. **

The study has been published in the journal Insect Conservation and Diversity. 

Senior author Dr Tonya Lander (Department of Biology, University of Oxford) said: “The results give us a simple and practical recommendation to help bees: to enhance hedgerows with early blooming species, especially ground ivy, red dead-nettle, maple, cherry, hawthorn, and willow, which improved colony success rate from 35% to 100%. This approach focuses on existing hedgerows in agricultural land and doesn’t reduce farm cropping area, so can appeal to land managers whilst also providing important conservation outcomes for pollinators.” 

These were assessed using the BEE-STEWARD model, which integrates data and runs simulations to predict how changes in different factors may impact bee populations over time.

Rays were more diverse 150 million years ago than previously thought

Aellopobatis bavarica: The newly discovered species, complete fossils are only known from Germany. This species is also the largest species of all and can grow up to 170 cm in size.
Photo Credit: Türtscher et al.

New fossil ray species discovered in Bavarica, Germany: Aellopobatis bavarica from the Late Jurassic

In a new study recently published in the journal Papers in Paleontology, an international team of scientists led by paleobiologist Julia Türtscher from the University of Vienna has explored the puzzling world of rays that lived 150 million years ago and discovered a previously hidden diversity – including a new ray species. This study significantly expands the understanding of these ancient cartilaginous fish and provides further insights into a past marine ecosystem.

In her new study, paleobiologist Julia Türtscher from the Institute of Paleontology at the University of Vienna examined 52 fossil rays from the Late Jurassic period. These rays are 150 million years old, from a time when Europe was largely covered by the sea, except for a few islands, comparable to today's Caribbean. The Late Jurassic specimens are particularly valuable to scientists because they are among the oldest known fully preserved ray specimens. As only the teeth of fossilized rays are usually preserved, such rare skeletal finds provide exciting insights into the early evolution of this group. Although the exceptionally well-preserved fossils (from Germany, France, and the UK) have been known for some time, they have been largely unexplored. Türtscher's study is the first comprehensive analysis of the variation in body shape in these rays.