Anti-cancer drug derived from fungus shows promise in clinical trials

An image of the fungus Cordyceps sinensis. This fungus grows naturally on caterpillars at high altitudes in the Himalayas.

A new industry-academic partnership between the University of Oxford and biopharmaceutical company NuCana as found that chemotherapy drug NUC-7738, derived from a Himalayan fungus, has 40 times greater potency for killing cancer cells than its parent compound.

Oxford University researchers have worked in collaboration with industry leaders NuCana to assess a novel chemotherapy drug derived from a fungus. A study in Clinical Cancer Research has shown that the new drug NUC-7738, developed by NuCana, has a up to 40 times greater potency for killing cancer cells than its parent compound, with limited toxic side effects.

The naturally-occurring nucleoside analogue known as Cordycepin (a.k.a 3’-deoxyadenosine) is found in the Himalayan fungus Cordyceps sinensis and has been used in traditional Chinese medicine for hundreds of years to treat cancers and other inflammatory diseases. However, it breaks down quickly in the blood stream, so a minimal amount of cancer-destroying drug is delivered to the tumor. In order to improve its potency and clinically assess its applications as a cancer drug, biopharmaceutical company NuCana has developed Cordycepin into a clinical therapy, using their novel ProTide technology, to create a chemotherapy drug with dramatically improved efficacy.

Environmentally friendly method to extract and separate rare earth elements

A new method improves the extraction and separation of rare earth elements from unconventional sources, including industrial waste, such as the mine tailings pictured here, and electronic waste.  Image: Barsamuphe, Wikimedia Commons

A new method improves the extraction and separation of rare earth elements — a group of 17 chemical elements critical for technologies such as smart phones and electric car batteries — from unconventional sources. New research led by scientists at Penn State and the Lawrence Livermore National Laboratory (LLNL) demonstrates how a protein isolated from bacteria can provide a more environmentally friendly way to extract these metals and to separate them from other metals and from each other. The method could eventually be scaled up to help develop a domestic supply of rare earth metals from industrial waste and electronics due to be recycled.

“In order to meet the increasing demand for rare earth elements for use in emerging clean energy technologies, we need to address several challenges in the supply chain,” said Joseph Cotruvo Jr., assistant professor and Louis Martarano Career Development Professor of Chemistry at Penn State, a member of Penn State’s Center for Critical Minerals, and co-corresponding author of the study. “This includes improving the efficiency and alleviating the environmental burden of the extraction and separation processes for these metals. In this study, we demonstrate a promising new method using a natural protein that could be scaled up to extract and separate rare earth elements from low-grade sources, including industrial wastes.”

Material protects against both biological and chemical threats

Programmable crystalline sponge-textile composite for
elimination of biological and chemical threats

 A Northwestern University research team has developed a versatile composite fabric that can deactivate both biological threats, such as the novel coronavirus that causes COVID-19, and chemical threats, such as those used in chemical warfare. A material that is effective against both classes of threats is rare.

The material also is reusable. It can be restored to its original state after the fabric has been exposed to threats by a simple bleach treatment. The promising fabric could be used in face masks and other protective clothing.

“Having a bifunctional material that has the ability to deactivate both chemical and biological toxic agents is crucial since the complexity to integrate multiple materials to do the job is high,” said Northwestern’s Omar Farha, an expert in metal-organic frameworks, or MOFs, which is the basis for the technology.

Farha, a professor of chemistry in the Weinberg College of Arts and Sciences, is a co-corresponding author of the study. He is a member of Northwestern’s International Institute for Nanotechnology.

The MOF/fiber composite builds on an earlier study in which Farha’s team created a nanomaterial that deactivates toxic nerve agents. With some small manipulations, the researchers were able to also incorporate antiviral and antibacterial agents into the material.

Earth’s inner core may contain both soft and hard iron

Earthquake locations (red) and seismic stations (yellow).
(Photo credit: Butler and Tsuboi, 2021.)

3,200 miles beneath Earth’s surface lies the inner core, a ball-shaped mass of mostly iron that is responsible for Earth’s magnetic field. According to NASA, this field acts like a protective shield around the planet, repelling and trapping charged particles from the Sun. In the 1950’s, researchers suggested the inner core was solid, in contrast to the liquid metal region surrounding it. New research led by Rhett Butler, a geophysicist at the University of Hawaiʻi at Mānoa School of Ocean and Earth Science and Technology (SOEST), suggests that Earth’s “solid” inner core is, in fact, endowed with a range of liquid, soft and hard structures, which vary across the top 150 miles of the inner core.

Earthquake waves provide clues

Seismic energy reflects in a circular pattern around top of inner core.
(Photo credit:Butler, Tsuboi, 2021.)

No human or machine has been to this region. The depth, pressure and temperature make inner Earth inaccessible. So Butler, a researcher at SOEST’s Hawaiʻi Institute of Geophysics and Planetology, and co-author Seiji Tsuboi, research scientist at the Japan Agency for Marine-Earth Science and Technology, relied on the only means available to probe the innermost Earth—earthquake waves.

“Illuminated by earthquakes in the crust and upper mantle, and observed by seismic observatories at Earth’s surface, seismology offers the only direct way to investigate the inner core and its processes,” said Butler.

As seismic waves move through various layers of Earth, their speed changes and they may reflect or refract depending on the minerals, temperature and density of that layer.

2,050-year-old Roman tomb offers insights on ancient concrete resilience

“Understanding the formation and processes of ancient materials can inform researchers of new ways to create durable, sustainable building materials for the future,” says Associate Professor Admir Masic. “The tomb of Caecilia Metella is one of the oldest structures still standing, offering insights that can inspire modern construction.” Seen here are the Tomb of Cecilia Metella and Castrum Caetani ruins in Rome.
Credits:Photo: Livioandronico2013/Wikimedia Commons

Concrete often begins to crack and crumble after a few decades of life — but curiously, that hasn’t been the case with many Roman structures. The structures are still standing, exhibiting remarkable durability despite conditions that would destroy modern concrete.

One particular structure is the large cylindrical tomb of first-century noblewoman Caecilia Metella. New research from MIT scientists and colleagues published in the Journal of the American Ceramic Society shows that the quality of the concrete of her tomb may exceed that of her male contemporaries’ monuments because of the volcanic aggregate the builders chose and the unusual chemical interactions with rain and groundwater that accumulate over two millennia.

Lead co-authors of the study, Admir Masic, associate professor of civil and environmental engineering at MIT, and Marie Jackson, research associate professor of geology and geophysics at the University of Utah, teamed up to understand the mineral composition of the ancient concrete structure.

“Understanding the formation and processes of ancient materials can inform researchers of new ways to create durable, sustainable building materials for the future,” says Masic. “The tomb of Caecilia Metella is one of the oldest structures still standing, offering insights that can inspire modern construction.”

Report calls for urgent action to address alarming lack of diversity in climate change decision making

Bristol prides itself on being a leading city in the UK and globally in its commitment to tackle climate change, but a new report has revealed extremely low levels of ethnically diverse and equal gender representation in the debate and decision-making process to make this transition just and fair.

The report, led by the University of Bristol, found that although the same number of white men and white women attended meetings, white men spoke two-thirds of the time – almost twice as much as their female counterparts. By contrast just five per cent of participants were men of color, who spoke only one per cent of the time. Women of color comprised 14 per cent of participants and they were found to speak just two per cent of the time.

Co-investigator Dr Alix Dietzel, who specializes in climate justice and climate policy and will be attending the 2021 United Nations Climate Change Conference, better known as COP26, said: “I was observing the first meeting of the study when I noticed men dominating the discussion. I spontaneously decided to count the number of times people spoke, organized by ethnicity and gender. The results were so stark I continued to do the same for the rest of the meetings we observed.”

The policy briefing recognizes Bristol as being among the first cities in the world to officially pledge to pursue a just transition to combat climate change with the launch of its One City Climate Strategy last year. A just transition to a post-carbon economy means one that is green, sustainable, and socially inclusive.

Extinction changes rules of body size evolution

A trilobite fossil from the Ordovician period, which lasted from about 485 to 443 million years ago. A new analysis of marine fossils from most of the past half-billion years shows the usual rules of body size evolution change during mass extinctions and their recoveries.
(Image credit: Smithsonian)

Scientific Frontline: "At a Glance" Summary: Extinction Changes Rules of Body Size Evolution

• Main Discovery: The rules governing body size evolution fundamentally shift during mass extinctions and their subsequent recovery periods, altering the specific traits that dictate a species' survival or extinction.
• Methodology: Researchers utilized statistical analyses and computer simulations on an extensive marine fossil dataset, evaluating 284,308 fossil occurrences across 10,203 genera spanning 485 million years.
• Key Data: During recovery intervals following mass extinctions, newly evolved genera in most classes are distinctly smaller than the surviving holdover species, reversing the normal background pattern where newly evolved genera are slightly larger.
• Significance: Revealing how body size selectivity changes after global annihilations provides critical insights into the origins of the modern biosphere and the underlying mechanics of ecosystem recovery.
• Future Application: These findings offer a predictive framework to project the long-term evolutionary consequences of the current global biodiversity crisis, specifically helping anticipate which species might go extinct and what types of organisms could eventually reemerge.
• Branch of Science: Paleontology and Evolutionary Biology.

Birds learn to avoid plants that host dangerous insects

Cinnabar larvae feeding on ragwort
Credit: Callum McLellan

Young birds that eat insects with conspicuous warning coloration to advertise their toxicity to would-be predators quickly learn to avoid other prey that carry the same markings. Developing on this understanding, a University of Bristol team have shown for the very first time that birds don’t just learn the colors of dangerous prey, they can also learn the appearance of the plants such insects live on.

To do this, the scientists exposed artificial cinnabar caterpillars, characterized by bright yellow and black stripes, and non-signaling fake caterpillar targets to wild avian predation by presenting them on ragwort and a non-toxic plant - bramble, which is not a natural host of the cinnabar. Both target types survived better on ragwort compared to bramble when experienced predators were abundant in the population.

They were also interested in whether birds use the bright yellow flowers of ragwort as a cue for

An adult cinnabar moth on a ragwort stem
Credit: Callum McLellan

avoidance. They tested this by removing spikes of flowers from the ragwort and pinning them onto bramble, then recording target survival on either plant. In this second experiment, only the non-signaling targets survived better on plants with ragwort flowers, compared to the same plant type without the flowers. The survival of the cinnabar-like target was equal across all plant treatments

Lead author Callum McLellan, a graduate student at the School of Biological Sciences, said “Cinnabar caterpillars have this really recognizable, stripy yellow and black appearance. They also only live and feed on ragwort, which itself has distinctive yellow flowers. We have shown that birds learn that the ragwort flowers are a cue for danger, so can avoid going anywhere near toxic prey. It’s more efficient to avoid the whole plant than make decisions about individual caterpillars.”

Co-author Prof Nick Scott-Samuel of the School of Psychological Science, said “Our findings suggest that insect herbivores that specialize on easily recognizable host plants gain enhanced protection from predation, independent of their warning signal alone.”

Ragwort Credit: Callum McLellan

Prof Innes Cuthill, who conceived the study, added “Interestingly, any camouflaged caterpillars living on the same plant also benefit from birds’ learnt wariness of ragwort, despite being perfectly good to eat.

“Our results provide the opening to a brand-new discussion on how toxicity initially evolved in insect prey, and the conditions under which warning coloration is, or is not, favored.”

Paper:
‘Birds learn to avoid aposematic prey by using the appearance of host plants’ in Current Biology by Callum F. McLellan, Nicholas E. Scott-Samueland Innes C. Cuthill

Source/Credit: University of Bristol

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The Climate-Driven Mass Extinction No One Had Seen

 

Fossils of the key groups used to unveil the Eocene-Oligocene extinction in Africa with primates on the left, the carnivorous hyaenodont, upper right, rodent, lower right. These fossils are from the Fayum Depression in Egypt. (Credit: Matt Borths)

Sixty-three percent. That’s the proportion of mammal species that vanished from Africa and the Arabian Peninsula around 30 million years ago, after Earth’s climate shifted from swampy to icy. But we are only finding out about it now.

Compiling decades of work, a new study published this week in the journal Communications Biology reports on a previously undocumented extinction event that followed the transition between the geological periods called the Eocene and Oligocene.

That time period was marked by dramatic climate change. In a reverse image of what is happening today, the Earth grew cooler, ice sheets expanded, sea levels dropped, forests started changing to grasslands, and carbon dioxide became scarce. Nearly two-thirds of the species known in Europe and Asia at that time went extinct.

Crayfish and carp among invasive species pushing lakes towards ecosystem collapse

Asian silver carp

Human activity and climate change are causing invasive non-native species to spread rapidly across the globe. Researchers have found that certain invasive species can push lake ecosystems beyond a critical ‘tipping point’, causing a sudden shift from healthy to degraded conditions that is difficult to reverse.

Invasive fish such as Asian silver carp Hypophthalmichthys molitrix, and crustaceans such as American signal crayfish Pacifastacus leniusculus, were found to significantly reduce the abundance of other important organisms in lakes and degrade water quality. The findings, published today in the journal Global Change Biology, also provide guidance on the best ways to manage waterbodies.

Shallow lakes naturally exist in one of two alternative stable states: either healthy - with clear water with an abundance of vegetation, or degraded - with cloudy water dominated by algae. When a lake is in the latter state, algae use up all the nutrients in the water and block sunlight, preventing the growth of aquatic vegetation that would aid ecosystem recovery.

Deteriorated, algae-dominated freshwater ecosystems also threaten the health and water security of human populations. Blooms of cyanobacteria, known as ‘blue-green algae’ can produce toxins that contaminate food webs and poison water supplies.