Common household cleaner can boost effort to harvest fusion energy on Earth

PPPL physicist Federico Nespoli at the Large Helical Device in Japan.
Photo courtesy of the Japanese National Institute of Fusion Science. Collage by Kiran Sudarsanan.

Scientists have found that adding a common household cleaning agent – the mineral boron contained in such cleaners as Borax – can vastly improve the ability of some fusion energy devices to contain the heat required to produce fusion reactions on Earth the way the sun and stars do.

Physicists at the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) working with Japanese researchers, made the observation on the Large Helical Device (LHD) in Japan, a twisty magnetic facility that the Japanese call a “heliotron.” The results demonstrated for the first time a novel regime for confining heat in facilities known as stellarators, similar to the heliotron. The findings could advance the twisty design as a blueprint for future fusion power plants.

Higher confinement

Researchers produced the higher confinement regime by injecting tiny grains of boron powder into the LHD plasma that fuels fusion reactions. The injection through a PPPL-installed dropper sharply reduced turbulent swirls and eddies and raised the confined heat that produces the reactions.

“We could see this effect very clearly,” said PPPL physicist Federico Nespoli, lead author of a paper that detailed the process in the journal Nature Physics. “The more power we put into the plasma the bigger the increase in heat and confinement, which would be ideal in real reactor conditions.”

Researchers discover a new approach to breaking bacterial antibiotic resistance and rescue frontline drug treatments

Researchers may have uncovered a key to making existing frontline antibiotics work again, against the deadly bacteria that cause pneumonia.

The international team from the Peter Doherty Institute for Infection and Immunity (Doherty Institute – a joint venture between the University of Melbourne and the Royal Melbourne Hospital), the University of Queensland, Griffith University, the University of Adelaide, and St Jude Children’s Research Hospital (USA), found how to repurpose a molecule called PBT2 - originally developed as a potential treatment for disorders such as Alzheimer's, Parkinson’s and Huntington’s diseases – to break bacterial resistance to commonly used frontline antibiotics.

Led by University of Melbourne Professor Christopher McDevitt, a laboratory head at the Doherty Institute, this discovery may see the comeback of readily available and cheap antibiotics, such as penicillin and ampicillin, as effective weapons in the fight against the rapidly rising threat of antibiotic resistance.

In a paper published today in Cell Reports, Professor McDevitt and his collaborators described how they discovered a way to break bacterial drug resistance and then developed a therapeutic approach to rescue the use of the antibiotic ampicillin to treat drug-resistant bacterial pneumonia caused by Streptococcus pneumoniae in a mouse model of infection.

Last year the World Health Organization (WHO) described antibiotic resistance as one of the greatest threats to global health, food security, and development. Rising numbers of bacterial infections – such as pneumonia, tuberculosis, gonorrhoea, and salmonellosis – are becoming harder to treat as the antibiotics used against them are becoming less effective.

Researchers Find Concerns for Animals Tied to Same Habitats

Many animals display strong site fidelity, including these
(clockwise from top left): Adélie penguins, mule deer, great gray owls,
sockeye salmon and northern elephant seals.
Credits: Daniel Costa, Jonathan Armstrong and Amanda Hancock 

Some wildlife are stuck in their ways. Like humans, wild animals often return to the same places to eat, walk on the same paths to travel and use the same places to raise their young.

A team of researchers led by scientists from the University of Wyoming and the University of Washington has reviewed the scientific literature and found that, while this “consistent” behavior may be beneficial when environmental conditions don’t change very fast, those benefits may not be realized in the ever-changing world dominated by humans. The research was published today (Tuesday) in the scientific journal Frontiers in Ecology and the Environment.

Ecologists use the term “site fidelity” to describe the behavior of animals that are stuck in their ways. Site fidelity is the tendency to return to previously visited locations and is common across many species, from fish to birds to mammals and insects. Think salmon returning to their natal streams to spawn, or birds returning year after year to the same nest site -- site fidelity is all around us in nature.

As animals become familiar with a place, site fidelity can help them know where to find good food or hiding spots from predators, and can help them move efficiently to and from these resources. However, the authors uncovered an emerging theme in the scientific literature.

“Animals that have strong site fidelity are having a tough time adjusting to the novel landscapes that are showing up around them as a result of humans,” says Jerod Merkle, an assistant professor at the University of Wyoming and the co-lead author of the paper.

Alzheimer’s Treatments on the Horizon

Memory disorders expert Zaldy Tan, MD, says new medications
for Alzheimer's disease patients are on the horizon.
Photo by Cedars-Sinai.

As 2022 gets underway, experts in the Cedars-Sinai Departments of Neurology and Neurosurgery are monitoring new Alzheimer’s treatments, while also advancing Cedars-Sinai-led research in noninvasive diagnostic tools for the disease.

Treatments for Alzheimer’s disease—a condition affecting more than 5 million Americans—have been slow to progress. But in mid-2021, the Food and Drug Administration (FDA) approved aducanumab—marketed under the brand name Aduhelm—the first new drug to treat Alzheimer’s disease since 2003.

The once-a-month intravenous infusion is intended to slow cognitive decline in patients in the early stages of the disease by eliminating the amyloid plaque that accumulates in the brain in Alzheimer’s patients. However, studies have not found that eliminating the plaque in the brain reverses cognitive and functional impairment or preserves brain function. Additional questions remain about the treatment’s side effects—including swelling and bleeding in the brain— safety and effectiveness as well as how much of the cost will be shouldered by patients and their families.

The FDA approval, however, spurred momentum in the field, bringing attention to two new therapies—lecanemab and donanemab.

“These two up-and-coming medications are ‘cousins’ of aducanumab because all three drugs target amyloid plaques that form in the spaces between brain cells and are thought to play a central role in Alzheimer’s disease,” said Zaldy Tan, MD, MPH, medical director of the Jona Goldrich Center for Alzheimer’s and Memory Disorders in the Department of Neurology. “What we don’t know yet is whether these new drugs will cause fewer side effects, or whether they will be more effective than aducanumab.”

Will this new superpower molecule revolutionize science?

When scientists discovered DNA and learned how to control it, not only science but society was revolutionized. Today researchers and the medical industry routinely create artificial DNA structures for many purposes, including diagnosis and treatment of diseases.

Now an international research team reports to have created a powerful supermolecule with the potential to further revolutionize science.

The work is published in Nature Communications . Authors are from University of Southern Denmark (DK), Kent State University (USA), Copenhagen University (Denmark), Oxford University (UK) and ATDBio (UK). Lead authors are Chenguang Lou, associate professor, University of Southern Denmark and Hanbin Mao, professor, Kent State University, USA.

"It may allow us to make more advanced nanostructures, for example, for detecting diseases"

Chenguang Lou, associate professor

The researchers describe their supermolecule as a marriage between DNA and peptides.

DNA is one of the most important biomolecules, and so are peptides; peptide structures are used, among other things, to create artificial proteins and various nanostructures.

If you combine these two, as we have, you get a very powerful molecular tool, that may lead to the next generation of nanotechnology; it may allow us to make more advanced nanostructures, for example, for detecting diseases, says corresponding author Chenguang Lou, associate professor at Department of Physics, Chemistry and Pharmacy, University of Southern Denmark.

Scientists move a step closer to understanding the “cold spot” in the cosmic microwave background

Observations for the Dark Energy Survey were carried out, using the Blanco Telescope in the Andes mountains of Chile. Scientists used its data to create a map of dark matter in the region of sky that contains the Eridanus supervoid and CMB Cold Spot.
Photo: Reidar Hahn, Fermilab

After the Big Bang, the universe, glowing brightly, was opaque and so hot that atoms could not form. Eventually cooling down to about minus 454 degrees Fahrenheit (-270 degrees Celsius), much of the energy from the Big Bang took the form of light. This afterglow, known as the cosmic microwave background, can now be seen with telescopes at microwave frequencies invisible to human eyes. It has tiny fluctuations in temperature that provide information about the early universe.

Now scientists might have an explanation for the existence of an especially cold region in the afterglow, known as the CMB Cold Spot. Its origin has been a mystery so far but might be attributed to the largest absence of galaxies ever discovered.

Scientists used data collected by the Dark Energy Survey to confirm the existence of one of the largest supervoids known to humanity, the Eridanus supervoid, as reported in a paper published in December 2021. This once-hypothesized but now-confirmed void in the cosmic web might be a possible cause for the anomaly in the CMB.

High Levels of PFAS Found in Anti-Fogging Sprays and Cloths

The anti-fogging sprays and cloths many people use to prevent condensation on their eyeglasses when wearing a mask or face shield may contain high levels of per- and polyfluorinated alkyl substances (PFAS), a new Duke University-led study finds.

The researchers tested four top-rated anti-fogging sprays and five top-rated anti-fogging cloths sold on Amazon. They found all nine products contained fluorotelomer alcohols (FTOHs) and fluorotelomer ethoxylates (FTEOs), two types of PFAS that largely have flown under the scientific radar until now.

Exposure to some PFAS, particularly perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), is associated with impaired immune function, cancer, thyroid disease, and other health disorders. Mothers and young children may be especially vulnerable to the chemicals, which can affect reproductive and developmental health.

“Our tests show the sprays contain up to 20.7 milligrams of PFAS per milliliter of solution, which is a pretty high concentration,” said Nicholas Herkert, a postdoctoral researcher at Duke’s Nicholas School of the Environment, who led the study.

Because FTOHs and FTEOs have received relatively little study, scientists don’t yet know what health risks they might pose, Herkert noted, but research suggests that once FTOHs have been inhaled or absorbed through the skin, they could break down in the body to PFOA or other long-lived PFAS substances that are known to be toxic. Additionally, the FTEOs used in all four spray mixtures that were analyzed in the new study exhibited significant cell-altering cytotoxicity and adipogenic activity in lab tests, he said.

Research uncovers key system in E. coli that could lead to new antibiotics

In addition to using the structure as a platform to generate antibiotics,
researchers can also use it to design new sensors of molecules of interest,
says Dr. Luis Rogelio (Roger) Cruz-Vera.
Image Credit: Michael Mercier | UAH

Research led by the University of Alabama in Huntsville (UAH) has for the first time identified the precise genetic operational structure of a key system in Escherichia coli (E. coli) bacteria, opening the door to possible new antibiotics to treat the infections it causes.

“The gene that we studied is involved in producing a bacterial hormone that is important for bacterial colonization. This hormone induces the production of sticky substances used by bacteria to adhere to inert surfaces, as well as plants and animal tissues,” says Dr. Luis Rogelio (Roger) Cruz-Vera, an associate professor in the Department of Biological Sciences at UAH, a part of the University of Alabama System.

“Our new structure will be used in future studies to obtain compounds that can modulate the production of this hormone in bacteria, reducing bacterial colonization by altering the bacterial cell’s capacity for attachment to surfaces and reduce communication with other cells.”

Most infectious E. coli cases are mild and result in vomiting, diarrhea, cramps, and fatigue, but some strains can cause severe illness and even life-threatening complications.

In 2015, Dr. Cruz-Vera teamed with Dr. Emily Gordon and Dr. Arnab Sengupta, both of whom were doctoral students in UAH’s Biotechnology Science and Engineering program at the time, and whose work during their graduate tenure produced the genetic and biochemical assays used in the research paper the trio wrote with other collaborators. The research was funded by the National Science Foundation.

Study finds Rwandan genocide chemically modified the DNA of victims and victims’ offspring

USF Professor Derek Wildman and Clarisse Mussanabaganwa,
visiting scholar from the University of Rwanda,
conduct research at USF.

Scientists with the USF Genomics program and the Center for Global Health and Infectious Disease Research have taken a significant step in providing the people of Rwanda the scientific tools they need to help address mental health issues that stemmed from the 1994 genocide of the Tutsi ethnic group.

In a first-of-its-kind study, Professors Monica Uddin and Derek Wildman of the College of Public Health looked at the entire genomes of Tutsi women who were pregnant and living in Rwanda at the time of the genocide and their offspring and compared their DNA to other Tutsi women pregnant at the same time and their offspring, who were living in other parts of the world.

In the study published in Epigenomics, they found that the terror of genocide was associated with chemical modifications to the DNA of genocide-exposed women and their offspring. Many of these modifications occurred in genes previously implicated in risk for mental disorders such as PTSD and depression. These findings suggest that, unlike gene mutations, these chemical “epigenetic” modifications can have a rapid response to trauma across generations.

“Epigenetics refers to stable, but reversible, chemical modifications made to DNA that help to control a gene’s function,” Uddin said. “These can happen in a shorter time frame than is needed for changes to the underlying DNA sequence of genes. Our study found that prenatal genocide exposure was associated with an epigenetic pattern suggestive of reduced gene function in offspring.”

An overuse of road salt in the winter has potentially harmful effects for everything from wildlife to groundwater

The winter months can bring dicey travel conditions, but those can be made safer with shovels, plows, and deicers like road salts. For road salts, a little can go a long way in improving safety, but its use is not without consequences. Researchers from the College of Agriculture, Health and Natural Resources and the College of Liberal Arts and Sciences are working to better understand the numerous environmental impacts of using too much salt on roads and walkways.

Bigger Frogs, More Mosquitos

Department of Natural Resources and the Environment researcher Tracy Rittenhouse and her group are investigating the effects road salts on amphibians.

“Previous research showed that tadpoles tend to metamorph larger in size from salty wetlands and high salinity conditions,” Rittenhouse says. “Generally, we think larger size as a good thing but we’re not sure why they’re larger or how they might be different physiologically.”

Rittenhouse explains that frogs starting life in saltier conditions, though larger, don’t seem to have any advantages later in life, whereas frogs from lower salt conditions started life smaller but grew much faster and larger over time. These results show that not only are amphibians amazingly tolerant to salt, but that we have much to learn. Despite the quantities of salt entering wetland environments, this resilience is why we have not seen massive declines in amphibian populations, says Rittenhouse.

Another experiment completed by an undergraduate student in her lab group showed that juvenile frogs not only detect if soil is salty, they will consistently avoid those conditions.

“That project opened up this whole arena of what we really should be looking at is the juvenile and adult frogs and how they might be responding to salinity in the terrestrial environment,” she says.