Researchers develop a cobalt-free cathode for lithium-ion batteries

Working with researchers at four U.S. national laboratories, Huolin Xin, UCI professor of physics & astronomy, has found a way to fabricate lithium-ion batteries without using cobalt, a rare, costly mineral extracted under inhumane conditions in Central Africa.
Credit: Steve Zylius / UCI

Researchers at the University of California, Irvine and four national laboratories have devised a way to make lithium-ion battery cathodes without using cobalt, a mineral plagued by price volatility and geopolitical complications.

In a paper published today in Nature, the scientists describe how they overcame thermal and chemical-mechanical instabilities of cathodes composed substantially of nickel – a common substitute for cobalt – by mixing in several other metallic elements.

“Through a technique we refer to as ‘high-entropy doping,’ we were able to successfully fabricate a cobalt-free layered cathode with extremely high heat tolerance and stability over repeated charge and discharge cycles,” said corresponding author Huolin Xin, UCI professor of physics & astronomy. “This achievement resolves long-standing safety and stability concerns around high-nickel battery materials, paving the way for broad-based commercial applications.”

Cobalt is one of the most significant supply chain risks threatening widespread adoption of electric cars, trucks and other electronic devices requiring batteries, according to the paper’s authors. The mineral, which is chemically suited for the purpose of stabilizing lithium-ion battery cathodes, is mined almost exclusively in the Democratic Republic of Congo under abusive and inhumane conditions.

Astronomers Unveil New – and Puzzling – Features of Mysterious Fast Radio Bursts

Artist's conception of Five-hundred-meter Aperture Spherical radio Telescope (FAST) in China.
Credit: Jingchuan Yu

Fast radio bursts (FRBs) are millisecond-long cosmic explosions that each produce the energy equivalent to the sun’s annual output. More than 15 years after the deep-space pulses of electromagnetic radio waves were first discovered, their perplexing nature continues to surprise scientists – and newly published research only deepens the mystery surrounding them.

In the Sept. 21 issue of the journal Nature, unexpected new observations from a series of cosmic radio bursts by an international team of scientists – including UNLV astrophysicist Bing Zhang – challenge the prevailing understanding of the physical nature and central engine of FRBs.

The cosmic FRB observations were made in late spring 2021 using the massive Five-hundred-meter Aperture Spherical radio Telescope (FAST) in China. The team, led by Heng Xu, Kejia Lee, Subo Dong from Peking University, and Weiwei Zhu from the National Astronomical Observatories of China, along with Zhang, detected 1,863 bursts in 82 hours over 54 days from an active fast radio burst source called FRB 20201124A.

“This is the largest sample of FRB data with polarization information from one single source”, said Lee.

Smashing Heavy Nuclei Reveals Proton Size

A model assuming smaller protons & neutrons & a “lumpier” arrangement of these building blocks (left) fits experimental data on the initial energy density in heavy ion collisions better than a model w/ larger protons, neutrons & smoother structure (right)
Image credit: Brookhaven National Laboratory

The nuclei of atoms are made up of protons and neutrons, collectively referred to as nucleons. Nucleons in turn consist of quarks and gluons. Understanding how those inner building blocks are distributed within nuclei can reveal how large protons and neutrons appear when probed at high energy. This work used comparisons between model calculations and new precision data from collisions of heavy ions (containing many protons and neutrons) to access the distribution of gluons and predict the size of the proton.

Identifying and precisely measuring factors that are sensitive to nucleon size will help physicists more accurately describe the quark-gluon plasma (QGP). This is a hot, dense form of nuclear matter created when individual protons and neutrons “melt” in heavy ion collisions, mimicking the conditions of the early universe. This knowledge can eliminate significant uncertainties about the initial state of the produced QGP. Knowing more about the initial state of QGP provides input for the model calculations that scientists use to infer the viscosity and other properties of the QGP. The results also add to measurements of proton size based on the distribution of quarks inside the proton.

Shutting down backup genes leads to cancer remission in mice

Abhinav Achreja, PhD, Research Fellow at the University of Michigan Biomedical Engineering and Deepak Nagrath, Ph.D. Associate Professor of Biomedical Engineering works on ovarian cancer cell research in the bio-engineering lab at the North Campus Research Center (NCRC).
Image credit: Marcin Szczepanski, Michigan Engineering

The way that tumor cells enable their uncontrolled growth is also a weakness that can be harnessed to treat cancer, researchers at the University of Michigan and Indiana University have shown.

Their machine-learning algorithm can identify backup genes that only tumor cells are using so that drugs can target cancer precisely.

“Most cancer drugs affect normal tissues and cells. However, our strategy allows specific targeting of cancer cells.”

Deepak Nagrath

The team demonstrated this new precision medicine approach for treating ovarian cancer in mice. Moreover, the cellular behavior that exposes these vulnerabilities is common across most forms of cancer, meaning the algorithms could provide better treatment plans for a host of malignancies.

“This could revolutionize the precision medicine field because the drug targeting will only affect and kill cancer cells and spare the normal cells,” said Deepak Nagrath, a U-M associate professor of biomedical engineering and senior author of the study in Nature Metabolism. “Most cancer drugs affect normal tissues and cells. However, our strategy allows specific targeting of cancer cells.”

Ocean scientists measure sediment plume stirred up by deep-sea-mining vehicle

The Launch and Recovery System deploying the Patania II pre-prototype collector vehicle from the surface operations vessel MV Normand Energy.
Credit: Global Sea Mineral Resources

What will be the impact to the ocean if humans are to mine the deep sea? It’s a question that’s gaining urgency as interest in marine minerals has grown.

The ocean’s deep-sea bed is scattered with ancient, potato-sized rocks called “polymetallic nodules” that contain nickel and cobalt — minerals that are in high demand for the manufacturing of batteries, such as for powering electric vehicles and storing renewable energy, and in response to factors such as increasing urbanization. The deep ocean contains vast quantities of mineral-laden nodules, but the impact of mining the ocean floor is both unknown and highly contested.

Now MIT ocean scientists have shed some light on the topic, with a new study on the cloud of sediment that a collector vehicle would stir up as it picks up nodules from the seafloor.

The study, appearing today in Science Advances, reports the results of a 2021 research cruise to a region of the Pacific Ocean known as the Clarion Clipperton Zone (CCZ), where polymetallic nodules abound. There, researchers equipped a pre-prototype collector vehicle with instruments to monitor sediment plume disturbances as the vehicle maneuvered across the seafloor, 4,500 meters below the ocean’s surface. Through a sequence of carefully conceived maneuvers. the MIT scientists used the vehicle to monitor its own sediment cloud and measure its properties.

Their measurements showed that the vehicle created a dense plume of sediment in its wake, which spread under its own weight, in a phenomenon known in fluid dynamics as a “turbidity current.” As it gradually dispersed, the plume remained relatively low, staying within 2 meters of the seafloor, as opposed to immediately lofting higher into the water column as had been postulated.

A new understanding of the neurobiology of impulsivity News

Photo Credit: Vitolda Klein

While not all impulsive behavior speaks of mental illness, a wide range of mental health disorders which often emerge in adolescence, including depression and substance abuse, have been linked to impulsivity. So, finding a way to identify and treat those who may be particularly vulnerable to impulsivity early in life is especially important.

A group of researchers, led by scholars at McGill University, have developed a genetically based score which could help identify, with a high degree of accuracy (greater than that of any impulsivity scores currently in use), the young children who are most at risk of impulsive behavior.

Their findings are especially compelling because the score they have developed was able to detect those at a higher risk of impulsivity within three ethnically diverse community samples of children, from a cohort of close to 6,000 children.

This discovery of a novel score for impulsivity in early life can inform prevention strategies and programs for children and adolescents who are at risk for psychiatric disorders. In addition, by describing the function of the gene networks comprising the score, the study can stimulate the development of new therapies in the future.

“COVID Time” is a real thing, and it’s not good

Credit: xaviandrew

Have you ever noticed that time seems to slow down sometimes? Like when you are waiting in line at a bank or grocery checkout, and it just seems to take forever?

During the peak of the pandemic, and mid-lockdown, many people reported they felt their days dragged on, inducing fatigue and making some tasks almost unbearable during “COVID time.”

An interdisciplinary team of researchers studied this effect of the COVID-19 pandemic, called Blursday, to understand how our perception of time is malleable and influenced by many factors. Blursday was the altered sense of time and difficulty in determining the day of the week during the lockdown.

Dr. Fuat Balci, a UM biologist and part of the research team, notes: “A new lingo emerged during the COVID-19 pandemic to capture the altered psychological state under the extraordinary conditions imposed by the pandemic such as the lockdown and social isolation, including doomscrolling and Blursday.”

The researchers had volunteers answer a questionnaire and perform 15 behavioral tasks, such as estimating how long they had been logged on to the study’s website. They were also asked to guess if a stated time interval was shorter or longer than they experienced to test how the pandemic affected temporal awareness.

Sifting through cellular recycling centers

A cartoon representation of the new method, which allows scientists to isolate the lysosomes (left) of any cell in a mouse to analyze and identify using mass spectrometry (right) all the molecules inside them.
Image credit: Cindy Lin

A new method allows scientists to determine all the molecules present in the lysosomes – the cell’s recycling centers – of mice. This could bring new understanding and treatment of neurodegenerative disorders.

Small but mighty, lysosomes play a surprisingly important role in cells despite their diminutive size. Making up only 1-3% of the cell by volume, these small sacs are the cell’s recycling centers, home to enzymes that break down unneeded molecules into small pieces that can then be reassembled to form new ones. Lysosomal dysfunction can lead to a variety of neurodegenerative or other diseases, but without ways to better study the inner contents of lysosomes, the exact molecules involved in diseases – and therefore new drugs to target them – remain elusive.

A new method, reported in Nature on Sept. 21, allows scientists to determine all the molecules present in the lysosomes of any cell in mice. Studying the contents of these molecular recycling centers could help researchers learn how the improper degradation of cellular materials leads to certain diseases. Led by Stanford University’s Monther Abu-Remaileh, institute scholar at Sarafan ChEM-H, the study’s team also learned more about the cause for a currently untreatable neurodegenerative disease known as Batten disease, information that could lead to new therapies.

Newly Discovered Barrier Prevents Immunity from Reaching Smell-Sensing Cells

Circulating antibody (white) is prevented from accessing olfactory epithelium (green) by a previously unknown blood-olfactory barrier, the BOB.
Credit: Ashley Moseman Lab, Duke University

Duke scientists have identified a previously unknown barrier that separates the bloodstream from smelling cells in the upper airway of mice, likely as a way to protect the brain.

But this barrier also ends up keeping some of the larger molecules of the body’s immune system out, and that may be hindering the effectiveness of vaccines.

It makes sense to have a protective barrier for the olfactory cells lining the nose, because they offer a direct path to the olfactory bulb of the brain, making them effectively extensions of the brain itself, said lead researcher Ashley Moseman, an assistant professor of immunology in the Duke School of Medicine.

However, the new barrier, which his team has dubbed the BOB – the blood-olfactory barrier -- also might be keeping vaccines against respiratory viruses from being more effective by preventing those antibodies from reaching the mucous on the surface of the nose, the first barrier a virus encounters.

The team was trying to understand better how the immune system protects the upper respiratory tract by infecting mice with a virus called vesicular stomatitis virus, or VSV, that is known to penetrate to the central nervous system. Once inhaled, VSV readily infects the olfactory sensing cells and rapidly replicates, reaching the olfactory bulb of the brain within a day. Although it can lead to paralysis and death, it is usually cleared by a T cell response.

Study finds high levels of PFAS in school uniforms

In yet another example of the prevalence of the hazardous chemicals known as PFAS (per- and polyfluoroalkyl substances) in consumer products, industrial products and textiles, researchers have found notably high levels in school uniforms sold in North America.

In a study published in Environmental Science and Technology Letters, scientists at the University of Notre Dame, Indiana University, the University of Toronto and the Green Science Policy Institute analyzed a variety of children’s textiles. Fluorine was detected in 65 percent of samples tested.

But concentrations were highest in school uniforms — and higher in those uniforms labeled as 100 percent cotton as opposed to synthetics.

“What was surprising about this group of samples was the high detection frequency of PFAS in the garments required for children to wear,” said Graham Peaslee, professor of physics at Notre Dame and a co-author of the study. “Children are a vulnerable population when it comes to chemicals of concern, and nobody knows these textiles are being treated with PFAS and other toxic chemicals.”

An estimated 20 percent of public schools in the United States require students to wear uniforms —meaning millions of children could be at risk of exposure to the toxic compounds.

Known as “forever chemicals,” PFAS are known to accumulate in the bloodstream and have been linked to an increased risk of several health problems including weakened immune systems, asthma, obesity, and neurodevelopmental and behavioral problems. The National Health and Nutrition Examination Surveys from the Centers for Disease Control and Prevention routinely find PFAS in blood samples of children between the ages of 3 and 11.