New study reveals high rates of iron deficiency in women during late-stage pregnancy

Photo Credit: Juan Encalada

Pregnant women may need to take more supplemental iron than current Health Canada guidelines recommend, after two UBC researchers found high rates of iron deficiency in a recent study.

The research investigated iron deficiency prevalence among 60 pregnant women in Metro Vancouver and found that over 80 per cent of them were likely iron-deficient in late pregnancy despite taking daily prenatal supplements that provided 100 per cent of the daily iron recommendation in pregnancy.

“This was much higher than I expected to see, which worries us because a woman who is iron-deficient in pregnancy is at higher risk for having an infant with iron deficiency,” said faculty of land and food systems professor Dr. Crystal Karakochuk (she/her), the study’s principal investigator.

Iron is an important nutrient during pregnancy and infancy as it supports optimal growth and development for the fetus and, eventually, the baby.

Kelsey Cochrane (she/her), a PhD candidate in the faculty of land and food systems and the study’s first author, explains that, for the first six months of their lives, babies rely on iron stores they built throughout gestation.

Limiting Global Warming Now Can Preserve Valuable Freshwater Resource

Spring snowmelt in the Ansel Adams Wilderness of the California Sierra Nevada. New research identifies how climate change could differentially alter spring snowmelt in iconic mountain landscapes of the American Cordillera.
Photo Credit: Alan Rhoades

Snowcapped mountains not only look majestic – They’re vital to a delicate ecosystem that has existed for tens of thousands of years. Mountain water runoff and snowmelt flows down to streams, rivers, lakes, and oceans – and today, around a quarter of the world depends on these natural “water towers” to replenish downstream reservoirs and groundwater aquifers for urban water supplies, agricultural irrigation, and ecosystem support.

But this valuable freshwater resource is in danger of disappearing. The planet is now around 1.1 degrees Celsius (1.9 degrees Fahrenheit) warmer than pre-industrial levels, and mountain snowpacks are shrinking. Last year, a study co-led by Alan Rhoades and Erica Siirila-Woodburn, research scientists in the Earth and Environmental Sciences Area of Lawrence Berkeley National Laboratory (Berkeley Lab), found that if global warming continues along the high-emissions scenario, low-to-no-snow winters will become a regular occurrence in the mountain ranges of the western U.S. in 35 to 60 years.

Now, in a recent Nature Climate Change study, a research team led by Alan Rhoades found that if global warming reaches around 2.5 degrees Celsius compared to pre-industrial levels, mountain ranges in the southern midlatitudes, the Andean region of Chile in particular, will face a low-to-no-snow future between the years 2046 and 2051 – or 20 years earlier than mountain ranges in the northern midlatitudes such as the Sierra Nevada or Rockies. (Low-to-no-snow occurs when the annual maximum water stored as snowpack is within the bottom 30% of historical conditions for a decade or more.)

Can a new technique for capturing ‘hot’ electrons make solar cells more efficient?

A scanning tunnelling microscope is used to study the dynamics of hot electrons through single molecule manipulation.
Photo Credit: Adrian Hooper

A new way of extracting quantitative information from state-of-the-art single molecule experiments has been developed by physicists at the University of Bath. Using this quantitative information, the researchers will be able to probe the ultra-fast physics of ‘hot’ electrons on surfaces – the same physics that governs and limits the efficacy of silicon-based solar cells.

Solar cells work by converting light into electrons, whose energy can be collected and harvested. A hot solar cell is a novel type of cell that converts sunlight to electricity more efficiently than conventional solar cells. However, the efficiency of this process is limited by the creation of energetic, or ‘hot’, electrons that are extremely short lived and lose most of their energy to their surrounding within the first few femtoseconds of their creation (1 femtosecond equals 1/1,000,000,000,000,000 of a second).

The ultra-short lifetime of hot electrons and the corresponding short distance they can travel mean probing and influencing the properties of hot electrons is experimentally challenging. To date, there have been a few techniques capable of circumventing these challenges, but none has proven capable of spatial resolution – meaning, they can’t tell us about the crucial connection between a material’s atomic structure and the dynamics of hot electrons within that material.

New process developed to extract high purity rare earth element oxides

Pennsylvania stream impacted by acid mine drainage.
Photo Credit: Pennsylvania State University

Critical minerals, including rare earth elements, are used to power devices like smartphones and computers and are essential to our nation’s economy and national security. Penn State’s Center for Critical Minerals has developed a new purification process that extracts mixed rare earth oxides from acid mine drainage and associated sludges at purities of 88.5%

Critical minerals (CMs), including the 17 rare earth elements (REEs), are used in many common household products like smartphones and computers, and in many commercial products such as electric vehicles, batteries and solar panels. Demand for them has skyrocketed, and they are classified as critical because they have high economic importance, high supply risk, and their absence would have significant consequences on the economic and national security of the United States.

Acid mine drainage (AMD) and associated solids and precipitates resulting from AMD treatment have been found to be viable sources of multiple CMs, including REEs, aluminum, cobalt and manganese.

The U.S. Department of Energy (DOE) has funded efforts to demonstrate both the technical feasibility and economic viability of extracting, separating and recovering REEs and CMs from U.S. coal and coal by-product sources, with the goal of achieving mixed rare earth oxides from coal-based resources with minimum purities of 75%.

Flocks of assembler robots show potential for making larger structures

Researchers at MIT have made significant steps toward creating robots that could practically and economically assemble nearly anything, including things much larger than themselves, from vehicles to buildings to larger robots. The new system involves large, usable structures built from an array of tiny identical subunits called voxels (the volumetric equivalent of a 2-D pixel).
Photo Credit: Massachusetts Institute of Technology | Courtesy of the researchers

Researchers at MIT have made significant steps toward creating robots that could practically and economically assemble nearly anything, including things much larger than themselves, from vehicles to buildings to larger robots.

The new work, from MIT’s Center for Bits and Atoms (CBA), builds on years of research, including recent studies demonstrating that objects such as a deformable airplane wing and a functional racing car could be assembled from tiny identical lightweight pieces — and that robotic devices could be built to carry out some of this assembly work. Now, the team has shown that both the assembler bots and the components of the structure being built can all be made of the same subunits, and the robots can move independently in large numbers to accomplish large-scale assemblies quickly.

The new work is reported in the journal Nature Communications Engineering, in a paper by CBA doctoral student Amira Abdel-Rahman, Professor and CBA Director Neil Gershenfeld, and three others.

A fully autonomous self-replicating robot assembly system capable of both assembling larger structures, including larger robots, and planning the best construction sequence is still years away, Gershenfeld says. But the new work makes important strides toward that goal, including working out the complex tasks of when to build more robots and how big to make them, as well as how to organize swarms of bots of different sizes to build a structure efficiently without crashing into each other.

A Solution for Reclaiming Valuable Resources Flushed Down the Drain

A problem at sewage treatment plants - the buildup of 'brown grease' - could yield a bounty of biofuel, thanks to the work of UConn researchers
Photo Credit: kubinger

For the everyday products we use, a pattern has become numbingly familiar: Something is made, we use it, we throw it away. Yet, for a sustainable future – one where we don’t simply extract and toss resources – we need to make this linear process circular, says UConn Department of Chemical and Biomolecular Engineering Emeritus Professor Richard Parnas.

Parnas and his team research biodiesel and how to make it out of waste resources. Parnas also co-founded REA Resource Recovery Systems, which supported UConn Chemical Engineering graduate student Cong Liu Ph.D. ‘22 to develop technology to improve a critical process of removing sulfur from biodiesel made from waste materials. In this case, the materials originate from sewage, and the technology is being implemented in a project at Danbury’s John Oliver Memorial Sewer Plant scheduled to go into operation in January 2023 that will convert fats, oils, and grease into biodiesel whose lifecycle emissions are more than 74% lower than petroleum-based diesel.

Earth might be experiencing 7th mass extinction, not 6th

Diorama depicting Ediacaran-era sea creatures.
Photo Credit: Smithsonian Institution

Earth is currently in the midst of a mass extinction, losing thousands of species each year. New research suggests environmental changes caused the first such event in history, which occurred millions of years earlier than scientists previously realized.

Most dinosaurs famously disappeared 66 million years ago at the end of the Cretaceous period. Prior to that, a majority of Earth’s creatures were snuffed out between the Permian and Triassic periods, roughly 252 million years ago.

Thanks to the efforts of researchers at UC Riverside and Virginia Tech, it’s now known that a similar extinction occurred 550 million years ago, during the Ediacaran period. This discovery is documented in a Proceedings of the National Academy of Sciences paper.

Although unclear whether this represents a true “mass extinction,” the percentage of organisms lost is similar to these other events, including the current, ongoing one.

Researchers believe environmental changes are to blame for the loss of approximately 80% of all Ediacaran creatures, which were the first complex, multicellular life forms on the planet.

Covid-19: the Spike protein is no longer the only target

Possible mechanism of action of a drug targeting Nsp1 of SARS-CoV-2. In infected cells, Nsp1 blocks the ribosome mRNA canal by acting as a "cap" that prevents the expression of the host's mRNA. Linking a ligand to the proposed cryptic pocket highlighted in purple could prevent blockage mediated by Nsp1 and, ultimately, restore the ability of the ribosome to initiate the translation of the mRNA.
Photo Credit: UNIGE Alberto Borsatto

A research team led by the UNIGE reveals a hidden cavity on a key SARS-CoV-2 protein to which drugs could bind.

With the continuous emergence of new variants and the risk of new strains of the virus, the development of innovative therapies against SARS-CoV-2 remains a major public health challenge. Currently, the proteins that are on the surface of the virus and/or are involved in its replication are the preferred therapeutic targets, like the Spike protein targeted by vaccines. One of them, the non-structural protein Nsp1, had been studied little until now. A team from the University of Geneva (UNIGE), in collaboration with University College London (UCL) and the University of Barcelona, has now revealed the existence of a hidden ''pocket’ on its surface. A potential drug target, this cavity opens the way to the development of new treatments against Covid-19 and other coronaviruses. These results can be found in the journal eLife.

Immune cells in ALS patients can predict the course of the disease

Solmaz Yazdani, PhD student at KI.
Photo Credit: Filip Mestanov

ALS is a disease in which nerve cells in the brain, brain stem and spinal cord die. 

By measuring immune cells in the spinal cord fluid when diagnosing ALS, it is possible to predict how the course of the disease will go, according to a study from the Karolinska Institutet published in Nature Communications.

The study shows that a high proportion of so-called effector T cells are associated with a low survival rate. At the same time, the study shows that a high proportion of activated regulatory T cells are protective against the disease. The findings provide new evidence of T-cell involvement in the course of the disease and show that certain types of effector T cells accumulate in the spinal cord fluid in ALS patients.

Genes and Languages

Schematic illustration of possible scenarios of matches and mismatches in the transmission of genes and languages. Genetic (demographic) history is represented by a broad branching tree. Linguistic history is represented by colored lines, differentiating five language families (a-e).
Illustration Credit Barbieri et al., PNAS

More than 7,000 languages are spoken in the world. This linguistic diversity is passed on from one generation to the next, similarly to biological traits. But have language and genes evolved in parallel over the past few thousand years, as Charles Darwin originally thought? An interdisciplinary team at the University of Zurich together with the Max Planck Institute for Evolutionary Anthropology in Leipzig (Germany) has now examined this question at a global level. The researchers put together a global database linking linguistic and genetic data entitled GeLaTo (Genes and Languages Together), which contains genetic information from some 4,000 individuals speaking 295 languages and representing 397 genetic populations.

One in five gene-language links point to language shifts

In their study, the researchers examined the extent to which the linguistic and genetic histories of populations coincided. People who speak related languages tend to also be genetically related, but this isn’t always the case. “We focused on cases where the biological and linguistic patterns differed and investigated how often and where these mismatches occur,” says Chiara Barbieri, UZH geneticist who led the study and initiated it together with colleagues when she was a postdoc at the Max-Planck-Institute.