Fewer moths, more flies

Insects such as the bumblebee hoverfly Volucella bombylans appear much less frequently than before.
Photo Credit: Carolien van Oijen

The complex relationships between plants and their pollinators have changed dramatically across the last century

In the far north of the planet, climate change is clearly noticeable. A new study in Finland now shows that in parallel there have been dramatic changes in pollinating insects. Researchers from the Martin Luther University Halle-Wittenberg (MLU), the Helmholtz Centre for Environmental Research (UFZ), and the German Centre for Integrative Biodiversity Research Halle-Jena-Leipzig (iDiv) have discovered that the network of plants and their pollinators there has changed considerably since the end of the 19th century. As the scientists warn in an article published in Nature Ecology & Evolution, this could lead to plants being pollinated less effectively. This, in turn, would adversely affect their reproduction.

Their service is invaluable. The army of insects and other animals that pollinates the numerous plants of this earth has an essential function. Without these flower visitors, numerous wild plants could reproduce only poorly - or not at all. Ecosystems would thus no longer be able to function in their current form. More than three quarters of the most important crops depend on pollinators in order to be able to produce a high yield and good quality. A loss of pollinators would therefore also lead to economic losses amounting to billions.

Self-assembling proteins can store cellular “memories”

MIT engineers have devised a way to induce cells to inscribe the history of cellular events in a long protein structure that can be imaged using a light microscope.
Credit: Courtesy of the researchers

As cells perform their everyday functions, they turn on a variety of genes and cellular pathways. MIT engineers have now coaxed cells to inscribe the history of these events in a long protein chain that can be imaged using a light microscope.

Cells programmed to produce these chains continuously add building blocks that encode particular cellular events. Later, the ordered protein chains can be labeled with fluorescent molecules and read under a microscope, allowing researchers to reconstruct the timing of the events.

This technique could help shed light on the steps that underlie processes such as memory formation, response to drug treatment, and gene expression.

“There are a lot of changes that happen at organ or body scale, over hours to weeks, which cannot be tracked over time,” says Edward Boyden, the Y. Eva Tan Professor in Neurotechnology, a professor of biological engineering and brain and cognitive sciences at MIT, a Howard Hughes Medical Institute investigator, and a member of MIT’s McGovern Institute for Brain Research and Koch Institute for Integrative Cancer Research.

Good and bad feelings for brain stem serotonin

An illustration of the facial expression changes in mice following stimulation and inhibition of the median raphe nucleus
Image Credit: Yu Ohmura

New insights into the opposing actions of serotonin-producing nerve fibers in mice could lead to drugs for treating addictions and major depression.

Scientists in Japan have identified a nerve pathway involved in the processing of rewarding and distressing stimuli and situations in mice.

The new pathway, originating in a bundle of brain stem nerve fibers called the median raphe nucleus, acts in opposition to a previously identified reward/aversion pathway that originates in the nearby dorsal raphe nucleus. The findings, published by scientists at Hokkaido University and Kyoto University with their colleagues in the journal Nature Communications, could have implications for developing drug treatments for various mental disorders, including addictions and major depression.

Previous studies had already revealed that activating serotonin-producing nerve fibers from the dorsal raphe nucleus in the brain stem of mice leads to the pleasurable feeling associated with reward. However, selective serotonin reuptake inhibitors (SSRIs), antidepressant drugs that increase serotonin levels in the brain, fail to exert clear feelings of reward and to treat the loss of ability to feel pleasure associated with depression. This suggests that there are other serotonin-producing nerve pathways in the brain associated with the feelings of reward and aversion.

A glimpse of a cell’s sense of touch

Confocal image of the presomitic mesoderm of a zebrafish embryo. N-cadherin adhesion molecules are shown (they appear black because the image is inverted). This shows the cell borders.
Image Credit: Campàs Lab

A research team at the Cluster of Excellence Physics of Life of TU Dresden and the University of California, Santa Barbara, reveals how cells sense their mechanical environment as they build tissues during embryogenesis.

Building tissues and organs is one of the most complex and essential tasks that cells must accomplish during embryogenesis. In this collective task, cells communicate through a variety of communication methods, including biochemical signals - similar to a cell's sense of smell - and mechanical cues - the cell's sense of touch. Researchers in a variety of disciplines have been fascinated by cell communication for decades. Professor Otger Campàs together with his colleagues from the Physics of Life (PoL) Cluster of Excellence at Technische Universität Dresden and from the University of California Santa Barbara (UCSB) have now been able to unravel another mystery surrounding the question of how cells use their sense of touch to make vital decisions during embryogenesis. Their paper has now been published in the journal Nature Materials.

Russian Scientists Learned to Create Analogues of Space Ice

Astronomers from Ural Federal University have grown ice in a vacuum installation.
Photo Credit: Aldebaran S

Employees of the Ural Federal University's Youth Research Laboratory of Astrochemical Research grew the first samples of interstellar ice analogs and for the first time obtained test infrared spectra of these ices (the quality of the spectra is not inferior to those obtained in foreign laboratories). Obtaining analogues of interstellar ice in the laboratories is important because it will help to analyze data from telescopes, in particular James Webb (JWST), and to determine the chemical composition of interstellar ice and its structure in space.

"Until a year ago, experiments to obtain spectra of interstellar ice analogs were conducted only abroad. Now we can conduct them in Russia as well. The quality of the obtained spectra is not inferior to those obtained in foreign laboratories. It is also important to note that one of the key elements of our experimental setup, the turbomolecular pump, is made in Russia," Anton Vasyunin, Head of the Scientific Laboratory for Astrochemical Research at UrFU, commented on the results.

Interstellar ice forms in the cold formation regions of stars and planets from atoms and molecules that freeze at low temperatures from gas on the surface of microscopic cosmic dust particles. Studies of interstellar ice are necessary to understand the chemical evolution of the galaxy and to find answers to fundamental questions, in particular about the origin of life in the universe.

Network neuroscience theory best predictor of intelligence

U. of I. Professor Aron Barbey, pictured, and co-author Evan Anderson found that taking into account the features of the whole brain – rather than focusing on individual regions or networks – allows the most accurate predictions of intelligence.     
Photo Credit: Fred Zwicky

Scientists have labored for decades to understand how brain structure and functional connectivity drive intelligence. Researchers report a new analysis offers the clearest picture yet of how various brain regions and neural networks contribute to a person’s problem-solving ability in a variety of contexts, a trait known as general intelligence, researchers report.

They detail their findings in the journal Human Brain Mapping.

The study used “connectome-based predictive modeling” to compare five theories about how the brain gives rise to intelligence, said Aron Barbey, a professor of psychology, bioengineering and neuroscience at the University of Illinois Urbana-Champaign who led the new work with first author Evan Anderson, now a researcher for Ball Aerospace and Technologies Corp. working at the Air Force Research Laboratory.

“To understand the remarkable cognitive abilities that underlie intelligence, neuroscientists look to their biological foundations in the brain,” Barbey said. “Modern theories attempt to explain how our capacity for problem-solving is enabled by the brain’s information-processing architecture.”

Antimalarial Drug Proves Ineffective at Saving Children’s Lives

A drug used for the initial treatment of malaria failed to improve child survival in real world circumstances.
Photo Credit: Matthis Kleeb, Swiss TPH

Rectal artesunate, a promising antimalarial drug, has no beneficial effect on the survival of young children with severe malaria when used as an emergency treatment in resource-constrained settings. These are the results of a large-scale study conducted by the Swiss Tropical and Public Health Institute and local partners in three African countries.

Rectal artesunate (RAS) proves ineffective at saving the lives of young children suffering from severe malaria, according to the results of a new study. A viewpoint about these findings was published in The Lancet Infectious Diseases.

The study, which investigated a large-scale roll-out of RAS in the Democratic Republic of the Congo, Nigeria and Uganda, found that when used as an emergency treatment under real-world conditions, RAS did not improve the odds of survival for young children with severe malaria.

Diving birds are more prone to extinction, says new study

Diving birds like puffins are highly adapted for their environment, but that means they can't adapt so well to changing conditions.
Photo Credit: Michael Blum

Diving birds like penguins, puffins and cormorants may be more prone to extinction than non-diving birds, according to a new study by the Milner Centre for Evolution at the University of Bath. The authors suggest this is because they are highly specialized and therefore less able to adapt to changing environments than other birds.

The ability to dive is quite rare in birds, with less than a third of the 727 species of water bird using this way of hunting for food.

Evolutionary scientists Joshua Tyler and Dr Jane Younger studied of the evolution of diving in modern waterbirds to investigate how diving impacted: the physical characteristics of the birds (morphology); how the species evolved to increase diversity (rate of speciation); and how prone the species were to extinction.

The study, published in Proceedings of the Royal Society B, found that diving evolved independently 14 times, and that once a group had evolved the ability to dive, subsequent evolution didn’t reverse this trait.

The researchers found that body size amongst the diving birds had evolved differently depending on the type of diving they did.

More stable states for quantum computers

The properties of gralmonium qubits are dominated by a tiny constriction of only 20 nanometers, which acts like a magnifying glass for microscopic material defects.
Illustration Credit: Dennis Rieger, KIT

Quantum computers are considered the computers of the future. A and O are quantum bits (qubits), the smallest computing unit of quantum computers. Since they not only have two states, but also states in between, qubits process more information in less time. Maintaining such a condition longer is difficult, however, and depends in particular on the material properties. A KIT research team has now produced qubits that are 100 times more sensitive to material defects - a crucial step to eradicate them. The team published the results in the journal Nature Materials.

Quantum computers can process large amounts of data faster because they perform many calculation steps in parallel. The information carrier of the quantum computer is the qubit. With qubits there is not only the information "0" and "1", but also values in between. The difficulty at the moment, however, is to produce qubits that are small enough and can be switched quickly enough to perform quantum calculations. Superconducting circuits are a promising option here. Superconductors are materials that have no electrical resistance at extremely low temperatures and therefore conduct electrical current without loss. This is crucial to maintain the quantum state of the qubits and to connect them efficiently.

Technique for tracking resistant cancer cells could lead to new treatments for relapsing breast cancer patients

Breast cancer cells
Image Credit: Anne Weston - Francis Crick Institute (CC BY-NC 4.0)

Tumors are complex entities made up of many types of cells, including cancer cells and normal cells. But even within a single tumor there are a diverse range of cancer cells – and this is one reason why standard therapies fail.

When a tumor is treated with anti-cancer drugs, cancer cells that are susceptible to the drug die, the tumor shrinks and the therapy appears to be successful. But in reality, a small number of cancer cells in the tumor may be able to survive the treatment and regrow, often more persistently, causing a relapse.

In a study published in eLife, scientists from Professor Greg Hannon’s IMAXT lab at the Cancer Research UK Cambridge Institute at the University of Cambridge have developed a new technique for identifying the different types of cells in a tumor. Their method – developed in mouse tumors – allows them to track the cells during treatment, seeing which types of cells die and which survive.

The IMAXT team was previously awarded £20 million by Cancer Grand Challenges, funded by Cancer Research UK.