Excavation of massive underground caverns for DUNE halfway complete

When complete later this year, this cavern will be around 500 feet long, 65 feet wide and 90 feet high. It will be one of three caverns that will provide space to house particle detector modules and other equipment for the Deep Underground Neutrino Experiment.
Photo Credit: David Smith, Fermilab

Deep below the surface in South Dakota, construction crews have been working tirelessly to carve out a network of caverns and tunnels that one day will house a huge neutrino experiment. Their efforts are paying off: With almost 400,000 tons of rock extracted from the earth, the excavation is now half complete.

Once finished, the Long-Baseline Neutrino Facility will be the site of the international Deep Underground Neutrino Experiment. DUNE will focus on studying neutrinos, elusive particles that may hold the answers to many of the universe’s mysteries, such as why our universe is made of matter and how black holes and neutron stars are born. More than 1,000 scientists and engineers from over 30 countries are a part of LBNF/DUNE.

LBNF will provide the space, infrastructure and particle beam for DUNE, hosted by the U.S. Department of Energy’s Fermi National Accelerator Laboratory. It includes underground caverns for a near detector at Fermilab, about 40 miles west of Chicago, and a far detector located 800 miles away at the Sanford Underground Research Facility in South Dakota.

Increased atmospheric dust is masking greenhouse gases’ warming effect

A visualization from space of the “Godzilla” dust storm on June 18, 2020, when desert dust traveled from the Sahara to North America. A UCLA study finds that an increase in microscopic dust in the atmosphere has concealed the full extent of greenhouse gases’ potential for warming the planet.
Image Credit: NASA Scientific Visualization Studio  

A new study shows that global atmospheric dust — microscopic airborne particles from desert dust storms — has a slight overall cooling effect on the planet that has hidden the full amount of warming caused by greenhouse gases.

The UCLA research, published today in Nature Reviews Earth and Environment, found that the amount of desert dust has grown roughly 55% since the mid-1800s, which increased the dust’s cooling effect.

This study is the first to demonstrate the overall cooling effect of atmospheric desert dust. Some effects of atmospheric dust warm the planet, but because other effects of dust actually counteract warming — for example by scattering sunlight back into space and dissipating high clouds that warm the planet — the study calculated that dust’s overall effect is a cooling one.

Should dust levels decline — or even simply stop growing — warming could ramp up, said UCLA atmospheric physicist Jasper Kok, the study’s lead author.

Climate Change Likely to Uproot More Amazon Trees

Members of NGEE-Tropics visit what they named “Blowdown Gardens,” an area that experienced windthrow near one of their field sites in the Amazon. Researchers have found a relationship between atmospheric conditions and large areas of tree death.
Photo Credit: Charlie Koven/Berkeley Lab

Tropical forests are crucial for sucking up carbon dioxide from the atmosphere. But they’re also subject to intense storms that can cause “windthrow” – the uprooting or breaking of trees. These downed trees decompose, potentially turning a forest from a carbon sink into a carbon source.

A new study finds that more extreme thunderstorms from climate change will likely cause a greater number of large windthrow events in the Amazon rainforest. This is one of the few ways that researchers have developed a link between storm conditions in the atmosphere and forest mortality on land, helping fill a major gap in models.

“Building this link between atmospheric dynamics and damage at the surface is very important across the board,” said Jeff Chambers, a senior faculty scientist at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), and director of the Next Generation Ecosystem Experiments (NGEE)-Tropics project, which performed the research. “It’s not just for the tropics. It’s high-latitude, low-latitude, temperate-latitude, here in the U.S.”

Chemists Created a Substance with Potential Antitumor Activity

The new antitumor substance was synthesized at Ural Federal University's Scientific-educational and Innovation Center of Chemical and Pharmaceutical Technologies.
Photo Credit: Rodion Narudinov

New compound could be the basis of a drug for tumor cells

Chemists from the Ural Federal University and Volgograd State Medical University have created a compound that suppresses cancer cells. The powerful new substance could become the basis for antitumor drugs because it affects the pathology that leads to the development of malignant tumors, such as cancer of the breast, lung, prostate, and lymph nodes. The substance and the results of the experiments were published in the journal Molecules.

"Type 2 casein kinase (CK2) is known to suppress apoptosis in cells, but increased levels of type 2 casein kinase are observed in tumor cells, indicating that these cells are resistant to apoptosis compared to normal cells. If you block this protein, you can achieve tumor cell death. So, our team managed to develop a universal approach to the synthesis of new azolopyrimidines and obtain a library of corresponding heterocycles as potential inhibitors of casein kinase type 2," explains Grigory Urakov, an Engineer of the Scientific Laboratory of Medical Chemistry and Advanced Organic Materials at UrFU.

Chloroplast from the father

Tobacco seedlings on growth medium with an antibiotic. Plants with exclusively maternally inherited chloroplasts sensitive to the antibiotic are pale. Two seedlings contain green, intact chloroplasts in the leaves (red arrows). These chloroplasts are resistant to the antibiotic and were passed on from the father plant.
Image Credit: MPI-MP

Under cold conditions, not only the mother plant but also the father plant can pass on its chloroplasts to the offspring

Scientists at the Max Planck Institute of Molecular Plant Physiology in Potsdam (Germany) analyzed for the first time the inheritance of chloroplasts under a wide range of environmental conditions. Contrary to the prevailing view that chloroplasts are only passed on by the mother plant, paternal chloroplasts can also be transmitted to the offspring under cold conditions. Maternal and paternal chloroplasts thus meet in the offspring and may be able to exchange genetic material with each other. The new findings may allow plant breeders for the first time to selectively use traits from the genetic material of chloroplasts.

A story of flowers and bees is the classic introduction to a topic that is still discussed far too scarcely in our society: sex in plants! When plants reproduce, the sperms within the pollen grains fuse with the egg cell within the flower the pollen has landed on. In this way, the genetic material of the cell nuclei of both parents is combined in the seed. This is important, as it allows harmful mutations to be purged that otherwise would accumulate in the genetic material over generations.

Speeding up sugar's conversion into fuel

The research has accelerated the production rate and yield of isobutanol from sugar.
Photo Credit: Bishnu Sarangi

University of Queensland researchers have found a way to more efficiently convert sugarcane into a building block of aviation fuel and other products.

By zeroing in on a specific enzyme, a UQ team working in collaboration with the Technical University of Munich (TUM) has sped up the slowest step in processing sugar into a chemical called isobutanol.

Professor Gary Schenk from UQ’s School of Chemistry and Molecular Biosciences said isobutanol from a renewable resource could be used to make fuels, plastics, rubbers and food additives.

“Our research into this particular enzyme means we can accelerate the production rate and yield of isobutanol from sugarcane, ultimately enabling biomanufacturers to make diverse products at scale sustainably and efficiently,” Professor Schenk said.

“Usually during a biomanufacturing process, cells such as yeasts are used as a production platform, but in our research only a small number of a sugar acid-specific dehydratase enzyme was used.

Early humans: Annual cycles in tooth enamel provide insights into life histories

Jülide Kubat and Wolfgang Müller load the LA-ICPMS with a thin section of tooth for analysis.
Photo Credit: Jülide Kubat

An interdisciplinary team of scientists, led by Goethe University Frankfurt and the Senckenberg Research Institute and Natural History Museum Frankfurt, has discovered – by analyzing their teeth – what our ancestors of the species Homo erectus ate hundreds of thousands of years ago on the island of Java in Southeast Asia: over the course of a year, these early humans switched from a plant-based diet to a mixed one, but were far less dependent on seasonal food supply than, for example, orangutans, which also inhabited the island.

If you take a magnifying glass and a torch and look at your teeth very carefully in the mirror, in places you can spot a pattern of fine, parallel lines running across your teeth. These correspond to the striae of Retzius that mark the growth of our tooth enamel. Enamel starts forming in the womb and continues to mineralize until adolescence, when the last milk teeth fall out and are replaced by permanent ones. Like in all land-dwelling vertebrates, tooth enamel mineralizes gradually in microscopically thin layers in humans too, represented by the striae of Retzius. The speed with which a human develops can be read from these Retzius lines. Physiological changes, such as birth, weaning or illness, for example, leave distinctive traces. The striae of Retzius also form the chronological framework for the chemical composition of tooth enamel, which in turn reflects changes in the diet of that individual.

Highly accurate test for common respiratory viruses uses DNA as ‘bait’

Doctor examining a patient
Photo Credit: Thirdman

The test uses DNA ‘nanobait’ to detect the most common respiratory viruses – including influenza, rhinovirus, RSV and COVID-19 – at the same time. In comparison, PCR (polymerase chain reaction) tests, while highly specific and highly accurate, can only test for a single virus at a time and take several hours to return a result.

While many common respiratory viruses have similar symptoms, they require different treatments. By testing for multiple viruses at once, the researchers say their test will ensure patients get the right treatment quickly and could also reduce the unwarranted use of antibiotics.

In addition, the tests can be used in any setting, and can be easily modified to detect different bacteria and viruses, including potential new variants of SARS-CoV-2, the virus which causes COVID-19. The results are reported in the journal Nature Nanotechnology.

The winter cold, flu and RSV season has arrived in the northern hemisphere, and healthcare workers must make quick decisions about treatment when patients show up in their hospital or clinic.

Mucosal antibodies in the airways provide durable protection against SARS-CoV-2

Charlotte Thålin, M.D. and associate professor at the Department of Clinical Sciences, Danderyd Hospital
Photo Credit: Ludvig Kostyal

Researchers hope that a nasal vaccine may generate mucosal immune responses that protect against SARS-CoV-2 infection.

High levels of mucosal IgA antibodies in the airways protect against SARS-CoV-2 infection for at least eight months. Omicron infection generates durable mucosal antibodies, reducing the risk of re-infection. These are the findings of a study published in The Lancet Infectious Diseases by researchers at Karolinska Institutet and Danderyd Hospital in Sweden. The results raise further hope for the feasibility of future nasal vaccine platforms to protect against infection.

“Antibodies in the blood protect from severe disease, but if we aim to limit infection, viral transmission and the emergence of new SARS-CoV-2 variants, we need to reinforce our immunity at the mucosal surface, which is the viral point of entry”, says Charlotte Thålin, M.D. and associate professor at the Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet who led the study. “This is not achieved by currently employed intramuscularly-delivered vaccines. But the hope is that a nasal vaccine may generate mucosal immune responses similar to those seen after infection, and thereby block the transmission chain”.

Deflecting lightning with a laser lightning rod

During tests carried out on the summit of the Säntis by Jean-Pierre Wolf and Aurélien Houard's team, the scientists noted that the discharge could follow the laser beam of the "LLR" for several dozen meters before reaching the tower of the operator Swisscom (in red and white).
Photo Credit: Xavier Ravinet - UNIGE

A European consortium led by UNIGE, École Polytechnique (Paris), EPFL, hes-so and TRUMPF has managed to guide lightning using a high-power laser installed at the top of Mount Säntis in Switzerland.

Forest fires, power cuts and damaged infrastructure…lightning fascinates and destroys in equal measure, causing as many as 24,000 deaths a year worldwide not to mention widespread destruction. Even today, the lightning rod invented by Benjamin Franklin is the best form of protection. And yet, these rods do not always provide optimal protection for sensitive sites. A European consortium consisting of the University of Geneva (UNIGE), École Polytechnique (Paris), EPFL, hes-so and TRUMPF scientific lasers (Munich) has developed a promising alternative: the Laser Lightning Rod or LLR. After testing the LLR on the summit of Säntis (in Switzerland), the researchers now have proof of its feasibility. The rod can deflect lightning over several dozen meters even in poor weather. The results of this research are published in the journal Nature Photonics.