A motion freezer for particles

Illustration Credit: Jakob Hüpfl / TU Wien

Tailor-made laser light fields can be used to slow down the movement of several particles and thus cool them down to extremely low temperatures - as shown by a team from TU Wien.

Using lasers to slow down atoms is a technique that has been used for a long time already: If one wants to achieve low-temperature world records in the range of absolute temperature zero, one resorts to laser cooling, in which energy is extracted from the atoms with a suitable laser beam.

Recently, such techniques have also been applied to small particles in the nano- and micro-meter range. This already works quite well for individual particles – but if you want to cool several particles at once, the problem turns out to be much more difficult. Prof. Stefan Rotter and his team at the Institute of Theoretical Physics at TU Wien have now presented a method with which extremely effective cooling can also be achieved in this case.

Steel Was Already Used in Europe 2900 Years Ago

Using geochemical analyses, the researchers were able to prove that stone stelae on the Iberian peninsula that date back to the Final Bronze Age feature complex engravings that could only have been done using tempered steel. This was backed up by metallographic analyses of an iron chisel from the same period and region that showed the necessary carbon content to be proper steel.
Photo Credits: Rafael Ferreiro Mählmann (A), Bastian Asmus (B), Ralph Araque Gonzalez (C-E)

A study by an international and interdisciplinary team headed by Freiburg archaeologist Dr. Ralph Araque Gonzalez from the Faculty of Humanities has proven that steel tools were already in use in Europe around 2900 years ago. Using geochemical analyses, the researchers were able to prove that stone stelae on the Iberian Peninsula that date back to the Final Bronze Age feature complex engravings that could only have been done using tempered steel. This was backed up by metallographic analyses of an iron chisel from the same period and region (Rocha do Vigio, Portugal, ca. 900 BCE) that showed the necessary carbon content to be proper steel. The result was also confirmed experimentally by undertaking trials with chisels made of various materials: only the chisel made of tempered steel was suitably capable of engraving the stone. 

Until recently it was assumed that it was not possible to produce suitable quality steel in the Early Iron Age and certainly not in the Final Bronze Age, and that it only came to be widespread in Europe under the Roman Empire. “The chisel from Rocha do Vigio and the context where it was found show that iron metallurgy including the production and tempering of steel were probably indigenous developments of decentralized small communities in Iberia, and not due to the influence of later colonization processes. This also has consequences for the archaeological assessment of iron metallurgy and quartzite sculptures in other regions of the world,” explains Araque Gonzalez. The study ‘Stone-working and the earliest steel in Iberia: Scientific analyses and experimental replications of final bronze age stelae and tools’ has been published in the Journal of Archaeological Science.

Child obesity linked to increased risk of several types of diabetes as an adult

Yuxia Wei, doctoral student at Institute of Environmental Medicine and the study's first author.
Photo Credit: Jingwei Zhao

Child obesity is linked to an increased risk of suffering from diabetes in adulthood and the risk increase concerns both autoimmune forms of diabetes and various forms of type 2 diabetes, according to a new study published in Diabetologia. For example, the risk of suffering from the most insulin-resistant form of diabetes is three times as high for obese children.

Diabetes affects about seven percent of the adult population and is one of the world's fastest growing diseases. Diabetes has traditionally been divided into two subgroups, type 1 and type 2 diabetes, but research suggests that this is a gross simplification.

In 2018, a Swedish study identified five subgroups of adult-duty diabetes. These are characterized by autoimmunity, severe insulin deficiency, severe insulin resistance, obesity and high age, respectively.

Diabetes affects about seven percent of the adult population and is one of the world's fastest growing diseases. Diabetes has traditionally been divided into two subgroups, type 1 and type 2 diabetes, but research suggests that this is a gross simplification.

Blood test for brain cancer may be on horizon, new research finds

Researchers at Penn State College of Medicine have identified a biomarker that can be used in blood tests to diagnose glioblastoma, the most common and deadliest type of brain cancer, and track its progression and guide treatment.
Photo Credit: National Cancer Institute

Glioblastoma (GBM) is the most common and deadliest type of brain cancer with a five-year survival rate of only 5%. Researchers at Penn State College of Medicine have identified a biomarker that can be used in blood tests to diagnose GBM, track its progression and guide treatment. The researchers said that such a non-invasive liquid biopsy for GBM could help patients get the care they need more quickly.

“Patients normally receive imaging, such as MRI or CT scans, to diagnose and track the progression of brain tumors, but it can be difficult for physicians to tell from those scans if the patient is getting better or worse because they don’t provide detail at the cellular or molecular level,” said Vladimir Khristov, graduate and medical student, Penn State. “That is why we need a supplemental diagnostic test to help physicians determine if the tumors are responding to therapy and regressing, or if they are getting worse and need additional treatment.”

Indeed, added Brad Zacharia, associate professor of neurosurgery and of otolaryngology, Penn State, a liquid biopsy for glioblastoma could be of tremendous value to patients suffering from this devastating tumor.

In the end, it's the individual advantage that counts

The three phases of exceptional dynamics: (1) Predation on the unprotected bacteria by predators, (2) toxin formation as cooperative defense and recovery of the bacterial population, (3) filament formation as individual defense through evolution and stabilization of densities.
Photo Credit: David Kneis/TU Dresden

Bacteria rely on cooperation and evolution in order to defend themselves against predatory protists

Eating and being eaten is a normal process in nature. These predator-prey dynamics help to stabilize ecosystems. It ensures that individual species do not become too abundant, controls their populations, and prevents damage caused by overpopulation (e.g., browsing by deer in the forest or damage to crops by caterpillars). But how is it that the predators do not simply eat away all the prey, thus breaking down the system? A research team from the Helmholtz Centre for Environmental Research (UFZ) together with scientists from the Technical University (TU) of Dresden and the University of Potsdam has investigated this using bacteria and protists that live in bodies of water and discovered something astonishing. According to an article recently published in ISME Journal, bacteria defend themselves against predatory protists with cooperative behavior and evolution.

In a lake or river, between one and 10 million bacteria live in just 1 ml of water. Such a high density is necessary because bacteria permanently break down organic compounds and pollutants and thus purify the water. However, if there are too many bacteria, this can lead to the spread of pathogens. Preventing this requires predators: microscopic protists of which there are usually between a few hundred and a few thousand individuals in 1 ml of water. They constantly eat bacteria and thus ensure that the bacteria fulfil their cleaning function but do not become too abundant. Using the bacterium Pseudomonas putida and the bacterivorous protist Poteriospumella lacustris, the research team investigated the role of the various defense strategies of the bacteria and how the formation of feeding resistance is related to the dynamics of ecological systems.

Breathing is going to get tougher

Dust rising at Noordoewer, Namibia. Research shows dust will be a major contributor to poor air quality as the climate changes.
Photo Credit: Matthieu Joannon

Not all pollution comes from people. When global temperatures increase by 4 degrees Celsius, harmful plant emissions and dust will also increase by as much as 14 percent, according to new UC Riverside research.

The research does not account for a simultaneous increase in human-made sources of air pollution, which has already been predicted by other studies. 

“We are not looking at human emissions of air pollution, because we can change what we emit,” said James Gomez, UCR doctoral student and lead author of the study. “We can switch to electric cars. But that may not change air pollution from plants or dust.”

Details of the degradation in future air quality from these natural sources have now been published in the journal Communications Earth & Environment. About two-thirds of the future pollution is predicted to come from plants.

All plants produce chemicals called biogenic volatile organic compounds, or BVOCs. “The smell of a just-mowed lawn, or the sweetness of a ripe strawberry, those are BVOCs. Plants are constantly emitting them,” Gomez said.

First patient receives milestone stem cell-based transplant for Parkinson’s Disease

On 13th of February, a transplant of stem cell-derived nerve cells was administered to a person with Parkinson’s at Skåne University Hospital, Sweden. The product has been developed by Lund University and it is now being tested in patients for the first time. The transplantation product is generated from embryonic stem cells and functions to replace the dopamine nerve cells which are lost in the parkinsonian brain. This patient was the first of eight with Parkinson’s disease who will receive the transplant.

“This is an important milestone on the road towards a cell therapy that can be used to treat patients with Parkinson’s disease. The transplantation has been completed as planned, and the correct location of the cell implant has been confirmed by magnetic resonance imaging. Any potential effects of the STEM PD-product may take several years. The patient has been discharged from the hospital and evaluations will be conducted according to the study protocol,” says Gesine Paul-Visse, principal investigator for the STEM-PD clinical trial, consultant neurologist at Skåne University Hospital and adjunct professor at Lund University in Sweden.

There are around eight million people living with Parkinson’s disease globally; a disease which involves loss of dopamine nerve cells deep in the brain, leading to problems in controlling movement. The standard treatment for Parkinson’s disease is medications that replace the lost dopamine, but over time these medications often become less effective and cause side effects. As of today, there are no treatments that can repair the damaged structures within the brain or that can replace the nerve cells that are lost.

Novel Peanut Allergy Treatment Shown to be Safe, Effective, and Lasting

Edwin Kim, MD, MS
A four-year clinical trial led by Edwin Kim, MD, at the UNC School of Medicine, has found that an increased dosage of a unique type of peanut allergy immunotherapy continues to show promise for children.
Photo Credit: Courtesy of UNC School of Medicine

A four-year phase 2 clinical trial demonstrated that a peanut allergy treatment called sublingual immunotherapy, or SLIT, is effective and safe, while offering durable desensitization to peanuts in peanut-allergic children.

SLIT is a treatment using a tiny amount of peanut protein that is the equivalent of only 1/75th of a peanut kernel. It is taken under the tongue, where it is absorbed into the body, as opposed to Palforzia® peanut oral immunotherapy, which requires patients to eat a medical grade peanut flour each day.

Published in the Journal of Allergy and Clinical Immunology, the research led by corresponding author Edwin Kim, MD, associate professor of pediatrics at the UNC School of Medicine, shows that a 4 mg dose of peanut SLIT provides strong desensitization that would be expected to protect against accidental exposures to peanut in the majority of children. And most importantly, the clinical study suggests the treatment is safe.

Researchers find sea urchin die-offs threaten Caribbean coral reefs

The urchin species Diadema antillarum has long been considered the most important grazer in the Caribbean, feeding on algae that would otherwise overrun the reef and make it difficult for coral to thrive.
Photo Credit: Rachel Best

The sustained loss of a once abundant species of sea urchin in the Caribbean could also result in the functional extinction of diverse coral species from the region’s reefs, according to new research from a Florida State University team.

The urchin species Diadema antillarum has long been considered the most important grazer in the Caribbean, feeding on algae that would otherwise overrun the reef and make it difficult for coral to thrive. But two mortality events over the past 40 years have caused much of that urchin population to die off.

New research led by FSU Professor of Biological Science Don Levitan shows that the loss of these algae-free areas due to the sea urchin die-off is threatening the existence of the corals that populate Caribbean reefs.

Levitan, along with collaborator Peter Edmunds, a professor at California State University Northridge, has been collecting data on D. antillarum since his first research trip to St. John, U.S. Virgin Islands, in 1983, recording population density of the species and tracking it through mass mortality events in 1983-1984 and in 2022.

3D bioprinting inside the human body could be possible thanks to new soft robot

The tiny flexible 3D bioprinter developed at UNSW Sydney was able to 3D print a variety of materials with different shapes on the surface of a pig’s kidney.
Photo Credit: Dr Thanh Do

UNSW researchers unveil prototype device that can directly 3D print living cells onto internal organs and potentially be used as an all-in-one endoscopic surgical tool.

Engineers from UNSW Sydney have developed a miniature and flexible soft robotic arm which could be used to 3D print biomaterial directly onto organs inside a person’s body.

3D bioprinting is a process whereby biomedical parts are fabricated from so-called bioink to construct natural tissue-like structures.

Bioprinting is predominantly used for research purposes such as tissue engineering and in the development of new drugs – and normally requires the use of large 3D printing machines to produce cellular structures outside the living body.

The new research from UNSW Medical Robotics Lab, led by Dr Thanh Nho Do and his PhD student, Mai Thanh Thai, in collaboration with other researchers from UNSW including Scientia Professor Nigel Lovell, Dr Hoang-Phuong Phan, and Associate Professor Jelena Rnjak-Kovacina is detailed in a paper published in Advanced Science.