23,000-year-old human genome from southern Spain decoded

Human tooth recovered Cueva de Malalmuerzo
Photo Credit: Pedro Cantalejo

A new study reports on genomic data from a 23,000-year-old individual who lived in what was probably the warmest place in Europe at the peak of the last Ice Age. The oldest human genome recovered from the southern tip of Spain adds an important piece of the puzzle to the genetic history of Europe.

An international team of researchers has analyzed ancient human DNA from several archaeological sites in Andalucía in southern Spain. The study, published in Nature Ecology and Evolution, reports on the oldest genome to date from Cueva del Malalmuerzo in southern Spain, as well as the 7,000 to 5,000-year-old genomes of early farmers from other well-known sites, such as Cueva de Ardales. The researchers describe their findings in the article ‘A 23,000-year-old southern-Iberian individual links human groups that lived in Western Europe before and after the Last Glacial Maximum’ in the Journal Nature Ecology and Evolution.

The Iberian Peninsula plays an important role in the reconstruction of human population history. As a geographic cul-de-sac in the southwest of Europe, it is on one hand considered a refuge during the last Ice Age with its drastic temperature fluctuations. On the other hand, it may have been one of the starting points for the recolonization of Europe after the glacial maximum. Indeed, previous studies had reported on the genomic profiles of 13,000 to 8,000-year-old hunter-gatherers from the Iberian Peninsula and provided evidence for the survival and continuation of a much older Paleolithic lineage that has been replaced in other parts of Europe and is no longer detectable. 

Fermilab completes the first-of-its-kind prototype of a superconducting accelerator module

The cavity string for the HB650 cryomodule after being assembled in April 2022. These cavities comprise the heart of the new cryomodule.
Photo Credit: Lynn Johnson, Fermilab

Technical staff at the U.S. Department of Energy’s Fermi National Accelerator Laboratory have completed a prototype of a special superconducting cryomodule, the first of its kind in the world. The national lab is home of the Proton Improvement Plan II, or PIP-II, a project to upgrade Fermilab’s particle accelerator complex.

The new high-beta 650-megahertz, or HB650, cryomodule is the longest and largest cryomodule in PIP-II. It will be responsible for accelerating protons to more than 80% of the speed of light. Ultimately, four of them will comprise the last section of the new linear accelerator, or linac, that will drive Fermilab’s accelerator complex.

In this final section of the linac, these superconducting cryomodules will power beams of protons to the final energy of 800 million electronvolts, or MeV, before the protons exit the linac. From there, the proton beam will transfer to the upgraded Booster and Main Injector accelerators, where it will gain more energy before being turned into a beam of neutrinos. These neutrinos will then be sent on a 1,300-kilometer journey through Earth to the Deep Underground Neutrino Experiment and the Long Baseline Neutrino Facility in Lead, South Dakota.

Wasps harness power of pitcher plants in first-ever observed defense strategy

This is a cynipid wasp, whose larvae were recently discovered to induce plant growths called galls containing acidity levels akin to lemons.
Photo Credit: Antoine Guiguet

As the saying goes, “When life gives you lemons, turn that tartness into little translucent balls in which to grow your young.” At least, that’s how the saying goes for a tiny insect called a cynipid wasp, whose larvae were recently discovered inducing plant growths called galls that contained acidity levels akin to lemons.

“This is exciting because it represents a novel defense system, one we haven’t seen before,” said Antoine Guiguet, an entomologist at Penn State and lead author on a paper about the discovery published today (March 1) in Biology Letters.

For decades, it has been known that most cynipid wasp species inject chemicals into leaves to induce oak trees to produce protective galls — or growths — around their larvae to ensure the safety of their developing offspring. The gall houses and feeds the insects during their larval development and serves a defensive function to ward off natural enemies. The galls eventually fall from the tree and the wasp larva eat their way out, leaving behind the little balls to decompose on the forest floor.

Could a Naturally Occurring Amino Acid Lead Us to a Cure for COVID-19?

An amino acid called 5-aminolevulinic acid (ALA) might be key to reduce the expression of ACE2, a cell membrane receptor that SARS-CoV-2 uses to infect cells. New insights gained by scientists at Tokyo Tech have clarified the relationship between ACE2, ALA, and the production of heme, which could pave the way to anti-viral drugs to cure COVID-19.

After more than two years since its discovery, six million deaths, and half a billion reported cases, there is still no effective cure for COVID-19. Even though vaccines have lowered the impact of outbreaks, patients that contract the disease can only receive supportive care while they wait for their own body to clear the infection.

A promising COVID-19 treatment strategy that has been gaining traction lately is targeting angiotensin-converting enzyme 2 (ACE2). This is a receptor found on the cell membrane that allows entry of the virus into the cell due to its high affinity for SARS-CoV-2’s spike protein. The idea is that reducing the levels of ACE2 on the membrane of cells could be a way to prevent the virus from entering them and replicating, thereby lowering its infectious capabilities.

Lipid nanoparticles highly effective in gene therapy

The RNP-ssODN is designed to ensure the CRISPR-Cas9 molecule is encapsulated by the LNP. Once inside the cells, the ssODN dissociates and CRISPR-Cas9 can carry out its effect.
Illustration Credits: Haruno Onuma, Yusuke Sato, Hideyoshi Harashima. Journal of Controlled Release. February 10, 2023.

Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.

Gene therapy is a potential mode of treatment for a wide variety of diseases caused by genetic mutations. While it has been an area of diverse and intense research, historically, only a very few patients have been treated using gene therapy—and fewer still cured. The advent of the genetic modification technique called CRISPR-Cas9 in 2012 has revolutionized gene therapy—as well as biology as a whole—and it has recently entered clinical trials for the treatment of some diseases in humans.

Haruno Onuma, Yusuke Sato and Hideyoshi Harashima at Hokkaido University have developed a new delivery system for CRISPR-Cas9, based on lipid nanoparticles (LNPs), that could greatly increase the efficiency of in vivo gene therapy. Their findings were published in the Journal of Controlled Release.

Social bird species may be less competitive

Northern mockingbird
Photo Credit: Brian E. Kushner/Cornell Lab of Ornithology 

Using Cornell Lab of Ornithology data, a new study finds that birds that have evolved to be more social are less likely to kick other birds off a bird feeder or a perch.

Spend any time watching backyard bird feeders and it becomes clear that some species are more “dominant” than others. They evict other birds from a feeder or perch, usually based on their body size. Scientists wanted to learn if birds that have evolved to be more social have also evolved to be less aggressive.

Their findings published March 1 in the Proceedings of the Royal Society B, “The Effect of Sociality on Competitive Interactions Among Birds.”

“We found that species’ sociality was inversely related to dominance,” said lead author Ilias Berberi from Carleton University in Ottawa, Canada. “Using data collected from thousands of birdwatching volunteers, we measured the sociality of different species based on their typical group size when seen at bird feeders. Though some species are often found in groups, other tend to be loners. When we examined their dominance interactions, we found that more social species are weaker competitors. Overall, the more social bird species are less likely to evict competing species from the feeders.”

Chemical imaging could help predict efficacy of radiation therapy for an individual cancer patient

Concept illustration of body chemistry.
Image Credit: Nicole Smith, made with Midjourney. Courtesy of University of Michigan

Decisions on cancer treatment could become better tailored to individual patients with the adoption of a new imaging method being developed by University of Michigan researchers that maps the chemical makeup of a patient’s tumor.

Today, treatment methods for cancer—whether surgery, radiation therapy or immunotherapy—are recommended based mainly on the tumor’s location, size and aggressiveness. This information is usually obtained by anatomical imaging—MRI or CT scans or ultrasound and by biological assays performed in tissues obtained by tumor biopsies.

Yet, the chemical environment of a tumor has a significant effect on how effective a particular treatment may be. For example, a low oxygen level in tumor tissue impairs the effectiveness of radiation therapy.

Now, a team of scientists from the University of Michigan and two universities in Italy has demonstrated that an imaging system that uses special nanoparticles can provide a real-time, high-resolution chemical map that shows the distribution of chemicals of interest in a tumor.

It could lead to a way to help clinicians make better recommendations on cancer therapy tailored to a particular patient—precision medicine.

Climate change raises the threat of multiple hurricanes

Princeton researchers explored the increasing risk of multiple destructive storms hitting locations on the Atlantic and Gulf coasts. In this image, three storms formed in the Atlantic basin in 2017. 
Photo Credit: NASA

Getting hit with one hurricane is bad enough, but new research from Princeton Engineering shows that back-to-back versions may become common for many areas in coming decades.

Driven by a combination of rising sea levels and climate change, destructive hurricanes and tropical storms could become far more likely to hit coastal areas in quick succession, researchers found. In an article published Feb. 27 in the journal Nature Climate Change, the researchers said that in some areas, like the Gulf Coast, such double hits could occur as frequently as once every three years.

“Rising sea levels and climate change make sequential damaging hurricanes more likely as the century progresses,” said Dazhi Xi, a postdoctoral researcher and a former graduate student in civil and environmental engineering and the paper’s lead author. “Today’s extremely rare events will become far more frequent.”

Supernova From the Year 185: A Rare View of the Entirety of This Supernova Remnant

Dark Energy Camera captures the glowing remains of the first-ever documented supernova
Full Size Hi-Res Image
Image Credit: CTIO/NOIRLab/DOE/NSF/AURA T.A. Rector (University of Alaska Anchorage/NSF’s NOIRLab), J. Miller (Gemini Observatory/NSF’s NOIRLab), M. Zamani & D. de Martin (NSF’s NOIRLab)

The tattered shell of the first-ever historically recorded supernova was captured by the US Department of Energy-fabricated Dark Energy Camera, which is mounted on the National Science Foundation’s (NSF) Víctor M. Blanco 4-meter Telescope at Cerro Tololo Inter-American Observatory in Chile, a Program of NSF’s NOIRLab. RCW 86’s ring of debris is all that remains of a white-dwarf star that exploded more than 1800 years ago, when it was recorded by Chinese stargazers as a ‘guest star’.

Draped around the outer edges of this star-filled image are wispy tendrils that appear to be flying away from a central point, like the tattered remains of a burst balloon. These cloud-like features are thought to be the glowing remains of a supernova that was witnessed by Chinese astronomers in the year 185 C.E. When it appeared, this baffling addition to the night sky was referred to as a ‘guest star’ by ancient astronomers. It remained visible to the naked eye for about eight months before fading from view. 

How to generate new neurons in the brain

Mitochondria (green) in proliferating (A) and dormant (B) cells. Newly produced neurons (C) (red) in the dentate gyrus with cell nuclei (blue) and a marker for immature neurons (green).
Image Credit: © Knobloch Lab – UNIL

A team of biologists led by UNIGE and UNIL has discovered how to awaken neural stem cells and reactivate them in adult mice.

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adults and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

Stem cells have the unique ability to continuously produce copies of themselves and give rise to differentiated cells with more specialized functions. Neural stem cells (NSCs) are responsible for building the brain during embryonic development, generating all the cells of the central nervous system, including neurons.