Clues to the cause of chronic gut pain

Professor Stuart Brierley
Photo Credit: Courtesy of Flinders University

New insights into chronic gut pain offer hope for improved treatments for irritable bowel syndrome and anxiety treatment.

A research team led by Flinders University Professor Stuart Brierley, based at the SA Health and Medical Research Institute, with Nobel Laureate Professor David Julius, Professor Holly Ingraham and Dr James Bayrer at the University of California San Francisco, has shown evidence of a specific pathway of cells and nerves linking the gut to the brain that may be responsible for the chronic gut pain.

Chronic gut pain is commonly experienced by 11% of the global population currently living with irritable bowel syndrome (IBS) and associated psychological conditions, including anxiety and depression.

Described in a new article in Nature, the team used genetic and pharmacologic tools in pre-clinical models to manipulate signals between gut epithelial cells and associated nerve fibers to determine how this pathway stimulates chronic gut pain and anxiety.

Researchers create artificial enzyme for fast detection of disease-related hormone in sweat

Photo Credit: Courtesy of Oregon State University

Researchers in the Oregon State University College of Engineering have developed a handheld sensor that tests perspiration for cortisol and provides results in eight minutes, a key advance in monitoring a hormone whose levels are a marker for many illnesses including various cancers.

Findings were published in the journal ACS Applied Materials & Interfaces. The material and sensing mechanism in the new device could be easily engineered to detect other specific hormones, the researchers say – for example, progesterone, a key marker for women’s reproductive health and pregnancy outcomes.

“We took inspiration from the natural enzymes used in blood glucose meters sold at pharmacies,” said Larry Cheng, associate professor of electrical engineering and computer science. "In glucose meters, specific enzymes are applied to an electrode, where they can capture and react with glucose molecules to generate an electrical signal for detection. However, finding natural enzymes for cortisol detection is not straightforward, and natural enzymes are prone to instability and have a short lifespan.

Volcanic Spring Water Will Help Researchers Make Plastic Electronics

Photo Credit: Courtesy of University of Tsukuba

Researchers from the University of Tsukuba have made electrically conductive polyaniline composites in mineral water. This work will increase the sustainability of manufacturing many consumer and industrial products

When you think of how to make electronic components, water probably doesn't top your list of raw materials. Nevertheless, in a study recently published in Journal of Water Chemistry and Technology, researchers from the University of Tsukuba have used volcanic spring water to help make the plastic that's an essential part of many modern technologies.

Plastic holds together the electronic components in many modern technologies. Polyaniline (PANI) is one of these plastics. Because millions of square meters of PANI are used every year for this and other purposes, there are clear benefits to making it in the most environmentally sustainable solvent possible. Many solvents can be used to make PANI—but most are rather toxic and incompatible with common mass-production device fabrication processes, such as inkjet printing.

Searching for life with space dust

Space dust. This piece of interplanetary dust is thought to be part of the early solar system and was found in our atmosphere, demonstrating lightweight particles could survive atmospheric entry as they do not generate much heat from friction.
Photo Credit: 2023 NASA CC-0

Following enormous collisions, such as asteroid impacts, some amount of material from an impacted world may be ejected into space. This material can travel vast distances and for extremely long periods of time. In theory this material could contain direct or indirect signs of life from the host world, such as fossils of microorganisms. And this material could be detectable by humans in the near future, or even now.

When you hear the words vacuum and dust in a sentence, you may groan at the thought of having to do the housework. But in astronomy, these words have different connotations. Vacuum of course refers to the void of space. Dust, however, means diffuse solid material floating through space. It can be an annoyance to some astronomers as it may hinder their views of some distant object. Or dust could be a useful tool to help other astronomers learn about something distant without having to leave the safety of our own planet. Professor Tomonori Totani from the University of Tokyo’s Department of Astronomy has an idea for space dust that might sound like science fiction but actually warrants serious consideration.

Climate change affects greenhouse gas emissions from stream networks

Photo Credit: Mitchell Kmetz

Natural greenhouse gas emissions from streams and lakes are strongly linked to water discharge and temperature according to a new study led by Linköping University, Sweden. This knowledge is necessary to assess how man-made climate change is altering greenhouse emissions from natural landscapes and has large implications for climate change mitigation measures.

“The study is a big step forward towards increased understanding of the greenhouse gas fluxes in stream networks, providing potential to predict future fluxes", says David Bastviken, professor at Thematic Studies Environmental Change. Charlotte Perhammar

“The use of agriculture and forestry as carbon sinks is debated at the moment and the question is how effective such carbon sinks are for mitigating climate change. Our new study shows that with increased precipitation, a larger amount of carbon may be washed into streams and lakes and an increased share of this carbon also ends up in the atmosphere. Hence, landscape carbon sinks may become less effective in the future,” says David Bastviken, professor at the Department of Thematic Studies Environmental Change at Linköping University.

Tackling counterfeit seeds with “unclonable” labels

As a way to reduce seed counterfeiting, MIT researchers developed a silk-based tag that, when applied to seeds, provides a unique code that cannot be duplicated.
Photo Credit: Photograph courtesy of the researchers. Edited by Jose-Luis Olivares, MIT
(CC BY-NC-ND 3.0)

Average crop yields in Africa are consistently far below those expected, and one significant reason is the prevalence of counterfeit seeds whose germination rates are far lower than those of the genuine ones. The World Bank estimates that as much as half of all seeds sold in some African countries are fake, which could help to account for crop production that is far below potential.

There have been many attempts to prevent this counterfeiting through tracking labels, but none have proved effective; among other issues, such labels have been vulnerable to hacking because of the deterministic nature of their encoding systems. But now, a team of MIT researchers has come up with a kind of tiny, biodegradable tag that can be applied directly to the seeds themselves, and that provides a unique randomly created code that cannot be duplicated.

The new system, which uses minuscule dots of silk-based material, each containing a unique combination of different chemical signatures, is described today in the journal Science Advances in a paper by MIT’s dean of engineering Anantha Chandrakasan, professor of civil and environmental engineering Benedetto Marelli, postdoc Hui Sun, and graduate student Saurav Maji.

New UBC water treatment zaps ‘forever chemicals’ for good

 

UBC researchers devised a unique adsorbing material that is capable of capturing all the PFAS present in the water supply.
Photo Credit: Mohseni lab

Engineers at the University of British Columbia have developed a new water treatment that removes “forever chemicals” from drinking water safely, efficiently – and for good.

“Think Brita filter, but a thousand times better,” says UBC chemical and biological engineering professor Dr. Madjid Mohseni, who developed the technology.

Forever chemicals, formally known as PFAS (per-and polyfluoroalkyl substances) are a large group of substances that make certain products non-stick or stain-resistant. There are more than 4,700 PFAS in use, mostly in raingear, non-stick cookware, stain repellents and firefighting foam. Research links these chemicals to a wide range of health problems including hormonal disruption, cardiovascular disease, developmental delays and cancer.

To remove PFAS from drinking water, Dr. Mohseni and his team devised a unique absorbing material that is capable of trapping and holding all the PFAS present in the water supply.

The PFAS are then destroyed using special electrochemical and photochemical techniques, also developed at the Mohseni lab and described in part in a paper published recently in Chemosphere.

How the brain's 'internal compass' works

New study reveals how the brain makes sense of changing environmental cues
Photo Credit: Albrecht Fietz

Scientists have gained new insights into the part of the brain that gives us a sense of direction, by tracking neural activity with the latest advances in brain imaging techniques. The findings shed light on how the brain orients itself in changing environments – and even the processes that can go wrong with degenerative diseases like dementia, that leave people feeling lost and confused.

“Neuroscience research has witnessed a technology revolution in the last decade allowing us to ask and answer questions that could only be dreamed of just years ago,” says Mark Brandon, an Associate Professor of psychiatry at McGill University and researcher at the Douglas Research Centre, who co-led the research with Zaki Ajabi, a former student at McGill University and now a postdoctoral research fellow at Harvard University.

Reading the brain's internal compass

To understand how visual information impacts the brain’s internal compass, the researchers exposed mice to a disorienting virtual world while recording the brain's neural activity. The team recorded the brain’s internal compass with unprecedented precision using the latest advances in neuronal recording technology.

Surprisingly simple explanation for alien comet ‘Oumuamua’s weird orbit

An artist’s depiction of the interstellar comet ‘Oumuamua, as it warmed up in its approach to the sun and outgassed hydrogen (white mist), which slightly altered its orbit. The comet, which is most likely pancake-shaped, is the first known object other than dust grains to visit our solar system from another star.
Image Credit: NASA, ESA and Joseph Olmsted and Frank Summers of STScI

In 2017, a mysterious comet dubbed ‘Oumuamua fired the imaginations of scientists and the public alike. It was the first known visitor from outside our solar system, it had no bright coma or dust tail, like most comets, and a peculiar shape — something between a cigar and a pancake — and its small size more befitted an asteroid than a comet.

But the fact that it was accelerating away from the sun in a way that astronomers could not explain perplexed scientists, leading some to suggest that it was an alien spaceship.

Now, a University of California, Berkeley, astrochemist and a Cornell University astronomer argue that the comet’s mysterious deviations from a hyperbolic path around the sun can be explained by a simple physical mechanism likely common among many icy comets: outgassing of hydrogen as the comet warmed up in the sunlight.

What made ‘Oumuamua different from every other well-studied comet in our solar system was its size: It was so small that its gravitational deflection around the sun was slightly altered by the tiny push created when hydrogen gas spurted out of the ice.

The oxygen-ion battery

Prof. Jürgen Fleig, Tobias Huber, Alexander Schmid (left to right)
Photo Credit: Courtesy of TU Wien

A new type of battery has been invented at TU Wien (Vienna): The oxygen-ion battery can be extremely durable, does not require rare elements and solves the problem of fire hazards.

Lithium-ion batteries are ubiquitous today - from electric cars to smartphones. But that does not mean that they are the best solution for all areas of application. TU Wien has now succeeded in developing an oxygen-ion battery that has some important advantages. Although it does not allow for quite as high energy densities as the lithium-ion battery, its storage capacity does not decrease irrevocably over time: it can be regenerated and thus may enable an extremely long service life.

In addition, oxygen-ion batteries can be produced without rare elements and are made of incombustible materials. A patent application for the new battery idea has already been filed together with cooperation partners from Spain. The oxygen-ion battery could be an excellent solution for large energy storage systems, for example to store electrical energy from renewable sources.