Eight Psychiatric Disorders Share the Same Genetic Causes

Image Credit: Won Lab

Scientific Frontline: Extended "At a Glance" Summary: Shared Genetic Origins of Psychiatric Disorders

The Core Concept: Specific genetic variations, known as pleiotropic variants, actively influence brain development and are shared across eight distinct psychiatric disorders, including schizophrenia, autism, and major depressive disorder.

Key Distinction/Mechanism: Unlike disorder-specific genetic variants, pleiotropic variants remain active for extended periods during neurodevelopment. The specific genes they regulate are highly interconnected and exceptionally sensitive to change, meaning disruptions create a biological ripple effect across neural protein networks.

Major Frameworks/Components:

• Pleiotropy: The biological phenomenon in which a single genetic variant influences multiple, seemingly unrelated phenotypic traits or coexisting clinical disorders.
• Massively Parallel Reporter Assay: A high-throughput screening technology utilized to insert 17,841 genetic variants into human neural cells to directly observe their impact on gene expression within a living system.
• Gene Regulation Modulation: The precise functional mechanism altered by these variants, which dictates the timing and volume of protein production necessary for proper neural synapse formation.
• Genome-Wide Association Studies (GWAS): The foundational epidemiological research method used to map the initial chromosomal regions across diverse patient populations.

Better prediction of epidemics

The curve calculated using a “reproduction matrix” (turquoise) reflects the actual infection rate (black) much more accurately than previous models (yellow and blue).
Graphic Credit: Empa

The reproduction number R is often used as an indicator to predict how quickly an infectious disease will spread. Empa researchers have developed a mathematical model that is just as easy to use but enables more accurate predictions than R. Their model is based on a reproduction matrix that takes into account the heterogeneity of society.

"Your friends have more friends than you do", wrote the US sociologist Scott Feld in 1991. Feld's so-called friendship paradox states that the friends of any given person have more friends on average than the person themselves. This is based on a simple probability calculation: Well-connected people are more likely to appear in other people's social circles. "If you look at any person's circle of friends, it is very likely that this circle contains very well-connected people with an above-average number of friends," explains Empa researcher Ivan Lunati, head of the Computational Engineering laboratory. A similar principle served Lunati and his team as the basis for a new mathematical model that can be used to more accurately predict the development of case numbers during an epidemic.

T cells rise up to fight infections in the gut

An image produced through Xenium analysis of mouse small intestines. Protruding “villi” stick up from the lining of the small intestine. Valley-like “crypts” fill in the gaps.
Image Credit: Reina Lab, La Jolla Institute for Immunology

Your gut is a battleground. The cells that line your small intestine have to balance two seemingly contradictory jobs: absorbing nutrients from food, while keeping a wary eye out for pathogens trying to invade your body.

“This is a surface where pathogens can sneak in,” says La Jolla Institute for Immunology (LJI) Assistant Professor Miguel Reina-Campos, Ph.D. “That’s a massive challenge for the immune system.”

So how do immune cells keep the gut safe? New research led by scientists at LJI, UC San Diego, and the Allen Institute for Immunology shows that pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation—and relocation—as they fight infections in the small intestine.

In fact, these cells literally rise up higher in the tissue to fight infections before pathogens can spread to deeper, more vulnerable areas.

Peeing with your peers

 

Male chimps socializing
Photo Credit: Kyoto University, Kumamoto Sanctuary

In Italy, it has been said, there is a proverb for everything.

Chi non piscia in compagnia o è un ladro o è una spia -- "Whoever doesn't pee in the company of others is either a thief or a spy" -- goes one such saying, describing a communal act that in Japanese is known as tsuré-shon.

Social urination can be found represented in artwork across the centuries and around the world, and even today continues to be represented in cultural tropes. Now, researchers in Japan -- observing chimpanzees -- are suggesting that this phenomenon has evolutionary roots even deeper than previously expected.

Despite decades of research into other contagious behaviors such as yawning, contagious urination has never been studied scientifically in any species. To tackle this, a team at Kyoto University conducted 604 hours of direct observation at the University's Kumamoto Sanctuary, documenting 1,328 urination events. The researchers analyzed whether these were aligned in time, triggered by nearby individuals, or influenced by social relationships.

Scientists Have Given a Second Life to Paper Production Waste

Lignosulphonate is a safe waste from pulp and paper industries.
Photo Credit: Rodion Narudinov

Ural Federal University specialists have developed a new method of obtaining growth stimulators for agriculture plants. Waste from pulp and paper industries, lignosulphonate, became the basis for the production of biologically active stimulants of prolonged action for plant crops. Due to the structural features, the obtained samples can be used not only to improve crop growth, but also to remove some toxic substances from wastewater. The results were published in the Journal of Molecular Liquids. 

The Sulfite method is one of the currently used methods for extracting cellulose (the basis of any paper) from wood. In addition to the target product, large-capacity waste is formed in the form of salts lignosulphonic acids or lignosulphonates. These compounds are not toxic, they are biocompatible, water-soluble and relatively cheap.

Lignosulphonate-based nanoparticles have a porous structure and high mass content of carbon atoms that can be absorbed by the soil. Due to this fact, researchers consider them as “sponges” for dyes that can enter wastewater, and even as sorbents for oil. However, there is currently no efficient and cheap way to produce nanomaterials from this class of waste in industry. 

Fluoride in Drinking Water

Photo Credit: Bluewater Sweden

Is Fluoride Safe in Drinking Water?

Do you ever stop to think about what's in your drinking water? While most of us are aware of the importance of clean water, the safety of fluoride in our water supply has been a topic of debate for many years. You might have heard about its benefits for preventing cavities, but also about potential health risks. This article aims to provide a comprehensive overview of the science and expert opinions surrounding fluoride in drinking water, exploring both its benefits and potential drawbacks.

Research Methodology

To ensure accuracy and comprehensiveness, this article draws on a variety of sources, including scientific studies, reports from reputable health organizations (such as the WHO and CDC), news articles, and expert opinions. By examining a wide range of perspectives, we aim to provide a balanced and well-informed analysis of the safety of fluoride in drinking water.

Rice researchers unlock new insights into tellurene, paving the way for next-gen electronics

Shengxi Huang is an associate professor of electrical and computer engineering and materials science and nanoengineering at Rice University, and corresponding author on a study published in Science Advances.
Photo Credit: courtesy of Shengxi Huang/Rice University

To describe how matter works at infinitesimal scales, researchers designate collective behaviors with single concepts ⎯ like calling a group of birds flying in sync a “flock” or “murmuration.” Known as quasiparticles, the phenomena these concepts refer to could be the key to next-generation technologies.

In a recent study published in Science Advances, a team of researchers led by Shengxi Huang, associate professor of electrical and computer engineering and materials science and nanoengineering at Rice, describe how one such type of quasiparticle ⎯ polarons ⎯ behaves in tellurene, a nanomaterial first synthesized in 2017 that is made up of tiny chains of tellurium atoms and has properties useful in sensing, electronic, optical and energy devices.

“Tellurene exhibits dramatic changes in its electronic and optical properties when its thickness is reduced to a few nanometers compared to its bulk form,” said Kunyan Zhang, a Rice doctoral alumna who is a first author on the study. “Specifically, these changes alter how electricity flows and how the material vibrates, which we traced back to the transformation of polarons as tellurene becomes thinner.”

Engineering Quantum Entanglement at the Nanoscale

Study authors P. James Schuck (left) and Chiara Trovatello from the Schuck lab at Columbia Engineering.
Photo Credit: Jane Nisselson/Columbia Engineering

Physicists have spent more than a century measuring and making sense of the strange ways that photons, electrons, and other subatomic particles interact at extremely small scales. Engineers have spent decades figuring out how to take advantage of these phenomena to create new technologies.

In one such phenomenon, called quantum entanglement, pairs of photons become interconnected in such a way that the state of one photon instantly changes to match the state of its paired photon, no matter how far apart they are. 

Nearly 80 years ago, Albert Einstein referred to this phenomenon as "spooky action at a distance." Today, entanglement is the subject of research programs across the world — and it’s becoming a favored way to implement the most fundamental form of quantum information, the qubit. 

Study explains why some osteoporosis drugs may protect against Covid-19

Drugs already in-use for other conditions could help in the fight against Covid-19 and its variants
Photo Credit: Courtesy of University of York

Researchers have provided the molecular explanation for why some osteoporosis drugs offer protection against Covid-19.

Drugs already in-use for other conditions could help in the fight against Covid-19 and its variants

The study, by researchers at the University of York, builds on work conducted by Harvard Medical School that compared more than 450,000 users of a class of drugs, called bisphosphonates, with non-users during the months leading up to the pandemic in 2020. 

The Harvard study showed that those who used drugs, such as alendronate and zoledronate, had lower odds of testing for SARS-CoV-2 infection, Covid-19 diagnosis and Covid-19-related hospitalization, but the study didn’t explain why this was the case.

Tracking delivery: new technology for nanocarriers

Lipid nanoparticles visualized using SCP-Nano technology at the cellular level in lung tissue.
Image Credit: © Ali Ertürk / Helmholtz Munich

How can we ensure that life-saving drugs or genetic therapies reach their intended target cells without causing harmful side effects? Researchers at Helmholtz Munich, LMU and Technical University Munich (TUM) have taken an important step to answer this question. They have developed a method that, for the first time, enables the precise detection of nanocarriers – tiny transport vehicles – throughout the entire mouse body at a single-cell level. This innovation, called “Single-Cell Profiling of Nanocarriers” or short “SCP-Nano”, combines advanced imaging with artificial intelligence to provide unparalleled insights into the functionality of nanotechnology-based therapies. The results, published in Nature Biotechnology, pave the way for safer and more effective treatments, including mRNA vaccines and gene therapies.

Nanocarriers will play a central role in the next wave of life-saving medicines. They enable the targeted delivery of drugs, genes, or proteins to cells within patients. With SCP-Nano, researchers can analyze the distribution of extremely low doses of nanocarriers throughout the entire mouse body, visualizing each cell that has taken them up. SCP-Nano combines optical tissue clearing, light-sheet microscopy imaging, and deep-learning algorithms. First, whole mouse bodies are made transparent. After the three-dimensional imaging of whole mouse bodies, nanocarriers within the transparent tissues can then be identified down to the single-cell level. By integrating AI-based analysis, researchers can quantify which cells and tissues are interacting with the nanocarriers and precisely where this occurs.