Simple test can predict risk of severe liver disease

The researchers' new method can contribute to earlier detection of cirrhosis and liver cancer.
Image Credit: Scientific Frontline / AI Generated

A new study from Karolinska Institutet, published in the scientific journal The BMJ, shows how a simple blood analysis can predict the risk of developing severe liver disease. The method may already start to be applied in primary care to enable the earlier detection of cirrhosis and cancer of the liver.

“These are diseases that are growing increasingly common and that have a poor prognosis if detected late,” says Rickard Strandberg, affiliated researcher at Karolinska Institutet’s Department of Medicine, Huddinge, who has developed the test with his departmental colleague Hannes Hagström. “Our method can predict the risk of severe liver disease within 10 years and is based on three simple routine blood tests.” 

For the study, the researchers at Karolinska Institutet and their colleagues in Finland evaluated how well the method can estimate the risk of severe liver disease. The model, which is called CORE, was produced with advanced statistical methods and is based on five factors: age, sex and levels of three common liver enzymes (AST, ALT and GGT), which are commonly measured during regular health checks. 

Cell death in microalgae resembles that in humans

Under the microscope, it is possible to see for the first time how microalgae undergo the same type of programmed cell death as animal cells. (Microalgae in purple and apoptotic bodies as small dots.)
 Image Credit: Luisa Fernanda Corredor Arias

For the first time, researchers at Umeå University have observed the same type of programmed cell death in microalgae as in humans. The discovery, published in Nature Communications, shows that this central biological process is older than previously thought.

“This is the first photosynthetic organism, and the first single-cell organism, shown to produce so called apoptotic bodies during cell death. This proves that apoptosis, a pathway of programmed cell death which was thought to be unique to animals, is more ancient and widespread than previously believed,” says Christiane Funk, Professor at the Department of Chemistry, Umeå University.

Cells can die naturally from age or disease, but organisms can also actively trigger the death of certain cells when needed. This is known as programmed cell death (PCD), a central biological system that allows the development of organs in our bodies and provides advantage during an organism’s life cycle. One example is the differentiation of fingers in a developing human embryo; others are the control of cell numbers or the elimination of non-functional cells.

Zorin OS and Linux Mint: A Comparative Report

Image Credit: Scientific Frontline

Summary and Core Philosophies

In the expansive landscape of Linux distributions, Zorin OS and Linux Mint have distinguished themselves as premier choices, particularly for users seeking a refined and accessible desktop experience. Both are built upon the stable foundation of Ubuntu's Long-Term Support (LTS) releases, yet they diverge significantly in their core philosophies, development models, and ultimate value propositions. This report provides an exhaustive comparison of these two leading operating systems, designed to equip prospective users with the nuanced understanding required to make an informed decision.

Zorin OS is engineered as a polished on-ramp to the Linux world, explicitly targeting users transitioning from proprietary operating systems like Windows and macOS. Its development, led by the independent company Zorin Group, is commercially driven, funded primarily through the sale of a feature-rich "Pro" edition. This model dictates a strategic focus on immediate familiarity, aesthetic perfection, and the elimination of technical barriers.

What Is: Schizophrenia

 

Image Credit: Scientific Frontline

Beyond the Misconceptions

Schizophrenia is one of the most misunderstood mental health conditions. It is not, as commonly portrayed, a "split personality" (that is a separate, rare condition called dissociative identity disorder). Rather, schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. At its core, it is a disorder of cognition and reality testing, characterized by a "fracturing" of the mind's essential functions, leading to a disconnect from reality for the individual experiencing it.

Globally, schizophrenia affects approximately 24 million people, or 1 in 300 worldwide. It is a universal human illness that does not discriminate based on race, culture, or socioeconomic status.

Capturing 100 years of antibiotic resistance evolution

The team analysed the DNA from bacterial samples as far back as 1917, before antibiotics were discovered, to see how they had evolved since.
Photo Credit: Edward Jenner

Researchers have dived into the pre-antibiotic history of plasmids — one of bacteria’s tools of antimicrobial resistance — to understand how they have facilitated the spread of treatment-resistant infections worldwide.

Experts at the Wellcome Sanger Institute, the University of Bath, the UK Health Security Agency (UKHSA) and their collaborators, analyzed over 40,000 plasmids from historical and present-day bacterial samples taken across six continents, the largest dataset of its kind.

Plasmids are transferable structures in bacteria that allow different strains to share genetic information. In this study, published in Science, researchers found that a minority of plasmids causes most of the multidrug resistance in the world. In the future, developing ways to target these could lead to new therapies to combat treatment-resistant infections worldwide.

Currently, treatment-resistant infections cause at least one million deaths worldwide every year, with this number expected to rise. While some bacteria and fungi carry antimicrobial resistance (AMR) genes naturally, the emergence and spread of MDR and AMR genes has been consistently linked to the use of antibiotics.

Study reveals how a single protein rewires leukemia cells to fuel their growth

IGF2BP3 IHC performed on a B-cell acute lymphoblastic leukemia (B-ALL) case; blasts are positive while normal hematopoietic cells are negative.
Image Credit: Courtesy of the Rao Lab.

Cancer cells are relentless in their quest to grow and divide, often rewiring their metabolism and modifying RNA to stay one step ahead. Now, researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a single protein, IGF2BP3, that links these two processes together in leukemia cells. The protein shifts how cells break down sugar, favoring a fast but inefficient energy pathway, while also altering RNA modifications that help produce the proteins leukemia cells need to survive and multiply.

The discovery published in Cell Reports, positions IGF2BP3 as a “master switch” in leukemia, linking metabolism and RNA regulation, processes long thought to operate independently. Understanding this connection could pave the way for new therapies aimed at cutting off the energy and survival pathways that cancer cells depend on.

Brain inflammation treatment could be ally in fight against dementia

Samira Aghlara-Fotovat
Photo Credit: Jeff Fitlow/Rice University

Scientists from Rice University and Houston Methodist have developed a new way to reduce inflammation in the brain, a discovery that could help fight diseases such as Alzheimer’s and Parkinson’s.

The team created “AstroCapsules,” small hydrogel capsules that enclose human astrocytes ⎯ star-shaped brain cells that support healthy nervous system function. Inside the capsules, the cells were engineered to release interleukin-1 receptor antagonist, an anti-inflammatory protein. Tests in human brain organoids and mouse models showed the treatment lowered neuroinflammation and resisted immune rejection.

Rice bioengineer Omid Veiseh, whose lab studies how to design biomaterials that work with the immune system, is co-corresponding author on the paper published in Biomaterials.

“Encapsulating cells in a way that shields them from immune attack has been a central challenge in the field,” said Veiseh, professor of bioengineering at Rice, Cancer Prevention and Research Institute of Texas Scholar and director of the Rice Biotech Launch Pad. “In our lab, we have been working on biomaterials for many years, and this project was an opportunity to draw from that experience to address the uniquely complex immune environment of the brain. Our hope is that this work will help move cell therapies closer to becoming real treatment options for patients with neurodegenerative disease.”

Lung-on-a-Chip Defends Itself

Ankur Singh and Rachel Ringquist point to the microscopic lung-on-a-chip that has a built-in immune system.
Photo Credit: Courtesy of Georgia Institute of Technology

On a clear polymer chip, soft and pliable like a gummy bear, a microscopic lung comes alive — expanding, circulating, and, for the first time, protecting itself like a living organ. 

For Ankur Singh, director of Georgia Tech’s Center for Immunoengineering, watching immune cells rush through the chip took his breath away. Singh co-directed the study with longtime collaborator Krishnendu “Krish” Roy, former Regents Professor and director of the NSF Center for Cell Manufacturing Technologies at Tech and now the Bruce and Bridgitt Evans dean of engineering and University Distinguished Professor at Vanderbilt University. Rachel Ringquist, Roy’s graduate student, and now a postdoctoral fellow with Singh, led the work as part of her doctoral dissertation. 

“That was the ‘wow’ moment,” Singh said. “It was the first time we felt we had something close to a real human lung.”

Lung-on-a-chip platforms provide researchers a window into organ behavior. They are about the size of a postage stamp, etched with tiny channels and lined with living human cells. Roy and Singh’s innovation was adding a working immune system — the missing piece that turns a chip into a true model of how the lung fights disease.

Now, researchers can watch how lungs respond to threats, how inflammation spreads, and how healing begins.

Captivity makes salmon less symmetrical

Photo Credit: Courtesy of Cardiff University

The stress of captivity is likely to be causing reared salmon to be less symmetrical in appearance, according to a new study.

Research by the University of Eastern Finland, Natural Resources Institute Finland, and Cardiff University has found that salmon reared in captivity are more asymmetrical in appearance compared to wild salmon, suggesting that captive fish are more stressed, and their appearance might have impacts on salmon in the wild.

Currently, hatcheries are used in some countries to help boost wild populations with captive reared salmon. Global sales of aquatic species reared in captivity for food are also worth over $300 billion annually, with the Atlantic salmon being the most valuable of these species.

Climate change is supercharging Europe’s biggest hail

Climate experts from Newcastle University, the Met Office and the University of Bristol used European-wide km-scale simulations to model future changes to hail with global warming. Published in the journal Nature Communications, the findings show that, under a high-emissions scenario (RCP8.5), severe hail is likely to become less common, except potentially for very large hail.

Severe hail has a diameter of 2 cm, while a diameter of 5 cm or more is considered very large. Bigger hailstones cause more damage than smaller ones, and even a small increase in their size could outweigh any benefits from having fewer hailstorms overall.  

The researchers attribute this decrease to more than one factor. Hail forms higher in the atmosphere as it warms, where storm updrafts could be weaker, and this gives hail more time to melt before reaching the ground. Another factor is the weakening large scale circulation, affecting the vertical profile of winds and leading to environments not beneficial for thunderstorm organization.

Importantly, the authors found that future warm seasons feature a warmer thunderstorm type similar to hail-producing storms found in the tropics, where the largest hailstones can still reach the surface. The findings suggest that, in the future, these storms will become most frequent over southern Europe, leading to regional increases in severe hail frequency.