Treatment for blinding blood vessel condition yields lasting vision improvement

A Penn State College of Medicine researcher and colleagues found that a treatment for retinal vein occlusion — one of the most common blinding conditions in the United States — may lead to long-term vision improvement.
Credit: Penn State College of Medicine / Penn State.

A treatment for retinal vein occlusion (RVO) — one of the most common blinding conditions in the United States — may lead to long-term vision improvement, according to new research published by a Penn State College of Medicine researcher and colleagues.

Without treatment, central retinal vein occlusion, the most severe type of retinal vein occlusion, often leads to significant and permanent vision loss. The disease can cause obstruction of the veins carrying blood away from the retina, the light-sensitive tissue at the back of the eye. This can lead to macular edema, where fluid becomes trapped within and under the retina, leading to rapid and severe loss of visual acuity. Injections of anti-vascular endothelial growth factor (anti-VEGF) drugs may help control blood vessel leakage and swelling in the retina and are considered the most effective treatment.

A report on five-year outcomes of the Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2), was published in the American Journal of Ophthalmology. Dr. Ingrid Scott, Jack and Nancy Turner Professor of Ophthalmology and professor of public health sciences, received more than $11 million from the National Eye Institute, a part of the National Institutes of Health, to lead the study.

Dog coronavirus jumps to humans, with a protein shift

N-terminus: The end of a peptide or protein primary structure in which the amino acid residue is not part of a peptide bond. The terminal group is often (but not always) an amine or ammonium cation.
Image Credit: Courtesy of Cornell University

Scientific Frontline: "At a Glance" Summary: Zoonotic Spillover of Canine Coronavirus

• Main Discovery: Researchers discovered a molecular shift in the N-terminus of the canine coronavirus spike protein, specifically the loss of the O-domain, which transforms the virus from a gastrointestinal and respiratory pathogen in animals to an exclusively respiratory pathogen in humans.
• Methodology: Scientists utilized advanced molecular evolution tools to evaluate natural selection pressures on the virus, comparing the genetic sequence of the canine coronavirus to related strains to identify the specific loss of the sialic acid-binding O-domain.
• Key Data: The modified canine coronavirus was initially identified in two Malaysian human patients with pneumonia between 2017 and 2018, and a similar variant was detected in Haiti in 2021, potentially marking it as the eighth known human coronavirus.
• Significance: The findings reveal a repeating evolutionary pattern of relaxed selection where coronaviruses lose their gastrointestinal binding capabilities to successfully jump to alternative hosts and establish respiratory infections.
• Future Application: Recognizing this tropism shift provides a critical framework for researchers to monitor the N-terminus domain of spike proteins, including in SARS-CoV-2, to predict, track, and potentially neutralize future zoonotic spillovers.
• Branch of Science: Virology, Evolutionary Biology, Veterinary Medicine
• Additional Detail: While the primary receptor for the Alphacoronavirus genus to enter human cells is APN, it is the degradation of the sialic acid co-receptor function within the O-domain that facilitates this specific transition to a human respiratory pathogen.

New nanotech imaging tool may allow smartphone disease diagnosis

This new technology could allow people to use the camera on their smartphone to diagnose diseases.
Credit: TMOS

Scientists have developed a low-cost microscopic imaging device small enough to fit on a smartphone camera lens, with the potential to make mobile medical diagnosis of diseases affordable and accessible.

Research published today in ACS Photonics from researchers at the University of Melbourne and the Australian Research Council Centre of Excellence for Transformative Meta-Optical Systems (TMOS), is helping miniaturize phase-imaging technology using metasurfaces, which are only a few hundred nanometers thick – about 350 times thinner than the thickness of a human hair – thus small enough to fit in the lens of a smartphone or other small camera.

The detection of diseases often relies on optical microscope technology to investigate changes in biological cells. Currently, these investigation methods usually involve staining the cells with chemicals in a laboratory environment as well as using specialized ‘phase-imaging’ microscopes. These aim to make invisible aspects of a biological cell visible, so early-stage detection of disease becomes possible. However, phase-imaging microscopes are bulky and cost thousands of dollars, putting them out of reach of remote medical practices.

‘Resetting’ the injured brain offers clues for concussion treatment

Jonathan Godbout, professor of neuroscience
Credit: Ohio State University

New research in mice raises the prospects for development of post-concussion therapies that could ward off cognitive decline and depression, two common conditions among people who have experienced a moderate traumatic brain injury.

The study in mice clarified the role of specific immune cells in the brain that contribute to chronic inflammation. Using a technique called forced cell turnover, researchers eliminated these cells in the injured brains of mice for a week and then let them repopulate for two weeks.

“It’s almost like hitting the reset button,” said senior study author Jonathan Godbout, professor of neuroscience in The Ohio State University College of Medicine.

Compared to brain-injured mice recovering naturally, mice that were given the intervention showed less inflammation in the brain and fewer signs of thinking problems 30 days after the injury.

Though temporarily clearing away these cells, called microglia, in humans isn’t feasible, the findings shed light on pathways to target that could lower the brain’s overall inflammatory profile after a concussion, potentially reducing the risk for behavioral and cognitive problems long after the injury.

“In a moderate brain injury, if the CT scan doesn’t show damage, patients go home with a concussion protocol. Sometimes people come back weeks, months later with neuropsychiatric issues. It’s a huge problem affecting millions of people,” said Godbout, faculty director of Ohio State’s Chronic Brain Injury Program and assistant director of basic science in the Institute for Behavioral Medicine Research.

Hydroponic native plants to detox PFAS-contaminated water

PFAS can be removed from contaminated water by Australian native rushes.

They’re the non-stick on Teflon cookware, the stain resistance in Scotchgard, and the suppression factor in firefighting foam, but while the staying power of PFAS chemicals was once revered, it’s now infamous as PFAS substances continue to infiltrate the environment and affect human health.

Now, new research from the University of South Australia is helping to remediate the ‘indestructible’ PFASs as scientists show that Australian native plants can significantly remediate PFAS pollutants through floating wetlands to create healthier environments for all.

Conducted in partnership with CSIRO and the University of Western Australia, the research found that PFAS chemicals (per- and poly-fluoroalkyl substances) can be removed from contaminated water via Australian native rushes - Phragmites australis, Baumea articulata, and Juncus kraussii.

Phragmites australis, otherwise known as the common reed, removed legacy PFAS contaminants by 42-53 per cent from contaminated surface water (level: 10 µg/L).

Decreased Genetic Diversity in Immune System Could Impact Endangered Toad Survival

Anaxyrus baxteri, the Wyoming toad.

A new study from North Carolina State University examines immune system diversity in the critically endangered Wyoming toad and finds that genetic bottlenecks could impact a species’ ability to respond to new pathogens. The findings could inform captive breeding strategies for endangered animal populations.

The Wyoming toad, Anaxyrus baxteri, suffered a severe population decline throughout the latter part of the 20th century due to factors including habitat destruction and fungal infection. The toad was brought into a captive breeding program in the 1990s in order to save the species. Scientists estimate a current wild population of only 400 to 1,500 animals, meaning that the toad is considered critically endangered.

“Population reduction in this species created a genetic bottleneck to begin with, meaning the level of genetic diversity is already very small,” says Jeff Yoder, professor of comparative immunology at NC State and co-corresponding author of a paper describing the work. “This is the first study to look specifically at genetic diversity in the immune systems of these toads and how it could impact them as a population.”

Yoder, with co-corresponding author Alex Dornburg of the University of North Carolina at Charlotte, performed RNA sequencing on immune tissues from three healthy, retired Wyoming toad breeders. Study co-author Michael Stoskopf, who was on the Wyoming Toad Recovery Implementation Team established in 2008, obtained the samples.

Search reveals eight new sources of black hole echoes

In this illustration, a black hole pulls material off a neighboring star and into an accretion disk.
Credits: Aurore Simonnet and NASA’s Goddard Space Flight Center

Scattered across our Milky Way galaxy are tens of millions of black holes — immensely strong gravitational wells of spacetime, from which infalling matter, and even light, can never escape. Black holes are dark by definition, except on the rare occasions when they feed. As a black hole pulls in gas and dust from an orbiting star, it can give off spectacular bursts of X-ray light that bounce and echo off the inspiraling gas, briefly illuminating a black hole’s extreme surroundings.

Now MIT astronomers are looking for flashes and echoes from nearby black hole X-ray binaries — systems with a star orbiting, and occasionally being eaten away by, a black hole. They are analyzing the echoes from such systems to reconstruct a black hole’s immediate, extreme vicinity.

In a study appearing today in the Astrophysical Journal, the researchers report using a new automated search tool, which they’ve coined the “Reverberation Machine,” to comb through satellite data for signs of black hole echoes. In their search, they have discovered eight new echoing black hole binaries in our galaxy. Previously, only two such systems in the Milky Way were known to emit X-ray echoes.

In comparing the echoes across systems, the team has pieced together a general picture of how a black hole evolves during an outburst. Across all systems, they observed that a black hole first undergoes a “hard” state, whipping up a corona of high-energy photons along with a jet of relativistic particles that is launched away at close to the speed of light. The researchers discovered that at a certain point, the black hole gives off one final, high-energy flash, before transitioning to a “soft,” low-energy state.

Researchers Create Self-Assembled Logic Circuits from Proteins

In a proof-of-concept study, researchers have created self-assembled, protein-based circuits that can perform simple logic functions. The work demonstrates that it is possible to create stable digital circuits that take advantage of an electron’s properties at quantum scales.

One of the stumbling blocks in creating molecular circuits is that as the circuit size decreases the circuits become unreliable. This is because the electrons needed to create current behave like waves, not particles, at the quantum scale. For example, on a circuit with two wires that are one nanometer apart, the electron can “tunnel” between the two wires and effectively be in both places simultaneously, making it difficult to control the direction of the current. Molecular circuits can mitigate these problems, but single-molecule junctions are short-lived or low-yielding due to challenges associated with fabricating electrodes at that scale.

“Our goal was to try and create a molecular circuit that uses tunneling to our advantage, rather than fighting against it,” says Ryan Chiechi, associate professor of chemistry at North Carolina State University and co-corresponding author of a paper describing the work.

Global warming accelerates the water cycle, with relevant climatic consequences

Global warming could lead to a destabilization of the global climate system
Credit: /ICM-CSIC.

According to a new study led by the ICM-CSIC, this could lead to a destabilization of the global climate system, an intensification of storms in specific areas, and an acceleration of ice melting at the poles.

Researchers at the Institut de Ciències del Mar (ICM-CSIC) in Barcelona have found that global warming is accelerating the water cycle, which could have significant consequences on the global climate system, according to an article published recently in the journal Scientific Reports.

This acceleration of the water cycle is caused by an increase in the evaporation of water from the seas and oceans resulting from the rise in temperature. As a result, more water is circulating in the atmosphere in its vapor form, 90 per cent of which will eventually precipitate back into the sea, while the remaining 10 per cent will precipitate over the continent.

New Model for Antibacterial Mechanism

Brookhaven Lab biologist Paul Freimuth and co-author Feiyue Teng, a scientist in Brookhaven Lab's Center for Functional Nanomaterials (CFN), at the light microscope used to image bacteria in this study.
Credit: Brookhaven National Laboratory

Biologists at the U.S. Department of Energy’s Brookhaven National Laboratory and their collaborators have discovered an aberrant protein that’s deadly to bacteria. In a paper just published in the journal PLOS ONE, the scientists describe how this erroneously built protein mimics the action of aminoglycosides, a class of antibiotics. The newly discovered protein could serve as a model to help scientists unravel details of those drugs’ lethal effects on bacteria—and potentially point the way to future antibiotics.

“Identifying new targets in bacteria and alternative strategies to control bacterial growth is going to become increasingly important,” said Brookhaven biologist Paul Freimuth, who led the research. Bacteria have been developing resistance to many commonly used drugs, and many scientists and doctors have been concerned about the potential for large-scale outbreaks triggered by these antibiotic-resistant bacteria, he explained.

“What we’ve discovered is a long way from becoming a drug, but the first step is to understand the mechanism,” Freimuth said. “We’ve identified a single protein that mimics the effect of a complex mixture of aberrant proteins made when bacteria are treated with aminoglycosides. That gives us a way to study the mechanism that kills the bacterial cells. Then maybe a new family of inhibitors could be developed to do the same thing.”

Revealing the secret language of dark matter

In the Universe, dark matter and standard matter “talk” to each other using a secret language. This “discussion” happens thanks to gravity, scientists say, but not in a way they can fully comprehend. A new SISSA study published in The Astrophysical Journal sheds light on this long-standing issue. The authors of the research, Ph.D Student Giovanni Gandolfi and supervisors Andrea Lapi and Stefano Liberati, propose a special property for dark matter called “non-minimal coupling with gravity”. This new type of interaction can modify dark matter gravitational influence on standard 'baryonic' matter.

According to the authors, the 'non-minimal coupling' could be the key to decrypting the enigmatic dialogue between the two components, possibly solving one of the biggest open questions about dark matter's nature. To prove the hypothesis, the assumption has been tested and then confirmed with experimental data from thousands of spiral galaxies.

The mysterious interplay with standard matter

“Dark matter is everywhere” says the research’s authors. “Like a cosmic scaffolding, it interconnects the Universe and holds galaxies together. Dark matter is as important as mysterious, though. Possibly, one of dark matter's greatest enigmas is its interplay with standard matter, or 'baryons'”. We know that in this dialogue gravity has an important role, but scientists still don’t entirely understand the phenomenon. “For this reason,” say Gandolfi, Lapi and Liberati “we asked ourselves: is gravity wrong or are we just missing something crucial about dark matter's nature? What if dark matter and standard 'baryonic' matter do not communicate in the way we have always imagined? With our research, we have tried to answer these intriguing questions”.

Fermilab engineers develop new control electronics for quantum computers that improve performance and cut costs

Gustavo Cancelo led a team of Fermilab engineers to create a new compact electronics board: It has the capabilities of an entire rack of equipment that is compatible with many designs of superconducting qubits at a fraction of the cost.
Photo: Ryan Postel, Fermilab

When designing a next-generation quantum computer, a surprisingly large problem is bridging the communication gap between the classical and quantum worlds. Such computers need specialized control and readout electronics to translate back and forth between the human operator and the quantum computer’s languages — but existing systems are cumbersome and expensive.

However, a new system of control and readout electronics, known as Quantum Instrumentation Control Kit, or QICK, developed by engineers at the U.S. Department of Energy’s Fermi National Accelerator Laboratory, has proved to drastically improve quantum computer performance while cutting the cost of control equipment.

“The development of the Quantum Instrumentation Control Kit is an excellent example of U.S. investment in joint quantum technology research with partnerships between industry, academia and government to accelerate pre-competitive quantum research and development technologies,” said Harriet Kung, DOE deputy director for science programs for the Office of Science and acting associate director of science for high-energy physics.

Engineers at UBC get under the skin of ionic skin

Dr. John Madden and Yuta Dobashi with one of the hydrogel sensors.
Photo by Kai Jacobson/UBC Faculty of Applied Science

In the quest to build smart skin that mimics the sensing capabilities of natural skin, ionic skins have shown significant advantages. They’re made of flexible, biocompatible hydrogels that use ions to carry an electrical charge. In contrast to smart skins made of plastics and metals, the hydrogels have the softness of natural skin. This offers a more natural feel to the prosthetic arm or robot hand they are mounted on, and makes them comfortable to wear.

These hydrogels can generate voltages when touched, but scientists did not clearly understand how — until a team of researchers at UBC devised a unique experiment, published in Science.

“How hydrogel sensors work is they produce voltages and currents in reaction to stimuli, such as pressure or touch – what we are calling a piezoionic effect. But we didn’t know exactly how these voltages are produced,” said the study’s lead author Yuta Dobashi, who started the work as part of his master’s in biomedical engineering at UBC.

Working under the supervision of UBC researcher Dr. John Madden, Dobashi devised hydrogel sensors containing salts with positive and negative ions of different sizes. He and collaborators in UBC’s physics and chemistry departments applied magnetic fields to track precisely how the ions moved when pressure was applied to the sensor.

Experts predict this hurricane season will only be slightly above average

Hurricane Ida, Tropical Storm Julian and Tropical Depression Ten - which intensified into Tropical Storm Kate on August 30 - as shown from NOAA's GOES-16 satellite on August 29, 2021.
Credit: NOAA

For the seventh year in a row, University of Arizona hurricane forecasters say to prepare for an above-average hurricane season, which runs from June 1 through Nov. 30. However, this year isn't expected to be as active as recent years.

The experts' forecast, released this month, shows 14 named storms and seven hurricanes developing over the Atlantic Ocean. Three of those seven hurricanes are expected to develop into major hurricanes – which are classified as category 3 or above. The UArizona experts also predict an accumulated cyclone energy, or ACE, index of 129 units. The ACE index provides a value for the combined strength and duration of a storm.

These predictions are only slightly higher than the seasonal median since 1980, which is 13 named storms and seven hurricanes, two of which are major hurricanes, and an ACE index of 107 units.

Professor of atmospheric sciences Xubin Zeng and former graduate student Kyle Davis developed their predictive model in 2014. It has since become one of the most accurate in the world for seasonal hurricane forecasting. It combines seasonal forecasts of sea surface temperature from the European Centre for Medium-Range Weather Forecasts with machine learning and the researchers' own understanding of hurricanes.

Higher COVID-19 Death Rates in the Southern U.S. Due to Behavior Differences

During the pre-Omicron phases of the COVID-19 pandemic, regions of the U.S. had markedly different mortality rates, primarily due to differences in mask use, school attendance, social distancing and other behaviors. Had the entire country reacted to the pandemic as the Northeast region, more than 316,000 deaths might have been avoided, 62% of those avoidable deaths being in the South.

The study, by Georgetown University’s School of Nursing & Health Studies researchers, appeared April 28, 2022, in PLOS ONE.

Excess mortality, which helps account for avoidable deaths from a new disease or situation, is defined by the difference between total current deaths and deaths expected based on earlier time period, usually the previous decade or so. The U.S. Centers for Disease Control and Prevention (CDC) calculate these numbers weekly. For this study, the CDC excess mortality data were analyzed for the period between January 3, 2020, to September 26, 2021. For regional comparison purposes, areas of the country were broken down into the Northeast, Midwest, South and West.

“Our goal was to carefully examine regional differences in COVID-19 death rates based on reliable statistical data,” says Michael Stoto, PhD, professor of Health Systems Administration and Population Health at the School of Nursing & Health Studies and corresponding author of the study. “Our study is the first to quantify avoidable deaths and confirm that both COVID-19 deaths and avoidable deaths disproportionately occurred in the South.”