What a reptile’s bones can teach us about Earth’s perilous past

An illustration of how Palacrodon may have looked.
Credit: K.M. Jenkins

An extinct reptile’s oddly shaped chompers, fingers, and ear bones may tell us quite a bit about the resilience of life on Earth, according to a new study.

In fact, paleontologists at Yale, Sam Houston State University, and the University of the Witwatersrand say the 250-million-year-old reptile, known as Palacrodon, fills in an important gap in our understanding of reptile evolution. It’s also a signal that reptiles, plants, and ecosystems may have fared better or recovered more quickly than previously thought after a mass extinction event wiped out most of the plant and animal species on the planet.

“We now know that Palacrodon comes from one of the last lineages to branch off the reptile tree of life before the evolution of modern reptiles,” said Kelsey Jenkins, a doctoral student in Yale’s Department of Earth and Planetary Sciences in the Faculty of Arts and Sciences and first author of the study, which appears in the Journal of Anatomy. “We also know that Palacrodon lived in the wake of the most devastating mass extinction in Earth’s history.”

That would be the Permian-Triassic extinction event, which occurred 252 million years ago. Known as “the Great Dying,” it killed off 70% of terrestrial species and 95% of marine species.

Although a large number of reptile species eventually bounced back from this extinction event, the details of how that happened are murky. Researchers have spent decades trying to fill in the gaps in our understanding of key adaptations that enabled reptiles to flourish after the Permian-Triassic extinction — and what those adaptations may reveal about the ecosystems where they lived.

Machine learning may enable bioengineering of the most abundant enzyme

Photo Credit: Melissa Askew

A Newcastle University study has for the first time shown that machine learning can predict the biological properties of the most abundant enzyme on Earth - Rubisco.

Rubisco (Ribulose-1,5-bisphosphate carboxylase/oxygenase) is responsible for providing carbon for almost all life on Earth. Rubisco functions by converting atmospheric CO2 from the Earth’s atmosphere to organic carbon matter, which is essential to sustain most life on Earth.

For some time now, natural variation has been observed among Rubisco proteins of land plants and modelling studies have shown that transplanting Rubisco proteins with certain functional properties can increase the amount of atmospheric CO2 crop plants can uptake and store.

Study lead author, Wasim Iqbal, a PhD researcher at Newcastle University’s School of Natural and Environmental Sciences, part of Dr Maxim Kapralov’s group, developed a machine learning tool which can predict the performance properties of numerous land plant Rubisco proteins with surprisingly good accuracy. The hope is that this tool will enable the hunt for a ‘supercharged’ Rubisco protein that can be bioengineered into major crops such as wheat.

The majority of reindeer grazing land is under cumulative pressures

 Male reindeer walking on a national road in Jämtland, Sweden.
Credit: Marianne Stoessel/Stockholm University.

Reindeer herding has a long history in northern Norway, Sweden and Finland. It has shaped the Fennoscandian mountain landscape, and is also seen as a means to mitigate climate change effects on vegetation. Yet a new study published in Scientific Reports shows that the majority of this grazing land is exposed to cumulative pressures, threatened by the expansion of human activities towards the north.

The grazing land in northern Fennoscandia is increasingly disturbed by cumulative land-use pressures. Intensive forestry, outdoor tourism, road and railway traffic, but also mining and wind farms are developing in the north. The newly published study has mapped and estimated the overall extent of these cumulative pressures, together with other stressors, namely predator presence and climate change.

Previous studies have mostly focused at regional scales, here the authors have used an integrated large-scale GIS analysis over three countries: Norway, Sweden and Finland. Their results suggest that about 60 per cent of the region is subjected to multiple pressures, and that 85 per cent is exposed to at least one pressure. This dramatically reduces the size and the quality of the summer grazing area. The study found that only 4 per cent of the area still remains undisturbed.

How Stiff Is the Proton?

Compton scattering setup at the High Intensity Gamma Ray Source. The central cylinder is the liquid hydrogen target. High energy gamma rays are scattered from the liquid hydrogen into eight large detectors that measure the gamma rays’ energy.
Image courtesy of Mohammad Ahmed, North Carolina Central University and Triangle Universities Nuclear Laboratory

The proton is a composite particle made up of fundamental building blocks of quarks and gluons. These components and their interactions determine the proton’s structure, including its electrical charges and currents. This structure deforms when exposed to external electric and magnetic (EM) fields, a phenomenon known as polarizability. The EM polarizabilities are a measure of the stiffness against the deformation induced by EM fields. By measuring the EM polarizabilities, scientists learn about the internal structure of the proton. This knowledge helps to validate scientific understanding of how nucleons (protons and neutrons) form by comparing the results to theoretical descriptions of gamma-ray scattering from nucleons. Scientists call this scattering process nucleon Compton scattering.

When scientists examine the proton at a distance and scale where EM responses dominate, they can determine values of EM polarizabilities with high precision. To do so, they use the theoretical frame of Effective Field Theories (EFTs). The EFTs hold the promise of matching the description of the nucleon structure at low energies to the current theory of the strong nuclear force, called quantum chromodynamics (QCD). In this research, scientists validated EFTs using proton Compton scattering. This approach also validated the framework and methodology that underlie EFTs.

Proton Compton scattering is the process by which scientists scatter circularly or linearly polarized gamma rays from a hydrogen target (in this case, a liquid target), then measure the angular distribution of the scattered gamma rays. High-energy gamma rays carry strong enough EM fields that the response of the charges and currents in the nucleon becomes significant. In this study, scientists performed new measurements of Compton scattering from the proton at the High Intensity Gamma Ray Source (HIGS) at the Triangle Universities Nuclear Laboratory. This work provided a novel experimental approach for Compton scattering from the proton at low energies using polarized gamma rays. The study advances the need for new high-precision measurements at HIGS to improve the accuracy of proton and neutron polarizabilities determinations. These measurements validate the theories which link the low-energy description of nucleons to QCD.

Funding:
This work was funded by the Department of Energy Office of Science, the National Science Foundation, the U.K. Science and Technology Facilities Council Grants, and funds from the Dean of the Columbian College of Arts and Sciences at George Washington University and its Vice-President for Research. The researchers also acknowledge the financial support of the Natural Sciences and Engineering Research Council of Canada and the support of Eugen-Merzbacher Fellowship.

Publications:
X. Li et al., “Proton Compton Scattering from Linearly Polarized Gamma Rays”, Physical Review Letters. 

Source/Credit: U.S. Department of Energy

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Queen Mary chemical engineers have developed technologies to slash energy consumption in industry

Photo Credit: Quinten de Graaf

In two papers published in the journals Nature and Science, Queen Mary's Professor Livingston and Dr Zhiwei Jiang present their work on nanomembranes – exquisitely thin membranes that can provide an energy efficient alternative to current industry practices.

They demonstrate their technology can be used to refine crude oil and cannabidiol (CBD) oil – two industry giants. Around 80 million barrels of crude oil are processed every day to create fuel and plastic, in a process which consumes massive amounts of energy. The cannabidiol oil industry is fast growing - the Global Cannabidiol (CBD) Market is estimated to reach USD 47.22 Billion by 2028, up from USD 4.9 Billion in 2021.

Andrew Livingston, Professor of Chemical Engineering at Queen Mary, said: 'A vast amount of energy is consumed in industry separating molecules. The aim of our research is to provide low energy alternatives to these processes. Due to the innovations in the chemistry we used to make these membranes, we can achieve molecular architectures that achieve exquisite separations, and provide less resource intensive techniques for the separation of molecules.'

Dr Zhiwei Jiang, Research Associate at Queen Mary, said: 'Thinner is better - the liquid passes through the membranes much more quickly, rapidly speeding up the process, and therefore reducing the plant footprint while processing the same quantity of liquids.’

Chipping away at the many unknowns of obscure animal viruses

Patas monkeys are among the wild African monkeys believed to be natural reservoirs for the simian hemorrhagic fever virus. 
Photo Credit: Andrew S

Researchers have identified enough biological details about a virus endemic in African primates to suggest that this virus, which causes a hemorrhagic fever disease in monkeys, has decent potential to spill over to humans.

The findings suggest a surveillance program is warranted for citizens in Africa who may be at risk for exposure to the virus. But the study teaches a much larger lesson as well, researchers say: It’s never too early to start preparing for the next animal virus to come along and unexpectedly cause disease in people.

“There are a lot of unknown animal viruses out there that may pose risk to humans,” said Cody Warren, first author of the study and assistant professor of veterinary biosciences at The Ohio State University.

“We need to be prospectively looking at animal viruses that have been ignored to see if they have the capacity to replicate in human cells. If they do, will we continue to ignore them? I don’t think we should,” he said.

Warren completed this work at the University of Colorado Boulder as a postdoctoral researcher in the lab of senior author Sara Sawyer, professor of molecular, cellular & developmental biology.

Research finds link between poor health and low breast milk production

Photo Credit: seeseehundhund

Research from the University of Cincinnati shows that poor metabolic health parameters are linked to low breast milk production. The study was published in the journal Breastfeeding Medicine.

“We wanted to see if we could understand what stands out as different in these moms. So, we conducted a case control study to see why, despite their best efforts at doing everything right with breastfeeding, they were not making enough milk,” says Laurie Nommsen-Rivers, PhD, associate professor of nutrition, and the Ruth Rosevear Endowed Chair of Maternal and Child Nutrition in the UC College of Allied Health Sciences. “The prevailing dogma is if you try hard enough at breastfeeding, your body will be able to do this.”

Nommsen-Rivers and her team analyzed data from a randomized controlled trial from February 2015 to June 2016 involving women screened for a low-milk supply. Mothers who were aged 20 years or older and one to eight weeks postpartum with a healthy infant born at 37 weeks of gestation or later were included. Participants completed at-home infant test-weighing to measure milk output.

New Superconducting Qubit Testbed Benefits Quantum Information Science Development

A superconducting qubit sits in a dilution refrigerator in a Pacific Northwest National Laboratory (PNNL) physics lab. This experimental device is the first step in establishing a qubit testbed at PNNL.
  Photo Credit: Andrea Starr | Pacific Northwest National Laboratory

If you’ve ever tried to carry on a conversation in a noisy room, you’ll be able to relate to the scientists and engineers trying to “hear” the signals from experimental quantum computing devices called qubits. These basic units of quantum computers are early in their development and remain temperamental, subject to all manner of interference. Stray “noise” can masquerade as a functioning qubit or even render it inoperable.

That’s why physicist Christian Boutan and his Pacific Northwest National Laboratory (PNNL) colleagues were in celebration mode recently as they showed off PNNL’s first functional superconducting qubit. It’s not much to look at. Its case—the size of a pack of chewing gum--is connected to wires that transmit signals to a nearby panel of custom radiofrequency receivers. But most important, it’s nestled within a shiny gold cocoon called a dilution refrigerator and shielded from stray electrical signals. When the refrigerator is running, it is among the coldest places on Earth, so very close to absolute zero, less than 6 millikelvin (about −460 degrees F).

Stone spheres could be from Ancient Greek board game

Groups of spheres from Akrotiri
Photo Credit: Konstantinos Trimmis

Scientific Frontline: "At a Glance" Summary

• Main Discovery: Archaeologists from the University of Bristol have determined that mysterious stone spheres found in ancient Aegean settlements, specifically Akrotiri, are likely playing pieces from one of the earliest known board games.
• Methodology: The research team analyzed 700 stone spheres dating between 4,500 and 3,600 years old, examining specific features such as size, material, and color to identify usage patterns.
• Key Statistic: The analysis revealed that the stones consistently fit into two distinct size clusters (large and small), contradicting the multiple groupings that would be expected if they were used for a counting or record-keeping system.
• Context: This hypothesis aligns the artifacts with similar ancient board games from the Levant and Egypt, such as Mehen and Senet, replacing previous theories that the stones were used for slings or tossing.
• Significance: The specific deposition of the spheres in stone cavities (kernos) indicates they were objects of social importance, providing new evidence of social interaction and leisure in the Bronze Age Aegean.
• Future Application: Researchers plan to utilize artificial intelligence techniques to determine the actual gameplay mechanics and will apply clustering analysis to the associated stone slabs to verify the link.

Container for Hazardous Radioactive Waste Storage Model Created

According to Oleg Tashlykov, the container protects from radiation in all directions.
Photo Credit: Anastasia Farafontova

Ural Federal University scientists designed a container to store solidified liquid radioactive waste containing "long-lived" cesium-137 and cobalt-60, the most potentially dangerous of all radioactive waste. Due to their innovative design and filling, the simulated containers are capable of reducing radiation from radioactive waste to safe levels. One such container could replace five or six of the standard type. An article about the scientific work was published in the journal Progress in Nuclear Energy.

The modeled container consists of three main layers: a stainless steel inner capsule, halloysite clay filler, and an outer cementation concrete layer. The stainless steel capsule holds more than 450,000 cm3 of radioactive waste. Radionuclides are concentrated in a special sorbent, which is used in ion-selective purification and is placed inside the capsule. Stainless steel was chosen because, unlike carbon steel, it is more resistant to corrosion and does not require shielding.

"As a rule, such containers consist of two layers: outer cementation concrete and an inner metallic hosting capsule with a radioactive sorbent (or a sorbent in a cement matrix is placed inside the container). The main disadvantage of such a container arrangement is that their shielding, i.e. protective, capacity is limited. We suggest a three-layer container - with an additional layer between the inner metal capsule and the outer shell. The material that fills this space must be inexpensive and still effectively reduce the gamma radiation emitted by the radioisotopes inside the radioactive waste container. In this case, we investigated the protective properties of the intermediate layer consisting of halloysite - a fine-dispersed nanoscale white clay with a chemical composition rich in aluminum and silicon," says Oleg Tashlykov, Associate Professor at the Department of Nuclear Power Plants and Renewable Energy Sources at UrFU, Head of Research and one of the authors of the article.

Dual-targeting CAR NK cells can prevent cell dysfunction and tumor escape

 Katy Rezvani, M.D., Ph.D
Credit: The University of Texas MD Anderson Cancer Center.

Researchers at The University of Texas MD Anderson Cancer Center have developed a new approach to engineering natural killer (NK) cells with a second chimeric antigen receptor (CAR) to act as a logic gate, requiring two signals to eliminate a target cell. In preclinical studies, these next-generation CAR NK cells improved tumor specificity and enhanced anti-tumor activity by overcoming a process that contributes to NK cell dysfunction and tumor relapse.

This study, published in Nature Medicine, demonstrated that a normal physiological process called trogocytosis contributes to tumor escape and poor responses after CAR NK cell therapy by causing tumor antigen loss, NK cell exhaustion and fratricide — the killing of sibling CAR NK cells.

“We identified a novel mechanism of relapse following CAR NK cell therapy, and we also have developed a strategy to mitigate this process,” said corresponding author Katy Rezvani, M.D., Ph.D., professor of Stem Cell Transplantation & Cellular Therapy. “We engineered CAR NK cells with dual-targeting CARs that are able to ignore tumor antigens on the surface of their sibling NK cells acquired as a result of trogocytosis and selectively eliminate tumor cells.”

Rezvani and Ye Li, M.D., a graduate student in the Rezvani Lab, led the study.

During trogocytosis, surface proteins from a target cell are transferred to the surface of an immune cell, such as an NK cell or T cell, in order to regulate their activity. Using preclinical models, Li and colleagues showed that CAR activation promotes trogocytosis, resulting in the transfer and expression of tumor antigens on CAR NK cells.

Traumatic brain injury ‘remains a major global health problem’ say experts

Photo Credit: Ian Valerio

The report – the 2022 Lancet Neurology Commission – has been produced by world-leading experts, including co-lead author Professor David Menon from the Division of Anesthesia at the University of Cambridge.

 "Over the last decade, large international collaborations have provided important information to improve understanding and care of TBI. However, significant problems remain, especially in low- and middle-income countries"

David Menon

The Commission documents traumatic brain injury (TBI) as a global public health problem, which afflicts 55 million people worldwide, costs over US$400 billion per year, and is a leading cause of injury-related death and disability.

TBI is not only an acute condition but also a chronic disease with long-term consequences, including an increased risk of late-onset neurodegeneration, such as Parkinson’s disease and dementia. Road traffic incidents and falls are the main causes, but while in low- and middle-income countries, road traffic accidents account for almost three times the number of TBIs as falls, in high-income countries falls cause twice the number of TBIs compared to road traffic accidents. These data have clear consequences for prevention.

Over 90% of TBIs are categorized as ‘mild’, but over half of such patients do not fully recover by six months after injury. Improving outcome in these patients would be a huge public health benefit. A multidimensional approach to outcome assessment is advocated, including a focus on mental health and post-traumatic stress disorder. Outcome after TBI is poorer in females compared with males, but reasons for this are not clear.

Molecular chaperones caught in flagrante

For an adequate immune response, it is essential that T lymphocytes recognize infected or degenerated cells. They do so by means of antigenic peptides, which these cells present with the help of specialized surface molecules (MHC I molecules). Using X-ray structure analysis, a research team from Frankfurt has now been able to show how the MHC I molecules are loaded with peptides and how suitable peptides are selected for this purpose.

As task forces of the adaptive immune system, T lymphocytes are responsible for attacking and killing infected or cancerous cells. Such cells, like almost all cells in the human body, present on their surface fragments of all the proteins they produce inside. If these include peptides that a T lymphocyte recognizes as foreign, the lymphocyte is activated and kills the cell in question. It is therefore important for a robust T-cell response that suitable protein fragments are presented to the T lymphocyte. The research team led by Simon Trowitzsch and Robert Tampé from the Institute of Biochemistry at Goethe University Frankfurt has now shed light on how the cell selects these protein fragments or peptides.

Peptide presentation takes place on so-called major histocompatibility complex class I molecules (MHC I). MHC I molecules are a group of very diverse surface proteins that can bind myriads of different peptides. They are anchored in the cell membrane and form a peptide-binding pocket with their outward-facing part. Like all surface proteins, MHC I molecules take the so-called secretory pathway: they are synthesized into the cell's cavity system (endoplasmic reticulum (ER) and Golgi apparatus) and folded there. Small vesicles then bud off from the cavity system, migrate to the cell membrane and fuse with it.

Study reveals how COVID-19 damages the heart

Image Credit: Sanjay k j

University of Queensland researchers have discovered how COVID-19 damages the heart, opening the door to future treatments.

This initial study – featuring a small cohort – found COVID-19 damaged the DNA in cardiac tissue, which wasn’t detected in influenza samples.

UQ Diamantina Institute researcher Dr Arutha Kulasinghe said the team found while COVID-19 and influenza are both severe respiratory viruses, they appeared to affect cardiac tissue very differently.

“In comparison to the 2009 flu pandemic, COVID has led to more severe and long-term cardiovascular disease but what was causing that at a molecular level wasn’t known,” Dr Kulasinghe said.

“During our study, we couldn’t detect viral particles in the cardiac tissues of COVID-19 patients, but what we found was tissue changes associated with DNA damage and repair.

“DNA damage and repair mechanisms foster genomic instability and are related to chronic diseases such as diabetes, cancer, atherosclerosis and neurodegenerative disorders, so understanding why this is happening in COVID-19 patients is important.”

Paleontologists Found Mammoth Baby, Ancient Bear Teeth, and Lair of Cave Hyenas

Scientists will open a new expedition season in spring.
Photo credit: TASS-Ural Press Center / Vladislav Burnashev

Paleontologists of Ural Federal University and the Institute of Plant and Animal Ecology of Ural Branch of Russian Academy of Sciences during summer expeditions found a large number of ancient bones, teeth, as well as wool and skin of a mammoth baby. The study of remains will allow us to recreate the specifics of the flora and fauna of ancient times in detail and to understand the specifics of animal nutrition. Scientists told about the results of summer expeditions at a press conference in TASS.

On the Gyda Peninsula (Far North), paleontologists found the well-preserved remains of a mammoth baby. The uniqueness of the discovery is its age - it is a six-year-old mammoth baby. If previously only single bones were found, now the researchers have found material that will help study mammoth babies, said Pavel Kosintsev, a leading expert of the Laboratory of Natural Science Methods in Humanities of UrFU, a Senior Researcher of the Institute of Plant and Animal Ecology of the Ural Branch of the Russian Academy of Sciences.