Reprogrammable materials selectively self-assemble

With just a random disturbance that energizes the cubes, they selectively self-assemble into a larger block. 

Credit: MIT CSAIL

While automated manufacturing is ubiquitous today, it was once a nascent field birthed by inventors such as Oliver Evans, who is credited with creating the first fully automated industrial process, in flour mill he built and gradually automated in the late 1700s. The processes for creating automated structures or machines are still very top-down, requiring humans, factories, or robots to do the assembling and making.

However, the way nature does assembly is ubiquitously bottom-up; animals and plants are self-assembled at a cellular level, relying on proteins to self-fold into target geometries that encode all the different functions that keep us ticking. For a more bio-inspired, bottom-up approach to assembly, then, human-architected materials need to do better on their own. Making them scalable, selective, and reprogrammable in a way that could mimic nature’s versatility means some teething problems, though.

Now, researchers from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) have attempted to get over these growing pains with a new method: introducing magnetically reprogrammable materials that they coat different parts with — like robotic cubes — to let them self-assemble. Key to their process is a way to make these magnetic programs highly selective about what they connect with, enabling robust self-assembly into specific shapes and chosen configurations.

Genes that influence dyslexia

A large-scale gene study identifies series of DNA variants linked to dyslexia

An international team of scientists, including researchers at the University of Edinburgh and the Max Planck Institute for Psycholinguistics in Nijmegen (Netherlands), has for the first time pinpointed a large number of genes that are reliably associated with dyslexia. Around a third of the 42 genetic variants identified have been previously linked to general cognitive abilities and educational attainment. The researchers say their findings may aid our understanding of the biology behind why some children struggle to read or spell.

Dyslexia is known to run in families – partly because of genetic factors – but, until now, little was known about the identities of the genes involved. The new study, led by the University of Edinburgh and published in the journal Nature Genetics, represents the largest molecular genetic investigation of dyslexia to date. Previous studies linking dyslexia to individual genes have been carried out with much smaller numbers of families and the evidence was unclear, the research team says.

The team analyzed DNA from more than 50,000 adults who have been diagnosed with dyslexia and more than one million adults who have not, identified via collaboration with the US company, 23andMe, Inc. “Over several decades of earlier research, more limited genetic investigations of dyslexia gave us tantalizing first clues to how DNA may be involved.” notes Simon Fisher, director of the Language and Genetics department at the Max Planck Institute. “Now, largescale genomic studies of this kind promise to transform understanding of how our genes help us learn to read and write.”

Alligators Exposed to PFAS Show Autoimmune Effects

Photo Credit: Jack Kelly

A recent study of alligators in the Cape Fear River found the animals had elevated levels of 14 different per- and polyfluoroalkyl (PFAS) chemicals in their blood serum, as well as clinical and genetic indicators of immune system effects. The work adds to the body of evidence connecting PFAS exposure with adverse immune system effects.

The research team, led by Scott Belcher, associate professor of biology at North Carolina State University, took blood samples and did health evaluations on 49 alligators living along the Cape Fear River between 2018 and 2019. They compared these results to a reference population of 26 alligators from Lake Waccamaw, located in the adjoining Lumber River basin.

“We looked at 23 different PFAS and saw clear differences between both types and levels of PFAS in the two populations,” Belcher says. “We detected an average of 10 different PFAS in the Cape Fear River samples, compared to an average of five different PFAS in the Lake Waccamaw population.

“Additionally, blood concentrations of fluoroethers such as Nafion byproduct 2 were present at higher concentrations in alligators from the Cape Fear River basin, whereas these levels were much lower – or not detected – in alligators from Lake Waccamaw. Our data showed that as we moved downstream from Wilmington to Bald Head Island, overall PFAS concentrations decreased.”

A pandemic ‘baby bump’ is happening in the U.S.

The birth rate increase in 2021 was driven largely by women having their first births and women with a college education who may have been more likely to benefit from working from home.
Photo credit: PublicDomainPictures

Do you have a friend, coworker or family member who recently welcomed a new baby? If so, they’re part of a nationwide trend. In the wake of the COVID-19 pandemic, the U.S. has experienced a subtle “baby bump,” according to a new paper published in the journal National Bureau of Economic Research; co-authored by Northwestern University economist Hannes Schwandt.

Schwandt and his coauthors — Martha Bailey of UCLA and Janet Currie of Princeton University — recently analyzed demographic data covering all U.S. births from 2015 through 2021 and all births in California from 2015 through August 2022. They found that birthrates in the U.S. declined slightly as lockdowns began in early 2020, but rose again in 2021 to create a net increase of 46,000 births above the pre-pandemic trend across the two years combined.

The decrease when lockdowns began in 2020 — nine months too early to represent a fertility response to the pandemic — were mostly due to fewer foreign-born women entering the United States as immigrants and having children here, according to the study.

Our brains use quantum computation

Scientists from Trinity believe our brains could use quantum computation after adapting an idea developed to prove the existence of quantum gravity to explore the human brain and its workings. The discovery may shed light on consciousness, the workings of which remain scientifically difficult to understand and explain. Quantum brain processes could also explain why we can still outperform supercomputers when it comes to unforeseen circumstances, decision making, or learning something new

Scientists from Trinity believe our brains could use quantum computation after adapting an idea developed to prove the existence of quantum gravity to explore the human brain and its workings.

The brain functions measured were also correlated to short-term memory performance and conscious awareness, suggesting quantum processes are also part of cognitive and conscious brain functions.

If the team’s results can be confirmed – likely requiring advanced multidisciplinary approaches –they would enhance our general understanding of how the brain works and potentially how it can be maintained or even healed. They may also help find innovative technologies and build even more advanced quantum computers.

New Chemosensors Can Detect Heavy Metals in the Body and Environment

According to Grigory Zyryanov, industrial partners, including foreign ones, are interested in the developments.
Photo credit: Anna Marinovich

Ural scientists are developing chemosensors for the diagnosis and therapy of various diseases. These are compounds that change their luminescent properties upon external exposure or contact with organic cells. They can be used to find and suppress cancer cells, diagnose cardiovascular diseases, and determine the level of sugar or drugs in the blood. One of the new developments of scientists from the UrFU is chemosensors for controlling the content of metals in the blood, since an overdose of metals can be dangerous for the body. Grigory Zyryanov, professor at the Department of Organic and Biomolecular Chemistry at Ural Federal University, spoke about this on the air of Komsomolskaya Pravda radio.

"One of our activities is the creation of chemosensors for the detection of zinc cations in biological fluids, including blood. Zinc is involved in many physiological processes in the body; it is necessary for normal growth and stabilization of cell membranes. In some cases, such as colds, taking zinc supplements can help boost the body's immune response and speed recovery. However, it is necessary to control zinc levels, since zinc overdose is toxic for the body," explains Grigory Zyryanov.

Thinnest ferroelectric material ever paves the way for new energy-efficient devices

A representation of a two-dimensional ferroelectric material.
Image credit: UC Berkeley/Suraj Cheema.

As electronic devices become smaller and smaller, the materials that power them need to become thinner and thinner. Because of this, one of the key challenges scientists face in developing next-generation energy-efficient electronics is discovering materials that can maintain special electronic properties at an ultrathin size.

Advanced materials known as ferroelectrics present a promising solution to help lower the power consumed by the ultrasmall electronic devices found in cell phones and computers. Ferroelectrics — the electrical analog to ferromagnets — are a class of materials in which some of the atoms are arranged off-center, leading to a spontaneous internal electric charge or polarization. This internal polarization can reverse its direction when scientists expose the material to an external voltage. This offers great promise for ultralow-power microelectronics.

Unfortunately, conventional ferroelectric materials lose their internal polarization below around a few nanometers in thickness. This means they are not compatible with current-day silicon technology. This issue has previously prevented the integration of ferroelectrics into microelectronics.

But now a team of researchers from the University of California at Berkeley performing experiments at the U.S.

Deeper understanding of the icy depths

Frazil ice formed below the ocean surface drives the generation of cold dense water.
Photo credit: Masato Ito

Scientific Frontline: "At a Glance" Summary: Deeper Understanding of the Icy Depths

• Main Discovery: Researchers discovered that frazil ice, which forms beneath the ocean surface, is a primary driver in generating the dense, cold Antarctic Bottom Water that sinks to the seabed and fuels global ocean circulation.
• Methodology: The research team utilized a combination of continuous satellite monitoring and data collected from moored sensors placed directly in the ocean near Cape Darnley in Antarctica.
• Key Data: The formation of frazil ice and the subsequent water cooling process can occur at surprising depths reaching 80 meters or more beneath the ocean surface.
• Significance: Because Antarctic Bottom Water is the coldest and densest water mass flooding the global abyss, uncovering its hidden underwater formation mechanisms is critical for predicting how global warming will disrupt worldwide climate and ocean circulation patterns.
• Future Application: These findings will be integrated into future models of Southern Ocean biogeochemistry and carbon circulation to better understand how melting ice releases sediment and nutrients that fertilize marine plankton.
• Branch of Science: Earth Science, Oceanography, and Environmental Science.
• Additional Detail: The critical underwater cooling process is heavily accelerated by strong winds from severely cold Antarctica blowing over open water areas within the pack ice, which are known as polynyas.

Electroshock Therapy More Successful for Depression than Ketamine

Electroconvulsive therapy, often viewed with skepticism by members of the public, outperforms the drug ketamine in treating depression, according to a new report.
Credit: Tiago Bandeira

An analysis of six studies found that electroconvulsive therapy (ECT) is better at quickly relieving major depression than ketamine, a team of researchers report in JAMA Psychiatry on October 19.

Depression is a common illness affecting about 5% of adults worldwide, according to the World Health Organization (WHO). Feeling sad, irritable, losing pleasure in activities that used to be enjoyable, and sometimes experiencing unexplained pain or fatigue for weeks at a time are all symptoms of depression. Most people diagnosed with depression are offered an oral antidepressant (in combination with psychotherapy) as a first-line treatment option. But if oral antidepressants don’t help, or if the person is at imminent risk of hurting themselves, there are other, more rapid treatment options: ECT, and more recently ketamine or esketamine.

Esketamine, a nasal spray approved by the Food and Drug Administration to treat depression, is more commonly used in the US than ketamine. But there are no studies comparing esketamine’s effectiveness with ECT. There are studies done with ketamine, a sister drug to esketamine. Ketamine is commonly used in medicine as an injected anesthetic but has recently been tested as a fast-acting intervention to help people with major depression.

Converting Carbon Dioxide to Minerals Underground

Mineralizing carbon dioxide underground is a potential carbon storage method.
Credit: Illustration by Cortland Johnson | Pacific Northwest National Laboratory

A new high-profile scientific review article in Nature Reviews Chemistry discusses how carbon dioxide (CO2) converts from a gas to a solid in ultrathin films of water on underground rock surfaces. These solid minerals, known as carbonates, are both stable and common.

“As global temperatures increase, so does the urgency to find ways to store carbon,” said Pacific Northwest National Laboratory (PNNL) Lab Fellow and coauthor Kevin Rosso. “By taking a critical look at our current understanding of carbon mineralization processes, we can find the essential-to-solve gaps for the next decade of work.”

Mineralization underground represents one way to keep CO2 locked away, unable to escape back into the air. But researchers first need to know how it happens before they can predict and control carbonate formation in realistic systems.

“Mitigating human emissions requires fundamental understanding how to store carbon,” said PNNL chemist Quin Miller, co-lead author of the scientific review featured on the journal cover. “There is a pressing need to integrate simulations, theory, and experiments to explore mineral carbonation problems.”

Researchers discover new monster black hole 'practically in our back yard'

Dr. Sukanya Chakrabarti, the Pei-Ling Chan Endowed Chair in the Department of Physics & Astronomy, is the paper’s lead author. 
Credit: Michael Mercier / UAH

The discovery of a so-called monster black hole that has about 12 times the mass of the sun is detailed in a new Astrophysical Journal research submission, the lead author of which is Dr. Sukanya Chakrabarti, a physics professor at The University of Alabama in Huntsville (UAH).

“It is closer to the sun than any other known black hole, at a distance of 1,550 light years,” says Dr. Chakrabarti, the Pei-Ling Chan Endowed Chair in the Department of Physics at UAH, a part of the University of Alabama System. “So, it's practically in our backyard.”

Black holes are seen as exotic because, although their gravitational force is clearly felt by stars and other objects in their vicinity, no light can escape a black hole so they can’t be seen in the same way as visible stars.

“In some cases, like for supermassive black holes at the centers of galaxies, they can drive galaxy formation and evolution,” Dr. Chakrabarti says.

“It is not yet clear how these noninteracting black holes affect galactic dynamics in the Milky Way. If they are numerous, they may well affect the formation of our galaxy and its internal dynamics.”

Physicists confirm hitch in proton structure

The real photon that is produced in the virtual Compton scattering reaction provides electromagnetic perturbation to the proton and allows to measure its electromagnetic generalized polarizabilities.
Image credit: Courtesy of Nikos Sparveris, Temple University

Nuclear physicists have confirmed that the current description of proton structure isn’t all smooth sailing. A new precision measurement of the proton’s electric polarizability performed at the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility has revealed a bump in the data in probes of the proton’s structure. Though widely thought to be a fluke when seen in earlier measurements, this new, more precise measurement has confirmed the presence of the anomaly and raises questions about its origin. The research has just been published in the journal Nature.

According to Ruonan Li, first author on the new paper and a graduate student at Temple University, measurements of the proton’s electric polarizability reveal how susceptible the proton is to deformation, or stretching, in an electric field. Like size or charge, electric polarizability is a fundamental property of proton structure.

What’s more, a precision determination of the proton’s electric polarizability can help bridge the different descriptions of the proton. Depending on how it is probed, a proton may appear as an opaque single particle or as a composite particle made of three quarks held together by the strong force.

Ecological imbalance: How plant diversity in Germany has changed in the past century

The cornflower is one of the "losers", its population has declined sharply over the past 100 years.
Photo Credit: André Künzelmann / UFZ

Germany's plant world has seen a greater number of losers than winners over the past one hundred years. While the frequencies and abundances of many species have shrunk, they have significantly increased in others. This has resulted in a very uneven distribution of gains and losses. It indicates an overall, large-scale loss of biodiversity, as a team lead by the Martin Luther University Halle-Wittenberg (MLU) and the German Centre for Integrative Biodiversity Research (iDiv) reports in the journal Nature.

It’s a weird paradox: While global biodiversity is lost at an alarming rate, at the local level, many studies are finding no significant decreases in animal and plant species numbers. "However, this doesn’t mean that the developments are not worrying," warns Professor Helge Bruelheide, an ecologist at MLU. After all, it also depends on which species we are talking about. For example, if survival artists that are specially adapted to peatlands or dry grasslands are displaced by common plants, the number of species often remains, in total, the same. However, diversity is still being lost because the once very distinct vegetation of different habitats is now becoming more and more similar.

To find out how strong this trend is in Germany, the team led by MLU looked at a multitude of local studies. Numerous experts provided data from more than 7,700 plots whose plant populations had been surveyed several times between 1927 and 2020. These studies, some of which have not been published before, cover a wide range of habitats and provide information on nearly 1,800 plant species. This includes about half of all the vascular plant species that grow in Germany. "Such time series can provide very valuable information," explains Dr Ute Jandt from MLU. This is because very precise botanical censuses can be conducted in plots that are often only ten or twenty square meters in size. ": It is highly unlikely that plants disappear or reappear unnoticed in such plots," Jandt adds.

Methane-Eating ‘Borgs’ Have Been Assimilating Earth’s Microbes

A digital illustration inspired by methane-eating archaea and the Borgs that assimilate them
Credit: Jenny Nuss/Berkeley Lab

In Star Trek, the Borg are a ruthless, hive-minded collective that assimilate other beings with the intent of taking over the galaxy. Here on nonfictional planet Earth, Borgs are DNA packages that could help humans fight climate change.

Last year, a team led by Jill Banfield discovered DNA structures within a methane-consuming microbe called Methanoperedens that appear to supercharge the organism’s metabolic rate. They named the genetic elements “Borgs” because the DNA within them contains genes assimilated from many organisms. In a study published today as the cover item in the journal Nature, the researchers describe the curious collection of genes within Borgs and begin to investigate the role these DNA packages play in environmental processes, such as carbon cycling.

First contact

Methanoperedens are a type of archaea (unicellular organisms that resemble bacteria but represent a distinct branch of life) that break down methane (CH4) in soils, groundwater, and the atmosphere to support cellular metabolism. Methanoperedens and other methane-consuming microbes live in diverse ecosystems around the world but are believed to be less common than microbes that use photosynthesis, oxygen, or fermentation for energy. Yet they play an outsized role in Earth system processes by removing methane – the most potent greenhouse gas – from the atmosphere. Methane traps 30 times more heat than carbon dioxide and is estimated to account for about 30 percent of human-driven global warming. The gas is emitted naturally through geological processes and by methane-generating archaea; however, industrial processes are releasing stored methane back into the atmosphere in worrying quantities.

Hands in people with diabetes more often affected by trigger finger

Mattias Rydberg, doctoral student at Lund University and resident physician at Skåne University Hospital
Source: Lund University

Locked fingers, known as trigger finger, are more common among people with diabetes than in the general population. A study led by Lund University in Sweden shows that the risk of being affected increases in the case of high blood sugar. The study has been published in Diabetes Care.

Trigger finger means that one or more fingers, often the ring finger or thumb, ends up in a bent position that is difficult to straighten out. It is due to the thickening of tendons, which bend the finger, and their connective tissue sheath, which means that the finger becomes fixed in a bent position towards the palm. It is a painful condition that can often be treated with cortisone injections, but sometimes requires surgery.

“At the hand surgery clinic, we have noted for a long time that people with diabetes, both type 1 and type 2, are more often affected by trigger finger. Over 20 percent of those who require surgery for this condition are patients who have, or will develop, diabetes,” says Mattias Rydberg, doctoral student at Lund University, resident physician at Skåne University Hospital and first author of the study.

To study whether high blood sugar (blood sugar dysregulation) increases the risk of trigger finger, the researchers examined two registers: Region Skåne’s healthcare database, which includes all diagnoses, and the Swedish national diabetes register. Between 1 and 1.5 per cent of the population are affected by trigger finger, but the diagnosis arises among 10-15 per cent of those who have diabetes, and the phenomenon appears most in the group with type 1 diabetes.