Stanford Medicine researchers measure thousands of molecules from a single drop of blood

A single drop of blood can yield measurements for thousands of proteins, fats and other biomarkers, researchers at Stanford Medicine found.
Photo Credit: PublicDomainPictures

Researchers at Stanford Medicine have shown they can measure thousands of molecules — some of which are signals of health — from a single drop of blood.

The new approach combines a microsampling device — a tool used to self-administer a finger prick — with “multi-omics” technologies, which simultaneously analyze a vast array of proteins, fats, by-products of metabolism and inflammatory markers.

“Even more importantly, we’ve shown you can collect the blood drop at home and mail it into the lab,” said Michael Snyder, PhD, director of the Center for Genomics and Personalized Medicine and senior author on the research, which was published in Nature Biomedical Engineering on Jan. 19.

Unlike finger-prick testing for diabetes, which measures a single type of molecule (glucose), multi-omics microsampling gives data about thousands of different molecules at once.

The research sounds similar to a well-known approach promoted in the past for testing a single drop of blood, but there are important differences: While the earlier approach was based on replicating existing diagnostic tests, multi-omic microsampling uses a different type of data analysis based on a technology called mass spectrometry, which sorts molecules based on their mass and electronic charge. In addition, the data analysis is performed in a lab, not in a portable box.

Removing water, stains, contaminants with hydrogel beads

Snapshots of the hydrogel bead impacting the droplet causing the droplet to lift off the surface.
Photo Credit: Courtesy of University of Hawaiʻi

There may be a more efficient future for water repellent materials and methods thanks to new research from the University of Hawaiʻi at Mānoa College of Engineering. Associate Professor John S. Allen III and an international team of researchers have discovered a method to remove liquid from non-stick surfaces using hydrogel beads, a material similar to gel cap medications.

“Ever want to remove a puddle completely without touching it? How about removing staining coffee off your clothes? Do you know that all the dangerous contaminants are off the surface? All these might be facilitated with low-cost hydrogel beads in the future,” Allen explained.

For a variety of everyday and industrial waterproof/water resistant objects, it is important to reduce the contact time of an impacting water or liquid drop with the surface. Many people are familiar with water repellent coating on buildings and on clothing. Repellants are also used to mitigate icing on a plane, as bouncing droplets are less likely to have time to freeze.

Traded species have distinctive life histories with extended reproductive lifecycles

Chameleon
Invasive species can cause huge environmental problems and monetary costs
Photo Credit: Pierre Bamin

A new study by researchers from Durham University, UK, Queen’s University Belfast, UK, University of Extremadura, Spain and Swansea University, UK have revealed that vertebrate species involved in the live wildlife trade have distinctive life history traits, biological characteristics that determine the frequency and timing of reproduction.

Researchers discovered that traded species produce large numbers of offspring across long reproductive lifespans, an unusual profile that is likely financially advantageous for trades involving captive breeding such as the pet, food and fur/skin trades.

Traded species that have also been introduced into non-native areas have a more extreme version of this same life history profile, suggesting that species most likely to become problematic invaders are at a heightened risk of trade and release.

The study suggests that humans favor species with high reproductive output for trade and release, which are the very species likely to become problematic invaders in future.

Researchers point out that life history traits are therefore potentially useful for predicting future invasions.

DARPA Selects Aurora Flight Sciences for Phase 2 of Active Flow Control X-Plane

DARPA CRANE X-Plane configuration in development for flight testing Active Flow Control (AFC) technologies
Image Credit: Defense Advanced Research Projects Agency

DARPA has selected Aurora Flight Sciences to move into the detailed design phase of the Control of Revolutionary Aircraft with Novel Effectors (CRANE) program. This follows successful completion of the project’s Phase 1 preliminary design, which resulted in an innovative testbed aircraft that used active flow control (AFC) to generate control forces in a wind tunnel test. Phase 2 will focus on detailed design and development of flight software and controls, culminating in a critical design review of an X-plane demonstrator that can fly without traditional moving flight controls on the exterior of the wings and tail.

The contract includes a Phase 3 option in which DARPA intends to fly a 7,000-pound X-plane that addresses the two primary technical hurdles of incorporation of AFC into a full-scale aircraft and reliance on it for controlled flight. Unique features of the demonstrator aircraft will include modular wing configurations that enable future integration of advanced technologies for flight testing either by DARPA or potential transition partners.

Sikorsky Delivers 5,000th “Hawk,” Highlights Versatility And Future Of Iconic Helicopter

Sikorsky marks the delivery of the 5,000th “Hawk” helicopter, a UH-60M (pictured), at its headquarters in Stratford, Conn., Jan. 20, 2023.
Resized Image using AI by SFLORG
Photo Credit: Courtesy Sikorsky, a Lockheed Martin company.

Sikorsky, a Lockheed Martin company (NYSE: LMT), today delivered its 5,000th “Hawk” variant helicopter, a U.S. Army UH-60M Black Hawk. The iconic aircraft will continue to support medium-lift requirements for the U.S. military and international operators for decades into the future.

Sikorsky celebrates its 100th anniversary this year.

“Sikorsky, as a company, has been forged by the Black Hawk,” said Sikorsky President Paul Lemmo. “The Black Hawk and its variants deliver when reliability and performance are nonnegotiable. Hawk aircraft continue to demonstrate their versatility and readiness with the latest technological advancements and ongoing U.S. and global investment in the aircraft.”

Customers worldwide depend on the Black Hawk platform and its derivatives, including MH-60R/S maritime operations helicopters, MH-60T multi-mission helicopters, HH-60W rescue helicopters and internationally built S-70 Black Hawks to include the baseline FIREHAWK, which have all proven their versatility and capability across a spectrum of challenging mission sets.

Ripples in the fabric of the universe may reveal the start of time

Numerical simulation of the neutron stars merging to form a black hole, with their accretion disks interacting to produce electromagnetic waves.
Illustration Credit: L. Rezolla (AEI) & M. Koppitz (AEI & Zuse-Institut Berlin

Scientists have advanced in discovering how to use ripples in space-time known as gravitational waves to peer back to the beginning of everything we know. The researchers say they can better understand the state of the cosmos shortly after the Big Bang by learning how these ripples in the fabric of the universe flow through planets and the gas between the galaxies.

“We can’t see the early universe directly, but maybe we can see it indirectly if we look at how gravitational waves from that time have affected matter and radiation that we can observe today,” said Deepen Garg, lead author of a paper reporting the results in the Journal of Cosmology and Astroparticle Physics. Garg is a graduate student in the Princeton Program in Plasma Physics, which is based at the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL).

Garg and his advisor Ilya Dodin, who is affiliated with both Princeton University and PPPL, adapted this technique from their research into fusion energy, the process powering the sun and stars that scientists are developing to create electricity on Earth without emitting greenhouse gases or producing long-lived radioactive waste. Fusion scientists calculate how electromagnetic waves move through plasma, the soup of electrons and atomic nuclei that fuels fusion facilities known as tokamaks and stellarators.

Unprecedented Levels of High-Severity Fire Burn in Sierra Nevada Forests

A firefighter helps containment efforts during the Creek Fire response in 2020.
Photo Credit: USDA, Pacific Southwest Forest Service

High-severity wildfire is increasing in Sierra Nevada and Southern Cascade forests and has been burning at unprecedented rates compared to the years before Euro-American settlement, according to a study from the Safford Lab at the University of California, Davis, and its collaborators. Those rates have especially shot up over the past decade. 

For the study, published in the journal Ecosphere, scientists analyzed fire severity data from the U.S. Forest Service and Google Earth Engine, across seven major forest types. 

They found that in low- and middle-elevation forest types, the average annual area that burned at low-to-moderate severity has decreased from more than 90% before 1850 to 60-70% today. 

At the same time, the area burned annually at high severity has nearly quintupled, rising from less than 10% to 43% today. (High-severity burns are those where more than 95% of aboveground tree biomass is killed by fire.)

Getting under your skin for better health

UC College of Engineering and Applied Science professor Jason Heikenfeld in his Novel Devices Lab.
 Photo Credit: Andrew Higley/UC Marketing + Brand

The next frontier of continuous health monitoring could be skin deep.

Biomedical engineers at the University of Cincinnati say interstitial fluid, the watery fluid found between and around cells, tissues or organs in the body, could provide an excellent medium for early disease diagnosis or long-term health monitoring.

In a paper published in the journal Nature Biomedical Engineering, they outlined the potential advantages and technological challenges of using interstitial fluid.

“Why we see it as a valuable diagnostic fluid is continuous access. With blood, you can’t easily take continuous readings,” said UC doctoral graduate Mark Friedel, co-lead author of the study.

“Can you imagine going about your day with a needle stuck in your vein all day? So, we need other tools.”

RUDN University chemist creates nanocatalysts for vanillin synthesis

Illustration Credit: RUDN University

RUDN University chemist proposed a new method to create catalysts on a porous silicon matrix with metal nanoparticles. Efficient catalysts for organic reactions are obtained, for example, for the synthesis of vanillin, which is in demand in the food and perfume industry.

Only 1% of the annually produced worldwide 20 thousand tons of vanillin is made from natural vanilla. Almost all vanillin in seasonings, pastries, pharmaceuticals and cosmetics is synthesized by chemical protocols. Usually, petrochemical raw materials are used for this, but synthesis from inexpensive plant biomass is also possible. The main ingredient is lignin. This polymer is widely available as it is part of the trees, and it is obtained in the production of paper as a by-product. It is easy to isolate eugenol and other substances suitable for the synthesis of vanillin from lignin, but the next step is challenging. In oxidation reactions, along with vanillin, several by-products similar to it in structure are formed. It is difficult to separate them. The RUDN University chemist proposed a number of eco-friendly nanocatalysts that will allow obtaining more vanillin from plant raw materials than traditional methods.

MIT researchers develop an AI model that can detect future lung cancer risk

Caption:Researchers from Massachusetts General Hospital and MIT stand in front of a CT scanner at MGH, where some of the validation data was generated. Left to right: Regina Barzilay, Lecia Sequist, Florian Fintelmann, Ignacio Fuentes, Peter Mikhael, Stefan Ringer, and Jeremy Wohlwend
 Photo Credit: Guy Zylberberg.

The name Sybil has its origins in the oracles of Ancient Greece, also known as sibyls: feminine figures who were relied upon to relay divine knowledge of the unseen and the omnipotent past, present, and future. Now, the name has been excavated from antiquity and bestowed on an artificial intelligence tool for lung cancer risk assessment being developed by researchers at MIT's Abdul Latif Jameel Clinic for Machine Learning in Health, Mass General Cancer Center (MGCC), and Chang Gung Memorial Hospital (CGMH).

Lung cancer is the No. 1 deadliest cancer in the world, resulting in 1.7 million deaths worldwide in 2020, killing more people than the next three deadliest cancers combined. 

"It’s the biggest cancer killer because it’s relatively common and relatively hard to treat, especially once it has reached an advanced stage,” says Florian Fintelmann, MGCC thoracic interventional radiologist and coauthor on the new work. “In this case, it’s important to know that if you detect lung cancer early, the long-term outcome is significantly better. Your five-year survival rate is closer to 70 percent, whereas if you detect it when it’s advanced, the five-year survival rate is just short of 10 percent.” 

Ionic Liquids' Good Vibrations Change Laser Colors with Ease

Shooting a green laser through a tube filled with a particular ionic liquid (right side of photo) can easily convert the green laser light to orange (upper left)—a long-sought color for medical applications. The method can be tailored for different color shifts by choosing different ionic liquids.
Photo Credit: Brookhaven National Laboratory

Lasers are intense beams of colored light. Depending on their color and other properties, they can scan your groceries, cut through metal, eradicate tumors, and even trigger nuclear fusion. But not every laser color is available with the right properties for a specific job. To fix that, scientists have found a variety of ways to convert one color of laser light into another. In a study just published in the journal Physical Review Applied, scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory demonstrate a new color-shifting strategy that’s simple, efficient, and highly customizable.

The new method relies on interactions between the laser and vibrational energy in the chemical bonds of materials called “ionic liquids.” These liquids are made only of positively and negatively charged ions, like ordinary table salt, but they flow like viscous fluids at room temperature. Simply shining a laser through a tube filled with a particular ionic liquid can downshift the laser’s energy and change its color while retaining other important properties of the laser beam.

Malformed seashells, ancient sediment provide clues about Earth’s past

A drone photo of the JOIDES Resolution in the Mentelle Basin, where Northwestern scientists drilled for ancient sediment.
Photo Credit: Gabriele Tagliaro, University Sao Paulo

Nearly 100 million years ago, the Earth experienced an extreme environmental disruption that choked oxygen from the oceans and led to elevated marine extinction levels that affected the entire globe. 

Now, in a pair of complementary new studies, two Northwestern University-led teams of geoscientists report new findings on the chronology and character of events that led to this occurrence, known as Ocean Anoxic Event 2 (OAE2), which was co-discovered more than 40 years ago by late Northwestern professor Seymour Schlanger. 

By studying preserved planktonic microfossils and bulk sediment extracted from three sites around the world, the team collected direct evidence indicating that ocean acidification occurred during the earliest stages of the event, due to carbon dioxide (CO2) emissions from the eruption of massive volcanic complexes on the sea floor.

In one of the new studies, the researchers also propose a new hypothesis to explain why ocean acidification led to a strange blip of cooler temperatures (dubbed the “Plenus Cold Event”), which briefly interrupted the otherwise intensely hot greenhouse period.

Algae Can Help Dispose of Hazardous Substances and Produce Bioethanol

Algae can absorb zinc, magnesium, iron, aluminum, silicon and lead.
Photo Credit: Rodion Narudinov

Scientists of the Ural Federal University have developed a technology for the production of environmentally friendly bioethanol fuel using waste heat from thermal power plants (TPP) and combined heat and power plants (CHPP) and freshwater algae produced in large quantities in cooling ponds. The use of this technology leads to a reduction in harmful emissions and makes energy production more efficient. The developers emphasize that the technology signifies a transition from hydrocarbon to green energy. An article describing the technology has been published in the International Journal of Hydrogen Energy.

TPPs and CHPPs are the main suppliers of heat, light, and hot water; at the same time, they are sources of greenhouse gas emissions generated during fuel combustion and saturated with carbon dioxide, soot, unburned particles, and various chemical substances. Another byproduct is the so-called waste heat - water heated during the cooling of superheated steam, rotating turbines of TPPs and CHPPs. The waste heat, in the form of steam, evaporates into the atmosphere in large quantities and is discharged together with industrial effluents into storage ponds. Process water containing solutions of hydrochloric acid, caustic soda, ammonia, ammonium salts, iron and other substances is discharged after flushing the flue gases and boiler units.

Researchers unravel the complex reaction pathways in zero carbon fuel synthesis

Chemical plant
Photo Credit: Robert Jones

When the eCO2EP: A chemical energy storage technology project started in 2018, the objective was to develop ways of converting carbon dioxide emitted as part of industrial processes into useful compounds, a process known as electrochemical CO2 reduction (eCO2R)

While eCO2R is not a new technique, the challenge has always been the inability to control the end products. Now, researchers from the University of Cambridge have outlined how carbon isotopes can be used to trace intermediates during the process, which will allow scientists to create more selective catalysts, control product selectivity, and promote eCO2R as a more promising production method for chemicals and fuels in the low-carbon economy. Their results are reported in the journal Nature Catalysis.

The project was led by Professor Alexei Lapkin, from Cambridge’s Centre for Advanced Research and Education in Singapore (CARES Ltd) and Professor Joel Ager, from the Berkeley Education Alliance for Research in Singapore (BEARS Ltd). Both organizations are part of the Campus for Research Excellence and Technological Enterprise (CREATE) funded by Singapore’s National Research Foundation.

Tracing the flow of water with DNA

Oliver Schilling analyzing spring water at Mount Fuji.
Photo Credit: T. Schilling

Scientific Frontline: "At a Glance" Summary

• Main Discovery: Environmental DNA (eDNA) analysis of microbial communities serves as a reliable tracer for determining the origins and flow paths of deep groundwater systems.
• Methodology: Researchers combined the analysis of microbial eDNA with natural inorganic tracers, including noble gases like helium and trace elements such as vanadium, to examine spring water sources on Mount Fuji.
• Key Data: The study identified specific microbial signatures in the spring water that only survive at depths of 500 to 1,000 meters, confirming the presence of systematic deep groundwater circulation.
• Significance: This technique provides a novel method for mapping complex hydrological cycles where standard methods fail, offering critical insights for pollution tracking and sustainable water resource management.
• Future Application: The approach allows for the calibration of global hydrological models to predict water availability and quality, specifically aiding regions like Switzerland in assessing glacial meltwater contributions in response to climate change.
• Branch of Science: Hydrogeology
• Additional Detail: The study site was selected because Mount Fuji sits at the unique convergence of three tectonic plates, creating a complex geological setting that rendered traditional investigation methods ineffective.