Brain implant at OHSU successfully controls both seizures and OCD

OHSU neurosurgeon Ahmed Raslan, M.D., and patient Amber Pearson.
Photo Credit: OHSU/Christine Torres Hicks

Scientific Frontline: Extended "At a Glance" Summary: Dual-Function Responsive Neurostimulation (RNS)

The Core Concept: A single implanted brain device successfully manages both drug-resistant epilepsy and severe obsessive-compulsive disorder (OCD) simultaneously.

Key Distinction/Mechanism: Unlike standard neurostimulation focused on a single condition, this system utilizes interactive programming and strategic electrode placement in the nucleus accumbens to modulate both seizure activity and compulsive behaviors.

Major Frameworks/Components:

• Responsive Neurostimulation (RNS) system, which monitors intracranial electrical activity.
• Nucleus accumbens targeting, which modulates reward processing and compulsive urges.
• Intraoperative electrode placement and long-term interactive programming.

Deep learning speeds up galactic calculations

A more efficient simulation.
During a supernova simulation, (left) shows the prediction by a current simulation method. (right) shows the prediction by 3D-MIM, which looks close enough to the that of the current leading method, but it takes far less time to execute, saving time, energy and costs for computing time.
Image Credit: ©2023 Hirashima et al.
(CC-BY-ND)

Supernovae, exploding stars, play a critical role in the formation and evolution of galaxies. However, key aspects of them are notoriously difficult to simulate accurately in reasonably short amounts of time. For the first time, a team of researchers, including those from The University of Tokyo, apply deep learning to the problem of supernova simulation. Their approach can speed up the simulation of supernovae, and therefore of galaxy formation and evolution as well. These simulations include the evolution of the chemistry which led to life.

When you hear about deep learning, you might think of the latest app that sprung up this week to do something clever with images or generate humanlike text. Deep learning might be responsible for some behind-the-scenes aspects of such things, but it’s also used extensively in different fields of research. Recently, a team at a tech event called a hackathon applied deep learning to weather forecasting. It proved quite effective, and this got doctoral student Keiya Hirashima from the University of Tokyo’s Department of Astronomy thinking.

A molten layer at the base of the Martian mantle ?

Artist view of Mars interior structure showing a molten layer at the base of the mantle and above the core. The purple line shows the path followed in Mars by the waves generated by the meteorite impact that occurred on September 2021 and diffracted along the CMB. The blue line represents the path followed by a seismic wave reflected at the top of the molten basal layer.
Illustration Credits: CNES/IPGP.

The analysis, by a team of scientists involved in the InSight mission, of seismic data recorded on Mars after a meteorite impact that occurred in September 2021 drastically changes our view of the internal structure and evolution of the Red Planet. Based on these results and previous geophysical data, a study published on October 26 in the journal Nature, in which researcher Attilio Rivoldini from the Royal Observatory of Belgium participated, proposes a new model for the interior of Mars, with a heterogeneous mantle containing a molten silicate layer above the liquid metal core.

The first results based on data from the InSight mission significantly improved our knowledge of the interior structure of Mars. Assuming that the mantle is compositionally homogeneous and entirely solid, the results showed that the liquid metal core has a radius of about 1830±40 km and a relatively low density (6-6.2 g/cm3) with a large concentration of light elements. The size of the metal core was determined by the detection of seismic waves reflected at a solid-liquid interface ascribed to be the Core-Mantle Boundary (CMB).

Zika Infection in Pregnant Macaques Slows Fetal Growth

Female rhesus macaque monkeys and infants at the California National Primate Research Center at UC Davis.
Photo Credit: Courtesy of University of California, Davis

Zika virus infection in pregnant rhesus macaques slows fetal growth and affects how infants and mothers interact in the first month of life, according to a new study from researchers at the California National Primate Research Center at the University of California, Davis. The work, published Oct. 25 in Science Translational Medicine, has implications for both humans exposed to Zika virus and for other viruses that can cross the placenta, including SARS-CoV2, responsible for the COVID-19 pandemic.

“Initially I thought this was a story about Zika, but as I looked at the results, I think this is also a story about how fetal infections in general affect developmental trajectories,” said Eliza Bliss-Moreau, professor of psychology at UC Davis and senior author on the paper.

In most people, Zika virus infection causes mild or no symptoms and leaves long-lasting immunity. But during pregnancy, the virus can cross the placenta and cause damage to the nervous system of the fetus. In extreme cases, it can cause microcephaly in humans.

Oregon State researchers uncover mechanism for treating dangerous liver condition

Illustration Credit: Julien Tromeur

A study spearheaded by Oregon State University has shown why certain polyunsaturated fatty acids work to combat a dangerous liver condition, opening a new avenue of drug research for a disease that currently has no FDA-approved medications.

Scientists led by Oregon State’s Natalia Shulzhenko, Andrey Morgun and Donald Jump used a technique known as multi-omic network analysis to identify the mechanism through which dietary omega 3 supplements alleviated nonalcoholic steatohepatitis, usually abbreviated to NASH.

The mechanism involves betacellulin, a protein growth factor that plays multiple positive roles in the body but also contributes to liver fibrosis, or scarring, and the progression to cirrhosis and liver cancer.

“We only succeeded in finding these surprising results because we implemented an entirely unbiased approach that incorporated a diverse type of big data analysis ranging from lipids and metabolites to whole tissue and single-cell RNA sequences,” said Morgun, a researcher in the OSU College of Pharmacy.

Simple blood test can help diagnose bipolar disorder

Providing a drop of blood for a test 
Photo Credit: Cambridge Centre for Neuropsychiatric Research

The researchers, from the University of Cambridge, used a combination of an online psychiatric assessment and a blood test to diagnose patients with bipolar disorder, many of whom had been misdiagnosed with major depressive disorder.

The researchers say the blood test on its own could diagnose up to 30% of patients with bipolar disorder, but that it is even more effective when combined with a digital mental health assessment.

Incorporating biomarker testing could help physicians differentiate between major depressive disorder and bipolar disorder, which have overlapping symptoms but require different pharmacological treatments.

Although the blood test is still a proof of concept, the researchers say it could be an effective complement to existing psychiatric diagnosis and could help researchers understand the biological origins of mental health conditions. The results are reported in the journal JAMA Psychiatry.

Bipolar disorder affects approximately one percent of the population – as many as 80 million people worldwide – but for nearly 40% of patients, it is misdiagnosed as a major depressive disorder.

A Comprehensive Picture of Health Benefits of Eggs

Farm fresh eggs
Photo Credit: Couleur

Are eggs good for you?

Scientists have been studying this divisive question for years. Some have found that egg intake increases LDL, or “bad” cholesterol, and inflammatory markers associated with heart disease and diabetes, while others have highlighted the benefits of egg consumption thanks to their nutritional density.

Catherine J. Andersen, associate professor of nutritional sciences in the College of Agriculture, Health and Natural Resources, recently published a study in Nutrients that provides a broader perspective on the nutritional outcomes of egg consumption in healthy young adults.

Most existing research articles that evaluate the health effects of eggs tend to focus on a more limited range of standard clinical measurements, looking at biomarkers for heart disease, diabetes, body composition, inflammation, immune health, and anemia in isolation, rather than all together. Participants in these studies also tend to have pre-existing risk factors for chronic disease. They typically also follow additional dietary regimen changes like weight loss plans. These factors can complicate interpretations of how eggs affect health markers in the general or young, healthy population.

Defect in fruit fly respiratory system may provide insights into human aortic aneurysms

Photo Credit: Erik Karits

A team of researchers led by Leipzig University has gained new insights into the respiratory system of fruit flies – the so-called tracheal system – which could be important for future research into aneurysms. Dr Matthias Behr from the Institute of Biology (Department of Cell Biology) at Leipzig University and his team, together with colleagues from the Max Planck Institute for Multidisciplinary Sciences in Göttingen, carried out genetic, cell biological and biochemical studies on Drosophila embryos. They found that the cells in the fruit fly’s tracheal system are connected to the extracellular matrix by the proteins Dumpy and Piopio. They have just published their research findings in the journal eLife.

Similar to the human circulatory system or lungs, the fruit fly’s tracheal system consists of a network of tubes. During the embryonic development of these insects, this network of tubes is filled with a special substance that gives them shape (an extracellular matrix), which is secreted by the surrounding cells. As the organs grow, the cells are closely connected to this extracellular matrix and “shimmy” along it to form the right shape and size of tubes.

Research reveals three new marsupial species – though all likely extinct

A Crest-Tail Mulgara.
Photo Credit: Bobby Tamayo, Simpson Desert, QLD

The exciting discovery of three new species of a small Australian marsupial has been tempered by the sad fact that each of the newly identified species of mulgara is likely already extinct.

The Curtin University-led study has identified three new species of mulgaras, which are small carnivorous marsupials related to the Tasmanian Devil and quoll and that are important to the arid and semi-arid regions they inhabit in South Australia, Western Australia, the Northern Territory and Queensland.

Led by Curtin PhD student Jake Newman-Martin, a collaboration with Dr Kenny Travouillon from the Western Australian Museum, Associate Professor Natalie Warburton from Murdoch University and Associate Professor Milo Barham and Dr Alison Blyth both from Curtin analyzed preserved specimens of mulgaras from museums across the country, including bones found in caves which had previously not been identifiable.

Mr. Newman-Martin said the research had identified six species of mulgaras, as opposed to the previously accepted two and it also concluded that a third previously named mulgara was indeed a valid species. However, four of the proposed species appeared to be already extinct.

Scientists uncover cause of mysterious deaths of elephants in Zimbabwe

Photo Credit: Charl Durand

Scientific Frontline: Extended "At a Glance" Summary: Elephant Deaths Linked to Bisgaard Taxon 45

The Core Concept: Scientists have discovered that a little-known bacterium, provisionally named Bisgaard taxon 45, caused the fatal septicemic infections responsible for the mysterious deaths of endangered African savanna elephants.

Key Distinction/Mechanism: Unlike initially suspected causes such as anthrax, cyanide poisoning, or poaching, the mortalities were definitively traced to an unclassified member of the Pasteurella bacterial family. This marks the first time this specific pathogen has been associated with elephant deaths, and researchers believe the infection is exacerbated by physiological stress from extreme weather events (like severe drought) and transmitted through the highly sociable behavior of the herds.

Origin/History: The investigation focused on the sudden deaths of thirty-five elephants in a 40-by-25-kilometer radius of northwestern Zimbabwe between August and September 2020. This incident closely followed a massive die-off of approximately 350 elephants in neighboring Botswana from May to June 2020.

Major Frameworks/Components:

• Postmortem examinations and field sampling of wildlife carcasses.
• Toxicological analyses to effectively rule out anthropogenic poisons, including cyanide.
• Bacterial isolation and genetic analysis to classify the unknown pathogen.
• Epidemiological assessment of the link between environmental stress factors, animal sociability, and disease transmission.

Post-COVID condition is not linked to ongoing infection or active brain damage

Post COVID-19 condition does not appear to be linked to direct viral invasion of the brain or active brain damage. This has been shown by a study at the University of Gothenburg. Searching for abnormal biomarkers among the participants yielded no hits in either blood or cerebrospinal fluid samples.

The condition that can follow the acute phase of COVID-19 infection, termed “Post-COVID condition,” or “long-covid” can persist for several months subsequent to the initial infection. The condition includes various combinations of fatigue, apathy, and difficulties with memory and concentration.

The current study, published in The Journal of Infectious Diseases, included 25 people with confirmed post-COVID condition, six people without residual symptoms after COVID-19, and 17 control subjects who were completely free of COVID-19.

The strength of the study lies not in the number of participants, which is fairly limited, but in the fact that they all – including the control subjects – underwent not only blood tests but also the considerably more invasive procedure of lumbar punctures to collect cerebrospinal fluid.

At the time when the samples were taken, at least three months had passed since the first symptoms of COVID-19 in those who had had the disease. The samples were taken between February and November 2021, and were analyzed for a total of 37 different biomarkers.

People with severe mental illness at 50 per cent higher risk of death following COVID-19 infection

Photo Credit: Darina Belonogova

New research from King’s College London has found that people in the UK with severe mental illness were at increased risk of death from all causes following COVID-19 infection compared to those without severe mental illness.

Published in the British Journal of Psychiatry, the study investigated the extent to which having severe mental illness, which includes schizophrenia and psychosis, increased the risk of death during the first two waves of the COVID-19 pandemic.

Researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) and ESRC Centre for Society and Mental Health analyzed data from over 660,000 UK patients between February 2020 and April 2021.

Among the 7146 people with severe mental illness, there was a 50 per cent greater risk of death from all causes following COVID-19 infection compared with those without severe mental illness.

Black Caribbean/Black African people were at 22 per cent higher risk of death following COVID-19 infection than White people, and this was similar for people with and without severe mental illness. However, in around 30 per cent of patient data, ethnicity was not recorded.

SLAC scientists shed light on potential breakthrough biomedical molecule

Researchers employed advanced X-ray spectroscopic techniques at SLAC’s Stanford Synchrotron Radiation Lightsource (SSRL), which allowed them to peer deeper into the chemical properties of nitroxide.
Illustration Credit: Greg Stewart/SLAC National Accelerator Laboratory

Scientists from the Department of Energy’s SLAC National Accelerator Laboratory have gained valuable insights into producing nitroxide, a molecule with potential applications in the biomedical field. While nitric oxide (NO) has long been on researchers' radar for its significant physiological effects, its lesser-known cousin, nitroxide (HNO), has remained largely unexplored.

The study, published recently in the Journal of the American Chemical Society, was born out of a joint endeavor between teams at SLAC’s Linac Coherent Light Source (LCLS) X-ray laser and Stanford Synchrotron Radiation Lightsource (SSRL).

Nitroxide has many of the same physiological effects of nitric oxide – such as its ability to fight germs, prevent blood clots, and relax and dilate blood vessels – with additional therapeutic properties, such as efficacy in treating heart failure, as well as more potent antioxidant activity and wound healing. However, it is not a chemically long-lived species so methods that enable its targeted delivery are key to future biomedical applications.

Killer whales’ diet more important than location for pollutant exposure

Photo Credit: Thomas Lipke

Both elegant and fierce, killer whales are some of the oceans’ top predators, but even they can be exposed to environmental pollution. Now, in the largest study to date on North Atlantic killer whales, researchers in the American Chemical Society’ Environmental Science & Technology report the levels of legacy and emerging pollutants in 162 individuals’ blubber. The animals’ diet, rather than location, greatly impacted contaminant levels and potential health risks — information that’s helpful to conservation efforts.

As the largest member of the dolphin family, killer whales, also known as orcas, are found worldwide. Marine vessel traffic can disturb the hunting and communication of these black-and-white marine mammals. But they face another type of human threat — legacy and emerging persistent organic pollutants (POPs) in their environments. POPs include chlorinated hydrocarbons and flame retardants, and can accumulate in animals’ fat stores as the contaminants move up the food chain though a process called biomagnification.

Getting maximum calories in shortest time is the priority for bumblebees

Photo Credit: Michael Hodgins

A new study investigating nectar drinking in one of the most common bumblebees in the UK, Bombus terrestris, has found that when foraging they maximize the amount of nectar sugar, they take back to the colony each minute.

To make their choices, the bumblebees trade off the time they spend collecting nectar with the energy content of that nectar. This means they will forage to collect nectar that’s hard to access – but only if the sugar content of that nectar makes it worth doing so.

This big-and-fast approach contrasts with honeybee foraging: honeybees make their decisions by optimizing their individual energy expenditure for any nectar they collect. This more measured approach should prolong the honeybee’s working life.

“As they forage, bumblebees are making decisions about which nectar sources will give the greatest immediate energetic return, rather than optimizing the energy efficiency of their foraging,” said Dr Jonathan Pattrick, joint first author of the report, who started the research while in the University of Cambridge’s Department of Plant Sciences.

Pattrick, now based at the University of Oxford, added: “Our results allow us to make predictions about the sorts of flowers the bumblebees are likely to visit, which could inform the choice of which flowers to plant in field margins to support these important pollinators. It’s also relevant to crop breeders who want to make varieties that are ‘better’ for bumblebees.”