Treating fibrosis with a chemical derived from Lawsonia inermis

Treatment with Lawsone converts a liver with fibrosis into a healthy liver.
Image Credit: Osaka Metropolitan University

Lawsonia inermis is best known for making henna, a versatile dye that is used to change the color of skin and clothes. Now, researchers from Osaka Metropolitan University have found another use for the pigments extracted from the dye: treating liver disease.

Specifically, they could treat liver fibrosis, a disease that causes excess fibrous scar tissue to build up in the liver as a result of chronic liver injury caused by lifestyle choices such as excessive drinking. Patients with liver fibrosis have increased risks of cirrhosis, liver failure, and cancer. Despite 3–4% of the population having the advanced form of the disease, treatment options remain limited.

Researchers Explore How AI Could Shape the Future of Student Learning

Johns Hopkins study reveals the strengths and pitfalls of incorporating chatbots into middle and high school classrooms as a 'co-tutor'
Image Credit: Scientific Frontline / AI generated

As students settle into the new school year, one question looms large: How will artificial intelligence tools like ChatGPT affect their learning? Seeking answers, a team from Johns Hopkins recently introduced a chatbot into a classroom of middle and high school students to act as a co-tutor and study the impact.

The pilot study included 22 students enrolled in the Johns Hopkins Center for Talented Youth's online course Diagnosis: Be the Doctor. It involved two virtual classrooms; both were taught by the same instructor and organized similarly, except for one key difference: Students in one classroom had access to a large language model designed to act like a coach, asking Socratic-style questions as students worked through medical case studies.

Dangerous E. coli strain blocks gut’s defense mechanism to spread infection

Isabella Rauch, Ph.D., is the senior author on a new study published in Nature that reveals how a dangerous strain of E. coli blocks the body’s immune defenses to spread infection.
Photo Credit: OHSU/Christine Torres Hicks

When harmful bacteria that cause food poisoning, such as E. coli, invade through the digestive tract, gut cells usually fight back by pushing infected cells out of the body to stop the infection from spreading.

In a new study published today in Nature, scientists from Genentech, a member of the Roche Group, in collaboration with researchers from Oregon Health & Science University, discovered that a dangerous strain of E. coli — known for causing bloody diarrhea — can block this gut defense, allowing the bacteria to spread more easily.

The bacteria inject a special protein called NleL into gut cells, which breaks down key enzymes, known as ROCK1 and ROCK2, that are needed for infected cells to be expelled. Without this process, the infected cells can’t leave quickly, allowing the bacteria to spread more easily.

Neutrinos ‘flavor’ may hold clues to the universe’s biggest secrets

Inside the Super-Kamiokande detector.
Photo Credit: Kamioka Observatory, ICRR (Institute for Cosmic Ray Research), The University of Tokyo.

In a new analysis, physicists provide the most precise picture yet of how neutrinos change ‘flavor’ as they travel through the cosmos. 

Neutrinos are fundamental particles of the universe, but also some of the most elusive; They pass through everything and can be extremely difficult to detect. While many of their properties are mysterious, scientists know neutrinos come in three types: electron, muon, and tau. 

Understanding these different identities can help scientists learn more about neutrino masses and answer key questions about the evolution of the universe, including why matter came to dominate over antimatter in the early universe, said Zoya Vallari, 

New observation method improves outlook for lithium metal battery

Stacey Bent (left), professor of chemical engineering and of energy science and engineering, Sanzeeda Baig Shuchi (right), chemical engineering PhD student, and Yi Cui (not pictured), professor of materials science and engineering and of energy science and engineering, led the research team that discovered a way to more accurately analyze key chemistries for rechargeable batteries and possibly many other chemistry applications.
Photo Credit: Bill Rivard

Stanford researchers developed a flash-freezing observation method that reveals battery chemistry without altering it, providing new insights to enhance lithium metal batteries.

In science and everyday life, the act of observing or measuring something sometimes changes the thing being observed or measured. You may have experienced this “observer effect” when you measured the pressure of a tire and some air escaped, changing the tire pressure. In investigations of materials involved in critical chemical reactions, scientists can hit the materials with an X-ray beam to reveal details about composition and activity, but that measurement can cause chemical reactions that change the materials. Such changes may have significantly hampered scientists learning how to improve – among many other things – rechargeable batteries.

To address this, Stanford University researchers have developed a new twist to an X-ray technique. They applied their new approach by observing key battery chemistries, and it left the observed battery materials unchanged and did not introduce additional chemical reactions. In doing so, they have advanced knowledge for developing rechargeable lithium metal batteries. This type of battery packs a lot of energy and can be recharged very quickly, but it short-circuits and fails after recharging a handful of times. The new study, published today in Nature, also could advance the understanding of other types of batteries and many materials unrelated to batteries.

Fungal secrets of a sunken ship

Robert Blanchette, a professor at the University of Minnesota, and Claudia Chemello, president and co-founder of Terra Mare Conservation, examine the wood of the USS Cairo.
Photo Credit: Paul Mardikian

University of Minnesota researchers studied the microbial degradation of the USS Cairo, one of the first ironclad and steam powered gunboats used in the United States Civil War. Studies of microbial degradation of historic woods are essential to help protect and preserve important cultural artifacts. 

Built in 1861, the ship hit a torpedo and sank in December 1862 and was recovered about 100 years later from the Yazoo River. It's been on display at the Vicksburg National Military Park in Mississippi. Although the ship has a canopy cover, it is exposed to environmental elements. 

Retreating Glaciers May Send Fewer Nutrients to the Ocean

Northwestern Glacier in Alaska has retreated approximately 15 kilometers (nine miles) since 1950.
Photo Credit: Kiefer Forsch/Scripps Institution of Oceanography.

The cloudy, sediment-laden meltwater from glaciers is a key source of nutrients for ocean life, but a new study suggests that as climate change causes many glaciers to shrink and retreat their meltwater may become less nutritious. 

Led by scientists at UC San Diego’s Scripps Institution of Oceanography, the study finds that meltwater from a rapidly retreating Alaskan glacier contained significantly lower concentrations of the types of iron and manganese that can be readily taken up by marine organisms compared to a nearby stable glacier. These metals are scarce in many parts of the ocean including the highly productive Gulf of Alaska, and they are also essential micronutrients for phytoplankton, the microorganisms that form the base of most marine food webs.

Dusty air is rewriting your lung microbiome

UCR researcher collecting dust from the Salton Sea.
Photo Credit: Linton Freund/UCR

Dust from California’s drying Salton Sea doesn’t just smell bad. Scientists from UC Riverside found that breathing the dust can quickly re-shape the microscopic world inside the lungs. 

Genetic or bacterial diseases have previously been shown to have an effect on lung microbes. However, this discovery marks the first time scientists have observed such changes from environmental exposure rather than a disease. 

Published in the journal mSphere, the study shows that inhalation of airborne dust collected close to the shallow, landlocked lake alters both the microbial landscape and immune responses in mice that were otherwise healthy.

“Even Salton Sea dust filtered to remove live bacteria or fungi is altering what microbes survive in the lungs,” said Mia Maltz, UCR mycologist and lead study author. “It is causing deep changes to our internal environment.”

Microbes at Red Sea vents show how life and geology shape each other

Microscopic images of the studied microbes.
Image Credit: Courtesy of King Abdullah University of Science and Technology

A new study led by King Abdullah University of Science and Technology (KAUST) Professor Alexandre Rosado has revealed an unusual microbial world in the Hatiba Mons hydrothermal vent fields of the central Red Sea, a site first discovered by one of his co-authors and colleagues, Assistant Professor Froukje M. van der Zwan. 

Published in Environmental Microbiome, the study delivers the first "genome-resolved" analysis of these hydrothermal systems, providing an unprecedented view into both the types of microbes present and the metabolic functions that sustain them. 

“Microbes from the Hatiba Mons fields show remarkable metabolic versatility,” said KAUST Ph.D. student and lead author of the study, Sharifah Altalhi. “By understanding their functions, we can see how life shapes its environment, and how geology and biology are deeply intertwined in the Red Sea.” 

Scientists discover clean and green way to recycle Teflon®

The Newcastle research team (L-R): Dr Matthew Hopkinson, Dr Roly Armstrong and Matthew Lowe.
Photo Credit: Courtesy of Newcastle University

New research demonstrates a simple, eco-friendly method to break down Teflon® – one of the world’s most durable plastics – into useful chemical building blocks.

Scientists from Newcastle University and the University of Birmingham have developed a clean and energy-efficient way to recycle Teflon® (PTFE), a material best known for its use in non-stick coatings and other applications that demand high chemical and thermal stability.

The researchers discovered that waste Teflon® can be broken down and repurposed using only sodium metal and mechanical energy – movement by shaking - at room temperature and without toxic solvents.

Publishing their findings today (22 October) in the Journal of the American Chemical Society (JACS), researchers reveal a low-energy, waste-free alternative to conventional fluorine recycling.

Carpenter Ants: Better Safe than Sorry

Camponotus maculatus
Photo Credit: April Nobile
(CC BY-SA 4.0)

Carpenter ants are not squeamish when it comes to caring for the wounded. To minimize the risk of infection, the insects immediately amputate injured legs – thereby more than doubling their survival rate.

As with humans, wound care plays an important role in the animal kingdom. Many mammals lick their wounds, some primates use antiseptic plants, and some ants even produce their own antimicrobial substances to treat infections. 

The latter was demonstrated by biologist Dr. Erik Frank, a researcher at Julius-Maximilians-Universität Würzburg (JMU), in the African Matabele Ant. In a new study, now published in the journal Proceedings of the Royal Society B, he takes a closer look at an ant species that uses a less refined but nevertheless effective approach: amputation.   

Erik Frank heads a junior research group in Würzburg funded by the Emmy Noether Programme of the German Research Foundation (DFG) at the Chair of Animal Ecology and Tropical Biology (Zoology III). 

Arctic in Transition: Greenland’s Caves Preserve Ancient Climate Archive

Inside the Cove Cave, northern Greenland: A team of Innsbruck scientists studies deposits from a time when the Arctic was much warmer than today.
Photo Credit: Robbie Shone

In a remote cave in northern Greenland, a research team led by geologists Gina Moseley, Gabriella Koltai, and Jonathan Baker have discovered evidence of a significantly warmer Arctic. The cave deposits show that the region was free of permafrost millions of years ago and responded sensitively to rising temperatures. The findings, published in Nature Geoscience, provide new insights into past climate conditions and their relevance for today’s climate protection efforts.

Understanding Earth’s climate during earlier warm periods is key to predicting how it may change in the future. One particularly revealing time is the Late Miocene, which began about 11 million years ago. During this period, Earth’s distribution of land and ocean was similar to today, and both temperatures and atmospheric CO₂ levels were comparable to projections for the coming decades. Although the Arctic is known to be highly sensitive to climate change, its environmental conditions during the Late Miocene have remained poorly understood.

Increasing Heat is Super-Charging Arctic Climate and Weather Extremes

Photo Credit: Master Unknown

By evaluating historical climate records, observational and projection data, an international team of researchers found a “pushing and triggering” mechanism that has driven the Arctic climate system to a new state, which will likely see consistently increased frequency and intensity of extreme events across all system components – the atmosphere, ocean and cryosphere – this century.

“We know that mean temperatures are rising, and the Arctic is commonly considered an indicator of global changes due to its higher sensitivity to any perturbation of external and internal forcings,” says Xiangdong Zhang, research professor at North Carolina State University and senior scientist at the North Carolina Institute for Climate Studies.

“The annual mean warming rate of the Arctic is more than three times the global average – this is known as Arctic amplification,” Zhang says. “But no systematic review has been done about the interplay of warmer temperatures with the dynamics of atmosphere, ocean and sea ice in weather and climate extremes around the Arctic.” Zhang is the lead author of the study.

Tropical rivers emit less greenhouse gases than previously thought

Lowland tropical rivers emit large quantities of greenhouse gases, with rates influenced by seasonal flooding.
Photo Credit: Jenny Davis

Tropical inland waters don’t produce as many greenhouse gas emissions as previously estimated, according to the results of an international study, led by Charles Darwin University and involving researchers from Umeå University.

The study, published in Nature Water, aimed to better understand greenhouse gas emissions in tropical rivers, lakes and reservoirs by collating the growing amount of observations from across the world’s tropics – including many systems that were previously less represented in global datasets.

Researchers from Umeå University played a key role in the work, estimating the surface area of rivers and contributing to the data analysis that underpins the study’s findings.

How Hard Is It to Dim the Sun

An illustration of climate geoengineering techniques, including stratospheric aerosol injection (SAI), cirrus cloud thinning (CCT), and marine cloud brightening (MCB), and their proposed delivery systems and potential impacts. Natural stratospheric aerosol release from a volcanic eruption is also shown for context. Surface albedo geoengineering (SAG), which is based on increasing the albedo of various surfaces, is also represented with two examples: installing white roofs on urban buildings and modifying plants and shrubs surface.
Image Credit: Licensed under Creative Commons.

Once considered a fringe idea, the prospect of offsetting global warming by releasing massive quantities of sunlight-reflecting particles into Earth’s atmosphere is now a matter of serious scientific consideration. Hundreds of studies have modeled how this form of solar geoengineering, known as stratospheric aerosol injection (SAI), might work. There is a real possibility that nations or even individuals seeking a stopgap solution to climate change may try SAI—but the proponents dramatically underestimate just how difficult and complicated it will be, say researchers from Columbia University.

“Even when simulations of SAI in climate models are sophisticated, they’re necessarily going to be idealized. Researchers model the perfect particles that are the perfect size. And in the simulation, they put exactly how much of them they want, where they want them. But when you start to consider where we actually are, compared to that idealized situation, it reveals a lot of the uncertainty in those predictions,” says V. Faye McNeill, an atmospheric chemist and aerosol scientist at Columbia’s Climate School and Columbia Engineering.