OHSU researchers develop promising drug for aggressive breast cancer

New research reveals a drug developed by scientists at Oregon Health & Science University may develop into a new treatment for an especially aggressive form of breast cancer.
Photo Credit: Oregon Health & Science University

A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer — a form of cancer that is notoriously aggressive and lacks effective treatments.

In a study published today in the journal Cell Reports Medicine, researchers describe the effect of a molecule known as SU212 to inhibit an enzyme that is critical to cancer progression. The research was conducted in a humanized mouse model.

“It’s an important step forward to treat triple-negative breast cancer,” said senior author Sanjay V. Malhotra, Ph.D., co-director of the Center for Experimental Therapeutics in the OHSU Knight Cancer Institute. “Triple-negative breast cancer is an aggressive form of cancer and there are no effective drugs available right now.”

McGill-led team maps ‘weather’ on a nearby brown dwarf in unprecedented detail

Study reveals patchy clouds and shifting atmospheric layers on a free-floating planetary-mass object just 20 light-years away, offering potential insights into planet and star formation
Image Credit: Anastasiia Nahurna.

Researchers at McGill University and collaborating institutions have mapped the atmospheric features of a planetary-mass brown dwarf, a type of space object that is neither a star nor a planet, existing in a category in-between. This particular brown dwarf’s mass, however, is just at the threshold between being a Jupiter-like planet and a brown dwarf. It has thus also been called a free-floating, or rogue, planet, not bound to a star. Using the James Webb Space Telescope (JWST), the team captured subtle changes in light from SIMP 0136, revealing complex, evolving weather patterns across its surface.

“Despite the fact that right now we cannot directly image habitable planets around other stars, we can develop methods of learning about the meteorology and atmospheric composition on very similar worlds,” said Roman Akhmetshyn, a McGill MSc student in physics and the study's lead author.

Deep-sea mining waste threatens life and food webs in ocean’s dim “twilight zone”

Illustration showing midwater impacts of deep sea mining operations. Image credit: Dowd et al 2025 (Nature Communications)
Illustration Credit: Amanda Merritt

Scientific Frontline: "At a Glance" Summary: Deep-Sea Mining Waste Disrupts Midwater Food Webs

• Main Discovery: Waste discharged from deep-sea polymetallic nodule mining operations in the Clarion-Clipperton Zone directly threatens midwater twilight zone ecosystems by replacing nutritious natural particles with nutrient-poor sediment.
• Methodology: Researchers collected and evaluated water samples and suspended particles from a 2022 deep-sea mining trial, specifically analyzing the amino acid concentrations to determine the nutritional viability of the discharged waste plumes.
• Key Data: The discharged mining waste would negatively impact 53 percent of all zooplankton and 60 percent of micronekton, as the plumes contained significantly lower concentrations of amino acids compared to natural marine detritus.
• Significance: Introducing empty-calorie sediment into the finely tuned twilight zone dilutes the fundamental food supply, posing severe risks of cascading disruptions throughout the entire marine food web, including commercially vital Pacific tuna populations.
• Future Application: These findings deliver essential empirical data to guide the International Seabed Authority and the National Oceanic and Atmospheric Administration in establishing stringent environmental safeguards and discharge depth regulations prior to commercial mining.
• Branch of Science: Marine Biology, Oceanography, and Ecology.

Researchers create simple method for viewing microscopic fibers

Computational scattered light imaging shows the orientation and organization of tissue fibers at micrometer resolution. The colors represent different fiber orientations.
Image Credit: Marios Georgiadis

Every tissue in the human body contains a network of microscopic fibers. Muscle fibers direct mechanical forces, intestinal fibers are involved in gut mobility, and brain fibers transmit signals and form the communication network to drive cognition. Together, these fibers shape how organs function and help maintain their structure.

Likewise, almost all diseases involve some form of degeneration or disruption of these fiber networks. In the brain, this translates to disturbances in neural connectivity that are found in all neurological disorders.

Despite their biological importance, these microscopic fibers have been difficult to study, as scientists have struggled to visualize their orientations within tissues.

Now, Stanford Medicine researchers and their colleagues have developed a simple, low-cost approach that makes those hidden structures visible in remarkable detail.

Detection of air-filled anomalies in Menkaure Pyramid could indicate new entrance

Researchers have identified two air-filled voids in the Menkaure Pyramid
Photo Credit: ScanPyramids project  

Researchers from Cairo University and TUM, as part of the ScanPyramids research project, have identified two hidden air-filled anomalies in the third-largest pyramid of Giza. The hypothesis of a possible entrance at this point on the eastern side of the Menkaure pyramid had existed for some time. The investigations using radar, ultrasound, and ERT prove the existence of two air-filled voids underneath the eastern facade, providing initial evidence to support the hypothesis.

For some time now, the structure of the granite blocks on the eastern side of the more than 60-meter-high Menkaure pyramid has puzzled researchers. The stones are remarkably polished over an area around four meters high and six meters wide. Such smooth stones are otherwise only found at what is currently the only entrance to the pyramid, on the north side. Researcher Stijn van den Hoven hypothesized a possible additional entrance for the first time in 2019.

Newly Discovered Host Mechanism in Coronaviruses

Cell culture cells expressing a kinase activity reporter (green) after infection with the human coronavirus HCoV-229E (red). Cell nuclei are stained blue.
Image Credit: © Molekulare und medizinische Virologie

The discovery could serve as a starting point for antiviral strategies.

A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated during infection with human coronavirus HCoV-229E and mediates the phosphorylation of the viral nucleocapsid (N) protein, an integral step in the virus cycle. These results aid in better understanding virus-host interactions and may open new approaches to exploring antiviral strategies in the long term. The team led by Dr. Yannick Brüggemann and Professor Eike Steinmann reports its findings in the journal npj Viruses.

UrFU Scientists Have Developed Ceramic Material that Protects Against Radiation

The material created by UrFU specialists is made from natural clay and recycled glass waste.
Photo Credit: Anna Marinovich

Scientists at Ural Federal University, in collaboration with colleagues from Iraq and Saudi Arabia, have developed a durable, inexpensive, and environmentally friendly ceramic material that protects against radiation. The new material is made from natural clay and recycled glass waste. 

Researchers believe this ceramic can be used in radiation-hazardous facilities, X-ray rooms, and laboratories to protect medical, scientific, and industrial personnel. The results of the study were published in the Journal of Science: Advanced Materials and Devices.

“We mixed clay imported from Iraq with glass production waste and a small amount of boric acid. This allowed us to create durable and inexpensive ceramics that effectively protect against gamma radiation. The addition of glass increases the strength of the tile. This method allows for the disposal of glass waste in building materials, including it, which is particularly important for the construction of radiation-hazardous facilities and X-ray rooms where the use of lead is undesirable,” said Karem Makhmud, Head Specialist of the Department of Nuclear Power Plants and Renewable Energy Sources.

Physicists observe key evidence of unconventional superconductivity in magic-angle graphene

MIT researchers observed clear signatures of unconventional superconductivity in magic-angle twisted trilayer graphene (MATTG). The image illustrates pairs of superconducting electrons (yellow spheres) traveling through MATTG, as the team’s new method (represented by magnifying glass) probes the material’s unconventional superconducting gap (represented by the V-shaped beam).
Image Credit: Sampson Wilcox and Emily Theobald, MIT RLE

Superconductors are like the express trains in a metro system. Any electricity that “boards” a superconducting material can zip through it without stopping and losing energy along the way. As such, superconductors are extremely energy efficient, and are used today to power a variety of applications, from MRI machines to particle accelerators.

But these “conventional” superconductors are somewhat limited in terms of uses because they must be brought down to ultra-low temperatures using elaborate cooling systems to keep them in their superconducting state. If superconductors could work at higher, room-like temperatures, they would enable a new world of technologies, from zero-energy-loss power cables and electricity grids to practical quantum computing systems. And so scientists at MIT and elsewhere are studying “unconventional” superconductors — materials that exhibit superconductivity in ways that are different from, and potentially more promising than, today’s superconductors.

In a promising breakthrough, MIT physicists have today reported their observation of new key evidence of unconventional superconductivity in “magic-angle” twisted tri-layer graphene (MATTG) — a material that is made by stacking three atomically-thin sheets of graphene at a specific angle, or twist, that then allows exotic properties to emerge.

Dry grass: Research project explores the effect of multi-year drought on grasslands

As a dry spell stretches from months to years, grasslands can adapt — to a point.
Photo Credit: Scientific Frontline / Heidi-Ann Fourkiller

A recent paper in the journal Science, “Drought intensity and duration interact to magnify losses in primary productivity,” explores how moderate and extreme droughts affect grasslands around the world. The paper has more than 180 international co-authors, with Binghamton University Assistant Professor of Ecosystem Science Amber Churchill among them.

Known as a distributed network, research projects of this type call upon collaborators to perform the same experiments locally, Churchill explained.

“The idea is that everyone uses the same methodology, but each local site is independently responsible for the maintenance of their site, data collection and ongoing measurements,” she said. “Often, individual sites will collect data in addition to the core project’s data.”

The experiment measured productivity, or how much plant biomass grows in a year. Less rain typically means less productivity, but the long-term picture is complicated by a number of factors. For one, not all grasslands are created equal; they come in a variety of types, with varying precipitation levels. Removing 10% of rainfall in an arid grassland is the equivalent of removing 40% of the precipitation in a wetter ecosystem, according to the research.

Three new toad species skip the tadpole phase and give birth to live toadlets

One of the newly described toad species, Nectophrynoides luhomeroensis.
Photo credit: John Lyarkurwa

An international team of researchers have identified three new species of enchanting, pustular, tree-dwelling toads from Africa. Their solution for having offspring away from water? Skipping the tadpole phase altogether, and giving birth to live toadlets. The study is published today in the open access scientific journal Vertebrate Zoology.

Most textbooks will tell you only one story of frog reproduction: Eggs to tadpoles to froglets to adults. But for three newly discovered species found in Tanzania this is not the case. The three new species of frogs belong to an unusual group of African toads in the genus Nectophrynoides — commonly called “Tree Toads.”

Instead of laying eggs that hatch into tadpoles, the female Tree Toads carry their offspring inside their bodies and give birth to fully formed, tiny toads. This makes them among the very few amphibians in the world capable of internal fertilization and true live birth.

Physicists discover new state of matter in electrons, platform to study quantum phenomena

From left, researchers Cyprian Lewandowski, Aman Kumar and Hitesh Changlani.
Photo Credit: Devin Bittner/FSU College of Arts and Sciences

Electricity powers our lives, including our cars, phones, computers and more, through the movement of electrons within a circuit. While we can’t see these electrons, electric currents moving through a conductor flow like water through a pipe to produce electricity.

Certain materials, however, allow that electron flow to “freeze” into crystallized shapes, triggering a transition in the state of matter that the electrons collectively form. This turns the material from a conductor to an insulator, stopping the flow of electrons and providing a unique window into their complex behavior. This phenomenon makes possible new technologies in quantum computing, advanced superconductivity for energy and medical imaging, lighting, and highly precise atomic clocks. 

A team of Florida State University-based physicists, including National High Magnetic Field Laboratory Dirac Postdoctoral Fellow Aman Kumar, Associate Professor Hitesh Changlani and Assistant Professor Cyprian Lewandowski, have shown the conditions necessary to stabilize a phase of matter in which electrons exist in a solid crystalline lattice but can “melt” into a liquid state, known as a generalized Wigner crystal. Their work was published in npj Quantum Materials, a Nature publication. 

Plant protection products change the behavior of non-target organisms

The honeybee (Apis mellifera) served as the model organism for pollinating insects.   
Photo Credit: André Künzelmann / UFZ

Plant protection products protect crops from pests, diseases and weeds. However, many of the fungicides, herbicides and insecticides also have a negative effect on terrestrial and aquatic organisms such as pollinators or fish that are not the primary target of their use. How their behavior changes after exposure to plant protection products is now the focus of a cross-habitat study by scientists from the Helmholtz Centre for Environmental Research (UFZ). The behavioral changes found in the animal models were significant and are an indication of the effect of plant protection products on non-target organisms in the wild. The work indicates that more complex and relevant behavioural tests should be included in the risk assessment of plant protection products in the future. The study was published in the journal Environment International.

The application of plant protection products in agriculture is subject to strict regulations. Nevertheless, organisms that are not the primary target of their use, so-called non-target organisms, inevitably come into contact with these substances and can potentially be harmed by them. "Wild bees and other pollinators can come into contact with quite high concentrations shortly after spraying. But animals in aquatic habitats are also at risk," says UFZ biologist Prof. Martin von Bergen, one of the two joint principal investigators. "Rainfall gradually washes plant protection products into the surrounding waters. They don't simply remain and only affect the area where they are applied."

New modeling shows difficult future for the GBR under climate change

Coral bleached by high water temperatures in the Pacific Ocean.
Photo Credit: Professor Peter Mumby

The most sophisticated modeling to date forecasts that under the current global emissions pathway the Great Barrier Reef could lose most of its coral by the end of the century, but curbing climate change and strategic management will help coral resilience.

A research team led by The University of Queensland simulated different future climate scenarios driven by a range of plausible global emissions trajectories.

Dr Yves-Marie Bozec from UQ’s School of the Environment said the comprehensive modelling of individual corals included their ability to adapt to warmer water, large-scale reef dynamics and their interconnections on ocean currents.

“We ran all of those factors with the most up to date climate projections – and the news was not good,” Dr Bozec said.

“We forecast a rapid coral decline before the middle of this century regardless of the emissions scenario.

“Corals may partially recover after 2050, but only if ocean warming is sufficiently slow to allow natural adaptation to keep pace with temperature changes.

“Adaptation may keep pace if global warming does not exceed 2 degrees by 2100.

“For that to happen, more action is needed globally to reduce carbon emissions which are driving climate change.”

Oxford scientists capture genome’s structure in unprecedented detail

Detailed map of the genome one pixel per nucleotide
Image Credit: Radcliffe Department of Medicine

Scientists from Oxford's Radcliffe Department of Medicine have achieved the most detailed view yet of how DNA folds and functions inside living cells, revealing the physical structures that control when and how genes are switched on.

Using a new technique called MCC ultra, the team mapped the human genome down to a single base pair, unlocking how genes are controlled, or, how the body decides which genes to turn on or off at the right time, in the right cells. This breakthrough gives scientists a powerful new way to understand how genetic differences lead to disease and opens up fresh routes for drug discovery.

‘For the first time, we can see how the genome’s control switches are physically arranged inside cells, said Professor James Davies, lead author of the study.

‘This changes our understanding of how genes work and how things go wrong in disease. We can now see how changes in the intricate structure of DNA leads to conditions like heart disease, autoimmune disorders and cancer.’

Long-lived contrails usually form in natural ice clouds

Contrails over Jülich, embedded in very thin and therefore barely visible cirrus clouds.
Photo Credit:© Andreas Petzold

Long-lived contrails form predominantly not in cloud-free skies, but within already existing ice clouds. This is the conclusion reached by a team of scientists from Forschungszentrum Jülich, the University of Cologne, the University of Wuppertal, and Johannes Gutenberg University Mainz. Using extensive observational data, the researchers were able, for the first time, to systematically determine the atmospheric conditions under which long-lasting contrails form – whether in cloudless skies, in very thin and barely visible ice clouds, or in more clearly visible ice clouds, known as cirrus clouds. The result: more than 80 percent of all persistent contrails form within pre-existing clouds, mostly within natural cirrus clouds. The effects of this on the climate are not yet clearly understood. The study, now published in Nature Communications, provides important insights for further research – and, beyond that, strong arguments for taking cloud cover into account when planning flight routes adapted to climate considerations.