Scientists discover what drives California's worst fire years

Two natural resource specialists walk through an area of Redwood Mountain Grove burned in the KNP Complex Fire in California’s Sierra Nevada Mountains to evaluate fire effects.
Photo Credit: National Park Service

What makes one fire season worse than another in fire-prone parts of the world like California is poorly understood, but in a new study, scientists at the University of California, Irvine reveal how clusters of lightning-ignited fires called fire complexes are the chief drivers of the most destructive fire years. It’s a finding that could help agencies better manage such fires when they occur.

“Nobody has ever looked into these kinds of fires before,” said Rebecca Scholten, a postdoctoral fellow in Earth system science and lead author of the Science Advances study. “We theorized that when two or more fires in a fire complex merge, they would just burn themselves out. But we found the opposite – the fires grow worse.”

What Is: The Anthropocene

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At a Glance

• The Core Concept: The Anthropocene, or "Age of Man," is a proposed geological epoch positing that human activity has superseded natural forces to become the primary driver of Earth's geological and ecological systems.
• Key Distinction/Mechanism: Unlike the Holocene—the stable epoch of the last 11,700 years that fostered human civilization—the Anthropocene represents a fundamental rupture in Earth's history where humanity operates as a geological force rather than merely a biological one. It is characterized by the human-driven alteration of the atmosphere, hydrosphere, cryosphere, and biosphere, shifting the planet into a volatile and unstable interval.
• Origin/History: The term was popularized by atmospheric chemist Paul Crutzen at the turn of the millennium (c. 2000) to describe the profound impact of humanity on the planet.

Major Frameworks/Components

• A Diachronous "Event": The scientific community increasingly views the Anthropocene not strictly as a defined epoch with a singular start date (a "golden spike"), but as an unfolding, diachronous geological event comparable to the Great Oxidation Event.
• Planetary Health Indicators: The framework highlights critical shifts such as the disruption of nitrogen and phosphorus cycles, rapid ocean acidification, and accelerating species extinction.
• Stratigraphic Alteration: The concept suggests that humanity has fundamentally altered the physical stratigraphic record of the Earth.
• Why It Matters: The Anthropocene redefines the current environmental crisis not as a series of isolated issues, but as a systemic transformation of the Earth caused by a single species. It serves as the dominant conceptual framework for understanding planetary instability and signals that the conditions necessary for known civilization are ending.

Researchers create cells that help the brain keep its cool

Parvalbumin cells play a central role in keeping brain activity in equilibrium. They control nervcell signalling, reduce overactivity and make sure that the brain is working to a rhythm
Image Credit: Scientific Frontline

Researchers at Lund University in Sweden have created a method that makes it possible to transform the brain’s support cells into parvalbumin-positive cells. These cells act as the brain’s rapid-braking system and are significantly involved in schizophrenia, epilepsy, and other neurological conditions. 

Parvalbumin cells play a central role in keeping brain activity in equilibrium. They control nerve cell signaling, reduce overactivity and make sure that the brain is working to a rhythm. Researchers sometimes describe them as the cells that “make the brain sound right”. 

When these cells malfunction or decrease in number, the balance of the brain is disrupted. Previous studies suggest that damaged parvalbumin cells may contribute to disorders such as schizophrenia and epilepsy.  

What Is: Psychedelic Renaissance

The current "Psychedelic Renaissance" is not a new discovery but a recovery of lost knowledge.
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The Fourth Wave of Psychiatry

The field of psychiatry is currently undergoing its most significant paradigm shift since the introduction of the first psychopharmaceuticals in the mid-20th century. For decades, the standard of care for mental health disorders has been dominated by the monoamine hypothesis—the idea that regulating neurotransmitters like serotonin, dopamine, and norepinephrine through daily maintenance medication can rectify chemical imbalances. However, a growing body of evidence, accumulated largely over the last two decades and culminating in the pivotal events of 2024 and 2025, suggests that this model is incomplete. We are witnessing the rise of a "fourth wave" of psychiatry, characterized by the use of psychedelics: compounds that do not merely suppress symptoms but appear to catalyze profound, rapid, and durable healing through mechanisms of neuroplasticity and network reorganization.

This report serves as an exhaustive analysis of the current state of psychedelic medicine as of late 2025. It moves beyond the simplistic "shroom boom" narratives to dissect the complex neurobiology, the rigorous clinical trials, and the volatile regulatory landscape that defines this sector. The subject matter encompasses "classic" psychedelics like psilocybin and lysergic acid diethylamide (LSD), which primarily target the serotonin 2A receptor, as well as "atypical" psychedelics or entactogens like 3,4-methylenedioxymethamphetamine (MDMA).

Researchers find breast cancer drug boosts leukemia treatment

Jeffrey Tyner, Ph.D., and Melissa Stewart, Ph.D., led a team at OHSU that discovered a new drug combination that may help people with acute myeloid leukemia.
Photo Credit: OHSU/Christine Torres Hicks

A research team at Oregon Health & Science University has discovered a promising new drug combination that may help people with acute myeloid leukemia overcome resistance to one of the most common frontline therapies.

In a study published in Cell Reports Medicine, researchers analyzed more than 300 acute myeloid leukemia, or AML, patient samples and found that pairing venetoclax, a standard AML drug, with palbociclib, a cell-cycle inhibitor currently approved for breast cancer, produced significantly stronger and more durable anti-leukemia activity than venetoclax alone. The findings were confirmed in human tissue samples as well as in mouse models carrying human leukemia cells.

“Of the 25 drug combinations tested, venetoclax plus palbociclib was the most effective. That really motivated us to dig deeper into why it works so well, and why it appears to overcome resistance seen with current therapy,” said Melissa Stewart, Ph.D., research assistant professor in the OHSU School of Medicine and Knight Cancer Institute and lead author of the study.

More than 20,000 Americans are diagnosed with AML each year, making it one of the most common types of leukemia — and one of the most aggressive.

How doubting your doubts may increase commitment to goals

Research explores what happens when people face goal obstacles
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When it comes to our most important long-term goals in life, it is not uncommon to face obstacles that may lead us to doubt whether we can achieve our ambitions.

But when life hands you doubts, the answer may be to question your doubts, a new study suggests.

A psychology professor found that when people who were worried about achieving an identity goal were induced to experience what is called meta-cognitive doubt, they actually became more committed to achieving their goal.

“What this study found is that inducing doubts in one’s doubts can provide a formula for confidence,” said Patrick Carroll, author of the study and professor of psychology at The Ohio State University at Lima.

Water’s Age and What It Can Tell Us

PhD student Joshua Snarski is using stable water isotopes to study how water is stored and released from soil in agricultural settings.
Photo Credit: Courtesy of University of Connecticut

When it rains, what happens to the water once it enters the soil? Does the new precipitation mix with all of the water that was already there? In their recent paper in Water Resources Research, Department of Natural Resources and the Environment Ph.D. student Joshua Snarski and assistant professor James Knighton show the answer is more complicated than previously assumed, but knowing the age of water gives a more accurate picture.

Hydrologists use models to simulate what is happening in natural systems. Since hydrologic processes are complex, researchers need to make assumptions about some aspects, such as how water mixes within the soil profile. Though previous hydrologic research is focused on the amount and timing of precipitation, Snarski says shifting the focus to the age of water within the soil profile can reveal more about what is happening beneath the surface.

Zoology: In-Depth Description

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Zoology is the branch of biology dedicated to the scientific study of the animal kingdom, encompassing the structure, embryology, evolution, classification, habits, and distribution of all living and extinct animals. As a discipline, it seeks to understand how animals interact with their ecosystems, how they function physiologically, and how they have adapted to diverse environments over millions of years.

Virology: In-Depth Description

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Virology is the branch of biological science dedicated to the study of viruses—submicroscopic, parasitic particles of genetic material contained in a protein coat—and virus-like agents. Its primary goal is to understand the structure, classification, and evolution of these pathogens, their mechanisms of infection and exploitation of host cells, and their interactions with host organism physiology and immunity.

Machine learning drives drug repurposing for neuroblastoma

Daniel Bexell leads the research group in molecular pediatric oncology, and Katarzyna Radke, first author of the study.
Photo Credit: Lund University

Using machine learning and a large volume of data on genes and existing drugs, researchers at Lund University in Sweden have identified a combination of statins and phenothiazines that is particularly promising in the treatment of the aggressive form of neuroblastoma. The results from experimental trials showed slowing of tumor growth and higher survival rates. 

The childhood cancer, neuroblastoma, affects around 15-20 children in Sweden every year. Most of them fell ill before the age of five. Neuroblastoma is characterized by, among other things, tumors that are often resistant to drug treatment, including chemotherapy. The disease exists in both mild and severe forms, and the Lund University researchers are mainly studying the aggressive form, high-risk neuroblastoma. This variant is the form of childhood cancer with the lowest survival rate. 

Veterinary Science: In-Depth Description

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Veterinary Science is the branch of medicine and science concerned with the prevention, control, diagnosis, and treatment of diseases, disorders, and injuries in animals. Beyond clinical care, the field encompasses animal rearing, husbandry, breeding, research on nutrition, and product development. Its primary goals are to safeguard animal health, relieve animal suffering, conserve animal resources, promote public health through the control of zoonotic diseases, and advance medical knowledge through comparative medicine.

Technology: In-Depth Description

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Technology is the rigorous application of scientific knowledge, mathematical principles, and engineering techniques to create tools, systems, and processes that solve practical problems and extend human capabilities. Its primary goal is to bridge the gap between theoretical understanding and real-world utility, transforming abstract discoveries into tangible solutions that enhance efficiency, communication, health, and sustainability.

Spacecrafts: In-Depth Description

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A spacecraft is a vehicle or machine designed to fly in outer space. A type of artificial satellite, a spacecraft is used for a variety of purposes, including communications, earth observation, meteorology, navigation, space colonization, planetary exploration, and transportation of humans and cargo. The discipline involves the complex integration of engineering, physics, and computer science to ensure these vehicles can survive the harsh environment of the vacuum, extreme temperatures, and radiation inherent to the cosmos.

Space Weather: In-Depth Description

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Space Weather refers to the dynamic, variable conditions within the Solar System—specifically the space environment surrounding the Earth—driven primarily by solar activity. It encompasses the physical processes occurring on the Sun, in the solar wind, and within Earth’s magnetosphere, ionosphere, and thermosphere that can influence the performance and reliability of space-borne and ground-based technological systems, as well as endanger human health and life.

Space Science: In-Depth Description

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Space Science is the multifaceted scientific discipline dedicated to the exploration and study of natural phenomena and physical bodies occurring beyond Earth's atmosphere. Its primary goals are to understand the origins, evolution, and future of the Universe, to discover the fundamental physical laws governing the cosmos, and to explore the potential for life beyond our planet.