New study identifies how blood vessel dysfunction can worsen chronic disease

OHSU researchers have uncovered how specialized cells surrounding small blood vessels, known as perivascular cells, contribute to blood vessel dysfunction in chronic diseases such as cancer, diabetes and fibrosis. The findings could change how these diseases are treated.
Photo Credit: OHSU/Christine Torres Hicks

Researchers at Oregon Health & Science University have uncovered how specialized cells surrounding small blood vessels, known as perivascular cells, contribute to blood vessel dysfunction in chronic diseases such as cancer, diabetes and fibrosis. The findings, published in Science Advances, could change how these diseases are treated.

The study, led by Luiz Bertassoni, D.D.S., Ph.D., founding director of the Knight Cancer Precision Biofabrication Hub and a professor at the OHSU Knight Cancer Institute and the OHSU School of Dentistry, shows that perivascular cells sense changes in nearby tissues and send signals that disrupt blood vessel function, worsening disease progression.

SwRI models pluto-charon formation scenario that mimics earth-moon system

Using advanced models, SwRI led new research that indicates that the formation of Pluto and Charon may parallel that of the Earth-Moon system. In the resulting 'kiss-and-captureâ regime, Pluto and Charon collide and stick together in the shape of a snowman. They rotate as one body until Pluto pushes Charon out into a stable orbit.
Image Credit: Courtesy of SwRI/Adeene Denton/Robert Melikyan

A NASA postdoctoral researcher at Southwest Research Institute has used advanced models that indicate that the formation of Pluto and Charon may parallel that of the Earth-Moon system. Both systems include a moon that is a large fraction of the size of the main body, unlike other moons in the solar system. The scenario also could support Pluto’s active geology and possible subsurface ocean, despite its location at the frozen edge of the solar system.

“We think the Earth-Moon system initiated when a Mars-sized object hit the Earth and led to the formation of our large Moon sometime later,” said Dr. Adeene Denton, who led the research, published in Nature Geoscience. “In comparison, Mars has two tiny moons that look like potatoes, while the moons of the giant planets make up a small fraction of their total systems.”

Scientists engineer CRISPR enzymes that evade the immune system

Image Credit: Natalie Velez, Broad Communications

The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate unwanted immune responses in people, increasing the chances of side effects and making these therapies potentially less effective. 

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The team identified protein sequences on each nuclease that trigger the immune system and used computational modeling to design new versions that evade immune recognition. The engineered enzymes had similar gene-editing efficiency and reduced immune responses compared to standard nucleases in mice.

Appearing today in Nature Communications, the findings could help pave the way for safer, more efficient gene therapies. The study was led by Feng Zhang, a core institute member at the Broad and an Investigator at the McGovern Institute for Brain Research at MIT.

“As CRISPR therapies enter the clinic, there is a growing need to ensure that these tools are as safe as possible, and this work tackles one aspect of that challenge,” said Zhang, who is also a co-director of the K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics, the James and Patricia Poitras Professor of Neuroscience, and a professor at MIT. He is an Investigator at the Howard Hughes Medical Institute.

Researchers find dialysis ‘astonishingly effective’ for treating wastewater

Menachem Elimelech and Yuanmiaoliang “Selina” Chen.
Photo Credit: Gustavo Raskosky/Rice University

Researchers at Rice University, in collaboration with Guangdong University of Technology, have uncovered an innovative approach to treating high-salinity organic wastewaters — streams containing both elevated salt and organic concentrations — by employing dialysis, a technology borrowed from the medical field.

For patients with kidney failure, dialysis uses a machine called a dialyzer to filter waste and excess fluid from the blood; blood is drawn from the body, cleansed in the dialyzer then returned through a separate needle or tube.

In a new study published in Nature Water, the team found that mimicking this same method can separate salts from organic substances with minimal dilution of the wastewater, simultaneously addressing key limitations of conventional methods. This novel pathway has the potential to reduce environmental impacts, lower costs and enable the recovery of valuable resources across a range of industrial sectors.

Dense human population is linked to longer urban coyote survival

Urban Coyote
Photo Credit: David Torres

Tracking coyote movement in metropolitan areas shows the animals spend lots of time in natural settings, but a new study suggests the human element of city life has a bigger impact than the environment on urban coyote survival. 

Researchers monitoring coyotes in Chicago found that habitat – areas with relatively high levels of vegetation cover and low levels of human infrastructure – did not influence coyote survival in positive or negative ways. Instead, areas densely populated with humans were associated with longer coyote lifespans. 

“What we found was really interesting, in that the societal characteristics seem to play a much more important role in predicting coyote survival time than the environmental characteristics,” said Emily Zepeda, first author of the study and a postdoctoral scholar in the School of Environment and Natural Resources at The Ohio State University. 

“And then we found this positive effect of human population density on survival time. Both of those things are unexpected because we usually associate human activity with detrimental effects on wildlife.” 

The study was published recently in the journal Urban Ecosystems. 

Quantum simulators: When nature reveals its natural laws

Photo Credit: © Oliver Diekmann/TU Wien

Quantum simulators are a completely new tool for research: quantum physics is studied by other kinds of quantum physics. Research teams from Innsbruck and Vienna are developing a new method that will allow this new technology to be reliably verified.

Quantum physics is a very diverse field: it describes particle collisions shortly after the Big Bang as well as electrons in solid materials or atoms far out in space. But not all quantum objects are equally easy to study. For some – such as the early universe – direct experiments are not possible at all. However, in many cases quantum simulators can be used instead: One quantum system (for example, a cloud of ultracold atoms) is studied in order to learn something about another system that looks physically very different, but still follows the same laws, i.e. adheres to the same mathematical equations.

It is often difficult to find out which equations determine a particular quantum system. Normally, one first has to make theoretical assumptions and then conduct experiments to check whether these assumptions prove correct. Strikingly, researchers at the University of Innsbruck, opens an external URL in a new window, the Institute of Quantum Optics and Quantum Information, opens an external URL in a new window (IQOQI) and TU Wien (Vienna) have now jointly achieved an important step in this field: they have developed a method that allows them to read directly from the experiment which physical theory effectively describes the behavior of the quantum system. This now allows for a new kind of quality control: it is possible to directly check whether the quantum simulator actually does what it is supposed to simulate. This should enable quantitative statements to be made about quantum systems that cannot be investigated directly.

Increased wildfire activity may be a feature of past periods of abrupt climate change, study finds

A new study investigating ancient methane trapped in Antarctic ice suggests that global increases in wildfire activity likely occurred during periods of abrupt climate change throughout the last Ice Age.

The study, just published in the journal Nature, reveals increased wildfire activity as a potential feature of these periods of abrupt climate change, which also saw significant shifts in tropical rainfall patterns and temperature fluctuations around the world.

“This study showed that the planet experienced these short, sudden episodes of burning, and they happened at the same time as these other big climate shifts,” said Edward Brook, a paleoclimatologist at Oregon State University and a co-author of the study. “This is something new in our data on past climate.”

The findings have implications for understanding modern abrupt climate change, said the study’s lead author, Ben Riddell-Young, who conducted the research as part of his doctoral studies in OSU’s College of Earth, Ocean, and Atmospheric Sciences.

“This research shows that we may not be properly considering how wildfire activity might change as the climate warms and rainfall patterns shift,” said Riddell-Young, who is now a postdoctoral scholar at the Cooperative Institute for Research in Environmental Sciences at the University of Colorado, Boulder.

New protective coating can improve battery performance

Mario El Kazzi and his team have developed a cathode surface coating that enables operating voltages of up to 4.8 volts.
Photo Credit: © Paul Scherrer Institute PSI/Mahir Dzambegovic

A research team at the Paul Scherrer Institute PSI has developed a new sustainable process that can be used to improve the electrochemical performance of lithium-ion batteries. Initial tests of high-voltage batteries modified in this way have been successful. This method could be used to make lithium-ion batteries, for example those for electric vehicles, significantly more efficient.

Lithium-ion batteries are considered a key technology for decarbonization. Therefore, researchers around the world are working to continuously improve their performance, for example by increasing their energy density. “One way to achieve this is to increase the operating voltage,” says Mario El Kazzi from the Center for Energy and Environmental Sciences at Paul Scherrer Institute PSI. "If the voltage increases, the energy density also increases.”

However, there is a problem: At operating voltages above 4.3 volts, strong chemical and electrochemical degradation processes take place at the transition between the cathode, the positive pole, and the electrolyte, the conductive medium. The surface of the cathode materials gets severely damaged by the release of oxygen, dissolution of transition metals, and structural reconstruction – which in turn results in a continuous increase in cell resistance and a decrease in capacity. This is why commercial battery cells, such as those used in electric cars, have so far only run at a maximum of 4.3 volts.

Membrane Anchor Suppresses Protein Aggregation

3 D reconstruction of a microscope image: red is the membrane and green clumped prion protein.
Image Credit: AG Tatzelt

Researchers have gained valuable insight into the development of prion diseases of the brain.

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer’s, Parkinson’s and prion diseases such as Creutzfeld-Jakob disease. A research team headed by Professor Jörg Tatzelt from the Department of Biochemistry of Neurodegenerative Diseases at Ruhr University Bochum, Germany, has now used new in vitro and cell culture models to show that a lipid anchor on the outer membrane of nerve cells inhibits the aggregation of the prion protein. “Understanding the mechanisms that cause the originally folded proteins to transform into pathogenic forms is of crucial importance for the development of therapeutic strategies,” says Jörg Tatzelt. The team published their findings in the journal Proceedings of the National Academy of Sciences.

Researchers discover how to mimic hibernation in non-hibernating animals

OHSU researcher Domenico Tupone, Ph.D., has discovered a method to control human body temperature, mimicking hibernation in non-hibernating animals. His research is focused on how controlled hypothermia may reduce tissue damage following a cardiac attack or stroke.
Photo Credit: OHSU/Christine Torres Hicks

In the same way a bear instinctively lowers its body temperature to survive the winter’s chill, scientists have discovered a groundbreaking method to control human body temperature —potentially saving lives in emergency situations.

Oregon Health & Science University researchers have identified a process that could one day help clinicians lower body temperature in people experiencing life-threatening events, such as heart attacks or strokes.

If applied in humans, who can’t naturally hibernate, the discovery could mimic the natural ability of certain animals to lower their body temperature during hibernation.

“The idea is to reduce the body temperature to a lower level so that tissues like the brain or heart don't need as much oxygen, allowing them to survive the ischemia [lack of oxygen to tissues] longer and improve the functional outcomes of strokes or heart attacks,” said Domenico Tupone, Ph.D., senior author of the study and research assistant professor of neurological surgery in the OHSU School of Medicine.