A Laser-Powered Upgrade to Cancer Treatment

Kei Nakamura, Antoine Snijders and Lieselotte Obst-Huebl (from left) at the BELLA laser facility aligning cartridges containing human cells in the proton beam path. This setup enabled measurements of the biological effects of laser-driven protons.
Credit: Lawrence Berkeley National Laboratory

Biologists and physicists at Lawrence Berkeley National Laboratory (Berkeley Lab) have teamed up to create new opportunities for cancer treatment using laser-generated proton beams.

The ongoing project seeks to adapt the nascent technology of laser-driven ion accelerators – which are as cool as they sound – to make a more effective type of radiation therapy more readily available to patients.

“Proton therapy centers are large, expensive facilities, so they are limited around the world,” said co-lead author Antoine Snijders, a cancer researcher and senior scientist in the Biological Sciences and Engineering (BSE) Division. “There is currently limited geographic distribution and access to proton therapy worldwide.  The way to get broader access, and potentially lower costs, is to reduce the cost and footprint of these types of facilities. And that means we need more compact sources of ions for proton accelerators.”

Scientists are also investigating the potential benefit of using these accelerators to deliver proton beam radiation therapy at ultrahigh doses within extremely short exposure times – a technology called FLASH radiotherapy. Though the approach remains experimental for now, FLASH radiotherapy could change the landscape of radiation oncology. “If our work could also bring FLASH radiotherapy to patients, it could be the best of both worlds,” Snijders added.

Artificial Intelligence Tool May Help Predict Heart Attacks

Damini Dey, PhD

Investigators from Cedars-Sinai have created an artificial intelligence-enabled tool that may make it easier to predict if a person will have a heart attack.

The tool described in The Lancet Digital Health accurately predicted which patients would experience a heart attack in five years based on the amount and composition of plaque in arteries that supply blood to the heart.

Plaque buildup can cause arteries to narrow, which makes it difficult for blood to get to the heart, increasing the likelihood of a heart attack. A medical test called a coronary computed tomography angiography (CTA) takes 3D images of the heart and arteries and can give doctors an estimate of how much a patient’s arteries have narrowed. Until now, however, there has not been a simple, automated and rapid way to measure the plaque visible in the CTA images.

“Coronary plaque is often not measured because there is not a fully automated way to do it,” said Damini Dey, PhD, director of the quantitative image analysis lab in the Biomedical Imaging Research Institute at Cedars-Sinai and senior author of the study. “When it is measured, it takes an expert at least 25 to 30 minutes, but now we can use this program to quantify plaque from CTA images in five to six seconds.”

Dey and colleagues analyzed CTA images from 1,196 people who underwent a coronary CTA at 11 sites in Australia, Germany, Japan, Scotland and the United States. The investigators trained the AI algorithm to measure plaque by having it learn from coronary CTA images, from 921 people, that already had been analyzed by trained doctors.

Preserving the past

Christina Chavez is Sandia National Laboratories’ first full-time archaeologist. She established the Labs’ cultural resources program within the Environment, Safety and Health group.
Photo by Bret Latter

When archaeologist Christina Chavez surveys Sandia National Laboratories land and finds rusted tobacco tins, ceramic fragments, glass shards or rocks resting in deliberate formations, she documents and determines who at the Labs needs to know.

“Archaeological resources are all around us, and even if most people don’t see them, there’s still a potential that they’re there,” Chavez said.

Chavez, the Labs’ first full-time archaeologist, works with teams throughout Sandia to ensure the U.S. Department of Energy remains in compliance with Section 106 of the National Historic Preservation Act. Established in 1966, the act requires federal agencies to consider the effects on historic properties when carrying out or funding projects. For Sandia, projects can mean anything from construction to an experiment or explosion taking place in remote areas.

Scientists discover when beetles became prolific

 Credit: Vladimka production

Researchers at the University of Bristol have found that beetles first roamed the world in the Carboniferous and later diversified alongside the earliest dinosaurs during the Triassic and Jurassic.

Using a previously published and carefully curated 68-gene dataset, the scientists ran a battery of mathematical models to reconstruct the evolution of protein sequences - the results of which have been published today in Royal Society Open Science.

After a year and a half of running on a supercomputer at the University of Bristol’s Advanced Computing Research Centre, the scientists were able to build a robust evolutionary tree of beetles which also included data on 57 beetle fossils to contain the timescale of beetle evolution. Their findings provide one of the most comprehensive evolutionary trees of beetles.

Different beetle clades diversified independently, as various new ecological opportunities opened up. “There was not a single epoch of beetle radiation, their secret seems to lie in their remarkable flexibility,” explained author Professor Chenyang Cai of Bristol’s School of Earth Sciences. “The refined timescale of beetle evolution will be an invaluable tool for investigating the evolutionary basis of the beetle’s success story.”

Nearby star could help explain why our sun didn’t have sunspots for 70 years

This image depicts a typical 11-year cycle on the sun, with the fewest sunspots appearing at its minimum (top left and top right) and the most appearing at its maximum (center).
Credit: NASA

The number of sunspots on our sun typically ebbs and flows in a predictable 11-year cycle, but one unusual 70-year period when sunspots were incredibly rare has mystified scientists for 300 years. Now a nearby sun-like star seems to have paused its own cycles and entered a similar period of rare starspots, according to a team of researchers at Penn State. Continuing to observe this star could help explain what happened to our own sun during this “Maunder Minimum” as well as lend insight into the sun's stellar magnetic activity, which can interfere with satellites and global communications and possibly even affect climate on Earth.

  The star — and a catalog of 5 decades of starspot activity of 58 other sun-like stars — is described in a new paper that appears online in the Astronomical Journal.

  Starspots appear as a dark spot on a star’s surface due to temporary lower temperatures in the area resulting from the star’s dynamo — the process that creates its magnetic field. Astronomers have been documenting changes in starspot frequency on our sun since they were first observed by Galileo and other astronomers in the 1600s, so there is a good record of its 11-year cycle. The exception is the Maunder Minimum, which lasted from the mid-1600s to early 1700s and has perplexed astronomers ever since.

A robot small enough to explore the lungs

The image shows a life-size model of part of a bronchial tree built from anatomical data. A section of the magnetic tentacle robot is seen on the right.
Credit: University of Leeds

Engineers and scientists have paved the way for a robot that can reach some of the smallest bronchial tubes in the lungs – to take tissue samples or deliver cancer therapy.

Known as a magnetic tentacle robot, it measures just 2 millimeters in diameter, about twice the size of the tip of a ballpoint pen.

Magnets on the outside of the patient will be used to guide the magnetic tentacle robot into place.

The device has been developed by a team of engineers, scientists and clinicians based at the STORM Lab at Leeds, which is pioneering the use of robotic systems to assist in endoscopy and catheter procedures, where a fine tube is inserted into the body.

The researchers have published their findings in the journal Soft Robotics.

The proof of concept they have developed was based on laboratory tests involving a 3D replica of a bronchial tree modelled from anatomical data. The next phase of the research will investigate the effectiveness of the device in navigating lungs taken from a cadaver.

No return to normal, permanent drought or wet conditions ahead

Credit: Oleksandr Sushko

Many regions of the world will enter nearly permanent drought or pluvial (wet) conditions in the coming decades, according to researchers from half a dozen institutions, including the University of Hawaiʻi at Mānoa, who investigated what the future might hold in terms of rainfall and soil moisture. The findings, published in Proceedings of the National Academy of Sciences, reveal the importance of rethinking how these events are classified as well as how communities adapt to a changing environment.

In some areas of the western United States, for instance, conditions have blown past severe and extreme drought into exceptional drought. But rather than add more superlatives to the descriptions, it could be time to reconsider the very definition of drought.

“When we talk about being in a drought, the presumption is that eventually the drought will end, and conditions will return to normal,” said Samantha Stevenson, lead author of the study, assistant professor at the University of California, Santa Barbara and former postdoctoral fellow at UH Mānoa’s School of Ocean and Earth Science and Technology (SOEST). “But if we’re never returning to normal, then we need to adapt all of the ways that we manage water with the expectation that normal will continually be drier and drier every year.”

‘Junk DNA’ key to controlling fear

A piece of “junk DNA” could be the key to extinguishing fear-related memories for people struggling with post-traumatic stress disorder (PTSD) and phobia, according to a study from The University of Queensland.

An international research project, led by the Queensland Brain Institute’s Associate Professor Timothy Bredy, discovered the new gene while investigating how the genome responds to traumatic experiences.

“Until recently, scientists thought the majority of our genes were made up of junk DNA, which essentially didn’t do anything.” Dr Bredy said.

“But when researchers began to explore these regions, they realized that most of the genome is active and transcribed.”

Using a powerful new sequencing approach, Dr Bredy’s team identified 433 long non-coding RNAs from relatively unknown regions of the human genome.

“The technology is a really interesting way to zero in on sites within the genome that would otherwise be masked,” Dr Bredy said.

“It’s like harnessing the power of the Hubble Telescope to peer into the unknown of the brain.”

A new gene, labelled ADRAM by the researchers, was found to not only act as a scaffold for molecules inside the cell, but also helped coordinate the formation of fear-extinction memory.

Until now, there have been no studies devoted to understanding these genes, or how they might influence brain function in the context of learning and memory.

Research suggests interrupting immune response improves multiple sclerosis outcomes

Multiple sclerosis is a chronic disease that damages neurons. A WVU doctoral student, Kelly Monaghan, is researching the role that a protein, STAT5, plays in the development of MS.
Credit: WVU Illustration/Aira Burkhart

A human immune system is a lot like the board game Mouse Trap: it’s a Rube Goldberg system of interacting parts. Only instead of a falling ball causing a tiny diver to leap into a tub—which, in turn, springs a trap on some plastic mice—proteins trigger other proteins to activate immune cells and direct them toward germs. But if those proteins mistakenly direct immune cells toward healthy tissue, autoimmune diseases like multiple sclerosis – which attacks neurons - can arise.

Kelly Monaghan
Footnote 1 Credit: WVU Photo/Tyler Mertins

A new study led by Kelly Monaghan—a researcher with the West Virginia University School of Medicine—suggests that part of the “Rube Goldberg” immune system shows promise as a potential target for MS therapies.

“Anytime you have any kind of central nervous system issues, you have to go through a series of steps to have cells get into the brain or spinal cord,” said Monaghan, a doctoral candidate in the Department of Microbiology, Immunology and Cell Biology. “Gaining a better understanding of those immune mechanisms associated with MS can help to inform novel therapies.”

Her findings appeared in the Proceedings of the National Academy of Science.

Her study—funded by the National Institutes of Health—focused on STAT5, one of the many proteins circulating in the body that can metaphorically turn genes on or off.

Nanoparticle-based COVID-19 vaccine could target future infectious diseases

SNAs are ball-like forms of DNA and RNA
arranged on the surface of a nanoparticle

Just one dose of a new nanoparticle-based COVID-19 vaccine was enough to produce an immune response in animals on track with vaccines currently in clinical use. And with minor changes, Northwestern University researchers hope the same vaccine platform could target other infectious diseases.

In a new study, 100% of mice who received the protein-based immunization survived when challenged with lethal doses of the SARS-CoV-2 virus, which causes COVID-19. None of the mice experienced lung damage due to SARS-CoV-2 exposure. All mice who did not receive this nanoparticle vaccine died in a 14-day trial.

The results, published this week in the Proceedings of the National Academy of Sciences, outline the structure-function relationships between the first spherical nucleic acid (SNA) vaccine developed to protect against viral infections.

“What makes this vaccine different than other vaccines is the approach we take to design them,” said Dr. Michelle Teplensky, co-first author of the paper. “Even as recently as a few years ago people focused on selecting the right target to train the immune system and the right stimulant to activate it, not on how those components were arranged structurally and presented to the body.”

Called SNAs, the nanoparticles that house the immune target are a form of globular DNA that can enter and stimulate immune cells with extreme efficiency. SNAs have been tested in more than 60 cell types. Researchers experimentally determined the ideal ratio between the SNA’s shell and core density that produces the most potent response.

SNA vaccines have been used to treat mice with triple negative breast cancer — and more vaccines for other cancers are in development.