COVID-19 vaccine not associated with birth defects detectable on ultrasound

Dr. Emily Miller explains elements of a fetal ultrasound to fellow study author Dr. Rachel Ruderman. Credit: Northwestern University

The exclusion of pregnant patients in initial COVID-19 vaccine clinical trials left many patients and doctors wondering how the vaccine might affect pregnant patients and their unborn babies. But a new Northwestern Medicine study finds the vaccine is not associated with birth defects that are detectable on ultrasound.

“This is yet another important piece of data that helps bridge the chasm that was left when pregnant individuals were excluded from those initial vaccine trials,” said corresponding author Dr. Emily Miller, chief of obstetrics at Northwestern Medicine and assistant professor of maternal fetal medicine at Northwestern University Feinberg School of Medicine.

The study was published April 4 in the journal JAMA Pediatrics.

“One of the reasons women struggle with the vaccine in pregnancy is they’re worried about their babies and don’t want to take any risks,” said first author Dr. Rachel Ruderman, a fourth-year resident in obstetrics and gynecology at Feinberg. “This study shows there really is no increased risk of birth defects, and it supports other evidence that shows the vaccine is safe and beneficial for mom and baby.”

New perspective highlights promise of hybrid approach for cellulosic biofuel production

Scientists with the Center for Bioenergy Innovation at ORNL highlighted a hybrid approach that uses microbes and catalysis to convert cellulosic biomass into fuels suitable for aviation and other difficult-to-electrify sectors.
Credit: ORNL, U.S. Dept. of Energy

The rapid pace of global climate change has added urgency to developing technologies that reduce the carbon footprint of transportation technologies, especially in sectors that are difficult to electrify. In response, researchers collaborating through the Center for Bioenergy Innovation make the case that scientific advances support a hybrid approach using biological and catalytic methods for producing cellulosic biofuel for use in airplanes, ships and long-haul trucks.

As presented in Energy & Environmental Science, this hybrid approach uses microbes to convert cellulosic biomass such as wood and grass into an intermediate, small-molecule product such as ethanol. The ethanol would then be catalytically upgraded into hydrocarbon fuels suitable for heavier vehicles.

The study states that using the combination of biological and catalytic methods “is a promising approach to bridge the current gap between the fuel molecules that biology most readily makes and the fuel molecules that the world would most value producing from biomass.”

“We’re looking at this as taking the best of both worlds: Using biology for what it really does well, which is to make these small molecules, and then using catalysis to do what it does well, which is to make hydrocarbon fuel mixtures rapidly,” said Brian Davison, co-author and chief science officer for CBI, headquartered at the Department of Energy’s Oak Ridge National Laboratory.

The global “plastic flood” reaches the Arctic

Collecting plastics after the catamaran.
Credit: Alfred-Wegener-Institute / Esther Horvath

Even the High North can’t escape the global threat of plastic pollution. An international review study just released by the Alfred Wegener Institute shows the flood of plastic has reached all spheres of the Arctic: large quantities of plastic - transported by rivers, the air and shipping- can now be found in the Arctic Ocean. High concentrations of microplastic can be found in the water, on the seafloor, remote beaches, in rivers, and even in ice and snow. Plastic is not only a burden for ecosystems; it could also worsen climate change. The study was just released in the journal Nature Reviews Earth & Environment.

The numbers speak for themselves. Today, between 19 and 23 million metric tons of plastic litter per year end up in the waters of the world – that’s two truckloads per minute. Since plastic is also very stable, it accumulates in the oceans, where it gradually breaks down into ever smaller pieces – from macro- to micro- and nanoplastic and can even enter the human bloodstream. And the flood of debris is bound to get worse: global plastic production is expected to double by 2045.

The consequences are serious. Today, virtually all marine organisms investigated – from plankton to sperm whales – come into contact with plastic debris and microplastic. And this applies to all areas of the world’s oceans – from tropical beaches to the deepest oceanic trenches. As the study published by the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) now shows, the High North is no exception. “The Arctic is still assumed to be a largely untouched wilderness,” says AWI expert Dr Melanie Bergmann. “In our review, which we jointly conducted with colleagues from Norway, Canada and the Netherlands, we show that this perception no longer reflects the reality. Our northernmost ecosystems are already particularly hard hit by climate change. This is now exacerbated by plastic pollution. And our own research has shown that the pollution continues to worsen.”

Flesh-eating bacteria in Ala Wai Canal could increase threefold by end of century

Field team casting off at the Ala Wai Harbor.
Photo credit: Brian Glazer, UH SOEST

Vibrio vulnificus, a “flesh-eating” bacterium that lives naturally in the water of the Ala Wai Canal in Waikīkī is likely to increase substantially in coming decades, but infections are rare. In recently published research, University of Hawaiʻi at Mānoa scientists highlight the potential for using oceanographic sensors to make accurate predictions of V. vulnificus. By assessing rainfall, water temperature, dissolved nutrients and organic matter the team can forecast potential spikes in levels of the bacteria.

V. vulnificus has been relatively understudied in tropical ecosystems and further, the implications of climate change for this and other coastal human pathogens are generally unknown.

The research team collaborated with the UH Strategic Monitoring and Resilience Training in the Ala Wai Watershed (SMART Ala Wai Program) where at least 20 undergraduate students and six graduate students from the UH Mānoa School of Ocean and Earth Science and Technology (SOEST) participated in sample collection from the canal and processing at the Daniel K. Inouye Center for Microbial Oceanography: Research and Education.

The art of smell: Research suggests the brain processes smell both like a painting and a symphony

What happens when we smell a rose? How does our brain process the essence of its fragrance? Is it like a painting – a snapshot of the flickering activity of cells – captured in a moment in time? Or like a symphony, an evolving ensemble of different cells working together to capture the scent? New research suggests that our brain does both.

“These findings reveal a core principle of the nervous system, flexibility in the kinds of calculations the brain makes to represent aspects of the sensory world,” said Krishnan Padmanabhan, Ph.D., an associate professor of Neuroscience and senior author of the study recently published in Cell Reports. “Our work provides scientists with new tools to quantify and interpret the patterns of activity of the brain.”

Researchers developed a model to simulate the workings of the early olfactory system – the network the brain relies on for smelling. Employing computer simulations, they found a specific set of connections, called centrifugal fibers, which carry impulses from other parts of the central nervous system to the early sensory regions of the brain, played a critical role. These centrifugal fibers act as a switch, toggling between different strategies to efficiently represent smells. When the centrifugal fibers were in one state, the cells in the piriform cortex – where the perception of an odor forms – relied on the pattern of activity within a given instant in time. When the centrifugal fibers were in the other state, the cells in the piriform cortex improved both the accuracy and the speed with which cells detected and classified the smell by relying on the patterns of brain activity across time.

These processes suggest the brain has multiple responses to representing a smell. In one strategy, the brain uses a snapshot, like a painting or a photograph, at a given moment to capture the essential features of the odor. In the other strategy, the brain keeps track of the evolving patterns. It is attuned to which cells turn on and off and when – like a symphony.

The dark matter of the brain

Electrical synapses connect neurons in almost all brains; however, little is known about them. A study now shows for the first time where these specific synapses occur in the fruit fly brain and that they influence the function and stability of nerve cells.
Credit: MPI for Biological Intelligence, i.f. / Julia Kuhl

They are part of the brain of almost every animal species, yet they remain usually invisible even under the electron microscope. "Electrical synapses are like the dark matter of the brain," says Alexander Borst, director at the MPI for Biological Intelligence, in foundation (i.f). Now a team from his department has taken a closer look at this rarely explored brain component: In the brain of the fruit fly Drosophila, they were able to show that electrical synapses occur in almost all brain areas and can influence the function and stability of individual nerve cells.

Neurons communicate via synapses, small contact points at which chemical messengers transmit a stimulus from one cell to the next. We may remember this from biology class. However, that is not the whole story. In addition to the commonly known chemical synapses, there is a second, little-known type of synapse: electrical synapse. "Electrical synapses are much rarer and are hard to detect with current methods. That's why they have hardly been researched so far," explains Georg Ammer, who has long been fascinated by these hidden cell connections. "In most animal brains, we therefore don't know even basic things, such as where exactly electrical synapses occur or how they influence brain activity."

Boeing’s Spectrolab to Power NASA’s Roman Space Telescope

Spectrolab, Inc., a wholly owned subsidiary of Boeing, will build the solar cells and integrate solar panels for NASA’s Roman Space Telescope.
Credit: GSFC/SVS

Spectrolab, Inc., a wholly owned subsidiary of Boeing [NYSE: BA], will manufacture, integrate and test approximately 4,000 XTJ Prime solar cells for NASA’s Nancy Grace Roman Space Telescope.

“Using Spectrolab’s XTJ Prime solar cells, NASA will be able to maximize the Roman Space Telescope’s power generation, allowing greater data gathering capability while operating in a unique mission environment at the L2 Lagrange point,” said Tony Mueller, president of Spectrolab. “These cells leverage both heritage and high efficiency for the agency’s newest universe studying telescope.”

Spectrolab’s NeXt Triple Junction (XTJ) Prime solar cells will provide power to the telescope, including its two main instruments – the Wide Field Instrument and the Coronagraph Instrument – as well as the primary mirror that is 2.4 meters in diameter (7.9 feet), and is the same size as the Hubble Space Telescope's primary mirror. The solar array consists of six panels, each approximately 3m-by-2.5m and consists of 4,000 triple junction solar cells. Triple junction solar cells leverage multiple bandgaps tuned to different wavelengths of the solar spectrum, allowing higher efficiencies not possible with commercially available silicon solar cell technology.

Historic Hypersonic Flight

Artist rendering of the Hypersonic Air-breathing Weapon Concept (HAWC), the result of a partnership between the Defense Advanced Research Projects Agency, Air Force Research Lab, Lockheed Martin and Aerojet Rocketdyne.
Credit: Lockheed Martin Corporation

The Defense Advanced Research Projects Agency (DARPA), Air Force Research Lab (AFRL), Lockheed Martin (NYSE: LMT) and Aerojet Rocketdyne (NYSE: AJRD) team successfully flight tested the Hypersonic Air-breathing Weapon Concept (HAWC). This historic flight reached speeds in excess of Mach 5, altitudes greater than 65,000 feet and furthers the understanding of operations in the high-speed flight regime.

"Our work with DARPA and AFRL on the HAWC program demonstrates that air-breathing hypersonic systems are a cost-effective solution to address rapidly emerging threats in the global security arena," said John Clark, vice president and general manager Lockheed Martin Skunk Works®. "The success of this flight test is evidence that a strong partnership between government and industry is key to solving our nation's most difficult challenges and enabling new capabilities to counter threats to U.S. and allied forces."

Evidence Shows Violent Collapse Responsible for Formation of Jupiter-Like Protoplanet

This is an artist's illustration of a massive, newly forming exoplanet called AB Aurigae b. Researchers used new and archival data from the Hubble Space Telescope and the Subaru Telescope to confirm this protoplanet is forming through an intense and violent process, called disk instability.
Credits: NASA, ESA, Joseph Olmsted (STScI)

NASA's Hubble Space Telescope has directly photographed evidence of a Jupiter-like protoplanet forming through what researchers describe as an "intense and violent process." This discovery supports a long-debated theory for how planets like Jupiter form, called "disk instability."

The new world under construction is embedded in a protoplanetary disk of dust and gas with distinct spiral structure swirling around, surrounding a young star that's estimated to be around 2 million years old. That's about the age of our solar system when planet formation was underway. (The solar system's age is currently 4.6 billion years.)

"Nature is clever; it can produce planets in a range of different ways," said Thayne Currie of the Subaru Telescope and Eureka Scientific, lead researcher on the study.

In the heat of the wound

Empa researcher Fei Pan is working on a membrane made of nanofibers that releases medication only when the material heats up. Such a membrane could, for example, become active in a bandage as soon as inflammation starts.
Image: Empa

A bandage that releases medication as soon as an infection starts in a wound could treat injuries more efficiently. Empa researchers are currently working on polymer fibers that soften as soon as the environment heats up due to an infection, thereby releasing antimicrobial drugs.

It is not possible to tell from the outside whether a wound will heal without problems under the dressing or whether bacteria will penetrate the injured tissue and ignite an inflammation. To be on the safe side, disinfectant ointments or antibiotics are applied to the wound before the dressing is applied. However, these preventive measures are not necessary in every case. Thus, medications are wasted and wounds are over-treated.

Even worse, the wasteful use of antibiotics promotes the emergence of multi-resistant germs, which are an immense problem in global healthcare. Empa researchers at the two Empa laboratories Biointerfaces and Biomimetic Membranes and Textiles in St. Gallen wants to change this. They are developing a dressing that autonomously administers antibacterial drugs only when they are really needed.

The idea of the interdisciplinary team led by Qun Ren and Fei Pan: The dressing should be "loaded" with drugs and react to environmental stimuli. "In this way, wounds could be treated as needed at exactly the right moment," explains Fei Pan. As an environmental stimulus, the team chose a well-known effect: the rise in temperature in an infected, inflamed wound.