Mucosal antibodies in the airways provide durable protection against SARS-CoV-2

Charlotte Thålin, M.D. and associate professor at the Department of Clinical Sciences, Danderyd Hospital
Photo Credit: Ludvig Kostyal

Researchers hope that a nasal vaccine may generate mucosal immune responses that protect against SARS-CoV-2 infection.

High levels of mucosal IgA antibodies in the airways protect against SARS-CoV-2 infection for at least eight months. Omicron infection generates durable mucosal antibodies, reducing the risk of re-infection. These are the findings of a study published in The Lancet Infectious Diseases by researchers at Karolinska Institutet and Danderyd Hospital in Sweden. The results raise further hope for the feasibility of future nasal vaccine platforms to protect against infection.

“Antibodies in the blood protect from severe disease, but if we aim to limit infection, viral transmission and the emergence of new SARS-CoV-2 variants, we need to reinforce our immunity at the mucosal surface, which is the viral point of entry”, says Charlotte Thålin, M.D. and associate professor at the Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet who led the study. “This is not achieved by currently employed intramuscularly-delivered vaccines. But the hope is that a nasal vaccine may generate mucosal immune responses similar to those seen after infection, and thereby block the transmission chain”.

Deflecting lightning with a laser lightning rod

During tests carried out on the summit of the Säntis by Jean-Pierre Wolf and Aurélien Houard's team, the scientists noted that the discharge could follow the laser beam of the "LLR" for several dozen meters before reaching the tower of the operator Swisscom (in red and white).
Photo Credit: Xavier Ravinet - UNIGE

A European consortium led by UNIGE, École Polytechnique (Paris), EPFL, hes-so and TRUMPF has managed to guide lightning using a high-power laser installed at the top of Mount Säntis in Switzerland.

Forest fires, power cuts and damaged infrastructure…lightning fascinates and destroys in equal measure, causing as many as 24,000 deaths a year worldwide not to mention widespread destruction. Even today, the lightning rod invented by Benjamin Franklin is the best form of protection. And yet, these rods do not always provide optimal protection for sensitive sites. A European consortium consisting of the University of Geneva (UNIGE), École Polytechnique (Paris), EPFL, hes-so and TRUMPF scientific lasers (Munich) has developed a promising alternative: the Laser Lightning Rod or LLR. After testing the LLR on the summit of Säntis (in Switzerland), the researchers now have proof of its feasibility. The rod can deflect lightning over several dozen meters even in poor weather. The results of this research are published in the journal Nature Photonics.

Sandia work at the heart of next generation nuclear reactor

A team of Sandia National Laboratories researchers is testing materials to make the next generation of fusion reactors. This container is used to expose the samples to nuclear fusion. It holds seven samples of innovative tungsten alloys, post exposure.
Photo Credit: Jonathan Coburn

A team of Sandia National Laboratories researchers working on the reactor at the DIII-D National Fusion Facility is testing materials to make the next generation of fusion reactors, in the quest to develop more carbon-free energy sources.

These magnetic confinement fusion reactors, called tokamaks, use magnetic fields to shape plasma into a donut shape that generates power from nuclear fusion. DIII-D is the largest such facility currently operating in the Department of Energy complex. Tokamaks create high heat and particle fluxes that can cause significant erosion of the reactor wall materials. If these materials contaminate the core plasma, it could make it impossible to bring the reactor to a temperature high enough to start stable, safe fusion.

Jonathan Coburn is one such researcher, part of a team of Sandians that collaborates with DIII-D to test and develop much needed specialized fusion materials for the hot fusion plasma environment.

By detecting tiny flashes of heat, scientist pave way for more stable quantum computers

Measuring the heat of a phase slip in a Josephson junction is a significant step forward for quantum thermodynamics toward better quantum technologies.
Photo Credit: Kuan Yen Tan/Aalto University

An international collaboration between quantum scientists resulted in a new way to measure heat dissipation in superconducting quantum circuits – crucial building blocks for quantum technologies such as computers. The discovery represents a step forward for experimental quantum thermodynamics, the field investigating the interaction of the quantum world and heat, and paves the way for improved quantum devices.

As heat sets limits for traditional computing, so it does for quantum computers. Detecting and controlling the heat dissipation of quantum computers is central for developing better and more stable machines. Researchers at Aalto, the Universitét Grenoble Alpes and University of Konstanz worked together to test a theory about heat dissipation in a so-called phase slip in a quantum device. The result was a reliable and efficient way to measure dissipation that could be scaled to cover a range of quantum applications. The discovery was recently published in Nature Physics.

Multi-layered ‘space skin’ can help future satellites and spacecraft harvest energy

Credit: NASA

A 'space skin' could help protect spacecraft and satellites from harsh solar radiation while also harvesting energy for future use in the craft's mission, according to a study from the University of Surrey and Airbus Defense and Space.

The research team has shown that their innovative nano-coating, called the Multifunctional Nanobarrier Structure (MFNS), can reduce the operating temperatures of space-qualified structures from 120°C to 60°C.

Thanks to its custom-built, room temperature application system, researchers were able to show that it is possible to use the MFNS alongside a craft's sensors and advanced composite materials.

Professor Ravi Silva, corresponding author of the study and Director of the Advanced Technology Institute at the University of Surrey, said:

"Space is a wondrous but dangerous place for us humans and other human-made structures. While solutions already on the market offer protection, they are bulky and can be restrictive when it comes to thermal control.

Rapid cognitive decline uncommon in ageing people with HIV on stable treatment

We need to determine whether people with HIV may require additional care as a result of mental and cognitive health changes as they reach their 60s.
Photo Credit: Sabine van Erp

As with all chronic conditions, a focus on cognitive and mental health should be part of ongoing care.

With successful treatment, HIV has become a chronic health condition which can be managed with life-long care.

Treatment reduces the amounts of HIV in the blood to an undetectable level and most people with the infection who take their medication live as long as people without HIV.

While there have been successful developments in treating the virus, it’s important to understand how it may impact the long-term cognitive function of those ageing with HIV.

Associate Professor Lucette Cysique at the School of Psychology, UNSW Sydney, and her team conducted a long-term study of cognitive function in people who are ageing with chronic stable HIV infection, from 17 care facilities across Australia, published in eClinicalMedicine.

Tens of thousands of possible catalysts on the diameter of a hair

The results of the sputtering process can be seen under the light microscope.
Image Credit: © Lars Banko

New methods make it possible to produce countless new materials in one step and to examine them quickly.

When looking for catalysts for the energy transition, materials made from at least five elements are particularly promising. Only there are theoretically millions of them - how do you find the most powerful? A Bochum research team led by Prof. Dr. Alfred Ludwig, head of the Materials Discovery and Interfaces chair, MDI, managed to accommodate all possible combinations of five elements on one carrier in a single step. In addition, the researchers developed a method to analyze the electrocatalytic potential of each of the combinations in this micromaterial library in high throughput. In this way, they want to speed up the search for potential catalysts many times over. The team at the Ruhr University Bochum reports in the journal Advanced Materials.

Controlling quantum states in individual molecules with two-dimensional ferroelectrics

Researchers used electricity to control the internal states of molecules.
Illustration Credit: Jose Lado/Aalto University

Researchers demonstrated how to control the quantum states of individual molecules with an electrically controllable substrate.

Controlling the internal states of quantum systems is one of the biggest challenges in quantum materials. At the deepest level, single molecules can display different quantum states, even while possessing the same number of electrons. These states are associated with different electron configurations, which can lead to dramatically different properties.

The capability of controlling the electronic configuration of single molecules could lead to major developments in both fundamental science and technology. On the one hand, controlling the internal states of molecules may allow for the development of new artificial materials with exotic properties. On the other hand, it might also make possible the ultimate miniaturization of classical computer memories, with the two configurations could make it possible to encode a 0 and a 1 in a classical memory unit at the molecular level. However, controlling the internal states of molecules still remains a challenge, and realistic, scalable strategies for overcoming it have not been proposed.

Excessive bed occupancy in hospitals leads to rising mortality

As shown in a new study by the University of Basel, individual empty beds do not necessarily mean a smaller burden on nursing staff.
Photo Credit: Gorden Murah Surabaya

Researchers have long suspected a link between bed occupancy and mortality in hospitals. Now, a study by the University of Basel has provided the missing data, revealing that smaller hospitals reach their capacity limit much earlier.

Since the outbreak of the coronavirus pandemic, if not before, we’ve got used to seeing figures relating to bed occupancy in Swiss hospitals in media reports. You might think that as long as there are free beds, there’s no problem. Now, a University of Basel study led by Professor Michael Simon has shown that, in some cases, the mortality rate in hospitals rises significantly before full capacity is reached.

For the study, the researchers analyzed data from over 1.1 million inpatient cases at 102 Swiss hospitals in order to investigate the relationship between bed occupancy and the 14-day mortality rate in hospitals. In other words, the cases were observed until the 14-day mark unless they were discharged earlier.

Jet engine lubrication oils are a major source of ultrafine particles

Lubrication oil in the hot exhaust plume of an aircraft engine can form ultrafine particles as soon as the plume cools down. This has now been corroborated in a study by Goethe University Frankfurt and the Hessian Agency for Nature Conservation, Environment and Geology.   
Photo Credit: Alexander Vogel, Goethe University Frankfurt

Measurements conducted by the Hessian Agency for Nature Conservation, Environment and Geology (HLNUG) in recent years have shown that Frankfurt International Airport is a major source of ultrafine particles and that these can disperse over long distances across the city. In collaboration with experts at the HLNUG, researchers at Goethe University Frankfurt have now discovered that ultrafine particles partly consist of synthetic jet oils. The research team has deduced that emissions from lubrication oils must be lowered in addition to those from kerosene in order to reduce the concentration of ultrafine particles and thus improve air quality.

Ultrafine particles form during combustion processes, for example when wood or biomass is burned, as well as in power and industrial plants. Alongside road traffic, large airports are a major source of these ultrafine particles, which are less than 100 millionths of a millimeter (100 nanometers) in size. Because they are so small, they can penetrate deep into the lower respiratory tract, overcome the air-blood barrier and, depending on their composition, cause inflammatory reactions in the tissue, for example. What's more, ultrafine particles are suspected of being capable of triggering cardiovascular diseases.