Chemists Created a Substance with Potential Antitumor Activity

The new antitumor substance was synthesized at Ural Federal University's Scientific-educational and Innovation Center of Chemical and Pharmaceutical Technologies.
Photo Credit: Rodion Narudinov

New compound could be the basis of a drug for tumor cells

Chemists from the Ural Federal University and Volgograd State Medical University have created a compound that suppresses cancer cells. The powerful new substance could become the basis for antitumor drugs because it affects the pathology that leads to the development of malignant tumors, such as cancer of the breast, lung, prostate, and lymph nodes. The substance and the results of the experiments were published in the journal Molecules.

"Type 2 casein kinase (CK2) is known to suppress apoptosis in cells, but increased levels of type 2 casein kinase are observed in tumor cells, indicating that these cells are resistant to apoptosis compared to normal cells. If you block this protein, you can achieve tumor cell death. So, our team managed to develop a universal approach to the synthesis of new azolopyrimidines and obtain a library of corresponding heterocycles as potential inhibitors of casein kinase type 2," explains Grigory Urakov, an Engineer of the Scientific Laboratory of Medical Chemistry and Advanced Organic Materials at UrFU.

Chloroplast from the father

Tobacco seedlings on growth medium with an antibiotic. Plants with exclusively maternally inherited chloroplasts sensitive to the antibiotic are pale. Two seedlings contain green, intact chloroplasts in the leaves (red arrows). These chloroplasts are resistant to the antibiotic and were passed on from the father plant.
Image Credit: MPI-MP

Under cold conditions, not only the mother plant but also the father plant can pass on its chloroplasts to the offspring

Scientists at the Max Planck Institute of Molecular Plant Physiology in Potsdam (Germany) analyzed for the first time the inheritance of chloroplasts under a wide range of environmental conditions. Contrary to the prevailing view that chloroplasts are only passed on by the mother plant, paternal chloroplasts can also be transmitted to the offspring under cold conditions. Maternal and paternal chloroplasts thus meet in the offspring and may be able to exchange genetic material with each other. The new findings may allow plant breeders for the first time to selectively use traits from the genetic material of chloroplasts.

A story of flowers and bees is the classic introduction to a topic that is still discussed far too scarcely in our society: sex in plants! When plants reproduce, the sperms within the pollen grains fuse with the egg cell within the flower the pollen has landed on. In this way, the genetic material of the cell nuclei of both parents is combined in the seed. This is important, as it allows harmful mutations to be purged that otherwise would accumulate in the genetic material over generations.

Speeding up sugar's conversion into fuel

The research has accelerated the production rate and yield of isobutanol from sugar.
Photo Credit: Bishnu Sarangi

University of Queensland researchers have found a way to more efficiently convert sugarcane into a building block of aviation fuel and other products.

By zeroing in on a specific enzyme, a UQ team working in collaboration with the Technical University of Munich (TUM) has sped up the slowest step in processing sugar into a chemical called isobutanol.

Professor Gary Schenk from UQ’s School of Chemistry and Molecular Biosciences said isobutanol from a renewable resource could be used to make fuels, plastics, rubbers and food additives.

“Our research into this particular enzyme means we can accelerate the production rate and yield of isobutanol from sugarcane, ultimately enabling biomanufacturers to make diverse products at scale sustainably and efficiently,” Professor Schenk said.

“Usually during a biomanufacturing process, cells such as yeasts are used as a production platform, but in our research only a small number of a sugar acid-specific dehydratase enzyme was used.

Early humans: Annual cycles in tooth enamel provide insights into life histories

Jülide Kubat and Wolfgang Müller load the LA-ICPMS with a thin section of tooth for analysis.
Photo Credit: Jülide Kubat

An interdisciplinary team of scientists, led by Goethe University Frankfurt and the Senckenberg Research Institute and Natural History Museum Frankfurt, has discovered – by analyzing their teeth – what our ancestors of the species Homo erectus ate hundreds of thousands of years ago on the island of Java in Southeast Asia: over the course of a year, these early humans switched from a plant-based diet to a mixed one, but were far less dependent on seasonal food supply than, for example, orangutans, which also inhabited the island.

If you take a magnifying glass and a torch and look at your teeth very carefully in the mirror, in places you can spot a pattern of fine, parallel lines running across your teeth. These correspond to the striae of Retzius that mark the growth of our tooth enamel. Enamel starts forming in the womb and continues to mineralize until adolescence, when the last milk teeth fall out and are replaced by permanent ones. Like in all land-dwelling vertebrates, tooth enamel mineralizes gradually in microscopically thin layers in humans too, represented by the striae of Retzius. The speed with which a human develops can be read from these Retzius lines. Physiological changes, such as birth, weaning or illness, for example, leave distinctive traces. The striae of Retzius also form the chronological framework for the chemical composition of tooth enamel, which in turn reflects changes in the diet of that individual.

Highly accurate test for common respiratory viruses uses DNA as ‘bait’

Doctor examining a patient
Photo Credit: Thirdman

The test uses DNA ‘nanobait’ to detect the most common respiratory viruses – including influenza, rhinovirus, RSV and COVID-19 – at the same time. In comparison, PCR (polymerase chain reaction) tests, while highly specific and highly accurate, can only test for a single virus at a time and take several hours to return a result.

While many common respiratory viruses have similar symptoms, they require different treatments. By testing for multiple viruses at once, the researchers say their test will ensure patients get the right treatment quickly and could also reduce the unwarranted use of antibiotics.

In addition, the tests can be used in any setting, and can be easily modified to detect different bacteria and viruses, including potential new variants of SARS-CoV-2, the virus which causes COVID-19. The results are reported in the journal Nature Nanotechnology.

The winter cold, flu and RSV season has arrived in the northern hemisphere, and healthcare workers must make quick decisions about treatment when patients show up in their hospital or clinic.

Mucosal antibodies in the airways provide durable protection against SARS-CoV-2

Charlotte Thålin, M.D. and associate professor at the Department of Clinical Sciences, Danderyd Hospital
Photo Credit: Ludvig Kostyal

Researchers hope that a nasal vaccine may generate mucosal immune responses that protect against SARS-CoV-2 infection.

High levels of mucosal IgA antibodies in the airways protect against SARS-CoV-2 infection for at least eight months. Omicron infection generates durable mucosal antibodies, reducing the risk of re-infection. These are the findings of a study published in The Lancet Infectious Diseases by researchers at Karolinska Institutet and Danderyd Hospital in Sweden. The results raise further hope for the feasibility of future nasal vaccine platforms to protect against infection.

“Antibodies in the blood protect from severe disease, but if we aim to limit infection, viral transmission and the emergence of new SARS-CoV-2 variants, we need to reinforce our immunity at the mucosal surface, which is the viral point of entry”, says Charlotte Thålin, M.D. and associate professor at the Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet who led the study. “This is not achieved by currently employed intramuscularly-delivered vaccines. But the hope is that a nasal vaccine may generate mucosal immune responses similar to those seen after infection, and thereby block the transmission chain”.

Deflecting lightning with a laser lightning rod

During tests carried out on the summit of the Säntis by Jean-Pierre Wolf and Aurélien Houard's team, the scientists noted that the discharge could follow the laser beam of the "LLR" for several dozen meters before reaching the tower of the operator Swisscom (in red and white).
Photo Credit: Xavier Ravinet - UNIGE

A European consortium led by UNIGE, École Polytechnique (Paris), EPFL, hes-so and TRUMPF has managed to guide lightning using a high-power laser installed at the top of Mount Säntis in Switzerland.

Forest fires, power cuts and damaged infrastructure…lightning fascinates and destroys in equal measure, causing as many as 24,000 deaths a year worldwide not to mention widespread destruction. Even today, the lightning rod invented by Benjamin Franklin is the best form of protection. And yet, these rods do not always provide optimal protection for sensitive sites. A European consortium consisting of the University of Geneva (UNIGE), École Polytechnique (Paris), EPFL, hes-so and TRUMPF scientific lasers (Munich) has developed a promising alternative: the Laser Lightning Rod or LLR. After testing the LLR on the summit of Säntis (in Switzerland), the researchers now have proof of its feasibility. The rod can deflect lightning over several dozen meters even in poor weather. The results of this research are published in the journal Nature Photonics.

Sandia work at the heart of next generation nuclear reactor

A team of Sandia National Laboratories researchers is testing materials to make the next generation of fusion reactors. This container is used to expose the samples to nuclear fusion. It holds seven samples of innovative tungsten alloys, post exposure.
Photo Credit: Jonathan Coburn

A team of Sandia National Laboratories researchers working on the reactor at the DIII-D National Fusion Facility is testing materials to make the next generation of fusion reactors, in the quest to develop more carbon-free energy sources.

These magnetic confinement fusion reactors, called tokamaks, use magnetic fields to shape plasma into a donut shape that generates power from nuclear fusion. DIII-D is the largest such facility currently operating in the Department of Energy complex. Tokamaks create high heat and particle fluxes that can cause significant erosion of the reactor wall materials. If these materials contaminate the core plasma, it could make it impossible to bring the reactor to a temperature high enough to start stable, safe fusion.

Jonathan Coburn is one such researcher, part of a team of Sandians that collaborates with DIII-D to test and develop much needed specialized fusion materials for the hot fusion plasma environment.

By detecting tiny flashes of heat, scientist pave way for more stable quantum computers

Measuring the heat of a phase slip in a Josephson junction is a significant step forward for quantum thermodynamics toward better quantum technologies.
Photo Credit: Kuan Yen Tan/Aalto University

An international collaboration between quantum scientists resulted in a new way to measure heat dissipation in superconducting quantum circuits – crucial building blocks for quantum technologies such as computers. The discovery represents a step forward for experimental quantum thermodynamics, the field investigating the interaction of the quantum world and heat, and paves the way for improved quantum devices.

As heat sets limits for traditional computing, so it does for quantum computers. Detecting and controlling the heat dissipation of quantum computers is central for developing better and more stable machines. Researchers at Aalto, the Universitét Grenoble Alpes and University of Konstanz worked together to test a theory about heat dissipation in a so-called phase slip in a quantum device. The result was a reliable and efficient way to measure dissipation that could be scaled to cover a range of quantum applications. The discovery was recently published in Nature Physics.

Multi-layered ‘space skin’ can help future satellites and spacecraft harvest energy

Credit: NASA

A 'space skin' could help protect spacecraft and satellites from harsh solar radiation while also harvesting energy for future use in the craft's mission, according to a study from the University of Surrey and Airbus Defense and Space.

The research team has shown that their innovative nano-coating, called the Multifunctional Nanobarrier Structure (MFNS), can reduce the operating temperatures of space-qualified structures from 120°C to 60°C.

Thanks to its custom-built, room temperature application system, researchers were able to show that it is possible to use the MFNS alongside a craft's sensors and advanced composite materials.

Professor Ravi Silva, corresponding author of the study and Director of the Advanced Technology Institute at the University of Surrey, said:

"Space is a wondrous but dangerous place for us humans and other human-made structures. While solutions already on the market offer protection, they are bulky and can be restrictive when it comes to thermal control.