Fluctuating blood pressure: a warning sign for dementia and heart disease

Photo Credit: CDC

A new study by Australian researchers has shown that fluctuating blood pressure can increase the risk of dementia and vascular problems in older people.

Short blood pressure (BP) fluctuations within 24 hours as well as over several days or weeks are linked with impaired cognition, say University of South Australia (UniSA) researchers who led the study.

Higher systolic BP variations (the top number that measures the pressure in arteries when a heart beats) are also linked with stiffening of the arteries, associated with heart disease.

The findings have been published in the journal Cerebral Circulation – Cognition and Behavior.

Lead author Daria Gutteridge, a PhD candidate based in UniSA’s Cognitive Ageing and Impairment Neuroscience Laboratory (CAIN), says it’s well known that high blood pressure is a risk factor for dementia, but little attention is paid to fluctuating blood pressure.

“Clinical treatments focus on hypertension, while ignoring the variability of blood pressure,” Gutteridge says.

Early farmers on the Baltic coast bucked New Stone Age trends and incorporated fish into their diets

Early Neolithic bog pot from Olvig Mose and wooden spoon from Tømmerup in Åmosen, Denmark Photo Credit: Arnold Mikkelsen, The National Museum of Denmark
(CC BY-SA 4.0 DEED)

Pioneering early farmers who arrived on the Baltic coast from six thousand years-ago may have taken up fishing after observing indigenous hunter-gatherer communities, a major new study has found.

Previous studies of prehistoric cooking pots in areas including Britain, Spain, France and Portugal have indicated that people completely stopped cooking fish once they started farming crops and animals, even in coastal areas.

In stark contrast, the new research, led by academics at the University of York in collaboration with the British Museum, has found that farmers who arrived on Northern Europe’s Baltic coast adopted a mixed diet which embraced both fish and domesticated animal products. 

The researchers say their study, which looked at fats preserved in fragments from more than a thousand prehistoric vessels uncovered in the coastal area stretching from western Denmark to southern Finland, suggests there may have been close cooperation and interaction between new arrivals and local forager communities.

Scientists discover a key molecular interaction in bacterial pathogens, opening the door for new treatment strategies

A science lab at UNLV.
Photo Credit: Josh Hawkins / University of Nevada, Las Vegas

The legendary Alexander Fleming, who famously discovered penicillin, once said “never to neglect an extraordinary appearance or happening.” And the path of science often leads to just that. New UNLV research is turning the page in our understanding of harmful bacteria and how they turn on certain genes, causing disease in our bodies.

A team of interdisciplinary scientists, led by professor and microbiologist Helen Wing, focuses on Shigella – a lethal bacterial pathogen that causes abdominal cramping, fever, and diarrhea. The Centers for Disease Control and Prevention estimates that Shigella cases lead to 600,000 deaths globally each year.

Shigella contains a major ‘switch’ protein (VirB), which triggers the bacterium to cause disease in humans. VirB does this by binding to Shigella’s DNA, activating the disease. The researchers showed that it is possible that interfering with VirB’s binding process can prevent Shigella from making us sick.

Ice sheet surface melt is accelerating in Greenland and slowing in Antarctic

Greenland is dotted with frozen meltwater lakes such as the one above, photographed during a NASA expedition in 2012. UCI Earth system scientists led a study into the role of warm, dry, downslope winds in accelerating thawing of the Greenland ice sheet. As part of the same project, the researchers found a contrasting outcome at the other end of the globe: less wind-driven melting in Antarctica.
Photo CXredit: NASA Operation IceBridge

Surface ice in Greenland has been melting at an increasing rate in recent decades, while the trend in Antarctica has moved in the opposite direction, according to researchers at the University of California, Irvine and Utrecht University in the Netherlands.

For a paper published recently in the American Geophysical Union journal Geophysical Research Letters, the scientists studied the role of Foehn and katabatic winds, downslope gusts that bring warm, dry air into contact with the tops of glaciers. They said that melting of the Greenland ice sheet related to these winds has gone up by more than 10 percent in the past 20 years; the impact of the winds on the Antarctic ice sheet has decreased by 32 percent.

“We used regional climate model simulations to study ice sheets in Greenland and Antarctica, and the results showed that downslope winds are responsible for a significant amount of surface melt of the ice sheets in both regions,” said co-author Charlie Zender, UCI professor of Earth system science. “Surface melt leads to runoff and ice shelf hydrofracture that increase freshwater flow to oceans – causing sea level rise.”

Genomic analysis in snakes shows link between neutral, functional genetic diversity

Eastern massasauga rattlesnake.
Photo Credit: Scott Martin

In the world of threatened and endangered species conservation, the genomic revolution has raised some complicated questions: How can scientists justify assessing species genetic diversity without consulting entire genomes now that they can be sequenced? But then again, how can scientists justify the time and expense of genome sequencing when age-old measures of neutral genetic diversity are much cheaper and easier to obtain?

A new study suggests making a transition from “old school” genetics to “new school” genomics for species conservation purposes probably isn’t necessary in all cases.

Researchers found the functional genetic diversity they detected by analyzing gene variations in fully sequenced genomes of 90 Eastern massasauga rattlesnakes correlated nicely with the neutral genetic diversity seen across broad sections of those same genomes containing no protein-coding genes – similar to the type of genetic material historically used to assess genetic diversity. 

“If we’re worried about the genetic health of populations, neutral diversity can give us a pretty good answer, as has long been argued. We have directly tested that for this species,” said H. Lisle Gibbs, professor of evolution, ecology and organismal biology at The Ohio State University and senior author of the study. 

Single cell genomics reveal key cell factor for dangerous identity loss in tumor cells

Maxim Frolov, professor of biochemistry and molecular genetics.
Photo: Jenny Fontaine/University of Illinois Chicago

When proliferating cells reach their mature form as part of the eye, kidney or blood, they typically differentiate and stop dividing. But in some cases, genetic errors cause these cells to turn back the clock and dedifferentiate — losing their final identity and regaining the ability to proliferate. This phenomenon can result in tumors, and pathologists often use the extent of dedifferentiation to assess the aggressiveness of a cancer. 

In a new paper published by Developmental Cell, UIC researchers used single-cell genomics to identify a key factor in this process. By carefully examining how two tumor suppressor pathways interact in the eye of the fruit fly, a team led by Maxim Frolov pinpointed the cellular elements responsible for dedifferentiation. 

Single-cell genomics is a laboratory method that allows researchers to measure the DNA and RNA from just one cell, instead of collectively across many cells in a sample. In 2018, Frolov’s group was the first at UIC to publish a study that used single-cell genomics to systematically identify cell types in a heterogeneous tissue based on gene expression.  

With a Proton Pump to More Growth

phytoplankton
Public Domain

An international research team with participation from Würzburg has discovered how algae compensate for nutrient deficiencies. Their discovery could help counteract the negative effects of climate change.

One of the building blocks of ocean life can adapt to cope with the effects of climate change, according to new research led by the University of East Anglia (UEA). The discovery holds promises for biotechnology developments that could counter the negative effects of changing environmental conditions, such as ocean warming and even the reduction in the productivity of crops.

Corresponding authors of the study, now published in the journal Nature Microbiology, are Thomas Mock, Professor of Marine Microbiology in the School of Environmental Sciences at UEA, and his former PhD student Dr. Jan Strauss. At Julius-Maximilians-Universität Würzburg (JMU), Professor Georg Nagel and Dr. Shiqiang Gao from the Department of Neurophysiology at the Institute of Physiology were involved.

Lockheed Martin's Next Generation Interceptor Program Advances Through Major Design Milestone

Lockheed Martin NGI Artist rendering of NGI.
Illustration Credit: Lockheed Martin

Lockheed Martin's Next Generation Interceptor (NGI) program executed its digital All Up Round (AUR) Preliminary Design Review (PDR), in partnership with the Missile Defense Agency (MDA), on September 29. The company remains on-plan to deliver NGI on an accelerated schedule for the warfighter.

NGI is part of the MDA's Ground-based Midcourse Defense (GMD) system and will provide a new, advanced interceptor to protect the homeland against long range ballistic missile threats from rogue nations. During this review, the MDA assessed the NGI program's readiness and maturity to continue into the detailed design phase, confirming that Lockheed Martin's solution continues to meet requirements for the mission.

"I am proud of our team's commitment to innovating with urgency to achieve expectations for this phase of the program," said Sarah Hiza, vice president and general manager of Strategic and Missile Defense at Lockheed Martin. "With this additional confidence in our NGI design through a week-long digital review with our MDA customer, we are on track to deliver the right solution to meet the needs of the nation."

Mimicking a Bird’s Sticky Spit to Create Cellulose Gels

Photo Credit: TheOtherKev

Using a small bird’s nest-making process as a model, researchers from North Carolina State University have developed a nontoxic process for making cellulose gels. The freeze-thaw process is simple, cost-effective, and can create cellulose gels that are useful in a number of applications, including tunable gels for timed drug delivery. The process also works with bamboo and potentially other lignin-containing plant fibers.

Cellulose is a wonderful material for making hydrogels – which are used in applications ranging from contact lenses to wound care and drug delivery. But creating hydrogels from cellulose is tricky, and often the processes used to create the hydrogels are themselves toxic.

“Normally, you have to first dissolve the cellulose and then induce it to crosslink or form the structure of interest, which often requires the use of difficult to handle, unstable, or toxic solvents,” says Lucian Lucia, professor of forest biomaterials and chemistry at NC State and co-corresponding author of the work.

Enter the Swift family of birds – small birds who use their saliva to hold twigs in place when building their nests.

New Biomarker Predicts Whether Neurons Will Regenerate

Neurons, shown here in red and yellow, are some of the slowest cells to regenerate after injury. In this section of a mouse brain, yellow neurons are regenerating while red neurons are non-regenerating.
Image Credit: Courtesy of University of California San Diego

Findings could help scientists develop regenerative therapies for spinal cord injuries and other neurological conditions

Neurons, the main cells that make up our brain and spinal cord, are among the slowest cells to regenerate after an injury, and many neurons fail to regenerate entirely. While scientists have made progress in understanding neuronal regeneration, it remains unknown why some neurons regenerate and others do not. 

Using single-cell RNA sequencing, a method that determines which genes are activated in individual cells, researchers from University of California San Diego School of Medicine have identified a new biomarker that can be used to predict whether or not neurons will regenerate after an injury. Testing their discovery in mice, they found that the biomarker was consistently reliable in neurons across the nervous system and at different developmental stages. The study was published October 16, 2023 in the journal Neuron.