Possible breakthrough in the development of effective biomaterials

Professor Dr. Shikha Dhiman from the Department of Chemistry of JGU
Photo Credit: © Ankit Sakhuja

When model cell membranes bind to biomaterials, it is not the binding strength but the speed of the receptors in the membranes that is crucial

Many hopes rested on so-called tissue engineering: With the help of stem cells, skin and other organs could be grown, thereby enabling better wound healing and better transplants. Although some of this is already a reality, the level expected around 20 years ago has not yet been achieved because the stem cells do not always bind to the required host material as they should in theory. An international research team led by chemist Professor Shikha Dhiman from Johannes Gutenberg University Mainz (JGU) has now found the reason for this: "Whether an interaction between model cell membrane and matrix material occurs depends not only on the strength of the interaction but also on the speed at which the binding partner molecules move. The understanding of this interaction that we have now gained is crucial for the development of effective biomaterials," says Dhiman. The team's results were recently published in the renowned scientific journal PNAS.

Decoding the selfish gene, from evolutionary cheaters to disease control

Malaysian stalk-eyed fly (Teleopsis dalmanni).
Photo Credit: Paul Richards

New research is shining a light on one of genetics’ enduring puzzles - how the workings of the so-called “selfish gene” could be harnessed to control harmful insect populations.

Scientists from the University of Sheffield have uncovered how to potentially control harmful insect populations by studying a "selfish gene" that manipulates inheritance

The new research focuses on meiotic drive, a process where a selfish gene gives itself a better chance of being passed on to the next generation, disrupting the normal 50/50 inheritance pattern

By studying the Malaysian stalk-eyed fly, researchers discovered that a selfish gene can damage rival sperm carrying a Y chromosome, leading to a population with far more females than males

Understanding this genetic mechanism could provide a new way to control insects that spread disease and cause food shortages by causing their populations to become unsustainably female-biased

Light-powered motor fits inside a strand of hair

The second gear from the right has an optical metamaterial that react to laserlight and makes the gear move. All gears are made in silica directly on a chip. Each gear is about 0.016 mm in diameter.
Photo Credit: Gan Wang

Researchers at the University of Gothenburg have made light-powered gears on a micrometer scale. This paves the way for the smallest on-chip motors in history, which can fit inside a strand of hair.

Gears are everywhere – from clocks and cars to robots and wind turbines. For more than 30 years, researchers have been trying to create even smaller gears in order to construct micro-engines. But progress stalled at 0.1 millimeters, as it was not possible to build the drive trains needed to make them move any smaller.

Researchers from Gothenburg University, among others, have now broken through this barrier by ditching traditional mechanical drive trains and instead using laser light to set the gears in motion directly.

Wolf protection downgrade highlights need for adaptive conservation frameworks

The protected category means greater flexibility in managing wolf populations
Photo Credit: Marcel Langthim

Following the European Parliament’s historic vote to move wolves from the strictly protected to protected category, experts are calling on policymakers to ensure the change becomes a catalyst for fairer, more adaptive and transparent wildlife management to meet the challenges of successful species recovery.

The protected category means greater flexibility in managing wolf populations

The reclassification reflects a remarkable recovery of the wolf population, having increased by 58% in a decade, with populations of brown bears, lynxes and wolverines also on the rise. 

The protected category affords member states greater flexibility in managing expanding wolf populations, but although protections remain in place, the move has raised fears among conservation groups of widespread culling. 

At the same time, farming and hunting communities and landowner associations see it as necessary to regulate the population and enable management that is adapted to local conditions. 

Shining a light on germs

Microbe hunters: Empa researchers Paula Bürgisser and Giacomo Reina from the Nanomaterials in Health laboratory in St. Gallen.
Photo Credit: Empa

Light on – bacteria dead. Disinfecting surfaces could be as simple as that. To turn this idea into a weapon against antibiotic-resistant germs, Empa researchers are developing a coating whose germicidal effect can be activated by infrared light. The plastic coating is also skin-friendly and environmentally friendly. A first application is currently being implemented for dentistry.

Antibiotic-resistant bacteria and emerging viruses are a rapidly increasing threat to the global healthcare system. Around 5 million deaths each year are linked to antibiotic-resistant germs, and more than 20 million people died during the COVID-19 virus pandemic. Empa researchers are therefore working on new, urgently needed strategies to combat such pathogens. One of the goals is to prevent the spread of resistant pathogens and novel viruses with smart materials and technologies.

Surfaces that come into constant contact with infectious agents, such as door handles in hospitals or equipment and infrastructure in operating theaters, are a particularly suitable area of application for such materials. An interdisciplinary team from three Empa laboratories, together with the Czech Palacký University in Olomouc, has now developed an environmentally friendly and biocompatible metal-free surface coating that reliably kills germs. The highlight: The effect can be reactivated again and again by exposing it to light.

Researchers Uncover a Major Shift in U.S. Landscape: ‘Wild’ Disturbances Are Overtaking Human-directed Changes

Disturbances like hurricanes and fires reshape the landscape and play vital roles in Earth’s systems, therefore, understanding what drives these kinds of disturbances is important for projecting what changes may be ahead.
Photo Credit: Malachi Brooks

If it feels like headlines reporting 100 or 1,000-year floods and mega fires seem more frequent these days, it’s not your imagination.

A project led by researchers from UConn’s Global Environmental Remote Sensing (GERS) Lab has yielded surprising insights into land disturbances and disasters in the United States since the late 1980s, including a shift in what drives those disturbances, and how they are increasing with frightening intensity and frequency. Their findings are published in Nature Geoscience.

The research is the result of a decade-long project to perform a CONterminous United States (CONUS)-wide disturbance agent classification and mapping project, explains GERS Director and Associate Professor in the Department of Natural Resources and the Environment in the College of Agriculture, Health and Natural Resources (CAHNR) Zhe Zhu. The ambitious project involved the careful analysis of Landsat satellite data spanning more than 40 years.

Disturbances like hurricanes and fires reshape the landscape and play vital roles in Earth’s systems; therefore, understanding what drives these kinds of disturbances is important for projecting what changes may be ahead.

Cosmic glass found only in Australia reveals ancient asteroid impact

The newly discovered tektites or ‘cosmic glass’.
Photo Credit: Et al. ‘Earth and Planetary Science Letters’

Curtin researchers have helped uncover evidence of a mysterious giant asteroid impact, hidden not in a crater but in tiny pieces of glass found only in Australia.

The discovery centers on rare tektites, which are natural glasses created when a space rock slams into Earth, melting surface material and hurling it hundreds or even thousands of kilometers. The newly discovered type of tektites has so far been found exclusively in an area mainly within South Australia.

Co-author Professor Fred Jourdan, from Curtin’s School of Earth and Planetary Sciences, said finding a new tektite field is like opening a fresh chapter in Earth’s violent geological past.

“These glasses are unique to Australia and have recorded an ancient impact event we did not even know about,” Professor Jourdan said.

Methane production may increase as Arctic lakes warm

 

Fältarbete vid sjöar nära Abisko naturvetenskapliga station.
Photo Credit: Sofia Kjellman

A warmer and wetter climate makes lakes more productive – which in turn leads to more methane being released from sediments. A new study involving Umeå University shows that Arctic lakes may contribute even more to the greenhouse effect in the future.

Methane is more than 25 times stronger as a greenhouse gas than carbon dioxide. Arctic lakes account for a significant share of global methane emissions, but until now, knowledge about the processes in northern lakes has been limited. An international team of researchers from Norway, Sweden and Spain has now shown that methane production varies greatly between lakes and is closely linked to their characteristics.

The researchers investigated ten lakes on Svalbard and in the subarctic region of Scandinavia, three of them via the Abisko Scientific Research Station. They found that most methane production occurs in the top ten centimeters of lake sediments, where there is abundant organic matter and favorable conditions for microbes.

Sandia team creates X-ray images of the future

Courtney Sovinec examines the multi-patterned target used to create a new type of X-ray image at Sandia National Laboratories.
Photo Credit: Vince Gasparich

When German physicist Wilhelm Röntgen discovered X-rays in the late 1800s while experimenting with cathode ray tubes, it was a breakthrough that transformed science and medicine. So much so that the basic concept remains in use today. But a team of researchers at Sandia National Laboratories believes they’ve found a better way, harnessing different metals and the colors of light they emit.

“It’s called colorized hyperspectral X-ray imaging with multi-metal targets, or CHXI MMT for short,” said project lead Edward Jimenez, an optical engineer. Jimenez has been working with materials scientist Noelle Collins and electronics engineer Courtney Sovinec to create X-rays of the future.

“With this new technology, we are essentially going from the old way, which is black and white, to a whole new colored world where we can better identify materials and defects of interest,” Collins said.

The team found they could achieve this using tiny, patterned samples of varied metals such as tungsten, molybdenum, gold, samarium and silver.

Stronger together: a new fusion protein boosts cancer immunotherapy

An immune cell (small, orange) attacking a cancer cell (large, dark red).
Image Credit: M Oeggerli (Micronaut 2019), M P Trefny, and A Zippelius, Translational Oncology, University Hospital Basel, supported by Pathology University Hospital Basel, and Bio-EM Lab, Biozentrum, University of Basel

A newly developed molecule brings together two powerful immunotherapy strategies in one treatment. Researchers at the University of Basel and University Hospital Basel have demonstrated that this fusion protein can both block the “do not attack” signal used by cancer cells and selectively activate tumor-fighting immune cells. This dual action could pave the way for more effective cancer therapies with fewer side effects.

Back in the early 1980s, Linda Taylor, just 33 years old, was diagnosed with advanced skin cancer and faced a grim prognosis. Luckily, she met Dr. Stephen Rosenberg from the National Cancer Institute in Bethesda, Maryland, who treated her with an experimental approach harnessing the body’s own immune system to fight the disease. In 1984, Taylor became the first patient ever to be cured through immunotherapy – a groundbreaking case that forever changed the landscape of cancer treatment.

That pioneering therapy relied on interleukin-2 (IL-2), a signaling molecule that activates many types of immune cells to attack tumors. IL-2 later became the first immunotherapy approved by the U.S. Food and Drug Administration (FDA). However, while effective, IL-2 therapy often causes severe side effects and can also stimulate regulatory T cells, which dampen the immune response instead of boosting it.